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Dietary supplement

Copper Ingredients & Drug Interactions

by Zemvelo

Copper label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Copper against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Copper is a dietary supplement by Zemvelo with 1 active ingredient. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 31 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Copper by Zemvelo

Ask about any prescription or over-the-counter medication and we check it for interactions with Copper by Zemvelo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Copper by Zemvelo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Zemvelo Copper is a straightforward liquid supplement: one active ingredient, copper, plus inactive ingredients (reverse osmosis water, CHD-FA fulvic acid, and sorbic acid as a preservative). That's it — no fillers or binders beyond what you see listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports mental clarity, nerve, skin and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Copper deficiency, Connective tissue health, Cholesterol management, Blood pressure regulation.
  • The strongest evidence on file: Copper is rated "Likely Effective" for Copper deficiency (Natural Medicines).
  • Also on file: Copper is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD).

Copper supplementation is likely effective for treating copper deficiency, which can develop from malabsorption disorders or certain medications. For Alzheimer disease, the evidence suggests it may actually be ineffective.

For acne, chemotherapy-related anemia, and brain tumors, we don't have enough reliable evidence to say whether it works or doesn't.

The evidence, ingredient by ingredient Copper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Copper from food and standard supplement doses is well tolerated in most people, but too much copper can be toxic, so staying within recommended amounts matters. Copper is needed during pregnancy and is considered likely safe at normal recommended doses, though you should avoid high-dose supplements without a doctor's guidance.

At recommended lactation doses, it's considered likely safe. Rarely, direct contact with copper (such as copper-containing toy alloys) has caused skin irritation in children.

There's also observational evidence that people with diabetes tend to have higher blood copper levels than those without, though it's unclear whether elevated copper contributes to diabetes development or worsening.

Side effects, ingredient by ingredient Copper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 31 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check penicillamine (Cuprimine, Depen) — you'll need to separate dosing by at least 2 hours. Also double-check oral contraceptive birth control pills, as copper may raise your blood copper levels higher than pills already do on their own.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have diagnosed copper deficiency, this supplement may help. If you take penicillamine or use oral contraceptives, check with your pharmacist first — spacing or adjusting dosing may be needed.

Stick to recommended amounts; excess copper carries toxicity risks. Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or managing diabetes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Copper, straight from the product label.

Brand Zemvelo
Barcode (UPC) 891663002049
Net contents 8.1 fl. Oz.; 240 mL
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250364
Product type Mineral
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Copper by Zemvelo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.5 mL
Maximum serving Sizes:
2.5 mL
Servings per container
96
UPC/BARCODE
891663002049
IngredientAmount% DV
Copper2 mg222%

Other ingredients: reverse osmosis Water, CHD-FA Fulvic Acid, non-GMO Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports mental clarity & nerve functions Supports collagen & elastin in skin & connective tissue Aids production of red blood cells & oxygen transfer Supports healthy cholesterol levels & blood pressure

Vegan

Gluten-free Non-GMO

Third party tested

Formula

+CHD-Fulvic Acid for enhanced absorption

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Place 1/2 teaspoon (2.5 mL) into 6-8 oz of water or juice as maintenance. Use more if needed or as recommended by your healthcare professional.

Shake well before use.

Precautions

Children under 4: Consult your physician.

Do not use if tamper evident seal is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Manufactured in the U.S.A. cGMP

Storage

For freshness, keep refrigerated after opening

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Copper by Zemvelo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Copper label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Copper by Zemvelo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.5 mL Dosage formLiquid Servings per container96 Amounts shown are per serving.

Copper

Interacts with
31 drugs
2 mg per serving Form: Copper Sulfate

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Other (inactive) ingredients: Reverse osmosis Water, CHD-FA Fulvic Acid, Non-GMO Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Copper by Zemvelo Drug Interactions

Want to check YOUR meds against Copper?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
31Drugs
1 Moderate 30 Minor

Ingredients driving the most interactions

Copper 31

Individual Drug Interactions

The ingredients in Copper interact with 31 drugs. Click any drug to see the details.

1 of the 1 ingredient in Copper interact with drugs. Each result below shows which ingredient is responsible. Copper

Each ingredient & the kinds of drugs it affects

For each ingredient in Copper with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Copper, from the product label.

Zemvelo

See all Zemvelo products
Name
Zemvelo "Love & Gratitude"
Street Address
1435 Woolsey Hts
City
Colorado Springs
State
CO
ZipCode
80915
Phone Number
800.303.1376
Web Address
zemvelo.com
Pharmacist Counseling Corner

Copper by Zemvelo: Common Questions

Does Copper by Zemvelo interact with any medications?
Yes. Based on its ingredients, Copper has a known interaction with 31 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Copper contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is copper safe during pregnancy?
Copper is likely safe during pregnancy at recommended amounts — your body does need it. Avoid high-dose supplements without medical guidance. Talk with your doctor or pharmacist about the right dose for you.
Can I take this if I have diabetes?
Studies show people with diabetes often have higher blood copper levels than those without. We don't know yet whether extra copper makes diabetes worse. Ask your doctor or pharmacist whether this supplement is right for your situation.
Does this really work for copper deficiency?
Yes — copper supplementation is likely effective for treating copper deficiency. If your doctor has confirmed you're deficient, this can help correct it.
What's the fulvic acid in the inactive ingredients?
Fulvic acid is listed as an inactive ingredient — it's part of the formulation but not the active supplement ingredient (copper is). We have no interaction data on file for it.
Are there any side effects from copper?
At recommended doses, copper is generally well tolerated. In rare cases, direct skin contact with copper-containing materials (like certain alloys) has caused rash or irritation. Taking too much copper can be toxic, so stick to recommended amounts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Copper label
Go deeper

The Full Monographs Behind Copper’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph →
Sources

Sources & How We Checked

Copper's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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