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Dietary supplement

Butterbur Extract 75 mg Ingredients & Drug Interactions

by Nutricost

Butterbur Extract 75 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butterbur Extract 75 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butterbur Extract 75 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Butterbur extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Butterbur Extract 75 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Butterbur Extract 75 mg by Nutricost — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Butterbur Extract 75 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Butterbur Extract 75 mg is a single-ingredient supplement. Each capsule delivers 75 mg of butterbur extract.

The extract comes from butterbur, a plant used in herbal medicine. Butterbur also contains inactive ingredients—rice flour, hypromellose (a capsule binder), and magnesium stearate—that help hold the capsule together and aren't active parts of the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Butterbur's overall clinical evidence instead.

Moderate

Some clinical evidence supports Butterbur for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Natural Medicines).

Butterbur extract is possibly effective for migraine headache and allergic rhinitis (hay fever), meaning there's some evidence it may help, but it's not conclusive. The evidence isn't strong enough yet to call it proven, but it's promising enough that people do use it for these conditions.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated when taken by mouth. The most common side effects are mild—belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, and stomach upset.

Rare serious adverse effects include liver injury from the pyrrolizidine alkaloids (PAs) in untreated butterbur. This product should be PA-free standardized butterbur to avoid liver damage, so check the label.

There are also rare reports of liver injury even from supplements labeled as PA-free, so if you have liver concerns, talk with your pharmacist. Butterbur is not safe to use during pregnancy or while breastfeeding.

The safety data advises against it in both cases because of the risk of liver and other harm.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product before starting, especially if you take any CYP3A4 inducers (a Moderate-severity interaction). A pharmacist can tell you whether any of your prescriptions fall into that group.

If you're unsure, use the medication checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Butterbur extract may help some people with migraines or seasonal allergies, but it's only a reasonable choice if your prescriptions don't include CYP3A4 inducers. Avoid it if you're pregnant or nursing.

Always make sure you're taking a PA-free standardized product. Run your medications through the checker on this page before you buy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butterbur Extract 75 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 857077008718
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269401
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butterbur Extract 75 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
857077008718
IngredientAmount% DV
Butterbur extract75 mg--

Other ingredients: Rice Flour, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare professional.

Precautions

Warning: For healthy individuals 18 years and older.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

75 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Guaranteed Nutricost

Formulation

Vegetarian

Non GMO Gluten Free Product

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butterbur Extract 75 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butterbur Extract 75 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butterbur Extract 75 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Butterbur extract

Interacts with
87 drugs
75 mg per serving

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Butterbur extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butterbur Extract 75 mg by Nutricost Drug Interactions

Want to check YOUR meds against Butterbur Extract 75 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Butterbur extract 87

Individual Drug Interactions

The ingredients in Butterbur Extract 75 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butterbur Extract 75 mg interact with drugs. Each result below shows which ingredient is responsible. Butterbur extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butterbur Extract 75 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Butterbur extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Butterbur extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butterbur Extract 75 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Butterbur Extract 75 mg by Nutricost: Common Questions

Does Butterbur Extract 75 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Butterbur Extract 75 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butterbur Extract 75 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take butterbur if I'm pregnant or breastfeeding?
No. The safety data advises against butterbur during pregnancy and while breastfeeding because of the risk of liver and other harm. Talk with your doctor or midwife before using any supplements while pregnant or nursing.
What are the most common side effects?
Belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, and stomach upset are the ones people report most often. They're mild and butterbur is generally well tolerated overall.
Does this product have liver risks?
Yes, butterbur contains compounds called pyrrolizidine alkaloids that can damage your liver if present in high amounts. This product should be PA-free standardized butterbur to minimize that risk. Even PA-free products have rare reports of liver injury, so it's worth discussing with your pharmacist if you have liver concerns.
Does butterbur really work for migraines and allergies?
The evidence says it's possibly effective for both migraine headache and allergic rhinitis (hay fever). That means there's promise, but the evidence isn't conclusive yet. It may help some people and not others.
What are the inactive ingredients?
This product contains rice flour, hypromellose (a capsule material), and magnesium stearate. These help form and stabilize the capsule but aren't active parts of the supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Butterbur Extract 75 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butterbur Extract 75 mg label
Go deeper

The Full Monographs Behind Butterbur Extract 75 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Butterbur Extract 75 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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