Major interaction on record — check this product against your medications before combining. Based on 7 of 8 ingredients. Check your meds →
Dietary supplement

Cramp ReLeaf (Menstrual) Ingredients & Drug Interactions

by Herbs Etc.

Cramp ReLeaf (Menstrual) label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cramp ReLeaf (Menstrual) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Cramp ReLeaf (Menstrual) is a dietary supplement by Herbs Etc. with 8 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,186 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Clove Flower Bud Extract, Cinnamon bark extract, Orange peel extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cramp ReLeaf (Menstrual) by Herbs Etc.

Ask about any prescription or over-the-counter medication and we check it for interactions with Cramp ReLeaf (Menstrual) by Herbs Etc. — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cramp ReLeaf (Menstrual) by Herbs Etc.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1 mL) without saying how much of each component you get.

Cramp ReLeaf contains 8 ingredients, 7 of which are herbal extracts. The active components include cinnamon bark extract, orange peel extract, bethroot root extract, clove flower bud extract, black haw stem bark extract, wild yam root extract, cardamom pod extract, and cramp bark bark extract.

A proprietary extract blend groups some of these together. These are suspended in a liquid base of alcohol, purified water, and glycerin.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Stops sharp menstrual cramps.
  • We looked for evidence on: Dysmenorrhea, Muscle cramps, Pregnancy-related leg cramps, Uterine spasms, Menstrual pain.
  • The closest evidence on file: Cramp Bark is rated "Insufficient Reliable Evidence To Rate" for Muscle cramps (Natural Medicines).
  • Also on file: Cramp Bark is rated "Insufficient Reliable Evidence To Rate" for Dysmenorrhea, Pregnancy-related leg cramps.
  • Also on file: Black Haw is rated "Insufficient Reliable Evidence To Rate" for Dysmenorrhea.

The evidence supporting these ingredients for menstrual cramps and related conditions is limited. Cinnamon bark has insufficient evidence for conditions like amenorrhea, blood sugar control, and diarrhea.

Orange peel, clove, and cardamom similarly lack solid evidence for the conditions listed in our data — clove shows possible effectiveness only for ventilator-associated pneumonia, which isn't what this product targets. Black haw, wild yam, and cramp bark have insufficient or no established evidence for their traditional uses, including dysmenorrhea (painful periods).

Wild yam is actually rated possibly ineffective for menopausal symptoms. We don't have effectiveness data in our database for how this combination works together for menstrual relief specifically.

The evidence, ingredient by ingredient Cassia Cinnamon Sweet Orange Clove Black Haw Wild Yam Cardamom Cramp Bark

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Individual ingredients are generally well tolerated in food amounts, but this is a concentrated supplement. Cinnamon bark poses a concern with coumarin — a compound that can harm the liver with very high doses or extended use; avoid large doses during pregnancy, and concentrate the dose only under medical guidance.

Orange peel is safe as the fruit but less data exist for concentrated extracts. Clove is safe as a food spice but can be irritating or toxic in large concentrated amounts — clove oil specifically is dangerous in children.

Wild yam lacks long-term safety data and should be avoided in pregnancy and while breastfeeding due to insufficient information. Black haw and cramp bark have limited human safety data; cramp bark's effects on the uterus are uncertain, so it's best avoided in pregnancy and while nursing.

Cardamom in food amounts is generally fine; one participant reported mild skin inflammation in a trial. We hold no pregnancy or breastfeeding data for cardamom.

Side effects, ingredient by ingredient Cassia Cinnamon Sweet Orange Clove Black Haw Wild Yam Cardamom Cramp Bark

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Clove, Sweet Orange, Wild Yam, Cassia Cinnamon.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on celiprolol, pravastatin, ivermectin, or fexofenadine — these have Major interactions with orange peel that can significantly change their absorption. If you take any drug that depends on an OATP transporter, you'll need to separate doses by at least 4 hours.

Check whether you're on diabetes medications (cinnamon and clove may lower blood sugar further), blood thinners or antiplatelet drugs (clove theoretically increases bleeding risk), or any medication your liver breaks down — particularly those handled by CYP2D6, CYP1A2, CYP3A4, or CYP2C9 enzymes (clove may increase their levels). If you take estrogen-based hormone therapy, wild yam's estrogenic effects are theoretically a concern.

Use the medication checker on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines several traditional menstrual herbs, but solid evidence for its effectiveness is lacking. If you take any diabetes medications, heart drugs, blood thinners, allergy or antiparasitic medications, or drugs metabolized by your liver, check your specific prescriptions with the tool below before starting — orange peel and clove interactions are real and could affect how well your medications work.

Pregnant or nursing? Talk to your pharmacist or doctor first, especially about wild yam and cramp bark.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cramp ReLeaf (Menstrual), straight from the product label.

Brand Herbs Etc.
Barcode (UPC) 765704107010
Net contents 1 Fluid Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320855
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Girls: (All), Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cramp ReLeaf (Menstrual) by Herbs Etc., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
40 Drop(s)
Maximum serving Sizes:
80 Drop(s)
Servings per container
30
UPC/BARCODE
765704107010
IngredientAmount% DV
Cinnamon bark extract0 NP--
Proprietary Extract Blend1 mL--
Orange peel extract0 NP--
Bethroot (root) extract0 NP--
Clove Flower Bud Extract0 NP--
Black Haw Stem Bark Extract0 NP--
Wild Yam Root Extract, Fresh0 NP--
Cardamom Pod Extract0 NP--
Cramp Bark Bark Extract0 NP--

Other ingredients: Alcohol, Water, Purified, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Stops sharp menstrual cramps

Gluten free

Vegan

Manufactured in Santa Fe, NM.

No artificial preservatives

FDA Disclaimer Statement

Herbal Supplement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Cramp Releaf (Menstrual) is made with sharp menstrual cramp stopping herbs, including Black Haw, Cramp bark, and Bethroot.

General Statements

We apply our company philosophy to Cramp ReLeaf (Menstrual), as we do to all of our herbal medicines. That philosophy is to do what's right, which extends to choosing the right herbs, using the right processes and making the right formulations that support your health needs. We do all of this to bring you herbal medicines made right.

Suggested/Recommended/Usage/Directions

Suggested use: Acute - Take 40 drops (one half teaspoon) in water every three to four hours. Increase suggested use to 80 drops (one teaspoon) in water should you need more support/relief. Proactive - As preventative measure take 40 drops in water twice a day prior to menstruation.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cramp ReLeaf (Menstrual) by Herbs Etc. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cramp ReLeaf (Menstrual) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cramp ReLeaf (Menstrual) by Herbs Etc.

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size40 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Alcohol, Water, Purified, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cramp ReLeaf (Menstrual) by Herbs Etc. Drug Interactions

Want to check YOUR meds against Cramp ReLeaf (Menstrual)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,186Drugs
48 Major 1,081 Moderate 57 Minor

Ingredients driving the most interactions

Clove Flower Bud Extract 977
Cinnamon bark extract 442
Orange peel extract 246
Wild Yam Root Extract, Fresh 41

Individual Drug Interactions

The ingredients in Cramp ReLeaf (Menstrual) interact with 1,186 drugs. Click any drug to see the details.

4 of the 8 ingredients in Cramp ReLeaf (Menstrual) interact with drugs. Each result below shows which ingredient is responsible. Clove Flower Bud Extract Cinnamon bark extract Orange peel extract Wild Yam Root Extract, Fresh

Each ingredient & the kinds of drugs it affects

For each ingredient in Cramp ReLeaf (Menstrual) with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove Flower Bud Extract7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove Flower Bud Extract full monograph & interactions

Cinnamon bark extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon bark extract full monograph & interactions

Orange peel extract7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Orange peel extract full monograph & interactions

Wild Yam Root Extract, Fresh1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam Root Extract, Fresh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cramp ReLeaf (Menstrual), from the product label.

Herbs Etc.

Name
Herbs, Etc., Inc.
Street Address
1340 Rufina Circle
City
Santa Fe
State
NM
ZipCode
87507
Web Address
www.herbsetc.com
Pharmacist Counseling Corner

Cramp ReLeaf (Menstrual) by Herbs Etc.: Common Questions

Does Cramp ReLeaf (Menstrual) by Herbs Etc. interact with any medications?
Yes. Based on its ingredients, Cramp ReLeaf (Menstrual) has a known interaction with 1,186 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cramp ReLeaf (Menstrual) contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
There isn't enough safety data for several ingredients in this product during pregnancy. Wild yam and cramp bark specifically advise against use during pregnancy due to insufficient information. Cinnamon bark in supplement doses is also not recommended during pregnancy, though food amounts are fine. Talk with your pharmacist or doctor before starting — they know your individual situation best.
Will this actually help with period cramps?
The evidence for these ingredients specifically for menstrual cramps is limited or insufficient in our data. Black haw, cramp bark, and wild yam are used traditionally for dysmenorrhea, but we don't have solid research backing their effectiveness. Clove, cinnamon, orange peel, and cardamom lack established evidence for this purpose in our database.
Can I take this if I'm breastfeeding?
Safety data for breastfeeding are not available for most ingredients here. Wild yam and cramp bark specifically advise against use while nursing due to lack of information. Talk with your pharmacist or doctor about whether this product is right for you during breastfeeding.
What does orange peel extract do in this formula?
Orange peel extract is included from the fruit of the sweet orange plant. In our data, it has no established evidence for menstrual symptoms specifically — the effectiveness ratings we hold are for other conditions like asthma and depression, where it also lacks solid evidence.
Are there any serious side effects I should watch for?
Serious adverse effects are rare but possible. Clove oil in large amounts can cause liver failure (orally) or seizure and coma in children — this product should be kept away from kids and used only as directed. Wild yam rarely can trigger anaphylaxis. Cinnamon in very high doses over time may harm the liver. Stick to the recommended dose and tell your doctor or pharmacist if you experience fever, headache, vomiting, or any unusual symptoms.
Can I take this with allergy medications like Allegra?
Orange peel extract in this product significantly reduces the absorption of fexofenadine (Allegra) — by about 72% in studies. This means your allergy medication may not work as well. Space the doses at least 4 hours apart, or talk to your pharmacist about whether this product is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cramp ReLeaf (Menstrual) label
Go deeper

The Full Monographs Behind Cramp ReLeaf (Menstrual)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Black Haw

Black Haw is a traditional herbal bark long used to ease menstrual cramps and uterine spasms, but modern human studies are very limited. It contains compounds that may relax smooth muscle, b...

Read the full Black Haw monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Cardamom

Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements...

Read the full Cardamom monograph → Herb & supplement monograph

Cramp Bark

Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very limited, so its effectiveness is not well...

Read the full Cramp Bark monograph →
Sources

Sources & How We Checked

Cramp ReLeaf (Menstrual)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 73 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
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See these in context on the Cassia Cinnamon monograph →

Sweet Orange 17 references
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Clove 26 references
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See these in context on the Clove monograph →

Black Haw 1 reference
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

See these in context on the Black Haw monograph →

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
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See these in context on the Wild Yam monograph →

Cardamom 2 references
  1. Mobacken, H. and Fregert, S. Allergic contact dermatitis from cardamom. Contact Dermatitis 1975;1(3):175-176. PubMed
  2. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agri PubMed

See these in context on the Cardamom monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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