Borage Oil 1000 mg Ingredients & Drug Interactions
by Vitabase
What is this page for?
First and foremost: checking Borage Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Borage Oil 1000 mg is a dietary supplement by Vitabase with 4 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 312 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Borage seed oil, Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Borage Oil 1000 mg by Vitabase
Ask about any prescription or over-the-counter medication and we check it for interactions with Borage Oil 1000 mg by Vitabase — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Borage Oil 1000 mg by Vitabase
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 4 active ingredients: Gamma-Linolenic Acid, Oleic Acid, Borage seed oil, and Linoleic Acid. Borage seed oil is the main component — it's rich in omega-6 fatty acids that your body uses for inflammation and immune function.
Oleic Acid (a monounsaturated fat) and the linoleic and gamma-linolenic acids work together as the fatty-acid backbone of the supplement. The softgel capsule also contains gelatin, glycerin, and water as inactive ingredients to hold everything together.
Does it work?
Moderate evidence
For Oleic Acid, there's possibly effective evidence for managing high cholesterol and supporting heart health. For borage seed oil itself, the evidence is mixed — it's rated possibly ineffective for eczema, and we don't have enough reliable data to rate it for ADHD, acute respiratory distress syndrome, or alcoholism.
If you're taking this for a specific condition, check the facts on borage with your doctor to see if the evidence supports it for your situation.
How safe is it?
Well-documented data
Borage seed oil is generally well tolerated, though some people experience belching, bloating, diarrhea, or soft stools. The bigger safety concern is pyrrolizidine alkaloids (PA) — liver-toxic compounds found in some borage plant parts.
Most borage seed oil supplements contain little to no PA, but the safety data advises against this product during pregnancy because of possible liver-toxic alkaloids and theoretical risk to the uterus. Breastfeeding safety data is also lacking.
Talk with your doctor or pharmacist if you're pregnant, breastfeeding, or have liver concerns.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate risk of increased bleeding), antidiabetes medications (Moderate risk of stronger blood-sugar-lowering effects), phenothiazine antipsychotics (Moderate risk of lowered seizure threshold), or CYP3A4-inducing drugs (Moderate theoretical risk). If you're unsure whether your medication falls into any of these groups, ask your pharmacist to run it through the tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Borage oil is worth considering if you're looking to support cholesterol or heart health, or if you're interested in omega-6 fatty acids for inflammation — but it's not right for everyone. If you take blood thinners, antipsychotics, antidiabetes drugs, or certain enzyme-inducing medications, you need to check with your doctor or pharmacist before starting.
Pregnant people and those breastfeeding should avoid it. Run your full medication list through the interaction checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Borage Oil 1000 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Borage Oil 1000 mg by Vitabase, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 9 {Calories} | -- |
| Calories from Fat | 9 {Calories} | -- |
| Total Fat | 1 g | 2% |
| Gamma-Linolenic Acid | 220 mg | -- |
| Oleic Acid | 160 mg | -- |
| Borage seed oil | 1000 mg | -- |
| Linoleic Acid | 380 mg | -- |
Other ingredients: Gelatin, Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, adults take one (1) softgel capsule, one (1) or two (2) times daily with meals, or as directed by a health care professional.
Storage
Store in a cool, dry place and away from direct light.
Precautions
Keep out of reach of children.
General Statements
QUALITY AND POTENCY GUARANTEED.
Vitabase uses only high quality ingredients.
Our Borage Oil is 100% pure expeller pressed and Hexane Free. It is derived from the seeds of the borage plant, one of the richest sources of Gamma Linolenic Acid (GLA).
MADE IN THE U.S.A.
FDA Statement of Identity
DIETARY SUPPLEMENT
Seals/Symbols
Vb
Formulation
Contains No Added sugar, salt, dairy, yeast, wheat, corn, soy, preservatives, artificial colors or flavors.
Hexane Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Borage Oil 1000 mg by Vitabase label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Borage Oil 1000 mg by Vitabase
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Gamma-Linolenic Acid
Oleic Acid
Interacts with86 drugs
Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it...
Oleic Acid monograph & interactionsBorage seed oil
Interacts with226 drugs
Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arth...
Borage seed oil monograph & interactionsLinoleic Acid
Other (inactive) ingredients: Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Borage Oil 1000 mg by Vitabase Drug Interactions
HelloPharmacist Interaction Report
Vitabase Borage Oil 1000 mg does interact with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (like warfarin and aspirin) — borage seed oil may increase bleeding risk by affecting how your blood cells clump together. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check if you're taking antidiabetes drugs. Oleic acid, one of this product's components, might strengthen how those medications work and lower your blood sugar further, which could be helpful but needs monitoring.
Additionally, there's a Moderate-severity theoretical concern with phenothiazines (antipsychotic medications) — borage seed oil might lower your seizure threshold if you're on one of these drugs. And if you're taking medications that induce CYP3A4 (a liver enzyme), theoretically borage could increase levels of certain toxic compounds.
We could not check two of the four ingredients — Gamma-Linolenic Acid and Linoleic Acid — because we hold no interaction data for them. Altogether, these interactions span 313 individual medications.
Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Borage Oil 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Borage Oil 1000 mg interact with 312 drugs. Click any drug to see the details.
2 of the 4 ingredients in Borage Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Borage seed oil Oleic Acid
AbciximabReoPro
How Abciximab interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilPhenothiazines Moderate
Interaction Summary
Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Read the full Borage Seed Oil + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Seed Oil + Aminoglutethimide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilPhenothiazines Moderate
Interaction Summary
Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Read the full Borage Seed Oil + Amitriptyline, Perphenazine interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Seed Oil + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Antithrombin Iii interactionApalutamideErleada
How Apalutamide interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Seed Oil + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Borage Seed Oil + Apixaban interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Seed Oil + Aprepitant interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Seed Oil + Aprobarbital, Butabarbital, Phenobarbital interactionAprocitentanTryvio
How Aprocitentan interacts with Borage Oil 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Borage Seed OilCytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Read the full Borage Seed Oil + Aprocitentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Borage Oil 1000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Borage seed oil
Anticoagulant/Antiplatelet Drugs
Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.
Cytochrome P450 3A4 (Cyp3A4) Inducers
Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.
Phenothiazines
Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.
Oleic Acid
Antidiabetes Drugs
Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Brand information
Manufacturer and brand details for Borage Oil 1000 mg, from the product label.
Borage Oil 1000 mg by Vitabase: Common Questions
Does Borage Oil 1000 mg by Vitabase interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is borage oil safe during pregnancy?
What are the most common side effects?
Will this help my high cholesterol?
Does this product contain liver-toxic alkaloids?
Is it safe if I'm breastfeeding?
Can I take this with my blood thinner?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Borage Oil 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Borage Oil 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Oleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph → Herb & supplement monographBorage
Interacts with 226 drugsBorage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arthritis with mixed results. The plant's le...
Read the full Borage monograph →Sources & How We Checked
Borage Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
- Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
- Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
- Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
- Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
- Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
- Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
- de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
- Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
- Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
- Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed
Borage 11 references
- Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
- WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
- Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411-4.
- Takwale A, Tan E, Agarwal S, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1385. PubMed
- Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
- Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
- Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
- Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
- Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
- Bard, J. M., Luc, G., Jude, B., Bordet, J. C., Lacroix, B., Bonte, J. P., Parra, H. J., and Duriez, P. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. Fundam.Clin.Pharmacol. 1997;1
- Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC