Digestive Health Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Digestive Health against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Health is a dietary supplement by Shakeology Boost with 8 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,134 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Psyllium (Plantago ovata) husk powder, Flax seed powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Digestive Health by Shakeology Boost
Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Health by Shakeology Boost — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Digestive Health by Shakeology Boost
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Shakeology Boost Digestive Health contains 8 active ingredients centered on dietary fiber. You're getting soluble fiber, insoluble fiber, flaxseed powder, a proprietary fiber blend (which includes pea fiber and psyllium husk powder), chicory root fiber, and chia seed powder.
The product also contains alpha-linolenic acid — a plant-based omega-3 fatty acid found in flax and chia. One inactive ingredient, mixed tocopherols (a form of vitamin E), is included as an antioxidant.
These ingredients work together to support digestive function through bulk, moisture, and fermentation in your gut. The mix of soluble fibers (which dissolve and form a gel) and insoluble fibers (which add bulk) is designed to promote regularity and feed your beneficial gut bacteria.
Does it work?
Strong evidence
The evidence is uneven across the ingredients. Psyllium husk is effective for constipation and likely effective for lowering cholesterol and supporting heart health.
Flaxseed is possibly effective for high cholesterol, blood sugar control, breast pain (mastalgia), high blood pressure, and constipation. Chia seed shows possibly ineffective results for cholesterol and weight, and the evidence for chicory is insufficient — we don't have reliable data on whether it helps with the conditions it's been studied for.
For soluble fiber, insoluble fiber, alpha-linolenic acid, and pea fiber, the effectiveness ratings are not on file.
How safe is it?
Well-documented data
Psyllium husk is generally well tolerated when taken with plenty of water and is likely safe during pregnancy and breastfeeding. Flaxseed is also generally well tolerated as a food, though you should start with small amounts and drink plenty of water to minimize bloating and gas.
The safety data advises against supplement doses of flaxseed during pregnancy and recommends caution while breastfeeding. Chicory is generally well tolerated in food amounts but may cause gas and trigger allergies in sensitive people; the safety data advises against medicinal amounts during pregnancy, and recommends caution while breastfeeding.
Chia is widely eaten as food and generally well tolerated, though the data recommends caution with concentrated supplement amounts. All four checked ingredients can cause mild gastrointestinal side effects — bloating, gas, diarrhea, or constipation — especially at higher doses.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take any blood sugar–lowering medications (antidiabetes drugs), as both flaxseed and chicory may increase their effect. Also confirm if you take blood pressure–lowering drugs, blood thinners or antiplatelet drugs, hormonal birth control or estrogen therapy, antibiotics, or any of these specific medications: metformin, lithium, carbamazepine, olanzapine, or digoxin.
Psyllium can change how your body absorbs many oral medications, so timing matters — take psyllium at least 30–60 minutes after other drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product is intended to support digestive health through multiple types of fiber and may be worth considering if you're looking for regularity support and have no medication interactions. Because it contains ingredients that interact with blood sugar drugs, blood pressure medications, blood thinners, hormonal contraceptives, and several other medications, check with your doctor or pharmacist before taking it alongside any prescription drugs.
If you have a history of psyllium or chicory allergies, avoid this product. Talk it over with your own healthcare provider to see if it fits your individual situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Health, straight from the product label.
| Brand | Shakeology Boost |
|---|---|
| Barcode (UPC) | SUSH31119 |
| Net contents | 9.17 Ounce(s); 260 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2020 |
| DSLD ID | 212755 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Qualified Health, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Health by Shakeology Boost, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 40 Calorie(s) | -- |
| Total Carbohydrates | 8 Gram(s) | 3% |
| Calories from Fat | 20 Calorie(s) | -- |
| Dietary Fiber | 7 Gram(s) | 28% |
| Total Fat | 2.5 Gram(s) | 4% |
| Soluble Fiber | 2 Gram(s) | -- |
| Insoluble Fiber | 5 Gram(s) | -- |
| Protein | 2 Gram(s) | 4% |
| Alpha-Linolenic Acid | 1.3 Gram(s) | -- |
| Flax seed powder | 0 NP | -- |
| Proprietary Fiber Blend | 12.9 Gram(s) | -- |
| Pea (Pisum spp.) fiber | 0 NP | -- |
| Psyllium (Plantago ovata) husk powder | 0 NP | -- |
| Chicory (Cichorium intybus) root fiber | 0 NP | -- |
| Chia (Salvia hispanica) seed powder | 0 NP | -- |
Other ingredients: Mixed Tocopherols
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Gently shake the jar to loosen compressed powder then combine one level scoop (13 g) of Digestive Health powder with Shakeology or the beverage of your choice. Add more liquid as needed, if too thick. Consume promptly.
Storage
Store in a cool, dry place.
Precautions
Allergen Information: This product is manufactured in a plant that also processes milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, and soy ingredients.
Warning: Consult with a healthcare professional if you are pregnant, breastfeeding, or if you have any medical conditions.
Keep out of reach of children.
Notice: This product should be eaten with at least a full glass of liquid. Eating this product without enough liquid may cause choking. Do not eat this product if you have difficulty in swallowing.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
2015 Beachbody, LLC. All rights reserved. Beachbody, LLC is the owner of the Shakeology, the Healthiest Meal of the Day, Beachbody Ultimate, Beachbody, and Team Beachbody trademarks, and all related designs, trademarks, copyrights, and other intellectual property.
Beachbody Ultimate
General Statements
To reorder, contact your Coach, log in at TeamBeachbody.com, or call 1 (800) 427-3809.
Formulation
Formulated with key ingredients to: Enhance your Shakeology for even healthier results Contain 7g of fiber per serving - 40% of daily value when added to Shakeology Help maintain regularity and digestive health Provide an optimal ratio of soluble and insoluble fiber
No artificial colors, flavors, sweeteners, or preservatives
FDA Statement of Identity
Dietary Supplement
Formula
ALA Omega-3 Fatty Acids help support cardiovascular health Excellent source of dietary fiber Soluble fiber from psyllium, as part of a healthy diet low in saturated fat and cholesterol, may reduce the risk of heart disease
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Health by Shakeology Boost label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Health by Shakeology Boost
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size13 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactions- › Soluble Fiber
- › Insoluble Fiber
Protein
Alpha-Linolenic Acid
Proprietary Fiber Blend
- › Flax seed powder
- › Pea (Pisum spp.) fiber
- › Psyllium (Plantago ovata) husk powder
- › Chicory (Cichorium intybus) root fiber
- › Chia (Salvia hispanica) seed powder
Other (inactive) ingredients: Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.
Digestive Health by Shakeology Boost Drug Interactions
HelloPharmacist Interaction Report
Shakeology Boost Digestive Health contains flaxseed powder, psyllium husk powder, and chicory root fiber — three ingredients with documented interactions with medications.
The most serious concern is with blood sugar–lowering drugs (antidiabetes medications): both flaxseed and chicory may add to their effect and raise the risk of low blood sugar (hypoglycemia).
Read the full breakdown — every affected drug type, severity by severity
Flaxseed also interacts with blood pressure–lowering drugs (antihypertensive medications), blood thinners and antiplatelet drugs, hormonal birth control and estrogen therapy, and antibiotics. Psyllium can affect how your body absorbs several specific medications — metformin (a diabetes drug), lithium (a mood stabilizer), carbamazepine (an anti-seizure medication), and olanzapine (an antipsychotic) — as well as digoxin (a heart medication) and oral medications in general.
We could not check soluble fiber, insoluble fiber, alpha-linolenic acid, pea fiber, or the proprietary fiber blend itself, so no interaction data is available for those.
Altogether, these interactions span 2,135 individual medications. Because this product contains multiple fiber sources and interacts with common drugs across several categories, check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Digestive Health?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Digestive Health interact with 2,134 drugs. Click any drug to see the details.
4 of the 8 ingredients in Digestive Health interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Psyllium (Plantago ovata) husk powder Flax seed powder Chicory (Cichorium intybus) root fiber
Bendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bendroflumethiazide, Nadolol interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bendroflumethiazide, Nadolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bendroflumethiazide, Rauwolfia Serpentina interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bendroflumethiazide, Rauwolfia Serpentina interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bendroflumethiazide, Rauwolfia Serpentina interactionBenznidazoleBenznidazole
How Benznidazole interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax Seed Powder + Benznidazole interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Benznidazole interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Benznidazole interactionBenzthiazideExna
How Benzthiazide interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Benzthiazide interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Benzthiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Betaxolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Betaxolol interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Betaxolol interactionBetrixabanBevyxxa
How Betrixaban interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax Seed Powder + Betrixaban interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Betrixaban interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Betrixaban interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax Seed Powder + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBisoprololZebeta
How Bisoprolol interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bisoprolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bisoprolol interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bisoprolol, Hydrochlorothiazide interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bisoprolol, Hydrochlorothiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bisoprolol, Hydrochlorothiazide interactionBivalirudinAngiomax, Angiomax Rtu, Angiox
How Bivalirudin interacts with Digestive Health — through 1 ingredient. Tap an ingredient for the detail:
Flax Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax Seed Powder + Bivalirudin interactionBosentanTracleer
How Bosentan interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bosentan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bosentan interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bosentan interactionBromfenac SodiumBromsite, Prolensa
How Bromfenac Sodium interacts with Digestive Health — through 1 ingredient. Tap an ingredient for the detail:
Flax Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax Seed Powder + Bromfenac Sodium interactionBumetanideBurinex
How Bumetanide interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bumetanide interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bumetanide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Digestive Health — through 1 ingredient. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Bumetanide (oral) interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Bumetanide (oral) interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bumetanide (oral) interactionCabliviCablivi
How Cablivi interacts with Digestive Health — through 1 ingredient. Tap an ingredient for the detail:
Flax Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax Seed Powder + Cablivi interactionCanagliflozinInvokana
How Canagliflozin interacts with Digestive Health — through 4 ingredients. Tap an ingredient for the detail:
Chicory (cichorium Intybus) Root FiberAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chicory (cichorium Intybus) Root Fiber + Canagliflozin interactionFlax Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flax Seed Powder + Canagliflozin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Canagliflozin interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Digestive Health — through 4 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flax Seed Powder + Canagliflozin, Metformin interactionPsyllium (plantago Ovata) Husk PowderOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Canagliflozin, Metformin interactionDietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Canagliflozin, Metformin interactionChicory (cichorium Intybus) Root FiberAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chicory (cichorium Intybus) Root Fiber + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Digestive Health — through 4 ingredients. Tap an ingredient for the detail:
Chicory (cichorium Intybus) Root FiberAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chicory (cichorium Intybus) Root Fiber + Canagliflozin, Metformin Hydrochloride interactionPsyllium (plantago Ovata) Husk PowderMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Psyllium (plantago Ovata) Husk Powder + Canagliflozin, Metformin Hydrochloride interactionFlax Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flax Seed Powder + Canagliflozin, Metformin Hydrochloride interactionDietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Canagliflozin, Metformin Hydrochloride interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Candesartan Cilexetil interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Candesartan Cilexetil interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Candesartan Cilexetil, Hydrochlorothiazide interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Candesartan Cilexetil, Hydrochlorothiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Candesartan Cilexetil, Hydrochlorothiazide interactionCangrelorKengreal
How Cangrelor interacts with Digestive Health — through 1 ingredient. Tap an ingredient for the detail:
Flax Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax Seed Powder + Cangrelor interactionCapreomycinCapastat
How Capreomycin interacts with Digestive Health — through 1 ingredient. Tap an ingredient for the detail:
Flax Seed PowderAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax Seed Powder + Capreomycin interactionCaptoprilAcepril, Capoten
How Captopril interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Captopril interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Captopril interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Captopril, Hydrochlorothiazide interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Captopril, Hydrochlorothiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Captopril, Hydrochlorothiazide interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Digestive Health — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Carbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbamazepine interactionPsyllium (plantago Ovata) Husk PowderOral Drugs, Carbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Carbamazepine interactionCarbenicillin Indanyl SodiumGeocillin
How Carbenicillin Indanyl Sodium interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax Seed Powder + Carbenicillin Indanyl Sodium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbenicillin Indanyl Sodium interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Carbenicillin Indanyl Sodium interactionCarteololCartrol, Ocupress
How Carteolol interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Carteolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carteolol interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax Seed Powder + Carvedilol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carvedilol interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Carvedilol interactionCefaclorCeclor, Ceclor CD
How Cefaclor interacts with Digestive Health — through 3 ingredients. Tap an ingredient for the detail:
Flax Seed PowderAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax Seed Powder + Cefaclor interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Cefaclor interactionPsyllium (plantago Ovata) Husk PowderOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Psyllium (plantago Ovata) Husk Powder + Cefaclor interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Digestive Health with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Psyllium (Plantago ovata) husk powder
Carbamazepine (Tegretol)
Theoretically, blond psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Blond psyllium might reduce carbamazepine absorption and serum levels. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug.
Lithium
Theoretically, taking blond psyllium at the same time as lithium might reduce lithium absorption.
The fiber in blond psyllium might decrease the absorption of lithium. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped.
Metformin (Glucophage)
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Concurrent use of blond psyllium with metformin slows and increases metformin absorption. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking blond psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in blond psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was taken concomitantly with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking blond psyllium at the same time as digoxin might reduce digoxin absorption.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking blond psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. However, this is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Conversely, case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin.
Flax seed powder
Antibiotic Drugs
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.
Anticoagulant/Antiplatelet Drugs
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.
Antidiabetes Drugs
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.
Estrogens
Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.
Chicory (Cichorium intybus) root fiber
Antidiabetes Drugs
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.
Brand information
Manufacturer and brand details for Digestive Health, from the product label.
Shakeology Boost
See all Shakeology Boost products- Name
- Beachbody, LLC
- City
- Santa Monica
- State
- CA
- ZipCode
- 90404
- Phone Number
- 1 (800) 427-3809
- Web Address
- TeamBeachbody.com
Digestive Health by Shakeology Boost: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Health is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Health’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographFlaxseed
Interacts with 597 drugsFlaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...
Read the full Flaxseed monograph → Herb & supplement monographBlond Psyllium
Interacts with 2,025 drugsBlond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements. It can help with both constipation and diarrhea and may modest...
Read the full Blond Psyllium monograph → Herb & supplement monographChicory
Interacts with 86 drugsChicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...
Read the full Chicory monograph → Herb & supplement monographChia
Chia seeds are a nutritious whole food rich in fiber, plant-based omega-3 fats (ALA), and protein. They are generally safe as part of a healthy diet, and may modestly help with regularity an...
Read the full Chia monograph →Sources & How We Checked
Digestive Health's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 108 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Flaxseed 37 references
- Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
- Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
- Thompson LU, Rickard SE, Cheung F, et al. Variability in anticancer lignan levels in flaxseed. Nutr Cancer 1997;27:26-30. PubMed
- Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
- Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
- Clark WF, Parbtani A, Huff MW, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475-80. PubMed
- Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. PubMed
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
- Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
- Clark WF, Kortas C, Heidenheim P, et al. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr 2001;20:143-8. PubMed
- Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991;60:135-42. PubMed
- Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 2000;161:47-55. PubMed
- Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
- Adlercreutz H, Fotsis T, Bannwart C, et al. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 1986;25:791-7.. PubMed
- Rose DP. Dietary fiber and breast cancer. Nutr Cancer 1990;13:1-8.. PubMed
- Lemay A, Dodin S, Kadri N, et al. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 2002;100:495-504.. DOI
- Brooks JD, Ward WE, Lewis JE, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr 2004;79:318-25.. PubMed
- Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
- Dodin S, Lemay A, Jacques H, et al. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 2005 PubMed
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
- Demark-Wahnefried W, Polascik TJ, George SL, et al. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 2008;17:3577-87. PubMed
- Thompson LU, Chen JM, Li T, et al. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res 2005;11:3828-35. PubMed
- Mani UV, Mani I, Biswas M, Kumar SN. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl 2011;8:257-65.
- Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J 2011;10:44. PubMed
- Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metab 2009;34:89-98. PubMed
- Cockerell KM, Watkins AS, Reeves LB, et al. Effects of linseeds on the symptoms of irritable bowel syndrome: a pilot randomised controlled trial. J Hum Nutr Diet 2012;25:435-43. PubMed
- Colli MC, Bracht A, Soares AA, et al. Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms. J Med Food 2012;15:840-5. PubMed
- Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
- Simbalista RL, Sauerbronn AV, Aldrighi JM, Areas JA. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. J Nutr 2010;140:293-7. PubMed
- Patade A, Devareddy L, Lucas EA, et al. Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Womens Health (Larchmt) 2008;17:355-66. PubMed
- Rodriguez-Leyva D, Weighell W, Edel AL, LaVallee R, Dibrov E, Pinneker R, Maddaford TG, Ramjiawan B, Aliani M, Guzman R, Pierce GN. Potent antihypertensive action of dietary flaxseed in hypertensive patients. Hypertension. 2013 Dec;62(6):1081-9. PubMed
- Bloedon LT, Balikai S, Chittams J, et al. Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. J Am Coll Nutr 2008;27:65-74. PubMed
- Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
- Mohammadi-Sartang M, Sohrabi Z, Barati-Bodaji R, Raeisi-Dehkordi H, Mazloom Z. Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Nutr Rev. 2018 Feb 1;76( PubMed
- Haidari F, Banaei-Jahromi N, Zakerkish M, Ahmadi K. The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Nutr J. 2020;19(1):8. PubMed
- Villarreal-Renteria AI, Herrera-Echauri DD, Rodríguez-Rocha NP, et al. Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomi
- Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
Blond Psyllium 28 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Agha FP, Nostrant TT, Fiddian-Green RG. Giant colonic bezoar: a medication bezoar due to psyllium seed husks. Am J Gastroenterol 1984;79:319-21.
- Anderson JW, Allgood LD, Lawrence A, et al. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 2000;71:472-9. PubMed
- Suhonen R, Kantola I, Bjorksten F. Anaphylactic shock due to ingestion of psyllium laxative. Allergy 1983;38:363-5. PubMed
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Freeman GL. Psyllium hypersensitivity. Ann Allergy 1994;73:490-2.
- Morgan MS, Arlian LG, Vyszenski-Moher DL, et al. English plantain and psyllium: lack of cross-allergenicity by crossed immunoelectrophoresis. Ann Allergy Asthma Immunol 1995;75:351-9.
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Schneider RP. Perdiem causes esophageal impaction and bezoars. South Med J 1989;82:1449-50. PubMed
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