Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Biome-xym Ingredients & Drug Interactions

by U.S. Enzymes

Biome-xym label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biome-xym against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Biome-xym is a dietary supplement by U.S. Enzymes with 6 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 627 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ginseng Root Extract, Astragalus Root Extract, Sodium Calcium Aluminosilicate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Biome-xym by U.S. Enzymes

Ask about any prescription or over-the-counter medication and we check it for interactions with Biome-xym by U.S. Enzymes — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Biome-xym by U.S. Enzymes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 17 active ingredients.
  • “Probiotic Bacteria Blend” is a proprietary blend — the label gives one combined amount (273.48 mg) without saying how much of each component you get.
  • “Proprietary AstraZyme Blend” is a proprietary blend — the label gives one combined amount (150 mg) without saying how much of each component you get.

Biome-xym contains 17 active ingredients: probiotic bacteria (live beneficial microorganisms including Lactobacillus and Bifidobacterium species, Bacillus subtilis, Saccharomyces boulardii yeast, and Lactococcus lactis), two proteolytic enzymes (Protease I and II, which break down proteins), Astragalus Root Extract, and Ginseng Root Extract. The product also includes inactive excipients—inulin, rice extract, LactoStim, hydroxypropyl methylcellulose, gellan gum, and water—which serve as fillers and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Diarrhea, Constipation, Crohn disease, Cystic fibrosis — and 4 related terms.
  • The strongest evidence on file: Sodium is rated "Likely Effective" for Cystic fibrosis (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea, Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS).

Evidence exists for several of the probiotic strains here. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea.

Saccharomyces boulardii is possibly effective for rotaviral diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, necrotizing enterocolitis, Clostridioides difficile infection, and Helicobacter pylori. For most other conditions listed (hay fever, anxiety, cognitive decline, asthma, and athletic performance), the evidence is insufficient to rate these strains.

We hold no effectiveness ratings for the proteolytic enzymes, Astragalus, or Ginseng in the data on file.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum Bifidobacterium Longum Bacillus Subtilis Lactobacillus Gasseri Saccharomyces Boulardii Proteolytic Enzymes (proteases) Astragalus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotic bacteria are generally well tolerated in healthy people, though those with weakened immune systems should be cautious—rare cases of bacterial infection (bacteremia or sepsis) have occurred in critically ill patients. Gastrointestinal side effects like bloating, flatulence, and abdominal discomfort are uncommon but possible with probiotic use.

Saccharomyces boulardii should be avoided by critically ill or immunocompromised people, as fungemia (a yeast infection in the bloodstream) has been rarely reported. The proteolytic enzymes may cause digestive upset or allergic reactions; occupational exposure to airborne protease has caused allergic rhinitis and asthma in rare cases.

Astragalus is generally well tolerated short-term in healthy adults but has limited human safety data; it should be avoided during pregnancy and breastfeeding. Sodium Calcium Aluminosilicate contributes dietary sodium—too much sodium is linked to high blood pressure and heart strain, so avoid sodium supplements or very high intake without medical advice.

Pregnancy and breastfeeding safety data are not on file for most of these ingredients; consult your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum Bifidobacterium Longum Bacillus Subtilis Lactobacillus Gasseri Saccharomyces Boulardii Proteolytic Enzymes (proteases) Astragalus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 9 of the 10 matched ingredients can interact with medications — Saccharomyces Boulardii, Lactobacillus Acidophilus, Astragalus, American Ginseng, Sodium, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 627 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Biome-xym, check with your pharmacist if you use antibiotics (space them apart), immunosuppressants, lithium, cyclophosphamide, antidiabetes drugs, antifungals, antihypertensive drugs, corticosteroids, didanosine, sodium phosphates, tolvaptan, or other sodium-containing medications. These are the drug types most affected by ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Biome-xym is a multi-strain probiotic with enzymes and herbal extracts, possibly effective for IBS, travelers' diarrhea, and some infections—but it interacts with antibiotics, immune-suppressing drugs, lithium, blood pressure medications, and sodium-containing products. If you take any prescription medication, especially antibiotics, immunosuppressants, or mood stabilizers, check with your pharmacist before starting.

Those with compromised immune systems should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biome-xym, straight from the product label.

Brand U.S. Enzymes
Barcode (UPC) 819242002709
Net contents 62 Delayed Release Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336285
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biome-xym by U.S. Enzymes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
31
UPC/BARCODE
819242002709
IngredientAmount% DV
Lactobacillus salivarius0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--
Lactobacillus casei0 NP--
Lactobacillus rhamnosus0 NP--
{Bifidobacterium} infantis0 NP--
Bifidobacterium longum0 NP--
Bacillus subtilis0 NP--
Lactobacillus gasseri0 NP--
Protease I0 NP--
Protease II0 NP--
Astragalus Root Extract0 NP--
Lactococcus lactis0 NP--
Probiotic Bacteria Blend273.48 mg--
Saccharomyces boulardii0 NP--
Ginseng Root Extract0 NP--
Proprietary AstraZyme Blend150 mg--
Sodium Calcium Aluminosilicate0 NP--

Other ingredients: Inulin, Rice extract, LactoStim, Hydroxypropyl Methylcellulose, Gellan Gum, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Available only through Healthcare practitioners

Formula

BIOME-XYM contains twelve compatible species of probiotic bacteria from five different genera for a total of 50 billion CFU (Colony Forming Units). AstraZyme provides important co-factors and LactoStim provides patented prebiotic activation.

50 Billion CFU per serving

Formulation

Biome-xym provides microbial diversity in the gut microbiome and supports overall digestive and immune health.

Probiotic Blend Supports digestive and immune health Promotes a balanced microbiome

This product is NON-GMO, NON-Dairy, Non-Soy and contains no fillers or preservatives.

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules on an empty stomach at bedtime with 8 ounces of water.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

AstraZyme is a registered trademark of ERCC, INC.

FDA Statement of Identity

Intestinal Support Supplement

Storage

This product does not require refrigeration.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biome-xym by U.S. Enzymes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biome-xym label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biome-xym by U.S. Enzymes

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container31 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Probiotic Bacteria Blend

Interacts with
182 drugs
273.48 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Bacteria Blend monograph & interactions

Proprietary AstraZyme Blend

150 mg per serving

Other (inactive) ingredients: Inulin, Rice extract, LactoStim, Hydroxypropyl Methylcellulose, Gellan Gum, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biome-xym by U.S. Enzymes Drug Interactions

Want to check YOUR meds against Biome-xym?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
627Drugs
2 Major 585 Moderate 40 Minor

Ingredients driving the most interactions

Ginseng Root Extract 217
Astragalus Root Extract 208
Sodium Calcium Aluminosilicate 205
Probiotic Bacteria Blend 182

Individual Drug Interactions

The ingredients in Biome-xym interact with 627 drugs. Click any drug to see the details.

4 of the 6 ingredients in Biome-xym interact with drugs. Each result below shows which ingredient is responsible. Ginseng Root Extract Astragalus Root Extract Sodium Calcium Aluminosilicate Probiotic Bacteria Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Biome-xym with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginseng Root Extract4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
Ginseng Root Extract full monograph & interactions

Astragalus Root Extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus Root Extract full monograph & interactions

Sodium Calcium Aluminosilicate7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Calcium Aluminosilicate full monograph & interactions

Probiotic Bacteria Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Bacteria Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biome-xym, from the product label.

U.S. Enzymes

See all U.S. Enzymes products
Name
Master Supplements, Inc.
City
Victoria
State
MN
ZipCode
55386
Phone Number
800 926-2961
Pharmacist Counseling Corner

Biome-xym by U.S. Enzymes: Common Questions

Does Biome-xym by U.S. Enzymes interact with any medications?
Yes. Based on its ingredients, Biome-xym has a known interaction with 627 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biome-xym contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product help with my irritable bowel syndrome?
Lactobacillus acidophilus and Bifidobacterium bifidum in this product are both rated possibly effective for IBS, so there's some evidence they may help. Results vary by person, though, and you should talk with your doctor about whether this product is right for your situation.
Can I take this while on antibiotics?
No—not at the same time. Antibiotics will kill the live bacteria in this product, making it ineffective. Separate your antibiotic dose from this supplement by a few hours, and check with your pharmacist on the best timing for your specific antibiotic.
What are the enzymes in here for?
This product contains two proteolytic enzymes—Protease I and Protease II—which break down proteins. The data we hold doesn't include effectiveness ratings for these enzymes, so I can't tell you what specific benefit they're meant to provide in this formula.
Does this product have any fillers?
Yes. The inactive ingredients are inulin, rice extract, LactoStim, hydroxypropyl methylcellulose, gellan gum, and water. These are standard excipients that help form and stabilize the capsule.
Is it safe to take this while pregnant or breastfeeding?
Safety data during pregnancy and breastfeeding aren't on file for most of these ingredients. Bifidobacterium longum is rated possibly safe, but the others lack specific guidance. Talk with your doctor or pharmacist about whether this product is appropriate for you during pregnancy or while nursing.
Can I take this if I have a weakened immune system?
You should avoid this product or use it only under medical supervision. The live bacteria and yeast in probiotics, especially Saccharomyces boulardii, have rarely caused serious bloodstream infections in critically ill or immunocompromised patients. Speak with your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biome-xym label
Go deeper

The Full Monographs Behind Biome-xym’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Biome-xym's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 157 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
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Bifidobacterium Longum 21 references
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Bacillus Subtilis 10 references
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Lactobacillus Gasseri 12 references
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Astragalus 13 references
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Saccharomyces Boulardii 26 references
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American Ginseng 12 references
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See these in context on the Sodium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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