Interactions on record — worth a quick check against your medications. Based on 2 of 9 ingredients. Check your meds →
Dietary supplement

Bio.Me Barrier Ingredients & Drug Interactions

by Invivo

Bio.Me Barrier label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio.Me Barrier against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bio.Me Barrier is a dietary supplement by Invivo with 9 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. bifidum W23, L. acidophilus W-37. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bio.Me Barrier by Invivo

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio.Me Barrier by Invivo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio.Me Barrier by Invivo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Ecologic Barrier Probiotics” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Bio.Me Barrier contains 9 active ingredients — all live probiotic bacteria. The ones we can describe are Bifidobacterium bifidum and Lactobacillus acidophilus, along with several Lactobacillus and Bifidobacterium strains (L. brevis, L. casei, L. salivarius, B. lactis, and L. lactis variants) for which we do not hold detailed data.

Each strain is designed to support your gut barrier function. The capsule itself is an inactive ingredient — a shell to hold the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Gut-brain microbiome health with clinically researched probiotics.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

Bifidobacterium bifidum is rated possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections. We don't have enough evidence to rate it for hay fever, Alzheimer disease, or generalized anxiety disorder.

Lactobacillus acidophilus is rated possibly effective for IBS, H. pylori (a stomach bacteria), antibiotic-related diarrhea, and bacterial vaginosis, but appears ineffective for atopic disease (eczema, asthma, allergies). We do not have established effectiveness ratings for the other bacterial strains in this product.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bifidobacterium bifidum and Lactobacillus acidophilus are generally well tolerated in healthy people. Those with weakened immune systems should be cautious and talk with their doctor first.

Gastrointestinal side effects like bloating, flatulence, and abdominal discomfort can occur with probiotic combinations, though these are uncommon. Very rare cases of serious infection (sepsis, endocarditis) have been reported with L. acidophilus in severely ill patients, but these are not typical.

Pregnancy is rated possibly safe for both strains; breastfeeding data is not on file. Check with your doctor before use if you're pregnant, nursing, or have a weakened immune system.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotic medications before starting this product — both Bifidobacterium bifidum and Lactobacillus acidophilus can lose effectiveness if taken at the same time. Your pharmacist can help you space them correctly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bio.Me Barrier may help if you have IBS or need to rebuild gut bacteria — especially during or after antibiotic treatment. The key is timing: separate your antibiotics from this probiotic by several hours so the antibiotic doesn't kill the live organisms.

Talk to your pharmacist or doctor about the right schedule for your medications, and mention if you have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio.Me Barrier, straight from the product label.

Brand Invivo
Barcode (UPC) 7105353660376
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259869
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio.Me Barrier by Invivo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
7105353660376
IngredientAmount% DV
Ecologic Barrier Probiotics0 NP--
L. brevis W630 NP--
L. casei W560 NP--
L. salivarius W240 NP--
B. bifidum W230 NP--
B. lactis W-510 NP--
B. lactis W-520 NP--
L. acidophilus W-370 NP--
L. lactis W-190 NP--
L. lactis W-580 NP--

Other ingredients: Probioact, Capsule Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formula

Clinically researched probiotics for the gut-brain microbiome

Formulation

GMO-free Gluten-free

Vegetarian

Storage

Shelf-stable

Store in the original packaging, at room temperature, in a dry place.

Suggested/Recommended/Usage/Directions

Directions: Take 3 capsules daily with water, on an empty stomach. Do not exceed the recommended dose, unless advised by your healthcare professional. When taking antibiotics, wait 2-3 hours before using Bio.Me Barrier.

Precautions

Do not use if immunocompromised or allergic to any of the ingredients.

Food supplements are not a substitute for a varied and balanced diet or lifestyle.

Keep out of reach of children.

Seals/Symbols

Probioact Technology

Certified B Corporation

Carbon Neutral

GMP Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio.Me Barrier by Invivo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio.Me Barrier label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio.Me Barrier by Invivo

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ecologic Barrier Probiotics

0 NP per serving
  • › L. brevis W63
  • › L. casei W56
  • › L. salivarius W24
  • › B. bifidum W23
  • › B. lactis W-51
  • › B. lactis W-52
  • › L. acidophilus W-37
  • › L. lactis W-19
  • › L. lactis W-58

Other (inactive) ingredients: Probioact, Capsule Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio.Me Barrier by Invivo Drug Interactions

Want to check YOUR meds against Bio.Me Barrier?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

B. bifidum W23 182
L. acidophilus W-37 182

Individual Drug Interactions

The ingredients in Bio.Me Barrier interact with 182 drugs. Click any drug to see the details.

2 of the 9 ingredients in Bio.Me Barrier interact with drugs. Each result below shows which ingredient is responsible. B. bifidum W23 L. acidophilus W-37

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio.Me Barrier with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

B. bifidum W231 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum W23 full monograph & interactions

L. acidophilus W-371 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus W-37 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio.Me Barrier, from the product label.

Invivo

See all Invivo products
Name
Invivo Healthcare
State
UK
ZipCode
GL5 2TE
Web Address
invivohealthcare.com
Pharmacist Counseling Corner

Bio.Me Barrier by Invivo: Common Questions

Does Bio.Me Barrier by Invivo interact with any medications?
Yes. Based on its ingredients, Bio.Me Barrier has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio.Me Barrier contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Bio.Me Barrier while I'm on antibiotics?
You can take them together, but not at the same time. Antibiotics kill the live bacteria in this probiotic, which defeats the purpose. Ask your pharmacist to help you stagger the doses — usually several hours apart works well. Many people take their antibiotic in the morning and the probiotic in the evening.
Does this probiotic actually work for IBS?
Both Bifidobacterium bifidum and Lactobacillus acidophilus in this product are rated possibly effective for IBS based on the evidence we hold. That means there's some support for it, but results vary person to person — it's not a guarantee.
What side effects should I watch for?
Bloating, gas, and abdominal discomfort are the most common, especially when you first start. These are usually mild and temporary. Vomiting and fever have been reported very rarely. If you develop a rash or any serious symptoms, contact your doctor or pharmacist.
Is Bio.Me Barrier safe to take while I'm pregnant?
Bifidobacterium bifidum and Lactobacillus acidophilus are both rated possibly safe in pregnancy based on the data we hold, but evidence is limited. Talk with your doctor before starting it — they can weigh the benefits for your specific situation.
Can I take this if my immune system is weak?
You should be cautious and check with your doctor first. The safety data advises caution for people with weakened immune systems because live probiotics carry a small risk in that population. Your doctor can tell you if it's right for you.
What bacteria are actually in this product?
It contains 9 bacterial strains: Bifidobacterium bifidum, Lactobacillus acidophilus, L. brevis, L. casei, L. salivarius, two types of B. lactis, and two types of L. lactis. We have detailed safety and effectiveness data for the first two; the others we could not fully check.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bio.Me Barrier is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio.Me Barrier label
Go deeper

The Full Monographs Behind Bio.Me Barrier’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Bio.Me Barrier's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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