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Dietary supplement

Choline Ingredients & Drug Interactions

by Doctor Recommended Supplements

Choline label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline is a dietary supplement by Doctor Recommended Supplements with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline by Doctor Recommended Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline by Doctor Recommended Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline by Doctor Recommended Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline. Choline is a nutrient your body uses to make and regulate acetylcholine, a chemical messenger in your brain and nervous system.

It also plays a role in cell structure and fat metabolism. The capsule itself is made from vegetable material, and rice flour is included as an inactive ingredient.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cognitive support and nervous system health.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, Infant development, Neural tube birth defects — and 4 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for TPN-associated hepatic steatosis, Alzheimer disease, Nonalcoholic fatty liver disease (NAFLD), Cognitive function, and more.

The evidence for choline is mixed and often thin. For athletic performance, the data suggests it's likely ineffective.

For several other uses—bronchitis, age-related cognitive decline, liver fat accumulation (TPN-associated hepatic steatosis), hay fever, and Alzheimer disease—we don't have enough reliable evidence in our data to say whether it works or doesn't. If you're considering choline for one of these purposes, talk it over with your doctor or pharmacist about what the broader research shows.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated at food amounts and typical supplement doses. High doses—especially above 3.5 grams daily—can cause side effects.

At very high doses (9 grams or more daily), people have reported diarrhea, nausea, vomiting, and a distinctive fishy body odor caused by how your gut breaks down excess choline. During pregnancy, choline is important for your baby's development, but doses should come from prenatal vitamins or supplements prescribed by your doctor.

Breastfeeding increases your choline needs, so again, supplements should be used only under professional guidance.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine (a medication used for certain nerve and muscle conditions), let your doctor or pharmacist know before starting choline—it may decrease atropine's effects. Altogether, these interactions span 16 individual medications.

Beyond atropine, no other interaction types are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Choline may be worth considering if you're looking for a nutrient your brain relies on, but the evidence for specific health claims is limited or missing. If you take atropine, check with your doctor or pharmacist before starting—this product may affect how well it works.

For any use during pregnancy or breastfeeding, talk with your healthcare provider first about the right dose for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline, straight from the product label.

Brand Doctor Recommended Supplements
Barcode (UPC) X000YGYNMR
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 206326
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline by Doctor Recommended Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
X000YGYNMR
IngredientAmount% DV
Choline500 mg--

Other ingredients: Vegetable Capsule, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) tablet twice daily with water.

Precautions

Caution: Do not exceed recommended dose.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or taking prescription medication should consult a physician before taking this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or taking prescription medication should consult a physician before taking this or any dietary supplement.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA GMP Good Manufacturing Practice Consistent Quality FDA registered facility Vegan friendly

Formulation

Vegan friendly

Formula

as Choline Bitartrate

General Statements

Helps maintain cellular health Supports metabolism Supports nervous system health Provides cognitive support

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline by Doctor Recommended Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline by Doctor Recommended Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Choline

Interacts with
16 drugs
500 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline by Doctor Recommended Supplements Drug Interactions

Want to check YOUR meds against Choline?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Choline interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline, from the product label.

Doctor Recommended Supplements

See all Doctor Recommended Supplements products
Name
New World Herbal Wellness, LLC
Street Address
3422 Old Capitol Trail, Suite #250
City
Wilmington
State
DE
ZipCode
19808
Web Address
www.doctor-recommended.com
Pharmacist Counseling Corner

Choline by Doctor Recommended Supplements: Common Questions

Does Choline by Doctor Recommended Supplements interact with any medications?
Yes. Based on its ingredients, Choline has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take choline during pregnancy?
Choline is rated likely safe during pregnancy and is actually important for your baby's development. That said, doses should come from a prenatal vitamin or a supplement your doctor has advised—not just any over-the-counter bottle. Talk with your doctor about what's right for you.
Can I take this while breastfeeding?
Your choline needs go up while you're breastfeeding, so supplementing may be helpful—but only under professional guidance. Check with your doctor or pharmacist about whether you need it and what dose is safe.
What dose should I take?
The facts on file here don't specify a recommended dose for this product. Follow the label on the bottle, or talk with your pharmacist or doctor to find out what's right for your situation.
Will choline give me side effects?
At typical doses, it's well tolerated with few problems. High doses—especially over 3.5 grams daily—can cause nausea, diarrhea, vomiting, and a fishy body odor. Stay within the upper limit of 3.5 grams daily to keep side effects at bay.
What is choline actually for?
Choline is a nutrient your brain and body use to make acetylcholine, a chemical messenger in your nervous system. It also helps build and maintain cell membranes and plays a role in how your body handles fats. The evidence for specific health claims—like boosting memory or helping athletic performance—is weak or lacking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline label
Go deeper

The Full Monographs Behind Choline’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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