Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

D-Limonene 500 mg Ingredients & Drug Interactions

by Jarrow Formulas

D-Limonene 500 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Limonene 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Limonene 500 mg is a dietary supplement by Jarrow Formulas with 1 active ingredient. Its ingredients are commonly taken for heartburn and acid reflux, digestive upset, stress and mood support.Based on those ingredients, 229 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Limonene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against D-Limonene 500 mg by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Limonene 500 mg by Jarrow Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of D-Limonene 500 mg by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-limonene, a natural compound found in citrus peel oil, at 500 mg per softgel capsule. The remaining ingredients — the softgel capsule itself and organic caramel — are inactive, used to hold and color the supplement.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: relief of occasional esophageal and stomach discomfort.
  • We looked for evidence on: gastroesophageal reflux disease, acid reflux, heartburn, dyspepsia.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for D-limonene isn't established yet in the data we hold. For cancer and irritable bowel syndrome (IBS), the research is insufficient to say whether it works.

If you're considering this supplement for a specific condition, talk it over with your doctor or pharmacist about whether the current evidence supports its use for your situation.

The evidence, ingredient by ingredient Limonene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, D-limonene is generally well tolerated, though it can cause nausea, vomiting, and diarrhea in some people. The safety data for high-dose supplements in humans is limited.

If you touch it or it touches your skin, it may cause contact dermatitis (an itchy rash), and people with fragrance allergies are at higher risk. When inhaled (for example, from fragrances or cleaning products), limonene is linked to wheezing and asthma, especially in children.

There isn't enough information to know whether supplement doses are safe during breastfeeding.

Side effects, ingredient by ingredient Limonene

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Limonene.
  • The most serious interaction on file is rated Moderate.
  • For scale: 229 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking D-Limonene, check with your doctor or pharmacist if you take any of the following: CYP2C19 inhibitors (cimetidine, fluvoxamine, omeprazole) or inducers (carbamazepine, prednisone, rifampin); CYP2C9 inhibitors (amiodarone, fluconazole, lovastatin, paroxetine) or inducers (rifampin, secobarbital); or nonsteroidal anti-inflammatory drugs. These interactions are preliminary and haven't been reported in humans yet, but limonene may affect how your body clears these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

D-Limonene 500 mg is a single-ingredient supplement generally well tolerated by mouth, but human safety data for high doses is sparse. If you take liver enzyme inhibitors or inducers, or nonsteroidal anti-inflammatory drugs, you'll want to check your exact medications with your doctor or pharmacist before starting — the preliminary interactions haven't shown up in patients yet, but they're worth watching for.

Talk it over with your own healthcare provider about whether this supplement fits your needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Limonene 500 mg, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011010340
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 243363
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Limonene 500 mg by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
790011010340
IngredientAmount% DV
D-Limonene1000 mg--

Other ingredients: Softgel, organic Caramel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Usage: Take 2 softgels per day, with or after a meal or as directed by your qualified healthcare professional.

Swallow softgel whole; Do not chew, bite or break.

Precautions

If persistent stomach upset occurs, discontinue use.

Note: If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your qualified healthcare professional before using this product.

Note: If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your qualified healthcare professional before using this product.

Do not use if sensitive to citrus or citrus-derived products.

Keep out of the reach of children.

Formula

Jarrow Formulas d-Limonene provides relief of occasional, milk esophageal and stomach discomfort. As a triterpene lactone, d-Limonene also supports the liver's detoxifying Phase I and Phase II enzyme systems. Jarrow Formulas d-Limonene is the major constituent of citrus essential oils.

Natural Orange Peel Oil

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

For occasional, mild esophageal & gastric discomfort Supports Phase I and II detoxifying enzyme systems

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

2020 Jarrow Formulas

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Limonene 500 mg by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Limonene 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Limonene 500 mg by Jarrow Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

D-Limonene

Interacts with
229 drugs
1000 mg per serving Form: Orange peel Oil

Limonene is a natural compound found in the peel of citrus fruits like oranges and lemons, and it is used as a flavoring agent and dietary supplement....

D-Limonene monograph & interactions

Other (inactive) ingredients: Softgel, Organic Caramel. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Limonene 500 mg by Jarrow Formulas Drug Interactions

Want to check YOUR meds against D-Limonene 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
229Drugs
229 Moderate

Ingredients driving the most interactions

D-Limonene 229

Individual Drug Interactions

The ingredients in D-Limonene 500 mg interact with 229 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Limonene 500 mg interact with drugs. Each result below shows which ingredient is responsible. D-Limonene

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Limonene 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Limonene5 drug types · 229 drugs

Cytochrome P450 2C19 (Cyp2C19) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). CYP2C19 inducers might decrease the effects of limonene. So far, this interaction has not been reported in humans. Inducers of CYP2C19 include carbamazepine (Tegretol), prednisone (Deltasone), and rifampin (Rifadin, Rimactane).

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Inhibitors

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). So far, this interaction has not been reported in humans. However, watch for an increase in the limonene levels when it is taken with drugs that inhibit CYP2C19. Some drugs that inhibit CYP2C19 include cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9). Inducers of CYP2C9 might decrease limonene levels. Inducers of CYP2C9 include rifampin (Rifadin, Rimactane) and secobarbital (Seconal).

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inhibitors

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9). So far, this interaction has not been reported in humans. However, watch for side effects in patients taking limonene and CYP2C9 inhibitors. Some CYP2C9 inhibitors include amiodarone (Cordarone), fluconazole (Diflucan), lovastatin (Mevacor), paroxetine (Paxil), zafirlukast (Accolate), and many others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction. So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP2C9 in patients taking limonene. Some drugs metabolized by CYP2C9 include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.

Likelihood Possible Evidence D
D-Limonene full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Limonene 500 mg, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas Superior Nutrition and Formulation
City
Los Angeles
State
CA
ZipCode
90035-4317
Phone Number
(866) 459-4154
Web Address
www.jarrow.com
Pharmacist Counseling Corner

D-Limonene 500 mg by Jarrow Formulas: Common Questions

Does D-Limonene 500 mg by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, D-Limonene 500 mg has a known interaction with 229 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Limonene 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is D-limonene, and where does it come from?
D-limonene is a natural compound found in citrus peel oil. It's been studied for potential effects on cancer and irritable bowel syndrome, though the evidence isn't established yet.
Can I take this while breastfeeding?
There isn't enough information to know whether supplement doses are safe while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects might D-limonene cause?
Taken by mouth, it can cause nausea, vomiting, and diarrhea in some people. If it touches your skin, it may cause a rash, especially if you have fragrance sensitivities. When inhaled, it's been linked to wheezing and asthma.
Is D-limonene safe to use long-term?
D-limonene is generally well tolerated in food amounts, but human safety data for high-dose supplements over time is limited. It's best to discuss long-term use with your doctor or pharmacist.
Will this supplement help with cancer or IBS?
The evidence for D-limonene in cancer and irritable bowel syndrome is insufficient — there isn't enough research to say whether it works. If you're considering it for either condition, talk with your doctor about the current state of the science.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Limonene 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Limonene 500 mg label
Go deeper

The Full Monographs Behind D-Limonene 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Limonene

Interacts with 229 drugs

Limonene is a natural compound found in the peel of citrus fruits like oranges and lemons, and it is used as a flavoring agent and dietary supplement. People take it for heartburn, digestion...

Read the full Limonene monograph →
Sources

Sources & How We Checked

D-Limonene 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Limonene 10 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Vigushin DM, Poon GK, Boddy A, et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother Pharmacol 1998;42:111-7. PubMed
  3. Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J Nutr 1999;129:775S-778S. PubMed
  4. Matura M, Goossens A, Bordalo O, et al. Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe. J Am Acad Dermatol 2002;47:709-14. PubMed
  5. Topham EJ, Wakelin SH. D-Limonene contact dermatitis from hand cleansers. Contact Dermatitis 2003;49:108-9.
  6. Miyazawa M, Shindo M, Shimada T. Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. Drug Metab Dispos 2002;30:602-7. PubMed
  7. Dales RE, Cakmak S. Is residential ambient air limonene associated with asthma? Findings from the Canadian Health Measures Survey. Environ Pollut 2019;244:966-70. PubMed
  8. Dittmar D, Schuttelaar MLA. Contact sensitization to hydroperoxides of limonene and linalool: results of consecutive patch testing and clinical relevance. Contact Dermatitis 2019;80(2):101-9. PubMed
  9. Gatica-Ortega ME, Pastor-Nieto MA, Schoendorff-Ortega C, Mollejo-Villanueva M, Giménez-Arnau A. Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products. Contac PubMed
  10. Nath NS, Liu B, Green C, Atwater AR. Contact allergy to hydroperoxides of linalool and D-limonene in a US population. Dermatitis 2017;28(5):313-6. PubMed

See these in context on the Limonene monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team