Diuretic II Ingredients & Drug Interactions
by Thompson
What is this page for?
First and foremost: checking Diuretic II against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Diuretic II is a dietary supplement by Thompson with 5 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 1,222 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi leaf extract, Short Buchu leaf extract, Parsley. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
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HelloPharmacist Scorecard of Diuretic II by Thompson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Thompson's Diuretic II contains 5 active ingredients: potassium, parsley, uva ursi leaf extract, juniper berry extract, and buchu leaf extract. The product also contains inactive ingredients — potassium Krebs, cellulose, gelatin, maltodextrin, magnesium stearate, and silica — which serve as fillers, binders, and capsule material.
Does it work?
Not established
The evidence for most of these ingredients is incomplete. Parsley's effectiveness for urinary tract infections, melasma, osteoarthritis, and certain skin conditions is rated insufficient.
Uva ursi is rated possibly ineffective for UTIs and insufficient for bronchitis and benign prostatic hyperplasia. Juniper berry's effectiveness for GERD, rheumatoid arthritis, UTIs, wound healing, kidney stones, and bronchitis is rated insufficient.
We hold no effectiveness data for potassium or buchu leaf extract in the facts provided.
How safe is it?
Well-documented data
Potassium from food is safe, but supplements can dangerously raise your blood level, especially if you have kidney disease — use only under medical guidance. In pregnancy, dietary potassium is fine; supplement use requires doctor guidance.
While breastfeeding, check with your doctor before using potassium supplements. Most people tolerate oral potassium well, but common side effects include stomach pain, belching, diarrhea, gas, nausea, and vomiting; rare serious effects are irregular heartbeat, heart block, low blood pressure, and confusion.
Parsley as food is safe, but concentrated extracts, seeds, and essential oil may not be in large amounts; medicinal or large amounts may stimulate the uterus and should be avoided in pregnancy. Uva ursi is generally tolerated short-term at low doses but can be toxic at high doses or with long-term use; avoid in pregnancy and breastfeeding.
Common side effects are diarrhea, nausea, stomach upset, and vomiting; at very high doses (20 grams or more), serious effects like collapse, convulsions, low oxygen, delirium, and ringing in the ears have been reported. Juniper berry is tolerated short-term in low doses but may irritate the kidneys and should not be used long-term; avoid in pregnancy and breastfeeding.
Buchu leaf extract lacks strong safety data at medicinal doses; avoid in pregnancy, and breastfeeding safety is uncertain.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take potassium-sparing diuretics, ACE inhibitors, or ARBs (Moderate severity) — this product's potassium could raise your levels dangerously. Also discuss if you're on blood thinners or antiplatelet drugs, diabetes medications, or lithium, as parsley, uva ursi, juniper berry, and buchu may interact with them.
If you take warfarin, note that parsley's vitamin K content may reduce its effectiveness.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is a combination of herbal diuretics and potassium, which can interact significantly with blood pressure medications, blood thinners, diabetes drugs, and lithium — all common prescriptions. If you take any regular medications, especially for your heart, blood pressure, bleeding, diabetes, or mood, talk to your doctor or pharmacist before starting.
Pregnant women and those breastfeeding should also check with their healthcare provider first, as several ingredients carry safety concerns for pregnancy.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Diuretic II, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Diuretic II by Thompson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Potassium | 60 mg | 2% |
| Parsley | 100 mg | -- |
| Uva Ursi leaf extract | 33 mg | -- |
| Juniper berry extract | 10 mg | -- |
| Short Buchu leaf extract | 25 mg | -- |
Other ingredients: Potassium Krebs, Cellulose, Gelatin, Maltodextrin, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
SINCE 1932
HERBAL FORMULA
FRESH HEALTHY
ONCE DAILY
Keep your licensed health care practitioner informed when using this product.
Formula
PLUS POTASSIUM
FDA Statement of Identity
DIETARY SUPPLEMENT
Precautions
WARNING: Do not use if safety seal is broken or missing.
Keep out of reach of children.
This product is not recommended for extended use, and is best if not taken before bedtime.
Do not use if pregnant or lactating or if diagnosed with a kidney disease.
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take one capsule up to three times daily as needed, preferably with food.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Our own laboratory analysis guarantees purity and freshness of all Thompson(R) products.
(C)2009
General
7079950 0409
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Diuretic II by Thompson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Diuretic II by Thompson
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Potassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsParsley
Interacts with443 drugs
Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a...
Parsley monograph & interactionsUva Ursi leaf extract
Interacts with803 drugs
Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...
Uva Ursi leaf extract monograph & interactionsJuniper berry extract
Interacts with162 drugs
Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...
Juniper berry extract monograph & interactionsShort Buchu leaf extract
Interacts with481 drugs
Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies...
Short Buchu leaf extract monograph & interactionsOther (inactive) ingredients: Potassium Krebs, Cellulose, Gelatin, Maltodextrin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Diuretic II by Thompson Drug Interactions
HelloPharmacist Interaction Report
Thompson's Diuretic II interacts with medications through its potassium, parsley, uva ursi leaf extract, juniper berry extract, and buchu leaf extract content.
The most serious interaction is a Moderate risk of dangerously high potassium levels (hyperkalemia) when potassium in this product is combined with potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers (ARBs) — drugs commonly used for blood pressure and heart conditions.
Read the full breakdown — every affected drug type, severity by severity
Parsley may theoretically affect how your body processes certain medications through liver enzymes, increase bleeding risk with blood thinners and antiplatelet drugs, lower blood sugar when combined with diabetes medications, and interfere with warfarin (a blood thinner) due to its vitamin K content. Uva ursi may slow the metabolism of medications processed through liver pathways (CYP2C19 and CYP3A4 substrates), increase lithium levels, and reduce the effectiveness of urinary acidifying medications.
Juniper berry extract may lower blood sugar further when taken with diabetes drugs and may interact with lithium. Buchu leaf extract may increase liver strain when combined with hepatotoxic drugs, enhance bleeding risk with blood thinners, and raise lithium levels.
Additionally, short-term uva ursi use carries a Minor interaction with P-glycoprotein substrates, juniper berry has a Minor interaction with diuretic drugs and lithium, and parsley has a Minor interaction with aspirin involving allergic reactions. Altogether, these interactions span 1,223 individual medications.
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Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Diuretic II interact with 1,222 drugs. Click any drug to see the details.
5 of the 5 ingredients in Diuretic II interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi leaf extract Short Buchu leaf extract Parsley Juniper berry extract Potassium
Afatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Afatinib Dimaleate interactionAlvimopanEntereg
How Alvimopan interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Alvimopan interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Avatrombopag Maleate interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Betamethasone Valerate interactionCeliprololCelicard
How Celiprolol interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Celiprolol interactionCimetidineCimetidine Injection, Tagamet, Tagamet HB
How Cimetidine interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Cimetidine interactionClobetasolClobex, Temovate
How Clobetasol interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Clobetasol interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Cortisone Acetate interactionDomperidoneMotilium
How Domperidone interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Domperidone interactionFam-trastuzumab, Deruxtecan-nxkiEnhertu
How Fam-trastuzumab, Deruxtecan-nxki interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Fam-trastuzumab, Deruxtecan-nxki interactionFidaxomicinDificid
How Fidaxomicin interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Fidaxomicin interactionFludrocortisoneFlorinef Acetate
How Fludrocortisone interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Fludrocortisone interactionIvermectinMectizan, Sklice, Soolantra, Stromectol
How Ivermectin interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Ivermectin interactionLedipasvir, SofosbuvirHarvoni
How Ledipasvir, Sofosbuvir interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Ledipasvir, Sofosbuvir interactionLoncastuximab Tesirine-lpylZynlontab
How Loncastuximab Tesirine-lpyl interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Loncastuximab Tesirine-lpyl interactionLoperamideImodium, Loperamide
How Loperamide interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Loperamide interactionLoperamide, SimethiconeImodium Advanced
How Loperamide, Simethicone interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Loperamide, Simethicone interactionLusutrombopagMulpleta
How Lusutrombopag interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Lusutrombopag interactionNiraparib TosylateZejula
How Niraparib Tosylate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Niraparib Tosylate interactionOmacetaxine MepesuccinateSynribo
How Omacetaxine Mepesuccinate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Omacetaxine Mepesuccinate interactionOpicaponeOngentys
How Opicapone interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Opicapone interactionPrucaloprideMotegrity, Resolor, Resotran
How Prucalopride interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Prucalopride interactionPseudoephedrine, TerfenadineTeldafen
How Pseudoephedrine, Terfenadine interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Pseudoephedrine, Terfenadine interactionRanitidineRanit, Ranitidine injection, Zantac, Zantac 150, Zantac 150 EFFER, Zantac 150 GEL +4 more
How Ranitidine interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Ranitidine interactionRanitidine Bismuth CitrateTritec
How Ranitidine Bismuth Citrate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Ranitidine Bismuth Citrate interactionRucaparib CamsylateRubraca
How Rucaparib Camsylate interacts with Diuretic II — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi Leaf ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Leaf Extract + Rucaparib Camsylate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Diuretic II with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Uva Ursi leaf extract
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Glucuronidated Drugs
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.
Lithium
Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.
Urinary Acidifying Agents
Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.
P-Glycoprotein Substrates
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Short Buchu leaf extract
Anticoagulant/Antiplatelet Drugs
Buchu may have antiplatelet effects. Theoretically, buchu may enhance the effects of anticoagulant or antiplatelet drugs and increase the risk of bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Hepatotoxic Drugs
Buchu contains pulegone, a known hepatotoxin. There is some concern that buchu may adversely affect the liver, especially when the leaf is used in large doses or the oil is ingested. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo)
Lithium
Buchu is thought to have diuretic properties. Theoretically, buchu might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Parsley
Anticoagulant/Antiplatelet Drugs
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Animal research suggests that parsley has antiplatelet effects.
Antidiabetes Drugs
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that parsley might decrease blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Laboratory research suggests that parsley can inhibit CYP1A2.
Diuretic Drugs
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Animal research suggests that parsley seed extract increases urine elimination. Parsley leaf and root might also interfere with diuretic therapy due their purported aquaretic effects.
Pentobarbital (Nembutal)
Theoretically, parsley might increase the duration of pentobarbital effects.
Animal research suggests that parsley juice prolongs the action of pentobarbital, perhaps by decreasing cytochrome P450 levels. It is not known if this occurs in humans or if this applies to other barbiturates or sedatives.
Sirolimus (Rapamune)
Theoretically, large quantities of parsley might increase sirolimus levels.
In one case report, an adult female with a history of kidney transplant presented with elevated blood sirolimus levels, approximately 4-7 times greater than previous measures, after daily consumption of a juice containing approximately 30 grams of parsley for 7 days. Sirolimus levels returned to normal a week after the parsley juice was discontinued.
Warfarin (Coumadin)
Theoretically, large amounts of parsley leaf and root might decrease the effects of warfarin.
Parlsey contains vitamin K.
Aspirin
Theoretically, aspirin might increase the severity of allergic reactions to parsley.
In one case, severe urticaria and swelling were reported after taking aspirin with parsley in an individual with a known mild parsley allergy.
Juniper berry extract
Antidiabetes Drugs
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.
Diuretic Drugs
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.
Lithium
Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Brand information
Manufacturer and brand details for Diuretic II, from the product label.
Diuretic II by Thompson: Common Questions
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Will this product work for urinary tract infections?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Diuretic II’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Potassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph → Herb & supplement monographParsley
Interacts with 443 drugsParsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a diuretic and for digestion, but solid hu...
Read the full Parsley monograph → Herb & supplement monographUva Ursi
Interacts with 803 drugsUva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...
Read the full Uva Ursi monograph → Herb & supplement monographJuniper
Interacts with 162 drugsJuniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...
Read the full Juniper monograph → Herb & supplement monographBuchu
Interacts with 481 drugsBuchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely...
Read the full Buchu monograph →Sources & How We Checked
Diuretic II's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 51 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Potassium 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
- Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
- Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
- Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
- Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
- Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
- Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
- Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
- Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
Parsley 21 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
- Eberhard P, Gall HM, Muller I, Moller R. Dramatic augmentation of a food allergy by acetylsalicylic acid. J Allergy Clin Immunol 2000;105:844 PubMed
- Tunali T, Yarat A, Yanardag R, et al. Effect of parsley (Petroselinum crispum) on the skin of STZ induced diabetic rats. Phytother Res 1999;13:138-41.. DOI
- Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed
- Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
- Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur.J Drug Metab Pharmacokinet. 2002;27(3):153-156. PubMed
- Kreydiyyeh, S. I. and Usta, J. Diuretic effect and mechanism of action of parsley. J Ethnopharmacol 2002;79(3):353-357. PubMed
- Yanardag, R., Bolkent, S., Tabakoglu-Oguz, A., and Ozsoy-Sacan, O. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bull. 2003;26(8):1206-1210. PubMed
- Bolkent, S., Yanardag, R., Ozsoy-Sacan, O., and Karabulut-Bulan, O. Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study. Phytother.Res 2004;18(12):996-999.
- Ozsoy-Sacan, O., Yanardag, R., Orak, H., Ozgey, Y., Yarat, A., and Tunali, T. Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats. J Ethnopharmacol 3-8-2006;104(1-2):175-181. PubMed
- Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):147 PubMed
- Gadi, D., Bnouham, M., Aziz, M., Ziyyat, A., Legssyer, A., Legrand, C., Lafeve, F. F., and Mekhfi, H. Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol 8-17-2009;125(1):170-174. PubMed
- Arslan S, Ucar R, Caliskaner AZ. A Cases of Near-fatal Anaphylaxis: Parsley "Over-use" as an Herbal Remedy. Med Arch. 2014;68(6):426-7.
- Foti C, Cassano N, Mistrello G, Amato S, Romita P, Vena GA. Contact urticaria to raw arugula and parsley. Ann Allergy Asthma Immunol. 2011 May;106(5):447-8. PubMed
- Farzaei MH, Abbasabadi Z, Ardekani MR, Rahimi R, Farzaei F. Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J Tradit Chin Med. 2013;33(6):815-26. PubMed
- Kurtaran M, Koc NS, Aksun MS, Yildirim T, Yilmaz SR, Erdem Y. Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: a case report. Ther Adv Drug Saf 2021;12:20420986211009358.
Uva Ursi 8 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
- Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
- de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
- Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
- Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
Juniper 7 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
- Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
- Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed
Buchu 3 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC