Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Cortisol Manager Allergen Free Ingredients & Drug Interactions

by Integrative Therapeutics

Cortisol Manager Allergen Free label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cortisol Manager Allergen Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cortisol Manager Allergen Free is a dietary supplement by Integrative Therapeutics with 5 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,534 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Epimedium extract, L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cortisol Manager Allergen Free by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Cortisol Manager Allergen Free by Integrative Therapeutics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cortisol Manager Allergen Free by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Magnolia Bark Extract” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Stress-Reducing Proprietary Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.
  • “Cortisol-Reducing Proprietary Blend” is a proprietary blend — the label gives one combined amount (450 mg) without saying how much of each component you get.

Cortisol Manager Allergen Free contains 6 active ingredients. L-Theanine is an amino acid meant to support calm focus and relaxation.

Sensoril ashwagandha (a standardized extract) is an adaptogenic herb traditionally used to help manage stress and support sleep. Magnolia Bark Extract, Honokiol, and Magnolol are compounds from magnolia that may support relaxation.

Sharp-PS Green is phosphatidylserine, a phospholipid thought to support cognitive function and stress resilience. The product also includes Epimedium extract.

The capsules themselves contain hypromellose, cellulose, and silica as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support healthy stress response and cortisol balance.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Stress, Insomnia, Fatigue, Cognitive function — and 4 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Theanine is rated "Possibly Effective" for Cognitive function.

The evidence for these ingredients varies. L-Theanine is possibly effective for supporting cognitive function, though evidence for age-related cognitive decline and Alzheimer disease is insufficient.

Ashwagandha (Sensoril) is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder—this is where the strongest data lies. Phosphatidylserine (Sharp-PS Green) is possibly effective for age-related cognitive decline and Alzheimer disease but has insufficient evidence for ADHD, athletic performance, and general cognitive function.

We hold no established effectiveness data for Epimedium extract, Honokiol, or Magnolol.

The evidence, ingredient by ingredient Theanine Ashwagandha Magnolia Horny Goat Weed Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Theanine is generally well tolerated for short-term use in healthy adults, though long-term safety isn't well studied. Reported side effects include headaches, drowsiness, and increased dream activity; a rare case of facial tics was reported in a child, though causation was unclear.

Ashwagandha is generally well tolerated short-term, but long-term safety data are limited. Common mild side effects are diarrhea, nausea, and gastrointestinal upset, though these don't typically occur at standard doses.

Rare serious cases of liver damage have been documented. One case report linked ashwagandha to excessively high thyroid hormone levels when taken alongside thyroid medication.

Phosphatidylserine is generally well tolerated in studies, with reported side effects including gastrointestinal upset, flatulence, headache, nausea, and insomnia—insomnia is more likely at higher doses (600 mg or more). Regarding pregnancy: L-Theanine and ashwagandha both have insufficient safety data and should be avoided during pregnancy; ashwagandha is traditionally thought to risk miscarriage.

For breastfeeding, there isn't enough data for L-Theanine or ashwagandha, and phosphatidylserine safety is unknown—talk with your doctor or pharmacist before use in either situation.

Side effects, ingredient by ingredient Theanine Ashwagandha Magnolia Horny Goat Weed Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Horny Goat Weed, Ashwagandha, Phosphatidylserine, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,535 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product before starting if you take: blood pressure medications (antihypertensives), sedatives or anti-anxiety drugs including benzodiazepines, diabetes medications, thyroid hormone replacements, drugs that suppress your immune system, liver-damaging medications, or anticholinergic or cholinergic drugs. The most serious potential interaction is with CNS depressants and blood pressure medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at people looking to manage stress and support sleep through herbal and amino-acid support. If you take blood pressure medications, diabetes medications, benzodiazepines, sedatives, thyroid hormones, or drugs for liver or immune conditions, you need to check with your pharmacist before starting—the interactions could be significant.

Pregnant or breastfeeding individuals should avoid it. Everyone else should run their medications through the interaction checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cortisol Manager Allergen Free, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791110113
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 313847
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cortisol Manager Allergen Free by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
15
UPC/BARCODE
871791110113
IngredientAmount% DV
L-Theanine0 NP--
Total Carbohydrate1 Gram(s)1%
Sensoril0 NP--
Magnolia Bark Extract0 NP--
Stress-Reducing Proprietary Blend500 mg--
Cortisol-Reducing Proprietary Blend450 mg--
Epimedium extract0 NP--
Honokiol6 mg--
Magnolol3 mg--
Sharp-PS Green100 mg--

Other ingredients: Hypromellose, Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information, please visit integrativepro.com

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Warning: Do not use if you are pregnant or nursing. If you are taking any medications, consult a healthcare professional before use.

Individuals with diabetes should monitor blood glucose levels closely while taking this product.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Sensoril is a registered trademark of Natreon, Inc. and is protected under U.S. Patent No. 7,318,938. Sharp PS is a registered trademark of IFF or its affiliates.

Copyright 2023 Integrative Therapeutics, LLC

Formulation

Contains no soy, wheat, gluten, egg, peanut, dairy, fish, tree nut, shellfish, sesame, salt, or artificial flavors, or preservatives.

Vegan

Stress-hormone stabilizer

Top 9 Allergen Free Manufactured verified

Seals/Symbols

Vegan

Top 9 Allergen Free

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 capsule before bedtime, or as recommended by a healthcare professional. Increase to 2 capsules during times of high stress. For nightly use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cortisol Manager Allergen Free by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cortisol Manager Allergen Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cortisol Manager Allergen Free by Integrative Therapeutics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stress-Reducing Proprietary Blend

500 mg per serving

Cortisol-Reducing Proprietary Blend

450 mg per serving

Sharp-PS Green

Interacts with
219 drugs
100 mg per serving Form: Phosphatidylserine

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp-PS Green monograph & interactions

Other (inactive) ingredients: Hypromellose, Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cortisol Manager Allergen Free by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Cortisol Manager Allergen Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,534Drugs
1,485 Moderate 49 Minor

Ingredients driving the most interactions

Sensoril 1,372
Epimedium extract 963
L-Theanine 565
Magnolia Bark Extract 351
Sharp-PS Green 219

Individual Drug Interactions

The ingredients in Cortisol Manager Allergen Free interact with 1,534 drugs. Click any drug to see the details.

5 of the 5 ingredients in Cortisol Manager Allergen Free interact with drugs. Each result below shows which ingredient is responsible. Sensoril Epimedium extract L-Theanine Magnolia Bark Extract Sharp-PS Green

Each ingredient & the kinds of drugs it affects

For each ingredient in Cortisol Manager Allergen Free with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Epimedium extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Epimedium extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Magnolia Bark Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia Bark Extract full monograph & interactions

Sharp-PS Green2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Sharp-PS Green full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cortisol Manager Allergen Free, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800.931.1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Cortisol Manager Allergen Free by Integrative Therapeutics: Common Questions

Does Cortisol Manager Allergen Free by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Cortisol Manager Allergen Free has a known interaction with 1,534 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cortisol Manager Allergen Free contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
The data we have advise against it. Both L-Theanine and ashwagandha have insufficient safety information during pregnancy—ashwagandha is traditionally thought to carry a miscarriage risk. For breastfeeding, there isn't enough safety data for either ingredient. Talk with your doctor or pharmacist about whether this product is right for you in either situation.
What's the difference between the three blends listed—Magnolia Bark Extract, the Stress-Reducing Blend, and the Cortisol-Reducing Blend?
The ingredient list shows Magnolia Bark Extract as a standalone item, while the other two are proprietary blends—meaning their exact ingredient breakdown and amounts aren't fully disclosed on the label. The magnolia compounds Honokiol and Magnolol are likely in those blends, but we can't be certain of their doses or what else is included.
Can L-Theanine cause drowsiness? I'm concerned about driving.
Yes, drowsiness has been reported by some people taking L-Theanine, along with increased dream activity and headaches. Start cautiously and see how you respond before driving or operating machinery. If you're also taking sedatives or other CNS depressants, the risk of drowsiness goes up.
What does phosphatidylserine (Sharp-PS Green) do?
It's thought to support cognitive function and has the strongest evidence for age-related cognitive decline and Alzheimer disease—rated possibly effective for both. The evidence for general cognitive function, ADHD, dementia, and athletic performance is insufficient.
I'm on thyroid medication. Is this product okay for me?
No—don't start this without talking to your pharmacist or doctor first. Ashwagandha in this product may increase thyroid hormone effects and adverse effects. There's even a case report of someone on thyroid medication who developed excessively high thyroid levels after taking ashwagandha.
What are the inactive ingredients, and are there fillers?
The inactive ingredients are hypromellose, cellulose, and silica—these are common capsule and tablet ingredients used as binders and flow agents. Yes, they are fillers, though they're standard and generally well tolerated.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cortisol Manager Allergen Free is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cortisol Manager Allergen Free label
Go deeper

The Full Monographs Behind Cortisol Manager Allergen Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Cortisol Manager Allergen Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
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See these in context on the Ashwagandha monograph →

Magnolia 9 references
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See these in context on the Magnolia monograph →

Horny Goat Weed 11 references
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See these in context on the Horny Goat Weed monograph →

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See these in context on the Phosphatidylserine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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