Coenzyme Active B6 Caps Ingredients & Drug Interactions
by Country Life
What is this page for?
First and foremost: checking Coenzyme Active B6 Caps against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Coenzyme Active B6 Caps is a dietary supplement by Country Life with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pyridoxine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Coenzyme Active B6 Caps by Country Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Coenzyme Active B6 Caps by Country Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Coenzyme Active B6 Caps by Country Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 4 ingredients, including three active forms of vitamin B6: pyridoxine hydrochloride, pyridoxal 5-phosphate, and vitamin B6 itself. All three are the same nutrient in slightly different forms that your body converts to its active working version.
The fourth ingredient, pyridoxine alpha-ketoglutarate hydrochloride, is also a B6 form, though we couldn't find full safety data for it. You'll also find inactive ingredients — cellulose, rice bran extract, vegetable glaze, silica, and sunflower oil — that make up the capsule and help it hold together.
Does it work?
Strong evidence
Vitamin B6 in this product is effective for sideroblastic anemia (a type of blood disorder), vitamin B6 deficiency itself, and pyridoxine-dependent epilepsy. It's likely effective for high homocysteine levels (hyperhomocysteinemia), which are linked to heart disease risk.
For pregnancy-related nausea and vomiting, the evidence is only possibly effective — it may help some people, but the science isn't definitive. We don't have effectiveness data on file for the pyridoxine alpha-ketoglutarate hydrochloride form.
How safe is it?
Well-documented data
Vitamin B6 is generally well tolerated in doses under 100 mg daily. At normal dietary amounts and standard supplement doses, it's considered safe, but high doses over time can harm your nerves (a condition called sensory neuropathy).
Common side effects at any dose include abdominal pain, headache, heartburn, loss of appetite, nausea, and drowsiness. The serious risk — nerve damage — shows up mainly with very high daily doses (over 1,000 mg) or very large total doses (1,000 grams or more), though it can happen at lower amounts too.
If you're considering this for morning sickness, use it only at recommended levels and under a doctor's guidance. There's no safety data on file for pregnancy or breastfeeding use of these specific forms.
Meds to double-check
Moderate interaction found
Before you take this, double-check any blood pressure medications you're on — vitamin B6 may add to their effect. Also check seizure medications (phenobarbital, phenytoin), the heart drug amiodarone, and levodopa for Parkinson's.
No interactions are documented for the pyridoxine alpha-ketoglutarate hydrochloride ingredient we couldn't check.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This B6 supplement works well for B6 deficiency and certain blood disorders, and may help with homocysteine levels. If you take blood pressure medications, seizure drugs, amiodarone for heart rhythm, or levodopa for Parkinson's, check your specific prescriptions with the tool below before starting.
At standard doses it's well tolerated, but don't take very high doses long-term without guidance from your pharmacist or doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Coenzyme Active B6 Caps, straight from the product label.
| Brand | Country Life |
|---|---|
| Barcode (UPC) | 015794062363 |
| Net contents | 30 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 326793 |
| Product type | Vitamin |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Coenzyme Active B6 Caps by Country Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pyridoxine Hydrochloride | 25 mg | -- |
| Pyridoxal 5-Phosphate | 25 mg | -- |
| Vitamin B6 | 50 mg | 2941% |
| Pyridoxine Alpha-Ketoglutarate Hydrochloride | 25 mg | -- |
Other ingredients: Cellulose, Cellulose, Rice Bran Extract, Vegetable Glaze, Silica, Sunflower Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Vitamin B6 helps metabolize lipids, carbohydrates, and proteins into energy. It also supports the function and growth of red blood cells as well as supporting the nervous and immune systems. P-5-P is a biologically active form of vitamin B6 and is utilized by the body.
Yes kosher
P-5-P/PAK
Biologically active form of B6
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Yes certified gluten-free by gfco.org No yeast, corn or wheat No soy, milk or salt No sugar or preservatives No artificial colors, flavors or sweeteners No magnesium stearate
Yes certified vegan by the AVA
Yes manufacturing supports wind power This product has been manufactured at a GMP registered facility.
GF Certified Gluten-free
Certified gluten-free
Support energy Supports nervous system health
Out Pledge of Integrity Authenticity Cleanliness Freshness Consistency Accuracy
General Statements
Yes recyclable packaging
Seals/Symbols
Certified B Corporation GF Certified Gluten-free
K (Kosher)
Brand IP Statement(s)
Established 1971 Country Life
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adults take one (1) capsule daily with food.
Precautions
As a reminder, discuss the supplements and medications that you take with your health care providers.
Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.
Stop using and consult a doctor if any adverse reactions occur.
Do not accept if seal is broken.
Keep out of reach of children.
Storage
Store in a dry place between 59 degrees - 86 degrees F.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Coenzyme Active B6 Caps by Country Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Coenzyme Active B6 Caps by Country Life
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pyridoxine Hydrochloride
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Pyridoxine Hydrochloride monograph & interactionsPyridoxal 5-Phosphate
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Pyridoxal 5-Phosphate monograph & interactionsVitamin B6
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Vitamin B6 monograph & interactionsPyridoxine Alpha-Ketoglutarate Hydrochloride
Other (inactive) ingredients: Cellulose, Cellulose, Rice Bran Extract, Vegetable Glaze, Silica, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.
Coenzyme Active B6 Caps by Country Life Drug Interactions
HelloPharmacist Interaction Report
Country Life's Coenzyme Active B6 Caps contains three forms of vitamin B6, all of which interact with several medication types.
The most serious concern is with blood pressure medications (antihypertensives) — at higher doses, vitamin B6 may add to their effect and lower your blood pressure further, creating a Moderate-severity risk.
Read the full breakdown — every affected drug type, severity by severity
Vitamin B6 also interacts with the heart rhythm drug amiodarone (Cordarone), potentially making your skin more sensitive to sunlight — another Moderate interaction. If you take seizure medications like phenobarbital (Luminal) or phenytoin (Dilantin), high-dose B6 may reduce how well they work by speeding up how your body clears them, again at Moderate severity.
There's also a Minor interaction with levodopa (a Parkinson's drug) if you take it without carbidopa; if you're on Sinemet (which combines levodopa with carbidopa), this interaction shouldn't occur.
We couldn't check one ingredient — pyridoxine alpha-ketoglutarate hydrochloride — because we hold no data for it. Altogether, these interactions span 208 individual medications.
Before you start this supplement, run your exact prescriptions through the checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Coenzyme Active B6 Caps?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Coenzyme Active B6 Caps interact with 210 drugs. Click any drug to see the details.
1 of the 4 ingredients in Coenzyme Active B6 Caps interact with drugs. Each result below shows which ingredient is responsible. Pyridoxine Hydrochloride
AcebutololRhotral, Sectral
How Acebutolol interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Amiodarone (cordarone) Moderate
Interaction Summary
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Read the full Vitamin B6 + Amiodarone interactionAmlodipineNorliqva
How Amlodipine interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Ammonium Chloride interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Aprobarbital, Butabarbital, Phenobarbital interactionAprocitentanTryvio
How Aprocitentan interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Aprocitentan interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Aspirin, Codeine Phosphate, Phenobarbital interactionAtenololAtenix, Tenormin
How Atenolol interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Atenolol, Chlorthalidone interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Atropine, Phenobarbital interactionAzilsartanEdarbi
How Azilsartan interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Azilsartan, Chlorthalidone interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Coenzyme Active B6 Caps — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladonna Extract, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Coenzyme Active B6 Caps with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pyridoxine Hydrochloride
Amiodarone (Cordarone)
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.
Antihypertensive Drugs
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Phenobarbital (Luminal)
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Phenytoin (Dilantin)
High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.
Levodopa
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.
Brand information
Manufacturer and brand details for Coenzyme Active B6 Caps, from the product label.
Country Life
See all Country Life products- Name
- Country Life, LLC
- Street Address
- 180 Vanderbilt Motor Parkway
- City
- Hauppauge
- State
- NY
- ZipCode
- 11788
- Web Address
- CountryLifeVitamins.com
Coenzyme Active B6 Caps by Country Life: Common Questions
Does Coenzyme Active B6 Caps by Country Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take long-term?
Can I use this for morning sickness during pregnancy?
What are the main side effects I might notice?
Does this really help with vitamin B6 deficiency?
Why are there three different forms of B6 in one capsule?
I'm on blood pressure medication. Can I still take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Coenzyme Active B6 Caps is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Coenzyme Active B6 Caps’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Coenzyme Active B6 Caps's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B6 32 references
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
- South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
- Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
- Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
- Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
- Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
- Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
- Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
- Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
- Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
- Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
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