Drug & supplement interaction

Soy + Candesartan Cilexetil, Hydrochlorothiazide

Candesartan Cilexetil, Hydrochlorothiazide brand name: Atacand HCT.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Candesartan Cilexetil, Hydrochlorothiazide falls into 2 drug categories that Soy can interact with; the most serious is rated moderate. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceA
What do Severity, Likelihood & Evidence mean?
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Interaction report

Soy and Candesartan Cilexetil, Hydrochlorothiazide

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Soy interacts with whole categories of medication. Candesartan Cilexetil, Hydrochlorothiazide falls into 2 of those categories, so it can interact with Soy in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Candesartan Cilexetil, Hydrochlorothiazide

Candesartan Cilexetil, Hydrochlorothiazide falls under ANTIHYPERTENSIVE DRUGS — the group Soy interacts with.

Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Although some contradictory research exists, most clinical evidence suggests that consuming soy protein modestly reduces systolic and diastolic blood pressure in individuals with prehypertension or hypertension.
Severity Moderate Likelihood Possible Evidence A

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Atacand HCT pairs candesartan, a blood pressure medicine, with a water pill (hydrochlorothiazide). Both work to lower your blood pressure. The thing to know about soy is that it can gently nudge blood pressure down on its own. So when you regularly eat a lot of soy protein, it may add to what your medication is already doing.

Most of the time this overlap is small and not a problem. But if your numbers drop too low, you could feel dizzy, lightheaded, tired, or off balance, especially when standing up quickly. Everyday soy foods like tofu, edamame, or soy milk are usually fine. Concentrated soy protein or isoflavone supplements are worth running by your pharmacist or doctor first, particularly if your pressure already runs low.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. He J, Gu D, Wu X, et al. Effect of soybean protein on blood pressure: A randomized, controlled trial. Ann Intern Med 2005;143:1-9. PubMed
  2. Sacks FM, Lichtenstein A, Van Horn L, et al. Soy protein, isoflavones, and cardiovascular health. An American Heart Association Science Advisory for Professionals from the Nutrition Committee. Circulation 2006;113:1034-44. PubMed
  3. Altorf-van der Kuil, W., Engberink, M. F., Brink, E. J., van Baak, M. A., Bakker, S. J., Navis, G., van, 't, V, and Geleijnse, J. M. Dietary protein and blood pressure: a systematic review. PLoS.One. 2010;5(8):e12102. PubMed
Moderate

DIURETIC DRUGS

2 of 2

Candesartan Cilexetil, Hydrochlorothiazide also falls under DIURETIC DRUGS.

Theoretically, soy might have additive effects when used with diuretic drugs.
Animal research suggests that genistein, a soy isoflavone, increases diuresis within 6 hours of subcutaneous administration in rats. The effects seem to be similar to those of furosemide. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with soy and your Atacand HCT. This combo already includes hydrochlorothiazide, a water pill, plus candesartan for blood pressure. The concern on file is purely theoretical: in one rat study, a soy compound called genistein increased urine output a bit, somewhat like a diuretic. So the worry is simply additive, meaning soy might nudge fluid loss in the same direction your water pill already pushes.

The honest truth is this has never been shown in people, and everyday soy foods like tofu, edamame, or soy milk are very unlikely to matter. Concentrated isoflavone supplements are a bigger question mark. If you're prone to dizziness, low blood pressure, or dehydration, just mention it to your pharmacist or doctor before adding soy supplements.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Gimenez, I., Martinez, R. M., Lou, M., Mayoral, J. A., Garay, R. P., and Alda, J. O. Salidiuretic action by genistein in the isolated, perfused rat kidney. Hypertension 1998;31(2):706-711. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Soy Also Interacts With Other Medications

Soy has 9 major, 342 moderate, 260 minor known drug interactions in our database — the Candesartan Cilexetil, Hydrochlorothiazide one above is among them. If you take anything else, check it against the full list below.

Major 9 Moderate 342 Minor 260 No known interaction 2,219 (incl. Candesartan Cilexetil, Hydrochlorothiazide)
Taking anything else?

Check Another of Your Medications Against Soy

Covers the 2,830 medications we’ve checked against Soy. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Candesartan Cilexetil, Hydrochlorothiazide

This page covers Soy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Candesartan Cilexetil, Hydrochlorothiazide page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 196 moderate · 26 minor.

From our pharmacist’s overview on the Candesartan Cilexetil, Hydrochlorothiazide page

“Supplements deserve genuine scrutiny alongside Atacand HCT (candesartan with hydrochlorothiazide, a blood pressure medicine paired with a water pill), and the ten major-rated entries on this list of 232 are the ones to understand first. Most of the interactions pull in one of two directions.”

Reviewed by 2 · Jul 18, 2026

Open the Candesartan Cilexetil, Hydrochlorothiazide interaction page

One more smart check

Taking Soy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 821 real supplement products containing Soy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Soy. Your product may carry other ingredients that interact with Candesartan Cilexetil, Hydrochlorothiazide too, on top of Soy — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Soy and Candesartan Cilexetil, Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Soy
Top 25%

#252 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Candesartan Cilexetil, Hydrochlorothiazide
Top 5%

#130 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Soy

What is Soy?

  • Menopause symptoms (hot flashes)
  • Heart and cholesterol health
  • Bone health
  • Plant-based protein source
  • General nutrition

Soy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones. Eating soy foods as part of a balanced diet is generally considered safe for most people, and there is moderate evidence it may modestly help cholesterol and some menopause symptoms, though results vary. Talk with your pharmacist or doctor before using concentrated soy isoflavone supplements, especially if you have a history of hormone-sensitive conditions.

Read the full Soy monograph & all interactions
Keep checking

Other Drugs & Soy

Browse every other medication we’ve checked against Soy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

9Major
342Moderate
260Minor
2,218No known interaction
9 Major 342 Moderate 260 Minor 2,218 No interaction
Major

9 interactions

Moderate

342 interactions

Showing 60 of 342 moderate interactions — see all 342 on the Soy page.

Minor

260 interactions

Showing 60 of 260 minor interactions — see all 260 on the Soy page.

No interaction 2,218 drugs checked — show the list

We also checked Soy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,218 medications checked with no known interaction — see the full Soy list.

See the full Soy interactions page
See every supplement checked against Candesartan Cilexetil, Hydrochlorothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Soy monograph › Uses, safety, and every drug interaction in one place Candesartan Cilexetil, Hydrochlorothiazide supplement interactions › Every supplement checked against Candesartan Cilexetil, Hydrochlorothiazide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Soy and Candesartan Cilexetil, Hydrochlorothiazide Together: Common Questions

Can you take Soy with Candesartan Cilexetil, Hydrochlorothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Soy and Candesartan Cilexetil, Hydrochlorothiazide?
Candesartan Cilexetil, Hydrochlorothiazide belongs to more than one drug category, and Soy interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Soy and Candesartan Cilexetil, Hydrochlorothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Candesartan Cilexetil, Hydrochlorothiazide and Soy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.