Major interaction on record — check this product against your medications before combining. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Chlora-xym Ingredients & Drug Interactions

by U.S. Enzymes

Chlora-xym label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chlora-xym against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Chlora-xym is a dietary supplement by U.S. Enzymes with 9 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 884 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chlorella, Spirulina, Ginseng Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Chlora-xym by U.S. Enzymes

Ask about any prescription or over-the-counter medication and we check it for interactions with Chlora-xym by U.S. Enzymes — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Chlora-xym by U.S. Enzymes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 10 active ingredients.
  • “Blend” is a proprietary blend — the label gives one combined amount (5 mg) without saying how much of each component you get.
  • “Proprietary AstraZyme Blend” is a proprietary blend — the label gives one combined amount (75 mg) without saying how much of each component you get.
  • “Superfood and Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Chlora-xym contains 10 active and supporting ingredients. The three main probiotics and microorganisms are Lactobacillus acidophilus, Bifidobacterium bifidus, and Blue Green Algae (spirulina), which are live organisms meant to support digestive and immune health.

The product also includes Protease I and Protease II — enzymes that break down proteins — along with Astragalus Root Extract, Chlorella, and Ginseng Root Extract, which are plant-based compounds. The remaining ingredients are blends (Superfood and Probiotic Blend and Proprietary AstraZyme Blend) and Sodium Calcium Aluminosilicate.

The inactive ingredients are pullulan and water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy detoxification and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Exercise-induced respiratory infections, Fatigue, Hypercholesterolemia — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Hypercholesterolemia, Lactose intolerance, Clostridioides difficile infection.

The evidence for Chlora-xym's active ingredients is mixed and mostly limited. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, though the research is not conclusive.

Astragalus Root Extract, Chlorella, and Blue Green Algae all have insufficient reliable evidence for most of the conditions they're marketed for — the data we hold does not establish clear effectiveness. The proteolytic enzymes (Protease I and II) have no effectiveness ratings in our data.

Ginseng and Bifidobacterium bifidus effectiveness data are not on file for us.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Astragalus American Ginseng Sodium Blue-green Algae Chlorella

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though live organisms carry a small theoretical risk of infection in certain patients; digestive upset like bloating, gas, and diarrhea is uncommon but possible. The proteolytic enzymes (Protease I and II) are generally well tolerated but may cause digestive upset or allergic reactions, and they should be avoided in pregnancy and used cautiously during breastfeeding.

Astragalus is well tolerated short-term but should be avoided in pregnancy and breastfeeding due to limited safety data; it has rarely been associated with dizziness or palpitations. Chlorella is generally well tolerated but quality varies widely; allergic reactions including anaphylaxis are rare, and digestive upset (especially in the first two weeks) is uncommon.

Blue Green Algae should be avoided in pregnancy and breastfeeding, and product quality and contamination risk are concerns; it may cause digestive upset, dizziness, or rash. Sodium Calcium Aluminosilicate contributes dietary sodium — high sodium intake is linked to high blood pressure and heart strain, so if you're on blood pressure medication or have heart or kidney disease, check with your doctor before taking this product.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Astragalus American Ginseng Sodium Blue-green Algae Chlorella

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Lactobacillus Acidophilus, Chlorella, Blue-green Algae, Astragalus, American Ginseng, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 884 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications in this order before taking Chlora-xym: antibiotics (Lactobacillus can be killed by them and lose effect), blood thinners like warfarin or antiplatelet drugs (Chlorella and Blue Green Algae may reduce their effectiveness or increase bleeding risk), blood pressure medications (sodium can interfere), lithium (sodium and Astragalus can alter lithium levels), immunosuppressants (Astragalus and Blue Green Algae may interfere), diabetes medications (Astragalus and Blue Green Algae raise hypoglycemia risk), corticosteroids, cyclophosphamide, didanosine, sodium phosphates, and tolvaptan. No interactions are documented for Spirulina, Bifidobacterium bifidus, or Ginseng Root Extract because we hold no data for them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Chlora-xym is a multi-ingredient probiotic and enzyme blend aimed at digestion and immunity. If you take antibiotics, blood thinners like warfarin, blood pressure medications, lithium, diabetes medications, immunosuppressants, or corticosteroids, check your exact prescriptions with the tool on this page before starting — this product has significant interactions with these drug types.

Talk to your pharmacist or doctor, especially if you're pregnant, breastfeeding, or have heart, kidney, or blood pressure concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chlora-xym, straight from the product label.

Brand U.S. Enzymes
Barcode (UPC) 819242002723
Net contents 62 NP Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336287
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chlora-xym by U.S. Enzymes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
62
UPC/BARCODE
819242002723
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Blend5 mg--
Spirulina300 mg--
Protease I0 NP--
Protease II0 NP--
Astragalus Root Extract0 NP--
Chlorella20 mg--
Bifidobacterium bifidus0 NP--
Blue Green Algae300 mg--
Ginseng Root Extract0 NP--
Proprietary AstraZyme Blend75 mg--
Sodium Calcium Aluminosilicate0 NP--
Superfood and Probiotic Blend0 NP--

Other ingredients: Pullulan, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Available only through healthcare practitioners

Formula

Chlora-xym is a blend of three organic green super foods; blue green algae, spirulina, and chlorella that provide nutrient dense sources of protein, vitamins, minerals, amino acids, and essential fatty acids. There is a maintenance dose of two probiotics for balanced microbiome support and AstraZyme for protein digestion and enhanced absorption of peptides and amino acids.

3 green superfoods Contains 2 probiotics and AstraZyme

Formulation

Chlora-xym supports healthy detoxification and overall systemic and immune support.

Supports lymphatic/immune health Promotes a balanced microbiome

This product is non-GMO, non-dairy, non-soy and contains no gluten, fillers or preservatives.

Suggested/Recommended/Usage/Directions

Suggested use: Take one (1) capsule twice a day with meals and a glass of water.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

AstraZyme is a registered trademark of ERCC, Inc.

FDA Statement of Identity

Superfood Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chlora-xym by U.S. Enzymes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chlora-xym label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chlora-xym by U.S. Enzymes

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container62 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary AstraZyme Blend

75 mg per serving

Superfood and Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Pullulan, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chlora-xym by U.S. Enzymes Drug Interactions

Want to check YOUR meds against Chlora-xym?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
884Drugs
2 Major 882 Moderate

Ingredients driving the most interactions

Chlorella 337
Spirulina 327
Ginseng Root Extract 217
Astragalus Root Extract 208
Sodium Calcium Aluminosilicate 205

Individual Drug Interactions

The ingredients in Chlora-xym interact with 884 drugs. Click any drug to see the details.

5 of the 9 ingredients in Chlora-xym interact with drugs. Each result below shows which ingredient is responsible. Chlorella Spirulina Ginseng Root Extract Astragalus Root Extract Sodium Calcium Aluminosilicate

Each ingredient & the kinds of drugs it affects

For each ingredient in Chlora-xym with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorella2 drug types · 337 drugs

Photosensitizing Drugs

Theoretically, chlorella might have additive effects with photosensitizing drugs.
Chlorella has been reported to cause photosensitization. In five case reports, patients who had ingested chlorella exhibited swelling followed by erythematopurpuric lesions on sun-exposed areas of the body. Theoretically, concomitant use with photosensitizing drugs may exacerbate effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, chlorella might reduce the clinical effects of warfarin.
Chlorella contains significant amounts of vitamin K. There is at least one case report of warfarin therapy becoming sub-therapeutic after initiation of chlorella supplements.

Likelihood Possible Evidence D
Chlorella full monograph & interactions

Spirulina3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
Spirulina full monograph & interactions

Ginseng Root Extract4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
Ginseng Root Extract full monograph & interactions

Astragalus Root Extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus Root Extract full monograph & interactions

Sodium Calcium Aluminosilicate7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Calcium Aluminosilicate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chlora-xym, from the product label.

U.S. Enzymes

See all U.S. Enzymes products
Name
Master Supplements, Inc.
City
Victoria
State
MN
ZipCode
55386
Phone Number
800 926-2961
Pharmacist Counseling Corner

Chlora-xym by U.S. Enzymes: Common Questions

Does Chlora-xym by U.S. Enzymes interact with any medications?
Yes. Based on its ingredients, Chlora-xym has a known interaction with 884 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chlora-xym contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the probiotics in this product for?
Lactobacillus acidophilus and Bifidobacterium bifidus are live beneficial bacteria meant to support your digestive and immune health. L. acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and related gut concerns, though the evidence isn't conclusive.
If I take antibiotics, can I take this at the same time?
No — you'll want to separate them. Antibiotics can kill the live organisms in this product, making the probiotics less effective. Space your antibiotic doses and your Chlora-xym several hours apart, or ask your pharmacist for the best timing.
Can I take this if I'm on warfarin (a blood thinner)?
You need to check with your doctor or pharmacist first. Chlorella in this product contains vitamin K, which can reduce how well warfarin works. Your doctor may need to adjust your dose or monitor you more closely.
What are the protease enzymes supposed to do?
Protease I and II are enzymes that break down proteins. They're included in digestive blends to support protein breakdown and digestion, though the data we hold doesn't establish effectiveness ratings for them.
Is this safe during pregnancy?
It depends on the ingredient — we don't have enough data to recommend Astragalus, Blue Green Algae, or the proteolytic enzymes in pregnancy. Talk to your doctor before starting, especially if you're pregnant or breastfeeding.
What are the most common side effects?
The live probiotics and algae may cause mild digestive upset — bloating, gas, diarrhea, nausea, or cramping — especially in the first week or two. These are uncommon but possible. Allergic reactions to the enzymes or algae are rare but have been reported.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chlora-xym is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chlora-xym label
Go deeper

The Full Monographs Behind Chlora-xym’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph → Herb & supplement monograph

Chlorella

Interacts with 337 drugs

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies suggest possible benefits for cholesterol, blo...

Read the full Chlorella monograph →
Sources

Sources & How We Checked

Chlora-xym's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 116 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Blue-green Algae 22 references
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Proteolytic Enzymes (proteases) 3 references
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Astragalus 13 references
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Chlorella 13 references
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American Ginseng 12 references
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Sodium 38 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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