Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Digestive Health Ingredients & Drug Interactions

by Shakeology Boost

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Digestive Health is a dietary supplement by Shakeology Boost with 8 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,134 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Psyllium (Plantago ovata) husk powder, Flax seed powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Digestive Health by Shakeology Boost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 7 active ingredients.
  • “Proprietary Fiber Blend” is a proprietary blend — the label gives one combined amount (12.90 Gram(s)) without saying how much of each component you get.

Shakeology Boost Digestive Health contains 8 active ingredients centered on dietary fiber. You're getting soluble fiber, insoluble fiber, flaxseed powder, a proprietary fiber blend (which includes pea fiber and psyllium husk powder), chicory root fiber, and chia seed powder.

The product also contains alpha-linolenic acid — a plant-based omega-3 fatty acid found in flax and chia. One inactive ingredient, mixed tocopherols (a form of vitamin E), is included as an antioxidant.

These ingredients work together to support digestive function through bulk, moisture, and fermentation in your gut. The mix of soluble fibers (which dissolve and form a gel) and insoluble fibers (which add bulk) is designed to promote regularity and feed your beneficial gut bacteria.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Constipation — rated "Effective" (Black Psyllium) (Natural Medicines).
  • On file: Hyperlipidemia — rated "Likely Effective" (Blond Psyllium) (Natural Medicines).
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Black Psyllium) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Blond Psyllium) (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Flaxseed) (Natural Medicines).

The evidence is uneven across the ingredients. Psyllium husk is effective for constipation and likely effective for lowering cholesterol and supporting heart health.

Flaxseed is possibly effective for high cholesterol, blood sugar control, breast pain (mastalgia), high blood pressure, and constipation. Chia seed shows possibly ineffective results for cholesterol and weight, and the evidence for chicory is insufficient — we don't have reliable data on whether it helps with the conditions it's been studied for.

For soluble fiber, insoluble fiber, alpha-linolenic acid, and pea fiber, the effectiveness ratings are not on file.

The evidence, ingredient by ingredient Black Psyllium Flaxseed Blond Psyllium Chicory Chia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Psyllium husk is generally well tolerated when taken with plenty of water and is likely safe during pregnancy and breastfeeding. Flaxseed is also generally well tolerated as a food, though you should start with small amounts and drink plenty of water to minimize bloating and gas.

The safety data advises against supplement doses of flaxseed during pregnancy and recommends caution while breastfeeding. Chicory is generally well tolerated in food amounts but may cause gas and trigger allergies in sensitive people; the safety data advises against medicinal amounts during pregnancy, and recommends caution while breastfeeding.

Chia is widely eaten as food and generally well tolerated, though the data recommends caution with concentrated supplement amounts. All four checked ingredients can cause mild gastrointestinal side effects — bloating, gas, diarrhea, or constipation — especially at higher doses.

Side effects, ingredient by ingredient Black Psyllium Flaxseed Blond Psyllium Chicory Chia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Chicory, Black Psyllium, Blond Psyllium, Flaxseed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,135 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any blood sugar–lowering medications (antidiabetes drugs), as both flaxseed and chicory may increase their effect. Also confirm if you take blood pressure–lowering drugs, blood thinners or antiplatelet drugs, hormonal birth control or estrogen therapy, antibiotics, or any of these specific medications: metformin, lithium, carbamazepine, olanzapine, or digoxin.

Psyllium can change how your body absorbs many oral medications, so timing matters — take psyllium at least 30–60 minutes after other drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is intended to support digestive health through multiple types of fiber and may be worth considering if you're looking for regularity support and have no medication interactions. Because it contains ingredients that interact with blood sugar drugs, blood pressure medications, blood thinners, hormonal contraceptives, and several other medications, check with your doctor or pharmacist before taking it alongside any prescription drugs.

If you have a history of psyllium or chicory allergies, avoid this product. Talk it over with your own healthcare provider to see if it fits your individual situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Health, straight from the product label.

Brand Shakeology Boost
Barcode (UPC) SUSH31119
Net contents 9.17 Ounce(s); 260 Gram(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 212755
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Qualified Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Health by Shakeology Boost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
13 Gram(s)
Maximum serving Sizes:
13 Gram(s)
Servings per container
20
UPC/BARCODE
SUSH31119
IngredientAmount% DV
Calories40 Calorie(s)--
Total Carbohydrates8 Gram(s)3%
Calories from Fat20 Calorie(s)--
Dietary Fiber7 Gram(s)28%
Total Fat2.5 Gram(s)4%
Soluble Fiber2 Gram(s)--
Insoluble Fiber5 Gram(s)--
Protein2 Gram(s)4%
Alpha-Linolenic Acid1.3 Gram(s)--
Flax seed powder0 NP--
Proprietary Fiber Blend12.9 Gram(s)--
Pea (Pisum spp.) fiber0 NP--
Psyllium (Plantago ovata) husk powder0 NP--
Chicory (Cichorium intybus) root fiber0 NP--
Chia (Salvia hispanica) seed powder0 NP--

Other ingredients: Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Gently shake the jar to loosen compressed powder then combine one level scoop (13 g) of Digestive Health powder with Shakeology or the beverage of your choice. Add more liquid as needed, if too thick. Consume promptly.

Storage

Store in a cool, dry place.

Precautions

Allergen Information: This product is manufactured in a plant that also processes milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, and soy ingredients.

Warning: Consult with a healthcare professional if you are pregnant, breastfeeding, or if you have any medical conditions.

Keep out of reach of children.

Notice: This product should be eaten with at least a full glass of liquid. Eating this product without enough liquid may cause choking. Do not eat this product if you have difficulty in swallowing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

2015 Beachbody, LLC. All rights reserved. Beachbody, LLC is the owner of the Shakeology, the Healthiest Meal of the Day, Beachbody Ultimate, Beachbody, and Team Beachbody trademarks, and all related designs, trademarks, copyrights, and other intellectual property.

Beachbody Ultimate

General Statements

To reorder, contact your Coach, log in at TeamBeachbody.com, or call 1 (800) 427-3809.

Formulation

Formulated with key ingredients to: Enhance your Shakeology for even healthier results Contain 7g of fiber per serving - 40% of daily value when added to Shakeology Help maintain regularity and digestive health Provide an optimal ratio of soluble and insoluble fiber

No artificial colors, flavors, sweeteners, or preservatives

FDA Statement of Identity

Dietary Supplement

Formula

ALA Omega-3 Fatty Acids help support cardiovascular health Excellent source of dietary fiber Soluble fiber from psyllium, as part of a healthy diet low in saturated fat and cholesterol, may reduce the risk of heart disease

See for yourself

Digestive Health by Shakeology Boost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Digestive Health by Shakeology Boost

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size13 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
7 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions
  • › Soluble Fiber
  • › Insoluble Fiber

Protein

2 Gram(s) per serving

Alpha-Linolenic Acid

1.3 Gram(s) per serving

Proprietary Fiber Blend

12.9 Gram(s) per serving

Other (inactive) ingredients: Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Health by Shakeology Boost Drug Interactions

Want to check YOUR meds against Digestive Health?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,134Drugs
600 Moderate 1,534 Minor

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Health with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B

Psyllium (Plantago ovata) husk powder7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, blond psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Blond psyllium might reduce carbamazepine absorption and serum levels. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug.

Likelihood Probable Evidence D
Lithium

Theoretically, taking blond psyllium at the same time as lithium might reduce lithium absorption.
The fiber in blond psyllium might decrease the absorption of lithium. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Concurrent use of blond psyllium with metformin slows and increases metformin absorption. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking blond psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in blond psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was taken concomitantly with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking blond psyllium at the same time as digoxin might reduce digoxin absorption.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking blond psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. However, this is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Conversely, case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin.

Likelihood Possible Evidence B

Flax seed powder5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D

Chicory (Cichorium intybus) root fiber1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Digestive Health, from the product label.

Shakeology Boost

See all Shakeology Boost products
Name
Beachbody, LLC
City
Santa Monica
State
CA
ZipCode
90404
Phone Number
1 (800) 427-3809
Web Address
TeamBeachbody.com
Pharmacist Counseling Corner

Digestive Health by Shakeology Boost: Common Questions

Does Digestive Health by Shakeology Boost interact with any medications?
Yes. Based on its ingredients, Digestive Health has a known interaction with 2,134 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Health contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my constipation?
Psyllium husk, one of the main ingredients here, is effective for constipation. Flaxseed is also possibly effective for it. Start with a small amount, drink plenty of water, and give your digestive system time to adjust — you may feel bloated or gassy at first.
Can I take this while pregnant or breastfeeding?
Psyllium husk is likely safe during both pregnancy and breastfeeding. Flaxseed is possibly unsafe during pregnancy, so it's best avoided in supplement doses if you're pregnant. The safety data for chicory and chia recommends caution or avoidance of medicinal amounts while pregnant or breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
What are the side effects I should expect?
Most people tolerate this product well when they drink plenty of water. The most common side effects are mild digestive ones — bloating, gas, diarrhea, or constipation — especially when you first start or at higher doses. These usually settle as your body adjusts. Rare but serious allergic reactions (such as anaphylaxis) have been reported with psyllium and chia.
Is this safe to use with my blood pressure medication?
Flaxseed in this product may have additive effects with blood pressure–lowering drugs and theoretically could increase the risk of low blood pressure. Check with your doctor or pharmacist before combining them — they may adjust timing or monitoring based on your specific medication.
Does this work for high cholesterol?
Psyllium husk is likely effective for lowering cholesterol, and flaxseed is possibly effective. Chia seed, however, shows possibly ineffective results for cholesterol in the data we hold. Talk with your doctor about whether this product is right alongside your cholesterol management plan.
Can I take this with my diabetes medication?
Both flaxseed and chicory in this product may add to the effect of blood sugar–lowering drugs and raise the risk of low blood sugar (hypoglycemia). Check with your doctor or pharmacist before taking it — they'll want to know what diabetes medication you use and may suggest timing or monitoring adjustments.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Health is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Health label
Go deeper

The Full Monographs Behind Digestive Health’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Digestive Health's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 108 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Flaxseed 37 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Thompson LU, Rickard SE, Cheung F, et al. Variability in anticancer lignan levels in flaxseed. Nutr Cancer 1997;27:26-30. PubMed
  4. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  5. Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
  6. Clark WF, Parbtani A, Huff MW, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475-80. PubMed
  7. Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. PubMed
  8. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  9. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  10. Clark WF, Kortas C, Heidenheim P, et al. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr 2001;20:143-8. PubMed
  11. Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991;60:135-42. PubMed
  12. Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 2000;161:47-55. PubMed
  13. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
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Chicory 13 references
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Chia 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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