DHEA 10 mg Ingredients & Drug Interactions
by Klaire Labs
What is this page for?
First and foremost: checking DHEA 10 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
DHEA 10 mg is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for anti-aging and low dhea levels, mood and depression, vaginal dryness and sexual health.Based on those ingredients, 776 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are DHEA. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against DHEA 10 mg by Klaire Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with DHEA 10 mg by Klaire Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of DHEA 10 mg by Klaire Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Klaire Labs DHEA 10 mg contains one active ingredient: DHEA (dehydroepiandrosterone), a hormone naturally made by your body that declines with age. The capsule also contains microcrystalline cellulose, L-leucine, and a vegetarian capsule shell as inactive ingredients.
Does it work?
Strong evidence
The evidence for DHEA's effectiveness is mixed and depends on what you're using it for. It's likely effective for vaginal atrophy (dryness and thinning of vaginal tissue).
For infertility, aging skin, and depression, the evidence is less certain — the data we hold shows these uses as possibly effective, meaning some research is promising but more study is needed. For any condition you're considering DHEA for, talk with your doctor about whether the evidence matches your situation.
How safe is it?
Well-documented data
DHEA is generally well tolerated at typical doses used short-term, but because it's a hormone, it carries real risks that require medical oversight. The most common side effects are acne (usually mild and dose-related), headache, insomnia, mood changes, and nausea.
Women may experience masculinizing effects like a deeper voice, irregular periods, excess facial or body hair, and oily skin. Men may report aggression or breast changes.
There is also concern that long-term oral use may be linked to a higher cancer risk, though this isn't conclusive. DHEA is not safe in pregnancy and should be avoided while breastfeeding due to insufficient safety data.
Meds to double-check
Moderate interaction found
Before starting DHEA, double-check with your doctor or pharmacist if you take antidepressants (especially SSRIs) — there's a risk of mania or other psychiatric effects. Also flag blood thinners (anticoagulants and antiplatelet drugs), the sleep medication triazolam (Halcion), hormone-blocking cancer drugs (aromatase inhibitors, tamoxifen, or fulvestrant), or any medications broken down by the liver enzyme CYP3A4, since DHEA may raise their levels.
If you're due for a tuberculosis vaccine, mention DHEA beforehand.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
DHEA may be worth considering if you have vaginal atrophy or are exploring infertility treatment, but it's a hormone and needs doctor oversight. If you take any antidepressants, blood thinners, cancer medications, or sleep aids like triazolam, or if you're younger with naturally higher DHEA levels, discuss this supplement with your own doctor or pharmacist first — the interaction risks are real.
Never start DHEA without medical guidance, and don't use it if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about DHEA 10 mg, straight from the product label.
| Brand | Klaire Labs |
|---|---|
| Barcode (UPC) | 828054016002 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2022 |
| DSLD ID | 264857 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for DHEA 10 mg by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| DHEA | 10 mg | -- |
Other ingredients: Microcrystalline Cellulose, Vegetarian Capsule, L-Leucine
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Precautions
Caution: Not for use by individuals under the age of 18 years.
Do not use if pregnant or breastfeeding. Consult a physician or licensed qualified healthcare professional before using this product if you are a woman under the age of 40; if you or someone in your family history has cancer, prostate enlargement, high blood pressure or heart disease, or low HDL ("good") cholesterol; or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.
Do not exceed the recommended serving. Monitor liver enzymes if using long-term. Discontinue use and call a physician immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.
Keep out of reach of children.
Do not use if shrinkwrap is broken or missing.
Formulation
Free of the following common allergens: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.
Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule, 1 to 2 times daily with food or as directed by a healthcare professional.
Formula
This product contains pure DHEA that has been micronized to a very small particle size to facilitate absorption. Vegetarian capsules made of plant cellulose are used.
Storage
Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
DHEA 10 mg by Klaire Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in DHEA 10 mg by Klaire Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
DHEA
Interacts with776 drugs
DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...
DHEA monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Vegetarian Capsule, L-Leucine. These complete the product’s ingredient list but are not active constituents.
DHEA 10 mg by Klaire Labs Drug Interactions
HelloPharmacist Interaction Report
Klaire Labs DHEA 10 mg interacts with several medication types through its single active ingredient.
The most serious documented concern is a Moderate-severity interaction with antidepressants (particularly SSRIs), where DHEA may increase the risk of psychiatric side effects including mania — a case report showed an SSRI user who developed a manic episode when DHEA was added, with greater concern in younger people.
Read the full breakdown — every affected drug type, severity by severity
DHEA also has Moderate interactions with blood thinners (anticoagulants and antiplatelet drugs): it may increase bleeding risk by interfering with how blood clots. It can raise the blood levels of the sleep medication triazolam (Halcion) by blocking its breakdown in the liver.
Additionally, because DHEA acts like estrogen in the body, it may work against hormone-blocking cancer drugs — aromatase inhibitors, tamoxifen (Nolvadex), and fulvestrant (Faslodex) — potentially reducing their anti-cancer effect. Finally, DHEA may reduce how well the tuberculosis vaccine works.
DHEA also affects a broad class of drugs broken down by a liver enzyme called CYP3A4, meaning it could theoretically raise the levels of many medications metabolized that way, though the real-world importance of this is not yet clear. Altogether, these interactions span 777 individual medications.
Use the interaction checker below to search your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against DHEA 10 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in DHEA 10 mg interact with 776 drugs. Click any drug to see the details.
1 of the 1 ingredient in DHEA 10 mg interact with drugs. Each result below shows which ingredient is responsible. DHEA
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dhea + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Abemaciclib interactionAbiraterone
How Abiraterone interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dhea + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dhea + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dhea + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dhea + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
DheaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in DHEA 10 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
DHEA
Anticoagulant/Antiplatelet Drugs
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.
Antidepressant Drugs
Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.
Aromatase Inhibitors
Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.
Fulvestrant (Faslodex)
Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.
Tamoxifen (Nolvadex)
Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.
Triazolam (Halcion)
DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.
Tuberculosis Vaccine
DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.
Estrogens
Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.
Testosterone
Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.
Brand information
Manufacturer and brand details for DHEA 10 mg, from the product label.
Klaire Labs
See all Klaire Labs products- Name
- SFI USA
- City
- Reno
- State
- NV
- ZipCode
- 89521
- Web Address
- Klaire.com
DHEA 10 mg by Klaire Labs: Common Questions
Does DHEA 10 mg by Klaire Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take DHEA if I'm pregnant or breastfeeding?
What's the most common side effect?
Is DHEA safe to take long-term?
Will DHEA help my depression?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if DHEA 10 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind DHEA 10 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
DHEA 10 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 98 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Dhea 98 references
- Frye RF, Kroboth PD, Folan MM, et al. Effect of DHEA on CYP3A-mediated metabolism of triazolam. Clin Pharmacol Ther 2000;67:109 (abstract PI-82).
- Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6. PubMed
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