Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Bladder Control With Go-Less & Weight Management Ingredients & Drug Interactions

by AZO

Bladder Control With Go-Less & Weight Management label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bladder Control With Go-Less & Weight Management against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Bladder Control With Go-Less & Weight Management is a dietary supplement by AZO with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 644 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Soy Germ (Glycine max) extract, Sodium, Cissus quadrangularis stem and leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bladder Control With Go-Less & Weight Management by AZO

Ask about any prescription or over-the-counter medication and we check it for interactions with Bladder Control With Go-Less & Weight Management by AZO — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bladder Control With Go-Less & Weight Management by AZO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Go-Less Proprietary Blend” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

This product contains 4 active ingredients. Sodium is the mineral that helps regulate fluid balance in your body.

Pumpkin seed extract comes from the seeds of Cucurbita pepo and is traditionally used for urinary tract health. Soy germ extract (from Glycine max) contains plant compounds called isoflavones.

Cissus quadrangularis is a plant extract sometimes used for weight and metabolic support. The remaining ingredients are inactive excipients — gelatin capsule, fillers, and colorants — that help hold the formula together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain bladder control and manage weight.
  • We looked for evidence on: Overactive bladder, Benign prostatic hyperplasia (BPH), Obesity, Metabolic syndrome, urinary urgency, occasional incontinence.
  • The strongest evidence on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Soy is rated "Possibly Effective" for Metabolic syndrome.
  • Also on file: Cissus Quadrangularis is rated "Possibly Effective" for Obesity.

The evidence for this product's main purpose is mixed and limited. Pumpkin seed extract is rated possibly effective for benign prostatic hyperplasia (enlarged prostate), but there isn't enough reliable evidence to rate it for urinary tract infections or interstitial cystitis (bladder pain).

Soy germ extract is possibly effective for diabetes, cholesterol, bone health, and blood pressure support. Cissus quadrangularis is rated possibly effective for weight loss and weight management in people with overweight or obesity, but the evidence for cholesterol is insufficient.

Sodium itself has limited established evidence in this context — it is rated likely effective only for cystic fibrosis, which is not the indication here.

The evidence, ingredient by ingredient Sodium Pumpkin Soy Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium in food is fine, but avoid sodium supplements or very high intakes without medical guidance; too much is linked to high blood pressure and heart strain. Pumpkin seed extract in concentrated form is generally well tolerated, though some people report mild abdominal discomfort, nausea, or diarrhea; rare cases of severe nausea and vomiting linked to wild pumpkin with high toxin levels have been reported.

Soy products in normal food amounts are generally safe, but concentrated isoflavone supplements warrant more caution. Cissus quadrangularis is generally well tolerated in short-term use, but long-term safety is not well studied.

Common side effects across the ingredients include bloating, nausea, diarrhea, and stomach discomfort. Allergic reactions to soy — skin rash, itching, or in rare cases anaphylaxis — are possible.

Side effects, ingredient by ingredient Sodium Pumpkin Soy Cissus Quadrangularis

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Pumpkin, Soy, Cissus Quadrangularis, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you're on MAOIs (antidepressants) — this is a Major risk. Also double-check Moderate interactions with blood pressure medications, corticosteroids, lithium, diabetes medications, diuretics, warfarin (blood thinners), levothyroxine (thyroid medication), estrogen replacement therapy, caffeine supplements, and didanosine.

Do not combine without talking to your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in weight management and bladder support and you don't take any medications that interact with sodium, blood pressure drugs, lithium, diabetes medications, MAOIs, warfarin, or thyroid medication. If you're on any prescription or over-the-counter medications, especially for blood pressure, diabetes, mood, or blood thinning, check with your pharmacist first.

People taking lithium should avoid this product without medical supervision.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bladder Control With Go-Less & Weight Management, straight from the product label.

Brand AZO
Barcode (UPC) 787651760148
Net contents 48 Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 180464
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bladder Control With Go-Less & Weight Management by AZO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
48
UPC/BARCODE
787651760148
IngredientAmount% DV
Sodium10 mg1%
Go-Less Proprietary Blend300 mg--
Pumpkin (Cucurbita pepo) seed extract0 NP--
Soy Germ (Glycine max) extract0 NP--
Cissus quadrangularis stem and leaf extract150 mg--

Other ingredients: Gelatin, Dicalcium Phosphate, Maltodextrin, Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Riboflavin, Titanium Dioxide, Carmine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Go less, worry less.

24 HR support

Frustrated with that feeling of having to go to the bathroom often or dealing with occasional urgency? Did you know that weight can contribute to occasional bladder control issues? There is hope.

The result is a safe and effective way to maintain bladder control from the inside out.

Vissers D, et al. Obes Rev., 2014;15(7):610-617.

"I wasn't sure about this...I didn't know how it could help with bladder control and weight management but it really does! Worth a try!" -Trinity Michelle Read more reviews on www.azoproducts.com Helps control the need to go and safely manages weight Safely helps reduce occasional urgency Promotes healthy metabolism to improve weight management Supports a good night's sleep

Formulation

Safe & drug free The safe, drug-free way to maintain bladder control in 2 ways.

Instead of worrying about your next bathroom break, take control with AZO Bladder Control & Weight Management: A drug-free daily supplement with ingredients that safely help reduce the urge to go to the bathroom and help manage your weight.

AZO Bladder Control & Weight Management does not contain artificial dyes, flavors, yeast, or gluten.

Brand IP Statement(s)

You can take control with AZO Bladder Control & Weight Management

How is AZO Bladder Control & Weight Management different? The naturally-sourced blend of ingredients in AZO Bladder Control & Weight Management help to support your bladder in 2 ways, so that you can feel in control day and night.

OWN YOUR DAY AZO Values: We believe in open, honest conversations about women's health We believe in helping you take charge of your health We believe in helping you live your life to the fullest We believe in delivering the best urinary, vaginal, and bladder health products available We believe in helping you, OWN YOUR DAY.

AZO Bladder Control and OWN YOUR DAY are trademarks of DSM. Go-Less is a trademark of Frutarom. Synetrim CQ is a trademark of Icon Group, LLC and is protected under U.S. Patent 7,175,859.

Formula

1 Go-Less helps maintain urinary control + 2 Synetrim CQ helps manage weight Go-Less with pumpkin seed and soy germ extracts, supports bladder health to help control the need to go to the bathroom and reduce occasional urgency. Clinically studied Synetrim CQ from the Cissus quadrangularis plant, supports serotonin balance and helps promote metabolic health for healthy weight management.

Contains: Soy

Suggested/Recommended/Usage/Directions

For best results, on-going daily use is encouraged.

Take daily for best results!

Daily

Directions: For the first two weeks: Take 1 capsule morning, noon, and night (3 total). After two weeks continue taking 1 capsule twice a day. For best results, a daily regimen for 30 days (minimum) is important. Product benefits are best realized with on-going, daily use.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

ABBM3268

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Soy

Tamper evident: Do not use if seal under cap is broken or missing.

While there are no known side effects directly attributed to the dietary ingredients in this product, it is advisable to speak with your health care provider before taking any dietary supplement or medication. Caution: AZO Bladder Control & Weight Management should not be used by pregnant or nursing women, or by children under the age of 18. If you are taking medication or planning a surgery, consult your doctor before using this product.

Caution: AZO Bladder Control & Weight Management should not be used by pregnant or nursing women, or by children under the age of 18. If you are taking medication or planning a surgery, consult your doctor before using this product.

For questions, concerns or to report an adverse event, call (800) 722-3476.

Storage

Store at room temperature. Do not expose to excessive heat, humidity or direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bladder Control With Go-Less & Weight Management by AZO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bladder Control With Go-Less & Weight Management label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bladder Control With Go-Less & Weight Management by AZO

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container48 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Go-Less Proprietary Blend

300 mg per serving

Cissus quadrangularis stem and leaf extract

Interacts with
86 drugs
150 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis stem and leaf extract monograph & interactions

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Maltodextrin, Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Riboflavin, Titanium Dioxide, Carmine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bladder Control With Go-Less & Weight Management by AZO Drug Interactions

Want to check YOUR meds against Bladder Control With Go-Less & Weight Management?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
644Drugs
9 Major 376 Moderate 259 Minor

Ingredients driving the most interactions

Soy Germ (Glycine max) extract 611
Sodium 205
Cissus quadrangularis stem and leaf extract 86
Pumpkin (Cucurbita pepo) seed extract 1

Individual Drug Interactions

The ingredients in Bladder Control With Go-Less & Weight Management interact with 644 drugs. Click any drug to see the details.

4 of the 4 ingredients in Bladder Control With Go-Less & Weight Management interact with drugs. Each result below shows which ingredient is responsible. Soy Germ (Glycine max) extract Sodium Cissus quadrangularis stem and leaf extract Pumpkin (Cucurbita pepo) seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bladder Control With Go-Less & Weight Management with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Soy Germ (Glycine max) extract12 drug types · 611 drugs

Monoamine Oxidase Inhibitors (Maois)

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.
Fermented soy products such as tofu and soy sauce contain tyramine, a naturally occurring chemical that affects blood pressure regulation. The metabolism of tyramine is decreased by MAOIs. Consuming more than 6 mg of tyramine while taking an MAOI can increase the risk of hypertensive crisis. The amount of tyramine in fermented soy products is usually less than 0.6 mg per serving; however, there can be significant variation depending on the specific product used, storage conditions, and length of storage. Storing one brand of tofu for a week can increase tyramine content from 0.23 mg to 4.8 mg per serving. Advise patients taking MAOIs to avoid fermented soy products that contain high amounts of tyramine.

Likelihood Likely Evidence C
Antidiabetes Drugs

Soy can lower blood glucose and have additive effects with antidiabetes drugs.
Clinical research shows that whole soy diets and soy-based meals reduce fasting glucose levels in diabetic and non-diabetic individuals. Also, individuals following a soy-based meal replacement plan seem to require lower doses of sulfonylureas and metformin to manage blood glucose levels when compared with individuals following a diet plan recommended by the American Diabetes Association.

Likelihood Possible Evidence A
Antihypertensive Drugs

Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Although some contradictory research exists, most clinical evidence suggests that consuming soy protein modestly reduces systolic and diastolic blood pressure in individuals with prehypertension or hypertension.

Likelihood Possible Evidence A
Caffeine

Theoretically, soy might reduce the clearance of caffeine.
Soy contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. This effect has been attributed to inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if this effect occurs with the lower amounts of genistein found in soy.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, soy might have additive effects when used with diuretic drugs.
Animal research suggests that genistein, a soy isoflavone, increases diuresis within 6 hours of subcutaneous administration in rats. The effects seem to be similar to those of furosemide. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, soy might competitively inhibit the effects of estrogen replacement therapy.
Soy contains phytoestrogens and has been shown to have estrogenic activity in some patients. Although this has not been demonstrated in humans, theoretically, concomitant use of soy with estrogen replacement therapy might reduce the effects of the estrogen replacement therapy.

Likelihood Possible Evidence D
Levothyroxine (Synthroid, Others)

Soy products might reduce the absorption of levothyroxine in some patients.
Preliminary clinical research and a case report suggest that soy-based formulas inhibit the absorption of levothyroxine in infants with congenital hypothyroidism. A levothyroxine dosage increase may be needed for infants with congenital hypothyroidism while using soy-based formulas, and the dose may need to be reduced when soy-based formulas are no longer administered. However, in postmenopausal adults, clinical research shows that taking a single dose of soy extract containing isoflavones 60 mg along with levothyroxine does not affect the oral bioavailability of levothyroxine.

Likelihood Possible Evidence B
Progesterone

Theoretically, combining soy isoflavones with transdermal progesterone may worsen bone density.
Clinical research suggests that significant bone loss may occur in females with osteoporosis who receive a combination of transdermal progesterone with soy milk containing isoflavones when compared with placebo, soy milk alone, or progesterone alone.

Likelihood Possible Evidence A
Tamoxifen (Nolvadex)

Theoretically, estrogenic soy isoflavones might alter the effects of tamoxifen.
Laboratory research suggests that genistein and daidzen, isoflavones from soy, can antagonize the antitumor effects of tamoxifen under some circumstances; however, soy isoflavones might have different effects when used at different doses. A relatively low in vitro concentration of soy isoflavones such as 1 microM/L seems to interfere with tamoxifen, whereas high in vitro concentrations such as those >10 microM/L might actually enhance tamoxifen effects. People on a high-soy diet have soy isoflavones levels ranging from 0.1-6 microM/L. Until more is known, advise patients taking tamoxifen to avoid therapeutic use of soy products.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, soy might interfere with the effects of warfarin.
Soy milk has been reported to decrease the international normalized ratio (INR) in a patient taking warfarin. The mechanism of this interaction is not known. However, animal and in vitro research suggests that soy may also inhibit platelet aggregation. Dosing adjustments for warfarin may be necessary.

Likelihood Possible Evidence D
Antibiotic Drugs

Theoretically, antibiotics may decrease the activity of soy isoflavones.
Intestinal bacteria are responsible in part for converting soy isoflavones into their active forms. Antibiotics may decrease the amount of intestinal bacteria and decrease its ability to convert isoflavones.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Soy might modestly induce CYP2C9 enzymes. However, this effect does not seem to be clinically significant.
In vitro research suggests that an unhydrolyzed soy extract might induce CYP2C9. However, the significance of this interaction is likely minimal. In healthy females taking a specific extract of soy (Genistein Soy Complex, Source Naturals), blood levels of losartan, a CYP2C9 substrate, were not significantly affected.

Likelihood Unlikely Evidence D
Soy Germ (Glycine max) extract full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Cissus quadrangularis stem and leaf extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis stem and leaf extract full monograph & interactions

Pumpkin (Cucurbita pepo) seed extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin (Cucurbita pepo) seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bladder Control With Go-Less & Weight Management, from the product label.

AZO

See all AZO products
Name
i-Health, Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
1-800-722-3476
Web Address
www.azoproducts.com
Pharmacist Counseling Corner

Bladder Control With Go-Less & Weight Management by AZO: Common Questions

Does Bladder Control With Go-Less & Weight Management by AZO interact with any medications?
Yes. Based on its ingredients, Bladder Control With Go-Less & Weight Management has a known interaction with 644 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bladder Control With Go-Less & Weight Management contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not without checking with your pharmacist first. Both the sodium content and the soy in this product can lower blood pressure, so taking them together might make your medication work too well and drop your pressure too far. Your dose might need adjusting, so talk to your pharmacist.
Is this safe during pregnancy?
The data is mixed. Sodium is rated possibly unsafe in pregnancy, and Cissus quadrangularis doesn't have enough safety data — the advice is to avoid it during pregnancy. Pumpkin seed extract and soy germ extract have insufficient pregnancy data on file. Talk with your doctor or pharmacist before taking this while pregnant.
What's the Go-Less Proprietary Blend?
That's a mixture of ingredients the brand doesn't break down on the label — its individual components are listed separately in the full ingredient list so you can check them. We hold data for pumpkin seed extract and soy germ extract; if there are other herbs in the blend, we don't have interaction details for those.
Can I take this if I'm on lithium?
No, not without your doctor's approval and monitoring. Both the sodium in this product and the pumpkin seed extract interact with lithium — sodium can lower lithium levels (making it less effective), while pumpkin may raise them (risking toxicity). Your lithium dose would need careful adjustment.
What's the most common side effect?
Digestive upset — bloating, nausea, diarrhea, and stomach discomfort — is most common across the ingredients. These effects are usually mild and similar to what's seen with placebo in studies. Stop and contact your doctor if you develop a rash, severe nausea, or difficulty breathing.
Is there enough evidence this actually works for bladder control?
Pumpkin seed extract is possibly effective for enlarged prostate but doesn't have strong evidence yet for urinary tract infections or bladder pain. For weight management, Cissus quadrangularis is possibly effective in people with overweight or obesity. The evidence is modest, not proven.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bladder Control With Go-Less & Weight Management label
Go deeper

The Full Monographs Behind Bladder Control With Go-Less & Weight Management’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Soy

Interacts with 611 drugs

Soy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones. Eating soy foods as part of a balanced diet is generally considered safe for most people...

Read the full Soy monograph → Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Bladder Control With Go-Less & Weight Management's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 136 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
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Pumpkin 5 references
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Cissus Quadrangularis 5 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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