Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Dicobalene-V Cherry Flavored Ingredients & Drug Interactions

by Hi-Tech Pharmaceuticals

Dicobalene-V Cherry Flavored label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dicobalene-V Cherry Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Dicobalene-V Cherry Flavored is a dietary supplement by Hi-Tech Pharmaceuticals with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 230 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Proprietary Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Dicobalene-V Cherry Flavored contains four active ingredients: vitamin B6, biotin, folate, and a proprietary blend listed as vitamin B12. Vitamin B6 helps your body use amino acids and make neurotransmitters and red blood cells.

Biotin is a B vitamin your body uses for hair, skin, and nail health and to break down nutrients. Folate supports cell division and DNA synthesis.

Vitamin B12 is essential for nerve function, DNA, and red blood cell formation.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: central nervous system and cardiovascular health energy.
  • We looked for evidence on: Cardiovascular disease (CVD), Fatigue, Cognitive function, Dementia, Age-related cognitive decline, Alzheimer disease — and 4 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Likely Effective" for Hyperhomocysteinemia (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.

Vitamin B6 is effective for sideroblastic anemia (a blood disorder affecting red blood cells) and vitamin B6 deficiency, and it's likely effective for lowering homocysteine levels (an amino acid linked to heart disease). It's possibly effective for pregnancy-related nausea and vomiting.

Biotin is likely effective for biotin deficiency but shows insufficient evidence for hair loss (alopecia areata) and appears possibly ineffective for seborrheic dermatitis and multiple sclerosis. Vitamin B12 is effective for B12 deficiency and a rare genetic disorder called Imerslund-Grasbeck disease, likely effective for cyanide poisoning, and possibly effective for canker sores and nerve pain after shingles.

We hold no data on folate's effectiveness for this product.

The evidence, ingredient by ingredient Vitamin B6 Biotin Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated in doses under 100 mg daily. Common mild side effects include headache, nausea, heartburn, and stomach pain.

At very high doses (over 1,000 mg daily or very high total intake over time), it can cause nerve damage (sensory neuropathy)—a rare but serious risk. Biotin is generally safe and well tolerated; high-dose biotin rarely causes mild diarrhea.

Vitamin B12 is very safe with no established upper limit and is removed in urine. It's generally well tolerated when taken by mouth or injection, though rare allergic reactions like rash can occur.

During pregnancy, vitamin B6 is likely safe but possibly unsafe depending on dose—only use it under your doctor's guidance. Biotin and vitamin B12 are both likely safe in pregnancy and lactation at recommended amounts.

Side effects, ingredient by ingredient Vitamin B6 Biotin Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 230 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take antihypertensive drugs (blood pressure medications)—vitamin B6 may add to their effect. Also clear it if you're on phenobarbital or phenytoin (seizure medications), amiodarone (heart rhythm drug), levodopa alone for Parkinson's disease, or metformin for diabetes.

No interactions are documented for biotin or folate among the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help if you have vitamin B6 or B12 deficiency, or if you're looking for biotin support for hair and nails. If you take blood pressure, seizure, heart rhythm, or diabetes medications, you need to check with your doctor or pharmacist before starting it.

Pregnant women should talk with their provider before taking this. Your own healthcare provider can review your exact medication list and decide whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dicobalene-V Cherry Flavored, straight from the product label.

Brand Hi-Tech Pharmaceuticals
Barcode (UPC) 857084000132
Net contents 200 Cherry Flavored Sublingual Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 10262
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
200
UPC/BARCODE
857084000132
IngredientAmount% DV
Vitamin B610 mg500%
Biotin25 mcg8.33%
Folate400 mcg100%
Proprietary Blend1000 mcg16888%

Other ingredients: Unidex, Beta-Cyclodextrin, Sodium starch glycolate, Magnesium Stearate, Naturally Sweet(TM) Cherry flavor, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

HI-TECH PHARMACEUTICALS HTP

FDA Statement of Identity

Dietary Supplement

Formula

- Hi potency sublingual B-12 tablet with the two active, coenzymated forms of Vitamin B-12 - Methylcobalamin and adenosyl cobalamin with pharmaceutical-grade B-12

brand of Pharmaceutical-Grade B-12

General Statements

- Hi-Tech B-12 supports a healthy central nervous system, Cardiovascular function. and increases energy.

Formulation

This product contains no wheat, yeast, gluten, soy or dairy. Contains no artificial sweeteners, flavors, or preservatives.

Suggested/Recommended/Usage/Directions

RECOMMENDED USE: Take one lozenge, one to eight times daily. Allow tablet to dissolve under tongue or allow to dissolve in the mouth before swallowing.

Precautions

WARNING: B-12 and its coenzymes are extremely heat and light sensitive, and will lose its potency when subjected to those elements.

Brand IP Statement(s)

Dicobalene-V(TM) utilizes a very unique Beta-Cyclodextrin delivery system in its tablets to ensure full potency. Dicobalene-V(TM) is manufactured in a highly controlled environment, making it the most perfect potent form of Vitamin B-12 in America.

Dicobalene-V(TM) is a revolutionary B-Complex Vitamin unlike any other product on the market. Dicobalene-V(TM) is active immediately upon absorption, while most B-12 products must be converted to methycobolamin by the body before it can be used. Methylcobalamin and Adenosylcobalamin are the two active coenzymated form of B-12 active in the central nervous system. Dicobalene-V's(TM) unique formula of B-12, B-6, Folic Acid and Biotin, when placed under the tongue are absorbed directly into the bloodstream, providing nutritional support for the central nervous system and cardiovascular function. Dicobalene-V(TM) is an excellent product to increase energy without the use of stimulants.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dicobalene-V Cherry Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container200 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Biotin

No known
interactions
25 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Folate

400 mcg per serving

Proprietary Blend

Interacts with
20 drugs
1000 mcg per serving Form: Adenosylcobalamin, Cyanocobalamin, Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Proprietary Blend monograph & interactions

Other (inactive) ingredients: Unidex, Beta-Cyclodextrin, Sodium starch glycolate, Magnesium Stearate, Naturally Sweet(TM) Cherry flavor, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against Dicobalene-V Cherry Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
230Drugs
205 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Proprietary Blend 20

Individual Drug Interactions

The ingredients in Dicobalene-V Cherry Flavored interact with 230 drugs. Click any drug to see the details.

2 of the 4 ingredients in Dicobalene-V Cherry Flavored interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Proprietary Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Dicobalene-V Cherry Flavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Proprietary Blend1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Proprietary Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dicobalene-V Cherry Flavored, from the product label.

Hi-Tech Pharmaceuticals

See all Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Drive
City
Norcross
State
GA
ZipCode
30071
Phone Number
1-888-855-7919
Pharmacist Counseling Corner

Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals: Common Questions

Does Dicobalene-V Cherry Flavored by Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Dicobalene-V Cherry Flavored has a known interaction with 230 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dicobalene-V Cherry Flavored contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Vitamin B6 is possibly unsafe in pregnancy depending on the dose, so only take it under your doctor's guidance. Biotin and vitamin B12 are both likely safe at recommended amounts during pregnancy, but talk with your provider first about whether this product is right for you.
What does biotin actually do?
Biotin is a B vitamin your body uses to support hair, skin, and nail health and to break down the nutrients you eat. It's likely effective if you have a biotin deficiency, but evidence is insufficient for hair loss and it appears ineffective for seborrheic dermatitis and multiple sclerosis.
Can high doses of this product cause nerve damage?
Vitamin B6 at very high doses—over 1,000 mg daily or very high total intake over time—can cause nerve damage (sensory neuropathy), which is rare but serious. This product's dose and form are worth confirming with your pharmacist to see if that risk applies to you.
Is this safe to take long-term?
Vitamin B6 is well tolerated at doses under 100 mg daily, and biotin and B12 are generally very safe even at higher doses. That said, high-dose vitamin B6 over a long time carries a nerve-damage risk, so discuss your personal plan with your doctor or pharmacist.
Will this help with my morning sickness?
Vitamin B6 is possibly effective for pregnancy-related nausea and vomiting, and it's often used at recommended levels for morning sickness—but only under your doctor's guidance. Talk with your provider about whether this product is appropriate for you and at what dose.
What's in the proprietary blend?
The product lists the proprietary blend as vitamin B12, which supports nerve function, DNA, and red blood cell formation. The exact amount of B12 and any other ingredients in that blend aren't separately listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dicobalene-V Cherry Flavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dicobalene-V Cherry Flavored label
Go deeper

The Full Monographs Behind Dicobalene-V Cherry Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Dicobalene-V Cherry Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
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See these in context on the Vitamin B12 monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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