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Dietary supplement

Choline Ingredients & Drug Interactions

by Country Life

Choline label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline is a dietary supplement by Country Life with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline by Country Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline by Country Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline, a nutrient your body uses to support brain function, cell structure, and liver health. It's found naturally in foods like eggs and chicken, but some people take supplements when their diet falls short.

The tablet also contains several inactive ingredients — cellulose, stearic acid, an organic coating, silica, and magnesium stearate — which are common binders and fillers that help hold the tablet together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Choline's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: nerve development and cholesterol metabolism.
  • We looked for evidence on: Infant development, Neural tube birth defects, Cardiovascular disease (CVD), Nonalcoholic fatty liver disease (NAFLD), Fetal development, Neurological function — and 2 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Neural tube birth defects, Infant development.

The evidence for choline is mixed. Our data shows insufficient reliable evidence to rate it for age-related cognitive decline, Alzheimer disease, allergic rhinitis (hay fever), bronchitis, or TPN-associated hepatic steatosis (liver fat from prolonged intravenous feeding).

For athletic performance, the evidence suggests it's likely ineffective. If you're considering choline for a specific condition, talk with your doctor about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated at normal food amounts and supplement doses used under professional guidance. At very high doses — above 3.5 grams daily — it can cause side effects including fishy body odor, diarrhea, nausea, vomiting, and excessive salivation.

These effects become more likely at doses of 9 grams daily or higher. Choline is rated likely safe during pregnancy and is actually important during that time, but use it only in amounts your doctor recommends — whether from food or supplements.

While breastfeeding, your choline needs are higher than usual; use supplements only under professional guidance to make sure you're taking the right dose.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine (used for certain eye conditions and other purposes), check with your doctor or pharmacist before starting this product — choline may decrease atropine's effectiveness. No interactions are documented for the ingredients we could check with any other common medication types, but that doesn't mean none exist; verify your full medication list with the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Choline is a nutrient supplement that may be worth considering if your diet is low in choline-rich foods and your doctor thinks you could benefit — but the evidence for specific health claims is thin. If you take atropine or any other medications, check with your doctor or pharmacist before you start.

Pregnant or breastfeeding? Talk with your healthcare provider about whether a supplement is right for you and what dose makes sense.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline, straight from the product label.

Brand Country Life
Barcode (UPC) 015794065104
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 208084
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
015794065104
IngredientAmount% DV
Choline266 mg48%

Other ingredients: Cellulose, Stearic Acid, organic Coating, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

In its natural state, choline is commonly found in whole eggs and fatty meats. If these are excluded from your diet, consider adding choline. It supports nerve development and the metabolism of cholesterol.

Yes Kosher-Parve

Yes Certified Halal by IFANCA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Yes Certified gluten-free by GFCO.org

Yes Certified vegan by the AVA

No Yeast, corn or wheat No Soy, milk or salt No Sugar or preservatives No Artificial colors, flavors or sweeteners No GMOs

Certified gluten-free

General Statements

Yes Recyclable packaging Yes Manufacturing supports wind power

This product has been manufactured at a GMP Registered facility.

Established 1971

Supports nerve health Supports metabolism of fats and cholesterol

Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy

Seals/Symbols

Ifanca Certified crescent M Halal K Parve Certified B Corporation GF Certified Gluten-free

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take one (1) tablet daily with food.

Precautions

As a reminder, discuss the supplements and medications that you take with your health care providers.

Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur.

Do not accept if seal is broken.

Keep out of the reach of children.

Storage

Store in a dry place between 59(0)-86(0)F.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline by Country Life

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Choline

Interacts with
16 drugs
266 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Organic Coating, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline by Country Life Drug Interactions

Want to check YOUR meds against Choline?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Choline interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Choline by Country Life: Common Questions

Does Choline by Country Life interact with any medications?
Yes. Based on its ingredients, Choline has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is choline safe to take while I'm pregnant?
Choline is rated likely safe during pregnancy, and it's actually an important nutrient at that time. However, use it only in the dose your doctor advises — whether you're getting it from food or a supplement. Your healthcare provider can recommend the right amount for you.
What does choline do in the body?
Choline supports brain function, helps build and maintain cell membranes, and plays a role in liver health. Your body can make some choline on its own, but you also need it from food or supplements.
Can I take too much choline?
Yes. At doses above 3.5 grams daily, choline can cause side effects like fishy body odor, nausea, vomiting, and diarrhea. Doses of 9 grams daily or higher are more likely to cause these problems. Stick to dosing guidance on the label or from your doctor.
Does choline actually improve athletic performance?
Our data shows the evidence suggests choline is likely ineffective for athletic performance, so it's probably not worth taking for that reason.
What's the fishy smell I've heard about?
At higher doses, choline can cause a fishy body odor. This happens because your gut bacteria break down choline into a compound called trimethylamine. Staying within recommended doses should help you avoid this side effect.
Can I breastfeed while taking a choline supplement?
Your need for choline is actually higher while breastfeeding, so adequate choline is important. Use supplements only under professional guidance so your healthcare provider can confirm you're taking a safe and appropriate dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline label
Go deeper

The Full Monographs Behind Choline’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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