Interactions on record — worth a quick check against your medications. Based on 8 of 20 ingredients. Check your meds →
Dietary supplement

Digestive Bliss Probiotic Ingredients & Drug Interactions

by Nature's Secret

Digestive Bliss Probiotic label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Bliss Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Bliss Probiotic is a dietary supplement by Nature's Secret with 20 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 387 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium, Lactobacillus helveticus, Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Bliss Probiotic by Nature's Secret

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Bliss Probiotic by Nature's Secret — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Bliss Probiotic by Nature's Secret

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 20 active ingredients.
  • “Proprietary Probiotic Blend 4 Billion CFU” is a proprietary blend — the label gives one combined amount (150 ng) without saying how much of each component you get.

Digestive Bliss Probiotic contains 20 ingredients, including sodium and fructooligosaccharides (a fiber-like carbohydrate that may feed beneficial gut bacteria), plus 10 named probiotic strains—Lactobacillus and Bifidobacterium species, Streptococcus thermophilus, and Enterococcus faecium—bundled together to provide 4 billion colony-forming units (CFU) total. The inactive ingredients are microcrystalline cellulose (a filler), hydroxypropyl methylcellulose, pectin, sodium bicarbonate, sodium carbonate anhydrous, silicon dioxide, stearic acid, guar gum, and turmeric.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and good bacteria balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Diarrhea, Dyspepsia, Constipation, Irritable bowel syndrome — and 2 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence we hold shows Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis; Bifidobacterium bifidum and B. longum are possibly effective for irritable bowel syndrome and respiratory tract infections (B. bifidum only), respectively. For most of the other probiotic strains and ingredients in this formula, the evidence is insufficient to rate their effectiveness.

Sodium is likely effective for cystic fibrosis and possibly effective for amphotericin B nephrotoxicity, though these are not typical reasons someone takes a digestive probiotic.

The evidence, ingredient by ingredient Sodium Fructo-oligosaccharides (fos) Lactobacillus Helveticus Streptococcus Thermophilus Lactobacillus Acidophilus Bifidobacterium Bifidum Bifidobacterium Longum Lactobacillus Gasseri

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary amounts but becomes a concern at high doses. Excess sodium is linked to high blood pressure, heart strain, and kidney disease; serious side effects are rare but can include worsening cardiovascular and kidney disease.

Population research ties high sodium intake to increased gastric cancer risk. Fructooligosaccharides are generally well tolerated but commonly cause gas, bloating, and abdominal pain, especially at higher doses—however, clinical trials suggest doses under 10 grams daily are mild or no worse than placebo.

The probiotic strains are generally well tolerated in healthy people but may rarely cause infection in those with weakened immune systems or serious illness. Pregnancy and lactation data are limited or absent for most ingredients; Streptococcus thermophilus is possibly safe in pregnancy, and several Lactobacillus and Bifidobacterium species are possibly safe in pregnancy, but specific dosing guidance is not on file.

Speak with your doctor or pharmacist about whether this product is right for you if you are pregnant or breastfeeding.

Side effects, ingredient by ingredient Sodium Fructo-oligosaccharides (fos) Lactobacillus Helveticus Streptococcus Thermophilus Lactobacillus Acidophilus Bifidobacterium Bifidum Bifidobacterium Longum Lactobacillus Gasseri

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lactobacillus Acidophilus, Sodium, Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Gasseri, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 387 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antihypertensive drugs (blood pressure medications)—sodium can reduce their effect. Also check if you take lithium, corticosteroids, antibiotics, didanosine, sodium phosphates, tolvaptan, or any other sodium-containing drug.

Antibiotic timing is critical; you'll need to separate doses from the probiotic strains to keep them active.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Digestive Bliss Probiotic may help with irritable bowel syndrome and antibiotic-associated diarrhea, based on evidence for L. acidophilus, though most of the other strains lack strong proof. If you take blood pressure medications, lithium, antibiotics, or any corticosteroid, clarify with your doctor or pharmacist before starting this product—sodium content and probiotic interactions need careful timing or dose adjustment.

For anyone on other medications, check the search tool here to see if your drugs interact.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Bliss Probiotic, straight from the product label.

Brand Nature's Secret
Barcode (UPC) 710363265212
Net contents 30 Patented Gel-Barrier Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69379
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Bliss Probiotic by Nature's Secret, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gel-Barrier Tablet(s)
Maximum serving Sizes:
1 Gel-Barrier Tablet(s)
Servings per container
30
UPC/BARCODE
710363265212
IngredientAmount% DV
Sodium35 mg1%
Fructooligosaccharides25 mg--
Lactobacillus paracasei0 NP--
Lactobacillus fermentum0 NP--
Lactobacillus helveticus0 NP--
Lactobacillus rhamnosus0 NP--
Streptococcus thermophilus0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium infantis0 NP--
Bifidobacterium bifidum0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum0 NP--
Lactobacillus reuteri0 NP--
Lactobacillus gasseri0 NP--
Lactobacillus salivarius0 NP--
Lactobacillus brevis0 NP--
Enterococcus faecium0 NP--
Proprietary Probiotic Blend 4 Billion CFU150 ng--
Lactobacillus casei0 NP--
Lactococcus lactis ssp. lactis0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Sodium Bicarbonate, Sodium Carbonate Anhydrous, Silicon Dioxide, Stearic Acid, Guar Gum, Turmeric

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Take control of your health Experience the sensation of whole-body wellness... Detoxify ~ Cleanse ~ Rebuild

Take a look at the way our medical system is organized- from cardiologists to dermatologists, we have a doctor for every body part. But nature has a well-kept secret... there is no separation between any of our systems. They are all intricately connected in a brilliant dance only nature could orchestrate.

Quality Tested

3161-BOX-NS076300-V11-11/15

Did you know that good bacteria can enhance your digestion and overall health?

This barrier helps preserve the delicate probiotic organisms inside as they travel to the high acid environmental of your stomach. The result? More probiotics reach the intestines alive and intact for maximum benefit.

This robust formula supplies 18 different types of "friendly" bacteria that can reside inside the intestinal tract and form part of a healthy gut flora. Maintaining an optimal balance of intestinal bacteria is vital to overall health and well-being.

Questions: Call Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM TO 5:00 PM (PST) [email protected] To join our Wellness Club and receive tips on how to improve your health, please visit us at www.NaturesSecret.com/wellness1

Available Exclusively in Fine Health Food Stores Everywhere

18 Probiotics to support a healthy intestinal tract Patented Gel-Barrier technology to replenish, rebuild & nourish

We understand, for example, that sluggish digestion can lead to low energy levels and shouldn't always be supported with caffeinated energy tablets. Our approach focuses on the origins of imbalance, not signs of imbalance.

Brand IP Statement(s)

At Nature's Secret, we develop our products using this whole-body philosophy.

This is Nature's Secret, total body wholeness and wellness.

Who is Nature's Secret? At Nature's Secret we believe that total body wellness is the key to overall health.

The key breakthrough of Digestive Bliss Probiotic is its patented delivery system, which forms a protective gel barrier around the probiotic as soon as it is ingested.

Nature's Secret Digestive Bliss Probiotic is a proprietary blend of probiotics that can help support a healthy intestinal tract.

Storage

Store in a cool, dry place.

Formula

Plus Prebiotic FOS

Contains: Dairy.

Suggested/Recommended/Usage/Directions

Directions: (Adult) Take one (1) gel-barrier tablet daily.

Precautions

Not intended for use by persons under 18. Keep out of reach of children.

Usage Warnings: Do not use is safety seal is broken.

Contains: Dairy.

Check with your doctor before using this product if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No artificial colors or preservatives added.

General

3157-LAB-NS036300-V11-11/15

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Bliss Probiotic by Nature's Secret label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Bliss Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Bliss Probiotic by Nature's Secret

These are the 20 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gel-Barrier Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
35 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Fructooligosaccharides

No known
interactions
25 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Proprietary Probiotic Blend 4 Billion CFU

150 ng per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Sodium Bicarbonate, Sodium Carbonate Anhydrous, Silicon Dioxide, Stearic Acid, Guar Gum, Turmeric. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Bliss Probiotic by Nature's Secret Drug Interactions

Want to check YOUR meds against Digestive Bliss Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
387Drugs
387 Moderate

Ingredients driving the most interactions

Sodium 205
Lactobacillus helveticus 182
Lactobacillus acidophilus 182
Bifidobacterium bifidum 182
Bifidobacterium longum 182

Individual Drug Interactions

The ingredients in Digestive Bliss Probiotic interact with 387 drugs. Click any drug to see the details.

6 of the 20 ingredients in Digestive Bliss Probiotic interact with drugs. Each result below shows which ingredient is responsible. Sodium Lactobacillus helveticus Lactobacillus acidophilus Bifidobacterium bifidum Bifidobacterium longum Lactobacillus gasseri

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Bliss Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Lactobacillus helveticus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus helveticus full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Lactobacillus gasseri1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus gasseri full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Bliss Probiotic, from the product label.

Nature's Secret

See all Nature's Secret products
Name
Nature's Secret
Street Address
P.O. Box 66457
City
Los Angeles
State
CA
ZipCode
90066
Web Address
www.NaturesSecret.com
Pharmacist Counseling Corner

Digestive Bliss Probiotic by Nature's Secret: Common Questions

Does Digestive Bliss Probiotic by Nature's Secret interact with any medications?
Yes. Based on its ingredients, Digestive Bliss Probiotic has a known interaction with 387 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Bliss Probiotic contains 20 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while on antibiotics?
Not at the same time. Several probiotic strains in this product—L. helveticus, L. acidophilus, B. bifidum, B. longum, and L. gasseri—are living organisms that antibiotics will kill. You'll need to space them several hours apart; ask your pharmacist for the best timing for your specific antibiotic.
Does this contain a lot of sodium?
The product facts don't specify the sodium amount per dose, so you'll need to check the label or ask the manufacturer. If you take blood pressure pills, lithium, or corticosteroids, your doctor should review the sodium content first.
Will this help my IBS or diarrhea?
Lactobacillus acidophilus in the blend is possibly effective for irritable bowel syndrome and antibiotic-associated diarrhea. The other strains don't have enough evidence to know if they help these conditions. Talk to your doctor about whether this is a fit for your situation.
Can I take this if I'm pregnant?
There isn't enough safety data on file for most of the strains; Streptococcus thermophilus is possibly safe in pregnancy, and some Lactobacillus and Bifidobacterium species are possibly safe, but you'll need to discuss this with your doctor or pharmacist for personalized advice.
What are the side effects?
Fructooligosaccharides commonly cause gas, bloating, and abdominal pain, though clinical trials suggest these are mild at typical doses. The probiotic strains rarely cause gastrointestinal discomfort, rash, or infection in healthy people with intact immune systems.
Is this safe if I have a weakened immune system?
The safety data warn that probiotics may rarely cause infection in people who are seriously ill or immune-compromised. Talk with your doctor before taking this if your immune system is weakened.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Bliss Probiotic is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Bliss Probiotic label
Go deeper

The Full Monographs Behind Digestive Bliss Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph →
Sources

Sources & How We Checked

Digestive Bliss Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
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Fructo-oligosaccharides (fos) 6 references
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See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Helveticus 2 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Streptococcus Thermophilus 21 references
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See these in context on the Streptococcus Thermophilus monograph →

Lactobacillus Acidophilus 15 references
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  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
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  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
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  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
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See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
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  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
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  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
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  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
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  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

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