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Dietary supplement

Copper Plus Ingredients & Drug Interactions

by Trace Nutrients

Copper Plus label
See full label image
Tablet Or Pill Category: Single Vitamin And Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Copper Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Copper Plus is a dietary supplement by Trace Nutrients with 2 active ingredients. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 51 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Copper, Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Copper Plus by Trace Nutrients

Ask about any prescription or over-the-counter medication and we check it for interactions with Copper Plus by Trace Nutrients — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Copper Plus by Trace Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Copper Plus contains 2 active ingredients: riboflavin (also called vitamin B2) and copper. Riboflavin is a B vitamin your body needs to convert food into energy and keep your eyes and nervous system healthy.

Copper is a mineral that helps with red blood cell formation, bone health, and immune function. The product also contains several inactive ingredients — cellulose, stearic acid, magnesium stearate, and silica — which are common tablet binders and fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Copper nutritional supplementation.
  • We looked for evidence on: Copper deficiency, Red blood cell formation, Bone health, Immune support.
  • The strongest evidence on file: Copper is rated "Likely Effective" for Copper deficiency (Natural Medicines).

Copper is likely effective for treating copper deficiency. For other uses, the evidence is less clear.

Copper is possibly ineffective for Alzheimer's disease. For acne, chemotherapy-related anemia, and brain tumors, there isn't enough reliable evidence to say whether copper helps or not.

Riboflavin's effectiveness is not established in the data we hold for this product.

The evidence, ingredient by ingredient Riboflavin Copper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is very well tolerated; any excess your body doesn't use is removed through urine. The most common side effects are dose-related nausea and bright yellow urine at high doses.

Rarely, diarrhea has been reported. Copper is safe in food and standard supplement amounts, but excess copper can be toxic, so stick to recommended doses.

Copper is needed during pregnancy and is likely safe at recommended amounts, though you should stay within those levels and avoid high-dose supplements without medical guidance. For breastfeeding, recommended amounts are considered acceptable.

Riboflavin is needed during pregnancy and generally safe at recommended amounts; check with your provider before using high-dose supplements. It's also safe while breastfeeding at recommended amounts; ask your provider about higher doses.

Side effects, ingredient by ingredient Riboflavin Copper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Copper, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 51 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Copper Plus, double-check if you're on penicillamine (a Moderate interaction with copper), tetracycline antibiotics (Moderate with riboflavin), or birth control pills (Minor with copper). If you take any prescription medications, run them through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Copper Plus may help if you have a copper deficiency. If you take penicillamine, tetracycline antibiotics, or birth control pills, check with us first — there are documented interactions.

Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or have diabetes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Copper Plus, straight from the product label.

Brand Trace Nutrients
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 74002
Product type Single Vitamin And Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Copper Plus by Trace Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Riboflavin500 mcg29%
Copper2 mg100%

Other ingredients: Cellulose, Stearic Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Hypo-allergenic

Vegetarian formula

This product contains no wheat, yeast, soy, alfalfa, milk or corn allergens and no salt, sugar, starch, wax, artificial colors, flavors or preservatives.

Formula

Copper (AAC) with vitamin B2

FDA Statement of Identity

Dietary Supplement

General

Formula #241

Suggested/Recommended/Usage/Directions

Suggested Usage: Adults, as a dietary supplement, take 1 tablet per day with a meal or follow the advice of your health care professional.

Precautions

Keep out of reach of children

Tamper resistant package Do not use if outer seal is broken

Storage

Store in a cool, dry place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Copper Plus by Trace Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Copper Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Copper Plus by Trace Nutrients

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Riboflavin

Interacts with
20 drugs
500 mcg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Copper

Interacts with
31 drugs
2 mg per serving Form: Copper Amino Acid Chelate, Copper Carbonate

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Copper Plus by Trace Nutrients Drug Interactions

Want to check YOUR meds against Copper Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
51Drugs
21 Moderate 30 Minor

Ingredients driving the most interactions

Copper 31
Riboflavin 20

Individual Drug Interactions

The ingredients in Copper Plus interact with 51 drugs. Click any drug to see the details.

2 of the 2 ingredients in Copper Plus interact with drugs. Each result below shows which ingredient is responsible. Copper Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Copper Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Copper Plus, from the product label.

Trace Nutrients

See all Trace Nutrients products
Name
Trace Elements, Inc.
City
Addison
State
Texas
ZipCode
75001
Pharmacist Counseling Corner

Copper Plus by Trace Nutrients: Common Questions

Does Copper Plus by Trace Nutrients interact with any medications?
Yes. Based on its ingredients, Copper Plus has a known interaction with 51 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Copper Plus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Copper Plus if I'm pregnant or breastfeeding?
Riboflavin is needed during pregnancy and is generally safe at recommended amounts, but check with your provider before using high-dose supplements. Copper is also needed in pregnancy and likely safe at recommended amounts — just stay within those levels and avoid high-dose supplements without guidance. Both are considered safe while breastfeeding at recommended amounts, though you should ask your provider about higher doses.
What are the side effects of riboflavin?
Riboflavin is generally well tolerated. The most common side effects are dose-related nausea and bright yellow urine at higher doses. Rarely, diarrhea has been reported.
Is copper safe to take long-term?
Copper is safe in standard supplement amounts, but excess copper can be toxic. Stick to recommended doses and avoid high-dose supplements unless a doctor advises otherwise. If you're on birth control pills, keep in mind that long-term use raises blood copper levels, so mention this to your doctor.
Does this product actually help with copper deficiency?
Yes — copper is likely effective for treating copper deficiency. For other uses like Alzheimer's disease, the evidence doesn't support it; for acne and some other conditions, there simply isn't enough reliable evidence to say either way.
Why would birth control pills affect my copper levels?
Research shows that chronic use of oral contraceptives raises blood copper levels by an average of 57 mcg/dL, and in most people this pushes levels above the normal range. This is a minor interaction, but it's something to be aware of and discuss with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Copper Plus label
Go deeper

The Full Monographs Behind Copper Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph →
Sources

Sources & How We Checked

Copper Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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