Borage Alcohol Free Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Borage Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Borage Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for eczema and dry skin, rheumatoid arthritis, inflammation.Based on those ingredients, 226 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Borage Flower, Herb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Borage Alcohol Free by Herbal Terra
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Borage Alcohol Free by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: borage flower and herb extract in liquid form. Borage is a plant whose seed oil and other parts have been studied for a range of conditions.
The liquid also contains glycerin and water as inactive ingredients.
Does it work?
Couldn't assess
The evidence for borage in the conditions we have data for is weak. For atopic dermatitis (eczema), borage rates as possibly ineffective.
For ADHD, acute respiratory distress syndrome, and alcoholism, there isn't enough reliable evidence to say whether it works or doesn't.
How safe is it?
Well-documented data
Borage seed oil is generally well tolerated, with most side effects being mild digestive complaints like belching, bloating, diarrhea, and soft stools. The real safety concern is with borage plant parts — the leaf, flower, and seed — which can contain liver-toxic alkaloids (pyrrolizidine alkaloids, or PAs).
This product contains borage flower and herb extract, which may harbor these toxins. Chronic exposure can cause serious liver damage, including veno-occlusive disease (a vascular liver injury).
The safety data advises against borage during pregnancy because of the risk from these alkaloids and a theoretical threat to the uterus. Breastfeeding safety is also not well established, and PA contamination is a concern — talk with your pharmacist or doctor before using it if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before starting Borage Alcohol Free, check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), phenothiazines (antipsychotics), or medications that induce the liver enzyme CYP3A4 — all carry Moderate-severity interaction risk. No interactions are documented for other ingredient classes, but the real concern here is the liver-toxic alkaloid content of borage flower and herb parts, which is separate from drug interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Borage flower and herb extract interacts with blood thinners, antipsychotics, and liver-enzyme-inducing drugs. More importantly, this plant part may contain liver-toxic alkaloids that pose a real safety risk with chronic use.
If you take any blood thinners, antipsychotics, or enzyme-inducing medications, check with your pharmacist first. Pregnant or breastfeeding?
This one isn't recommended.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Borage Alcohol Free, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7386004866952 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 323999 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Borage Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Borage Flower, Herb Extract, Dry | 1156 mg | -- |
Other ingredients: Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free Alcohol free
Expertly extracted 100% natural Premium product
No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Borago officinalis
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA Natural Gluten free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Borage Alcohol Free by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Borage Alcohol Free by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Borage Flower, Herb Extract, Dry
Interacts with226 drugs
Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arth...
Borage Flower, Herb Extract, Dry monograph & interactionsOther (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Borage Alcohol Free by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Borage Alcohol Free by Herbal Terra contains one active ingredient — borage flower and herb extract — that interacts with several medication types.
The most serious concern is blood thinners and antiplatelet drugs (Moderate severity): borage seed oil may theoretically increase bleeding risk, though in healthy people it hasn't shown effects on platelet clumping in studies. The active compound gamma-linolenic acid does lower platelet aggregation in lab work.
Read the full breakdown — every affected drug type, severity by severity
Two other Moderate-severity interactions exist. Phenothiazines (antipsychotic medications) may have an increased seizure risk when combined with borage, based on concern that gamma-linolenic acid could lower the seizure threshold — though data is limited.
Additionally, drugs that induce CYP3A4 (a liver enzyme) may raise levels of toxic borage metabolites, since some borage plant parts contain liver-toxic alkaloids that this enzyme processes.
Although borage seed oil contains little to no of these toxic alkaloids, this product contains borage flower and herb extract — parts that may harbor them. Altogether, these interactions span 224 individual medications.
Run your exact prescriptions through the checker below before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Borage Alcohol Free?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Borage Alcohol Free interact with 226 drugs. Click any drug to see the details.
1 of the 1 ingredient in Borage Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Borage Flower, Herb Extract, Dry
AbciximabReoPro
How Abciximab interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryPhenothiazines Moderate
Interaction Summary
Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Read the full Borage Flower, Herb Extract, Dry + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Aminoglutethimide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryPhenothiazines Moderate
Interaction Summary
Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Read the full Borage Flower, Herb Extract, Dry + Amitriptyline, Perphenazine interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Antithrombin Iii interactionApalutamideErleada
How Apalutamide interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Apixaban interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Aprepitant interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Aprobarbital, Butabarbital, Phenobarbital interactionAprocitentanTryvio
How Aprocitentan interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Aprocitentan interactionArgatrobanArgatroban
How Argatroban interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Flower, Herb Extract, Dry + Armodafinil interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Borage Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Borage Flower, Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Flower, Herb Extract, Dry + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Borage Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Borage Flower, Herb Extract, Dry
Anticoagulant/Antiplatelet Drugs
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.
Cytochrome P450 3A4 (Cyp3A4) Inducers
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.
Phenothiazines
Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.
Brand information
Manufacturer and brand details for Borage Alcohol Free, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Borage Alcohol Free by Herbal Terra: Common Questions
Does Borage Alcohol Free by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this borage product have the toxic alkaloids that borage can contain?
Can I take this if I'm on a blood thinner?
What are the most common side effects?
Is borage proven to work for eczema or ADHD?
Is it safe to use during pregnancy?
Why does the product say 'alcohol free' if borage seed oil doesn't naturally contain alcohol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Borage Alcohol Free is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Borage Alcohol Free’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Borage Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Borage 11 references
- Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
- WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
- Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411-4.
- Takwale A, Tan E, Agarwal S, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1385. PubMed
- Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
- Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
- Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
- Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
- Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
- Bard, J. M., Luc, G., Jude, B., Bordet, J. C., Lacroix, B., Bonte, J. P., Parra, H. J., and Duriez, P. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. Fundam.Clin.Pharmacol. 1997;1
- Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC