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Dietary supplement

Crampbark & False Unicorn Root Ingredients & Drug Interactions

by Pure Herbs

Crampbark & False Unicorn Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Crampbark & False Unicorn Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Crampbark & False Unicorn Root is a dietary supplement by Pure Herbs with 2 active ingredients. Its ingredients are commonly taken for menstrual cramps, menopausal symptoms, female infertility support.Based on those ingredients, 740 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are False Unicorn Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Crampbark & False Unicorn Root by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Crampbark & False Unicorn Root by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Crampbark & False Unicorn Root by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,909 mg) without saying how much of each component you get.

This product contains 2 active ingredients: Crampbark Bark Extract and False Unicorn Root Extract, delivered in liquid form as a Proprietary Blend. The inactive ingredient list shows none.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supporting male and female reproductive functions.
  • We looked for evidence on: Dysmenorrhea, menstrual cramps, irregular periods, menopausal symptoms.
  • The closest evidence on file: Cramp Bark is rated "Insufficient Reliable Evidence To Rate" for Dysmenorrhea (Natural Medicines).

The evidence backing these ingredients isn't established in the data we hold. Crampbark has been used traditionally for muscle cramps, dysmenorrhea (painful periods), and pregnancy-related leg cramps, but the scientific evidence to rate how well it works is insufficient.

There's no effectiveness data on file for False Unicorn Root.

The evidence, ingredient by ingredient False Unicorn Cramp Bark

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

False Unicorn Root is generally well tolerated at typical doses, but large amounts can cause nausea and vomiting. Human safety data for both ingredients are limited.

The safety data advises against False Unicorn in pregnancy because of its traditional use to affect the uterus and lack of rigorous safety testing. There isn't enough information to know if it's safe while breastfeeding, so your doctor or pharmacist should weigh the decision for you.

Crampbark similarly should be avoided in pregnancy and breastfeeding due to insufficient safety information.

Side effects, ingredient by ingredient False Unicorn Cramp Bark

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — False Unicorn.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 741 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check your medications against Moderate-severity interactions: CYP2D6 substrates (antidepressants like amitriptyline and desipramine, pain relievers like codeine and fentanyl, and heart rhythm drugs), CYP3A4 substrates (calcium channel blockers and chemotherapy agents), and lithium. If you take any of these, run them through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take medications broken down by your liver — especially antidepressants, pain relievers, heart drugs, or chemotherapy — check with us before adding this product. The traditional use of both herbs suggests they may affect the uterus, so pregnancy or breastfeeding is a conversation to have with your pharmacist or doctor first.

Altogether, these interactions span 730 individual medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Crampbark & False Unicorn Root, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 279987
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Crampbark & False Unicorn Root by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Proprietary Blend1909 mg--
False Unicorn Root Extract0 NP--
Crampbark Bark Extract0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for supporting male and female reproductive functions.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Crampbark & False Unicorn Root by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Crampbark & False Unicorn Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Crampbark & False Unicorn Root by Pure Herbs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1909 mg per serving

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Crampbark & False Unicorn Root by Pure Herbs Drug Interactions

Want to check YOUR meds against Crampbark & False Unicorn Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
740Drugs
740 Moderate

Ingredients driving the most interactions

False Unicorn Root Extract 740

Individual Drug Interactions

The ingredients in Crampbark & False Unicorn Root interact with 740 drugs. Click any drug to see the details.

1 of the 2 ingredients in Crampbark & False Unicorn Root interact with drugs. Each result below shows which ingredient is responsible. False Unicorn Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Crampbark & False Unicorn Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

False Unicorn Root Extract3 drug types · 740 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity. Theoretically, false unicorn might increase the levels of CYP2D6 substrates. Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity. Theoretically, false unicorn might increase the levels of CYP3A4 substrates. Drugs that might be affected include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, cisapride (Propulsid), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), and numerous others.

Likelihood Possible Evidence D
Lithium

False unicorn is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, false unicorn might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
False Unicorn Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Crampbark & False Unicorn Root, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Crampbark & False Unicorn Root by Pure Herbs: Common Questions

Does Crampbark & False Unicorn Root by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Crampbark & False Unicorn Root has a known interaction with 740 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Crampbark & False Unicorn Root contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is False Unicorn Root safe to take in large amounts?
Large doses have been reported to cause nausea and vomiting. Human safety data are limited overall, so it's best to stick to the dose on the label and talk to your pharmacist if you're thinking of taking more.
Can I take this while pregnant?
No. False Unicorn has a history of traditional use to affect the uterus, and safety data in pregnancy are lacking — the data rate it as likely unsafe. Crampbark should also be avoided in pregnancy. Talk to your doctor before considering this product if you're pregnant or planning to become pregnant.
Is it safe to breastfeed while taking this?
There isn't enough safety information for either ingredient during breastfeeding. Your doctor or pharmacist can help you weigh whether the benefit is worth the uncertainty for your situation.
Does Crampbark actually work for muscle cramps?
Crampbark has a long history of traditional use for muscle cramps and period pain, but the scientific evidence to confirm how well it works isn't established in the data we hold. It may help some people, but we can't say for certain.
What is False Unicorn Root used for?
False Unicorn Root Extract is included in this blend, but we don't have effectiveness data on file that tells us what it's specifically meant to do in this formulation. Your pharmacist can explain the traditional role it's thought to play.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Crampbark & False Unicorn Root label
Go deeper

The Full Monographs Behind Crampbark & False Unicorn Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

False Unicorn

Interacts with 740 drugs

False Unicorn is a North American plant whose root has long been used in traditional medicine for women's reproductive and menstrual concerns. There is very little reliable human research to...

Read the full False Unicorn monograph → Herb & supplement monograph

Cramp Bark

Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very limited, so its effectiveness is not well...

Read the full Cramp Bark monograph →
Sources

Sources & How We Checked

Crampbark & False Unicorn Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

False Unicorn 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Ho SH, Singh M, Holloway AC, Crankshaw DJ. The effects of commercial preparations of herbal supplements commonly used by women on the biotransformation of fluorogenic substrates by human cytochromes P450. Phytother Res. 2011;25(7):983-9. PubMed

See these in context on the False Unicorn monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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