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Dietary supplement

Ceylon Cinnamon 4000 mg Ingredients & Drug Interactions

by Carlyle

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Ceylon Cinnamon 4000 mg is a dietary supplement by Carlyle with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, indigestion and gas.Based on those ingredients, 599 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ceylon Cinnamon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Ceylon Cinnamon 4000 mg by Carlyle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Ceylon Cinnamon” is listed as a grouped ingredient — the label gives one combined amount (4,000 mg) without saying how much of each component you get.

This product contains one active ingredient: Ceylon Cinnamon Bark Extract at 4000 mg per serving. The extract comes as part of a blend with inactive ingredients — rice powder, gelatin, magnesium stearate, and silica — that serve as fillers and capsule materials.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cassia Cinnamon product and its label doesn't state a use — see Cassia Cinnamon's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Ceylon cinnamon's effectiveness isn't established in our data. The facts we hold show insufficient reliable evidence to rate it for common conditions people ask about, including diabetes, blood sugar control, high cholesterol (dyslipidemia), diarrhea, and common cold.

If you're considering this supplement for a specific health concern, talk with your pharmacist about what the broader research shows.

The evidence, ingredient by ingredient Ceylon Cinnamon Cassia Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cinnamon in food amounts is generally well tolerated. At supplement doses — especially high doses over a long time — there's concern about liver damage because cinnamon contains coumarin, a compound that can harm the liver in large quantities.

In clinical trials, doses ranging from 360 mg to 12 grams daily for three months did not significantly raise liver enzyme levels, but very high coumarin doses (50–7000 mg per day) have caused reversible liver damage in humans. A small number of trial participants reported a rash or allergic skin reaction.

One person had a seizure with low blood sugar (hypoglycemic seizure) while taking cinnamon, though the link is unclear. During pregnancy and breastfeeding, food amounts are likely fine, but avoid concentrated supplement doses because safety data is limited.

Side effects, ingredient by ingredient Ceylon Cinnamon Cassia Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 443 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Carlyle's Ceylon Cinnamon, check with your pharmacist if you take drugs that stress the liver (hepatotoxic drugs) or diabetes medications. Cinnamon may lower blood sugar and could theoretically add to liver strain at high supplement doses.

Altogether, these interactions span 443 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is worth a conversation with your pharmacist, especially if you take diabetes medications or drugs that affect the liver. The evidence for its effectiveness isn't solid in the data we hold, so ask yourself whether you have a specific reason to try it.

Before you start, check your exact medications against the list on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ceylon Cinnamon 4000 mg, straight from the product label.

Brand Carlyle
Barcode (UPC) X003SA4CO5
Net contents 120 Quick Release Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 331354
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ceylon Cinnamon 4000 mg by Carlyle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Quick Release Capsule(s)
Maximum serving Sizes:
2 Quick Release Capsule(s)
Servings per container
60
UPC/BARCODE
X003SA4CO5
IngredientAmount% DV
Ceylon Cinnamon4000 mg--
Ceylon Cinnamon Bark Extract400 mg--

Other ingredients: Rice, Powder, Gelatin, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Our non-GMO Pledge visit our website 100% Highest Quality Ethically sourced ingredients Packaged and Lab tested in the USA GMP Good Manufacturing Practice

General Statements

At Carlyle, our roots run deep with over 40 years experience in health and wellness. Three generations later, our family is committed to providing quality products that you can count on. Our expertise in sourcing the purest ingredients combined with advanced technologies make us proud to delivery premium, honest supplements at the best value. We're dedicated to supporting you and thanks for choosing us in your pursuit to healthy living!

Traditional herb

New

Precautions

Warning: Not intended for use by pregnant or nursing women or persons under the age of 18. If you are taking any medications, planning any medical or surgical procedure or have any medical condition, including diabetes or hypoglycemia, consult your doctor before use.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Warning: Not intended for use by pregnant or nursing women or persons under the age of 18. Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2023 Carlyle Nutritionals LLC

Formula

Ceylon Cinnamon 4000 mg equivalent per serving Equivalent from 400 mg of 10:1 extract per serving

Formulation

Non-GMO Gluten free

No Gluten Wheat Yeast Milk Lactose Soy Artificial color Artificial flavor Artificial sweetener Preservatives Non-GMO

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) quick release capsules daily, preferably with a meal.

See for yourself

Ceylon Cinnamon 4000 mg by Carlyle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Ceylon Cinnamon 4000 mg by Carlyle

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Quick Release Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Ceylon Cinnamon

Interacts with
258 drugs
4000 mg per serving Form: Cinnamomum verum

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evid...

Ceylon Cinnamon monograph & interactions

Other (inactive) ingredients: Rice, Powder, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ceylon Cinnamon 4000 mg by Carlyle Drug Interactions

Want to check YOUR meds against Ceylon Cinnamon 4000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
599Drugs
599 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Ceylon Cinnamon 4000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ceylon Cinnamon2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Ceylon cinnamon may lower blood glucose levels. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Ceylon Cinnamon 4000 mg, from the product label.

Carlyle

See all Carlyle products
Name
Carlyle Nutritionals LLC
City
Melville
State
NY
ZipCode
11747
Phone Number
1-888-692-8862
Pharmacist Counseling Corner

Ceylon Cinnamon 4000 mg by Carlyle: Common Questions

Does Ceylon Cinnamon 4000 mg by Carlyle interact with any medications?
Yes. Based on its ingredients, Ceylon Cinnamon 4000 mg has a known interaction with 599 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ceylon Cinnamon 4000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use while I'm pregnant or breastfeeding?
Food amounts of cinnamon are likely fine, but high-dose supplements like this one haven't been studied enough in pregnancy and breastfeeding. Talk with your doctor or pharmacist before you start — they can weigh the benefits and risks for your situation.
Will this lower my blood sugar?
Cinnamon may lower blood glucose, which is why it could interact with diabetes medications. If you have diabetes or take blood-sugar-lowering drugs, you'll want to check with your pharmacist first.
Can too much cinnamon hurt my liver?
Yes — there's concern about liver damage with high-dose supplements taken over time because cinnamon contains coumarin. In clinical trials at lower doses (360 mg to 12 grams daily for three months), liver enzymes didn't rise much, but very high coumarin doses have caused reversible liver damage in humans. If you take medications that affect the liver, ask your pharmacist before starting.
Does Ceylon cinnamon work for diabetes or high cholesterol?
The evidence we have is insufficient to rate this supplement for diabetes, high cholesterol, or most other conditions. If you're looking at it for a specific health issue, talk with your pharmacist about what research exists outside our data.
What's in this product besides the cinnamon?
The capsule contains rice powder, gelatin, magnesium stearate, and silica — these are inactive ingredients that serve as fillers and help make the capsule.
Could I have an allergic reaction to cinnamon?
Allergic reactions to cinnamon are uncommon but possible. A small number of trial participants reported a rash, and in rare cases, people allergic to cinnamic alcohol (a compound in cinnamon) have had skin reactions. If you have a known cinnamon allergy, avoid this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ceylon Cinnamon 4000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ceylon Cinnamon 4000 mg label
Sources

Sources & How We Checked

Ceylon Cinnamon 4000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ceylon Cinnamon 22 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. PubMed
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70. PubMed
  6. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. PubMed
  7. Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
  8. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  9. Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
  10. Oliveira JdA, da Silva IC, Trindade LA, et al. Safety and tolerability of essential oil from Cinnamomum zeylanicum blume leaves with action on oral candidosis and its effect on the physical properties of the acylic resin. Evid Based Complement Alternat Me
  11. Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275. PubMed
  12. Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5. PubMed
  13. Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
  14. Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
  15. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  16. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  17. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  18. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  19. Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 2017;17(1):550. PubMed
  20. Zareie A, Sahebkar A, Khorvash F, Bagherniya M, Hasanzadeh A, Askari G. Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial. Phytother Res 2020;34(11):2945-52. PubMed
  21. Zobeiri M, Parvizi F, Shahpiri Z, et al. Evaluation of the effectiveness of cinnamon oil soft capsule in patients with functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. Evid Based Complement Alternat Med 2021;2021:6634115. PubMed
  22. Chase C, Doyle A, John SS, Laurent T, Griffith S. Post-operative haemorrhage secondary to cinnamon use. A case report. Int J Surg Case Rep 2022;95:107179. PubMed

See these in context on the Ceylon Cinnamon monograph →

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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