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Dietary supplement

Boswellia Extract 500 mg Ingredients & Drug Interactions

by Protocol For Life Balance

Boswellia Extract 500 mg label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boswellia Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boswellia Extract 500 mg is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boswellia extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boswellia Extract 500 mg by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with Boswellia Extract 500 mg by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boswellia Extract 500 mg by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Boswellia extract at 500 mg per softgel capsule. Boswellia serrata is a tree resin traditionally used in herbal medicine.

The capsule itself and the inactive ingredients — MCT oil, sunflower lecithin, and beeswax — are there to deliver and stabilize the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: balanced immune response.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for Boswellia is mixed. It's rated possibly effective for osteoarthritis, meaning some evidence supports its use for joint pain and stiffness.

For other conditions — hay fever (allergic rhinitis), Alzheimer's disease, asthma, and cluster headaches — the evidence isn't established in our data, so we can't say whether it works for those uses. If you're considering this for a specific condition, talk with your doctor about what the research actually shows for your situation.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia extract is generally well tolerated when taken by mouth, though product quality and dose vary widely between brands. The most common side effects are mild — abdominal pain, diarrhea, headache, heartburn, itching, and nausea — and were reported in clinical studies at low rates.

In one study, roughly 11% of people taking a specific Boswellia extract reported headache; dizziness and vertigo occurred less often. A rare serious side effect is bezoar formation (a blockage in the gut) when very large amounts of boswellia gum resin are consumed — this is not a concern with normal use.

Safety data in pregnancy is insufficient, so it's best avoided during pregnancy. Safety while breastfeeding is unknown, so avoid use then as well.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you take any medications broken down by your liver's CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 enzymes — Boswellia may raise their blood levels. Also check if you take immunosuppressants (drugs that weaken your immune system), as Boswellia may alter how they work.

Use the medication checker on this page to see your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Boswellia may help with osteoarthritis, but it interacts with a very large number of medications through liver metabolism and potentially with immune-suppressing drugs. If you take any regular prescription medications — especially for immune conditions, heart or blood pressure problems, or cholesterol — check them with your doctor or pharmacist before starting.

Otherwise, it's generally well tolerated at typical doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boswellia Extract 500 mg, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359149366
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 73815
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boswellia Extract 500 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
707359149366
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Boswellia extract500 mg--

Other ingredients: MCT Oil, Softgel Capsule, Sunflower Lecithin, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 softgel 1 to 2 times daily with food, or as directed by your healthcare practitioner.

General Statements

How It Works: Extracts from the gum resin of Boswellia serrata have been valued by Ayurvedic herbalists for centuries. Modern scientists have since discovered that Boswellia and some of its constituents, including Boswellic Acids, can affect signaling cascades that mediate critical immune system functions.* Through these pathways, Boswellia may support balanced immune system responses to typical everyday challenges, thus helping to naturally maintain normal, healthy tissues.*

~ Balanced immune response*

Natural color variation may occur in this product.

Precautions

Cautions/Interactions: May cause minor, transient GI discomfort.

Boswellia may interact with anti-inflammatory agents and asthma medications. Consult physician if pregnant/nursing, taking medication, have a medical condition, or if planning any surgical procedures before using this product.

MCT Oil from coconut/palm kernel oil.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

CODE P4936 V3

Formula

~ 65% standardized extract in MCT oil base

MCT Oil from coconut/palm kernel oil.

FDA Statement of Identity

A Dietary Supplement

Formulation

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boswellia Extract 500 mg by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boswellia Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boswellia Extract 500 mg by Protocol For Life Balance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Boswellia extract

Interacts with
952 drugs
500 mg per serving Form: Boswellic Acid, organic Acids

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Boswellia extract monograph & interactions

Other (inactive) ingredients: MCT Oil, Softgel Capsule, Sunflower Lecithin, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boswellia Extract 500 mg by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against Boswellia Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

Boswellia extract 952

Individual Drug Interactions

The ingredients in Boswellia Extract 500 mg interact with 952 drugs. Click any drug to see the details.

1 of the 1 ingredient in Boswellia Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Boswellia extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Boswellia Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Boswellia extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Boswellia extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boswellia Extract 500 mg, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.protocolforlife.com
Pharmacist Counseling Corner

Boswellia Extract 500 mg by Protocol For Life Balance: Common Questions

Does Boswellia Extract 500 mg by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, Boswellia Extract 500 mg has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boswellia Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my osteoarthritis?
Boswellia is rated possibly effective for osteoarthritis, so some evidence backs its use for joint pain and stiffness. That said, results vary, and you should discuss whether it's right for your situation with your doctor.
Is it safe to take while I'm pregnant or breastfeeding?
Safety data in pregnancy is insufficient — it's best avoided during pregnancy. Safety while breastfeeding is unknown, so avoid use then too. Talk with your doctor about what's right for you.
What side effects might I get?
The most common ones are mild: abdominal pain, diarrhea, headache, heartburn, and nausea. In clinical studies, headache was reported in roughly 11% of people taking a specific Boswellia extract, while dizziness and vertigo occurred less often. Very large amounts can rarely cause a gut blockage, but this isn't a concern at normal doses.
Does product quality matter?
Yes. Quality and dose vary widely between Boswellia products, so what you get depends on the brand. That's why it matters to use a trusted source.
What is Boswellia extract?
It's a resin from the Boswellia serrata tree, traditionally used in herbal medicine. This product delivers 500 mg of that extract per softgel.
Why does this interact with so many medications?
Boswellia may slow down five liver enzymes that break down a huge range of common drugs — from antidepressants and blood pressure meds to statins. When your liver processes these drugs more slowly, their blood levels can climb, which may change how they work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boswellia Extract 500 mg label
Go deeper

The Full Monographs Behind Boswellia Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Boswellia Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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