Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Collagen Peptides Ingredients & Drug Interactions

by NaturesPlus

Collagen Peptides label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen Peptides against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Collagen Peptides is a dietary supplement by NaturesPlus with 3 active ingredients. Its ingredients are commonly taken for skin health and wrinkles, joint pain and osteoarthritis, bone health.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Collagen Peptides by NaturesPlus

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen Peptides by NaturesPlus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Collagen Peptides by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Collagen Enzyme” is listed as a grouped ingredient — the label gives one combined amount (30 mg) without saying how much of each component you get.
  • “Collagenase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Collagen Boosting Enzyme Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This powder contains 3 active ingredients: proteases (enzymes that break down proteins), serrapeptase (a fibrinolytic enzyme), and a collagen peptides blend made from grass-fed beef, fish, chicken, and eggshell membrane collagen. The collagen is hydrolyzed, meaning it's been broken down into smaller peptides your body can more easily absorb.

There are no inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hair, skin, nails, joints, immune system health.
  • We looked for evidence on: Aging skin, Atopic dermatitis (eczema), Back pain, Brittle nails, Cellulite, Dermatoporosis — and 4 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Dry skin.
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Back pain.

The collagen peptides in this product are rated possibly effective for aging skin and dry skin. For muscle strength, the evidence suggests it's possibly ineffective.

The data on serrapeptase for conditions like chronic bronchitis, asthma, back pain, and osteoporosis shows insufficient reliable evidence to rate its benefit. Proteases' effectiveness isn't established in our data.

The evidence, ingredient by ingredient Collagen Peptides

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Collagen peptides are generally well tolerated as a dietary protein; rare side effects include nausea, indigestion, diarrhea, and bloating. Serrapeptase is generally tolerated short-term, though long-term safety isn't well studied; some people report stomach pain, gastrointestinal upset, or nausea at about the same rate as placebo, and very rarely bullous pemphigoid (a skin condition) has been reported.

Proteases may cause digestive upset or allergic reactions in some people. During pregnancy, serrapeptase and proteases are best avoided unless prescribed; collagen peptides are not well studied in pregnancy, so check with your doctor.

While breastfeeding, serrapeptase should be avoided, and both proteases and collagen peptides have little safety data—talk to your healthcare provider.

Side effects, ingredient by ingredient Collagen Peptides

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs—warfarin, aspirin, clopidogrel, or similar medications—double-check this product with your pharmacist or doctor before you start. Serrapeptase may increase your risk of bruising and bleeding when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in collagen support for skin or general protein intake. If you take blood thinners or antiplatelet drugs, check with your pharmacist first—the serrapeptase could increase bleeding risk.

Pregnant or breastfeeding women should talk to their doctor before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Peptides, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467459618
Net contents 0.65 Pound(s); 294 Gram(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 249656
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Peptides by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10.5 Gram(s), 21 Gram(s)
Maximum serving Sizes:
10.5 Gram(s), 21 Gram(s)
Servings per container
14
UPC/BARCODE
097467459618
IngredientAmount% DV
Calories80 Calorie(s), 40 Calorie(s)--
Calories from Fat0 Gram(s), 0 Gram(s)--
Protein20 Gram(s), 10 Gram(s)--
Proteases0 NP, 0 NP--
Serrapeptase0 NP, 0 NP--
Collagen Enzyme30 mg, 15 mg--
Collagenase0 NP, 0 NP--
Hydrolyzed grass-fed Beef Collagen, Fish Collagen, Chicken Collagen and Eggshell Membrane Collagen concentrate20 Gram(s), 10 Gram(s)--
Collagen Boosting Enzyme Blend0 NP, 0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Look and feel your best with NaturesPlus Collagen Peptides. Boost the health of your hair, skin, nails, joints, immune system and much more with the power of collagen protein peptides. NaturesPlus Collagen Peptides provides the highest quality Collagen available: Sourced from Grass-Fed Beef, Wild-Caught Cod, Cage-Free Chicken and Eggshell Membrane. Clean, sustainable ingredients are the best choice of collagen sources. These 6 major Collagen Types (I, II, II, IV, V & X) provide a powerful profile delivering exceptional whole body benefits. Maximized Absorption Superior Source Hydrolyzed Collagen with Collagen Digesting Enzymes to maximize absorption. Full Spectrum Collagen provides whole body results: Type I - Skin elasticity Type II - Joints and immune system Type III - Joints, blood vessels, vital organs Type IV - Cell health and growth Type V -Skin, tendons and immune system Type X - Joints, bones, muscles and hair

Grass fed Sustainably caught Cage-free chicken Eggshell membrane I II III IV V X Types of natural collagen

Formulation

Full Spectrum Collagen provides whole body results: Type I - Skin elasticity Type II - Joints and immune system Type III - Joints, blood vessels, vital organs Type IV - Cell health and growth Type V -Skin, tendons and immune system Type X - Joints, bones, muscles and hair

Certified NON-GMO Gluten Free

GMP Independently certified

Clean Pure Optimized Don't settle for non-hydrolyzed collagen!

Soft skin Strong nails Hair growth Gut health Joint relief Clean ingredients, clean taste

Free from artificial colors and preservatives. Does not contain milk, crustacean shellfish, tree nut, peanut, wheat or soybean allergens.

High-quality collagen protein is naturally free from the essential amino acid tryptophan an therefore has no % daily value.

General Statements

Environmentally responsible Recyclable/renewable

Notice: This product is sold by weight not volume, therefore settling of contents may occur during shipping and handling.

FDA Disclaimer Statement

These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Add 1 scoop (10.5g) or 2 scoops (21g) Collagen Peptides powder to 8 fl. oz. of water, juice or a hot or color liquid or recipe of your choice.

NaturesPlus superior collagen forms mix quickly and easily. No blender required!

Precautions

Contains egg and fish.

Keep out of reach of children.

Not to be used as the sole source of dietary calories.

Storage

Keep tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen Peptides by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen Peptides label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen Peptides by NaturesPlus

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size10.5 Gram(s) Dosage formPowder Servings per container14 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

20 Gram(s) per serving

Collagen Enzyme

30 mg per serving
  • › Collagen Boosting Enzyme Blend

Hydrolyzed grass-fed Beef Collagen, Fish Collagen, Chicken Collagen and Eggshell Membrane Collagen concentrate

No known
interactions
20 Gram(s) per serving Form: Chicken Collagen, Eggshell Membrane Collagen, Fish Collagen, grass-fed Beef Collagen

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Hydrolyzed grass-fed Beef Collagen, Fish Collagen, Chicken Collagen and Eggshell Membrane Collagen concentrate monograph & interactions
Interaction report

Collagen Peptides by NaturesPlus Drug Interactions

Want to check YOUR meds against Collagen Peptides?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Collagen Peptides interact with 122 drugs. Click any drug to see the details.

0 of the 3 ingredients in Collagen Peptides interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Peptides with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Collagen Peptides, from the product label.

NaturesPlus

See all NaturesPlus products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Collagen Peptides by NaturesPlus: Common Questions

Does Collagen Peptides by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Collagen Peptides has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Peptides contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my skin?
Collagen peptides in this product are rated possibly effective for aging skin and dry skin, so there's some evidence it may help with those concerns. Results vary from person to person.
What does serrapeptase do?
Serrapeptase is an enzyme that breaks down fibrin (a protein involved in clot formation). We don't have enough reliable evidence to say it works for conditions like asthma, back pain, or bronchitis, though it's being studied for those uses.
Can I take this while pregnant?
Collagen peptides aren't well studied in pregnancy, so you should check with your doctor first. The serrapeptase and proteases in this product are best avoided during pregnancy unless your doctor prescribes them.
Is this safe while breastfeeding?
Serrapeptase should be avoided while breastfeeding. Both proteases and collagen peptides have little safety data during breastfeeding, so talk to your healthcare provider before using this product.
What side effects might I notice?
Digestive symptoms—nausea, stomach discomfort, diarrhea, or bloating—are rare but possible. Some people report these same symptoms at about the same rate with placebo. Allergic reactions to proteases are uncommon.
How long is it safe to take?
Collagen peptides and serrapeptase are generally well tolerated short-term. Long-term safety for serrapeptase isn't well studied, so talk to your pharmacist or doctor about how long you plan to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Collagen Peptides is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Peptides label
Go deeper

The Full Monographs Behind Collagen Peptides’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph →
Sources

Sources & How We Checked

Collagen Peptides's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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