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Dietary supplement

Butterbur Extract 50 mg Ingredients & Drug Interactions

by SuperSmart

Butterbur Extract 50 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butterbur Extract 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butterbur Extract 50 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are extract of Petasites hybridus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Butterbur Extract 50 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Butterbur Extract 50 mg by SuperSmart — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Butterbur Extract 50 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: extract of Petasites hybridus (butterbur) at 50 mg per capsule. The inactive ingredients are acacia gum and rice flour.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Butterbur's overall clinical evidence instead.

Moderate

Some clinical evidence supports Butterbur for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Natural Medicines).

Butterbur is rated possibly effective for two conditions: migraine headache prevention and allergic rhinitis (hay fever). That means there's some clinical evidence it may help, but the data isn't definitive yet.

If you're considering it for either of these, talk with your pharmacist or doctor about whether the evidence is strong enough for your situation.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated, but side effects do occur. The most common are belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset.

Rarely, it can cause liver damage (hepatotoxicity) because of the pyrrolizidine alkaloids it may contain—even some PA-free products have rare reports of liver injury. It can also rarely cause abdominal pain, nausea, and pain in your joints or limbs.

During pregnancy, butterbur is rated likely unsafe because there isn't enough safety data and there are possible liver and other risks. During breastfeeding, safety is unknown, so it's best to avoid it.

If you're pregnant or breastfeeding, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting if you take drugs that induce CYP3A4 (the enzyme that processes butterbur). This is a Moderate-severity interaction affecting a large list of medications—seizure drugs, some TB treatments, and rifampin are among them.

Your pharmacist can tell you if any of your prescriptions are on that list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Butterbur is worth considering if you're dealing with migraines or seasonal allergies and want a plant-based option—but only if you take a PA-free extract like this one. Check your medications against the 85 that may interact with butterbur's enzyme effects before you start.

If you're pregnant, breastfeeding, or have any liver concerns, talk with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butterbur Extract 50 mg, straight from the product label.

Brand SuperSmart
Net contents 60 Vegetarian Capsule(s)
Market status Off market
Date entered into DSLD Jun 24, 2020
DSLD ID 222742
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butterbur Extract 50 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
extract of Petasites hybridus100 mg--

Other ingredients: Acacia Gum, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Phytonutrient

Each capsule contains 50 mg of Petasites hybridus extract.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take two capsules per day.

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butterbur Extract 50 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butterbur Extract 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butterbur Extract 50 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Extract of Petasites hybridus

Interacts with
87 drugs
100 mg per serving Form: Sesquiterpene Lactones

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Extract of Petasites hybridus monograph & interactions

Other (inactive) ingredients: Acacia Gum, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butterbur Extract 50 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Butterbur Extract 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

extract of Petasites hybridus 87

Individual Drug Interactions

The ingredients in Butterbur Extract 50 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butterbur Extract 50 mg interact with drugs. Each result below shows which ingredient is responsible. extract of Petasites hybridus

Each ingredient & the kinds of drugs it affects

For each ingredient in Butterbur Extract 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

extract of Petasites hybridus1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
extract of Petasites hybridus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butterbur Extract 50 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
Smart Nutrition S.A.
Street Address
18 Rue de l'Eau
City
Luxembourg
ZipCode
L-1449
Pharmacist Counseling Corner

Butterbur Extract 50 mg by SuperSmart: Common Questions

Does Butterbur Extract 50 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Butterbur Extract 50 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butterbur Extract 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use butterbur if I'm pregnant?
No—butterbur is rated likely unsafe in pregnancy because there isn't enough safety data and there are possible liver and other risks. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before using it.
Is this product safe for my liver?
This is a PA-free standardized extract, which is important because raw butterbur can damage your liver. That said, even PA-free butterbur supplements have rare reports of liver injury, so it's not risk-free. If you have liver disease or concerns, ask your pharmacist before starting.
What are the most common side effects?
The most common are belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset. Most people tolerate it well, but if any of these bother you, tell your pharmacist.
Does butterbur actually work for migraines?
It's rated possibly effective for migraine headaches, which means there's some clinical evidence it may help prevent them—but the data isn't definitive yet. It's also possibly effective for allergic rhinitis (hay fever). Talk with your doctor about whether it's worth trying for your situation.
Why do I need to check my medications before taking this?
Butterbur contains pyrrolizidine alkaloids that your liver processes through an enzyme called CYP3A4. Certain medications that activate this enzyme could theoretically increase how your body turns these alkaloids into toxic forms. There are 85 individual medications on the interaction list, so a quick check with your pharmacist is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Butterbur Extract 50 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butterbur Extract 50 mg label
Go deeper

The Full Monographs Behind Butterbur Extract 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Butterbur Extract 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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