Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

David Winston's Original Bitters Ingredients & Drug Interactions

by Herbalist & Alchemist

David Winston's Original Bitters label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking David Winston's Original Bitters against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

David Winston's Original Bitters is a dietary supplement by Herbalist & Alchemist with 6 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 1,192 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Peppermint Flowering Tops Extract, Dandelion Root Extract, Artichoke Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against David Winston's Original Bitters by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with David Winston's Original Bitters by Herbalist & Alchemist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of David Winston's Original Bitters by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.50 mL) without saying how much of each component you get.

David Winston's Original Bitters contains six active herbal ingredients in a proprietary blend: gentian root extract, artichoke leaf extract, angelica root extract, orange peel extract, dandelion root extract, and peppermint flowering tops extract. Each contributes traditional digestive or liver-support properties.

The product is delivered as a liquid in ethyl alcohol and distilled water, which allows the herbs to be concentrated and preserved.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“supports digestive function”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Irritable bowel syndrome (IBS) — rated "Likely Effective" (Peppermint) (Natural Medicines).
  • On file: Barium enema-related colonic spasm — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Chemotherapy-induced nausea and vomiting (CINV) — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Dyspepsia — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Endoscopy-associated adverse effects — rated "Possibly Effective" (Peppermint) (Natural Medicines).

The evidence varies widely by herb and use. Peppermint is likely effective for irritable bowel syndrome and possibly effective for indigestion, nausea from chemotherapy, and other digestive complaints.

Artichoke leaf is possibly effective for high cholesterol and indigestion. For gentian root, orange peel, dandelion root, and angelica root, the data we hold shows insufficient evidence to rate their effectiveness for the conditions they've been studied in—meaning the research is too limited or mixed to draw firm conclusions.

If you're considering this product for a specific health goal, check with your doctor or pharmacist about whether the evidence supports its use for your situation.

The evidence, ingredient by ingredient Gentian Artichoke Ashitaba Sweet Orange Dandelion Peppermint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Overall, these herbs are generally well tolerated in small amounts. Gentian root can upset the stomach and should be avoided during pregnancy and breastfeeding due to lack of safety data.

Artichoke leaf is generally well tolerated as a short-term supplement but is best avoided in concentrated supplement form during pregnancy and breastfeeding. Orange peel (sweet orange) is safe as food and likely safe in pregnancy, though concentrated extracts are less studied.

Angelica root, dandelion root, and peppermint have limited safety data for pregnancy and breastfeeding—talk with your provider before use if you're pregnant or nursing. Some people may have allergic reactions to artichoke or dandelion if they're sensitive to the ragweed family of plants (Asteraceae).

Common side effects from the herbs themselves include stomach upset, diarrhea, heartburn, and nausea. Peppermint oil at high doses can cause burns in the mouth and throat.

Side effects, ingredient by ingredient Gentian Artichoke Ashitaba Sweet Orange Dandelion Peppermint

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Peppermint, Dandelion, Gentian, Artichoke, Sweet Orange, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of these medication types: OATP substrate drugs, pravastatin, ivermectin, or celiprolol (all Major interactions through the orange peel); blood pressure medications, blood thinners or antiplatelet drugs, diabetes medications, or drugs metabolized by liver enzymes CYP2C19, CYP2C9, CYP3A4, CYP2B6, or CYP1A2 (Moderate interactions across multiple herbs); lithium, potassium-sparing diuretics, cyclosporine, quinolone antibiotics, or fexofenadine (Moderate interactions). If you don't take any of these, still verify your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This bitters product is built on herbs with long traditional use for digestion, and peppermint has solid evidence for irritable bowel syndrome and indigestion. However, the orange peel extract carries several Major-severity interactions with specific medications, and the other ingredients interact with blood pressure drugs, blood thinners, diabetes medications, and multiple liver enzyme systems.

If you're on any prescription medication—especially for blood pressure, blood thinning, diabetes, heart rhythms, or immune suppression—check your exact drugs with your doctor or pharmacist before starting. Pregnant or breastfeeding individuals should also discuss use with their provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about David Winston's Original Bitters, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056102302
Net contents 2 Fluid Ounce(s); 60 Milliliter(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 297465
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for David Winston's Original Bitters by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.75 mL
Maximum serving Sizes:
1.5 mL
Servings per container
40
UPC/BARCODE
667056102302
IngredientAmount% DV
Proprietary Blend1.5 mL--
Gentian root extract0 NP--
Artichoke Leaf Extract0 NP--
Angelica root extract0 NP--
Orange peel extract0 NP--
Dandelion Root Extract0 NP--
Peppermint Flowering Tops Extract0 NP--

Other ingredients: Ethyl Alcohol, Water, Distilled

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports digestive function

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 15-30 drops (0.75-1.5 mL) in juice or water. Take 10-15 minutes before meals. Shake well before using.

Precautions

Contraindications: Do not use if you have hyperchlorhydria. Use cautiously if you have gastric ulcers, gastritis or GERD.

Keep out of children's reach.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

OK (Kosher)

OK (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

David Winston's Original Bitters by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

David Winston's Original Bitters label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in David Winston's Original Bitters by Herbalist & Alchemist

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.75 mL Dosage formLiquid Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Ethyl Alcohol, Water, Distilled. These complete the product’s ingredient list but are not active constituents.

Interaction report

David Winston's Original Bitters by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against David Winston's Original Bitters?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,192Drugs
48 Major 1,144 Moderate

Ingredients driving the most interactions

Peppermint Flowering Tops Extract 796
Dandelion Root Extract 457
Artichoke Leaf Extract 363
Orange peel extract 246
Angelica root extract 186

Individual Drug Interactions

The ingredients in David Winston's Original Bitters interact with 1,192 drugs. Click any drug to see the details.

6 of the 6 ingredients in David Winston's Original Bitters interact with drugs. Each result below shows which ingredient is responsible. Peppermint Flowering Tops Extract Dandelion Root Extract Artichoke Leaf Extract Orange peel extract Angelica root extract Gentian root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in David Winston's Original Bitters with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint Flowering Tops Extract5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint Flowering Tops Extract full monograph & interactions

Dandelion Root Extract7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion Root Extract full monograph & interactions

Artichoke Leaf Extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke Leaf Extract full monograph & interactions

Orange peel extract7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Orange peel extract full monograph & interactions

Angelica root extract1 drug type · 186 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2. Theoretically, concomitant use of ashitaba with CYP1A2 substrates might decrease the clearance of these substrates and increase the risk for adverse effects. However, this interaction has yet to be reported in humans. Until more is known, use with caution.

Likelihood Possible Evidence D
Angelica root extract full monograph & interactions

Gentian root extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for David Winston's Original Bitters, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

David Winston's Original Bitters by Herbalist & Alchemist: Common Questions

Does David Winston's Original Bitters by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, David Winston's Original Bitters has a known interaction with 1,192 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
David Winston's Original Bitters contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Gentian and artichoke are best avoided during pregnancy and breastfeeding due to insufficient safety data. Orange peel is likely safe in pregnancy as food, but concentrated supplement forms lack study. Angelica root, dandelion root, and peppermint all have limited safety information for pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice based on your situation.
What is gentian root used for in this product?
Gentian root is a traditional bitter herb used to support digestive function. However, the data we hold shows insufficient evidence to rate its effectiveness for wound healing, obesity, or other conditions studied.
Does peppermint really work for digestive issues?
Yes—peppermint is likely effective for irritable bowel syndrome and possibly effective for indigestion and related digestive discomfort. It's one of the better-studied herbs in this blend.
What are the most common side effects?
The herbs in this product may cause stomach upset, diarrhea, heartburn, nausea, or belching. Allergic reactions are rare but possible, especially in people sensitive to the ragweed family of plants.
Why does the product contain alcohol?
Ethyl alcohol is the liquid carrier that extracts and preserves the herbal ingredients. It's a standard method for herbal tinctures and bitters.
Is this safe to use with my blood pressure medication?
Gentian and artichoke in this product may theoretically increase the risk of low blood pressure when combined with blood pressure drugs. Check your specific medications with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

David Winston's Original Bitters label
Go deeper

The Full Monographs Behind David Winston's Original Bitters’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph → Herb & supplement monograph

Ashitaba

Interacts with 186 drugs

Ashitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benefits. Most of the supporting research comes from la...

Read the full Ashitaba monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph →
Sources

Sources & How We Checked

David Winston's Original Bitters's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 108 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
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Sweet Orange 17 references
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