Coenzyme Q-10 Plus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Coenzyme Q-10 Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Coenzyme Q-10 Plus is a dietary supplement by Douglas Laboratories with 3 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 220 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coenzyme Q-10, L-Tyrosine, L-Carnitine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Coenzyme Q-10 Plus by Douglas Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Coenzyme Q-10 Plus by Douglas Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Coenzyme Q-10 Plus by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Coenzyme Q-10 Plus contains three active ingredients. L-Tyrosine is an amino acid that serves as a building block for neurotransmitters and thyroid hormones.
L-Carnitine helps transport fatty acids into cells for energy production and is particularly important in heart and muscle function. Coenzyme Q-10 is an antioxidant compound that plays a role in cellular energy production and is found naturally throughout your body.
The product also contains inactive ingredients (cellulose, gelatin, and vegetable stearate) that serve as fillers and capsule material.
Does it work?
Strong evidence
L-Tyrosine is established as effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, though it's rated possibly ineffective for athletic performance and insufficient evidence exists for alcohol use disorder and dementia. L-Carnitine is effective for L-carnitine deficiency and possibly effective for high cholesterol, congestive heart failure, and angina.
Coenzyme Q-10 is likely effective for Coenzyme Q-10 deficiency and possibly effective for fibromyalgia, migraine headaches, congestive heart failure, and diabetic nerve pain. The evidence varies by ingredient and condition, so talk with your pharmacist about whether this combination fits your specific needs.
How safe is it?
Well-documented data
Coenzyme Q-10 is generally well tolerated by most adults when used as directed, with no serious adverse effects documented in clinical studies. L-Tyrosine and L-Carnitine are generally well tolerated in healthy adults at typical doses, though both can cause gastrointestinal side effects—heartburn, nausea, and diarrhea are most common.
Larger doses of L-Tyrosine or L-Carnitine may cause headache, fatigue, or stomach upset; these effects can often be reduced by lowering the dose. High doses of L-Carnitine have been associated with a fishy body odor.
All three ingredients lack sufficient safety data for regular supplemental use without medical supervision, so talk with your doctor or pharmacist before starting this product on an ongoing basis.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you're on blood thinners like warfarin or acenocoumarol (Moderate severity)—all three ingredients may interfere with how well they work. Also flag thyroid hormone replacement medications (Moderate severity, from L-Tyrosine and L-Carnitine), levodopa for Parkinson's disease (Moderate severity, from L-Tyrosine), chemotherapy drugs, especially alkylating agents (Moderate severity, from Coenzyme Q-10), and blood pressure medications (Minor severity, from Coenzyme Q-10).
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you have a specific deficiency or condition where one of these ingredients has evidence of benefit—and especially if you're not on blood thinners, thyroid medications, or chemotherapy. If you take any prescription medications, check them against the interaction tool on this page before you start.
Your pharmacist or doctor can help you decide whether the benefits outweigh any interaction risks for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Coenzyme Q-10 Plus, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2012 |
| DSLD ID | 8658 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Coenzyme Q-10 Plus by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Tyrosine | 75 mg | -- |
| L-Carnitine | 75 mg | -- |
| Coenzyme Q-10 | 25 mg | -- |
Other ingredients: Cellulose, Gelatin, Vegetable Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Storage
For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)
Formulation
This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial color-ing, preservatives or flavoring.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 capsule daily or as directed by your healthcare professional.
Precautions
Tamper resistant package, do not use if outer seal is missing.
KEEP OUT OF REACH OF CHILDREN.
General
Formula #7418
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Coenzyme Q-10 Plus by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Coenzyme Q-10 Plus by Douglas Laboratories
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Tyrosine
Interacts with21 drugs
L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...
L-Tyrosine monograph & interactionsL-Carnitine
Interacts with19 drugs
L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...
L-Carnitine monograph & interactionsCoenzyme Q-10
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
Coenzyme Q-10 monograph & interactionsOther (inactive) ingredients: Cellulose, Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.
Coenzyme Q-10 Plus by Douglas Laboratories Drug Interactions
HelloPharmacist Interaction Report
Coenzyme Q-10 Plus by Douglas Laboratories contains three active ingredients, and together they interact with a significant number of medications.
The most serious concern is with blood thinners (anticoagulants): both L-Carnitine and Coenzyme Q-10 may reduce the effectiveness of warfarin, a common blood thinner, by different mechanisms — L-Carnitine theoretically enhances an unrelated anticoagulant (acenocoumarol), while Coenzyme Q-10 works similarly to vitamin K and can counteract warfarin's effects. Case reports of reduced warfarin efficacy linked to Coenzyme Q-10 have been documented.
Read the full breakdown — every affected drug type, severity by severity
L-Tyrosine and L-Carnitine both interact with thyroid hormone replacement medications at Moderate severity, potentially interfering with how well they work. L-Tyrosine may compete with levodopa (used for Parkinson's disease) for absorption, reducing levodopa's effectiveness.
Coenzyme Q-10 also interacts with chemotherapy drugs called alkylating agents, as its antioxidant effects may protect tumor cells from these cancer treatments. Additionally, Coenzyme Q-10 may have minor additive blood pressure-lowering effects with blood pressure medications.
Altogether, these interactions span 220 individual medications. If you're on any prescription medication—especially blood thinners, thyroid hormones, levodopa, cancer medications, or blood pressure drugs—run them through the interaction checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Coenzyme Q-10 Plus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Coenzyme Q-10 Plus interact with 220 drugs. Click any drug to see the details.
3 of the 3 ingredients in Coenzyme Q-10 Plus interact with drugs. Each result below shows which ingredient is responsible. Coenzyme Q-10 L-Tyrosine L-Carnitine
LurbinectedinZepzelca
How Lurbinectedin interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Lurbinectedin interactionMechlorethamine HydrochlorideValchlor
How Mechlorethamine Hydrochloride interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Mechlorethamine Hydrochloride interactionMelphalanAlkeran, Hepzato
How Melphalan interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Melphalan interactionMelphalan FlufenamidePepaxto
How Melphalan Flufenamide interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Melphalan Flufenamide interactionMelphalan HydrochlorideEvomela
How Melphalan Hydrochloride interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Melphalan Hydrochloride interactionMenotropinsMenopur, Repronex
How Menotropins interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
L-carnitineThyroid Hormone Moderate
Interaction Summary
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
Read the full L-carnitine + Menotropins interactionL-tyrosineThyroid Hormone Moderate
Interaction Summary
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Read the full L-tyrosine + Menotropins interactionOspemifeneOsphena
How Ospemifene interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
L-carnitineThyroid Hormone Moderate
Interaction Summary
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
Read the full L-carnitine + Ospemifene interactionL-tyrosineThyroid Hormone Moderate
Interaction Summary
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Read the full L-tyrosine + Ospemifene interactionOxaliplatinEloxatin
How Oxaliplatin interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Oxaliplatin interactionProcarbazineMatulane
How Procarbazine interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Procarbazine interactionStreptozocinZanosar
How Streptozocin interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Streptozocin interactionTemozolomideTemodar
How Temozolomide interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Temozolomide interactionTestosterone UndecanoateAndriol, Aveed, Jatenzo, Kyzatrex
How Testosterone Undecanoate interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
L-carnitineThyroid Hormone Moderate
Interaction Summary
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
Read the full L-carnitine + Testosterone Undecanoate interactionL-tyrosineThyroid Hormone Moderate
Interaction Summary
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Read the full L-tyrosine + Testosterone Undecanoate interactionThiotepaTepadina, Thioplex
How Thiotepa interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Thiotepa interactionThyroglobulinProloid
How Thyroglobulin interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
L-carnitineThyroid Hormone Moderate
Interaction Summary
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
Read the full L-carnitine + Thyroglobulin interactionL-tyrosineThyroid Hormone Moderate
Interaction Summary
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Read the full L-tyrosine + Thyroglobulin interactionThyroid HormoneEtwon
How Thyroid Hormone interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
L-tyrosineThyroid Hormone Moderate
Interaction Summary
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Read the full L-tyrosine + Thyroid Hormone interactionL-carnitineThyroid Hormone Moderate
Interaction Summary
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
Read the full L-carnitine + Thyroid Hormone interactionTrabectedinYondelis
How Trabectedin interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Trabectedin interactionWarfarinWarfarin
How Warfarin interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
Coenzyme Q-10Warfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q-10 + Warfarin interactionL-carnitineWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
Read the full L-carnitine + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Coenzyme Q-10 Plus — through 2 ingredients. Tap an ingredient for the detail:
Coenzyme Q-10Warfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q-10 + Warfarin Sodium interactionL-carnitineWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
Read the full L-carnitine + Warfarin Sodium interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Coenzyme Q-10 Plus — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Amlodipine, Celecoxib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Coenzyme Q-10 Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Coenzyme Q-10
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
L-Tyrosine
Levodopa
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.
Thyroid Hormone
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.
L-Carnitine
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Brand information
Manufacturer and brand details for Coenzyme Q-10 Plus, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Web Address
- www.douglaslabs.com
Coenzyme Q-10 Plus by Douglas Laboratories: Common Questions
Does Coenzyme Q-10 Plus by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to take this while I'm pregnant?
Can I take this while breastfeeding?
What's L-Carnitine for?
Does CoQ-10 work for migraine headaches?
What side effects might I get from this?
Is this product made with any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Coenzyme Q-10 Plus is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Coenzyme Q-10 Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Tyrosine
Interacts with 21 drugsL-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...
Read the full Tyrosine monograph → Herb & supplement monographL-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographCoenzyme Q10
Interacts with 198 drugsCoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...
Read the full Coenzyme Q10 monograph →Sources & How We Checked
Coenzyme Q-10 Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 85 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tyrosine 4 references
- Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
- DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
- Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
- van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed
L-carnitine 41 references
- Ellaway CM, Williams K, Leonard H, et al. Rett syndrome: randomized controlled trial of L-carnitine. J Child Neurol 1999;14:162-7. PubMed
- Anon. Carnitor (levocarnitine) package insert. Sigma-Tau Pharmaceuticals Inc, Gaithersburg, MD. December 1999.
- Cherchi A, Lai C, Angelino F, et al. Effects of L-carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized, placebo-controlled, crossover study. Int J Clin Pharmacol Ther Toxicol 1985;23:569-72.
- Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology 1997;35:16-23. PubMed
- Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
- Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
- Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
- Evans AM, Fornasini G. Pharmacokinetics of L-carnitine. Clin Pharmacokinet 2003;42:941-67. PubMed
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