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Dietary supplement

DMAE 390 mg Ingredients & Drug Interactions

by SuperSmart

DMAE 390 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE 390 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE 390 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE 390 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE 390 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE 390 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “DMAE” is listed as a grouped ingredient — the label gives one combined amount (390 mg) without saying how much of each component you get.

This supplement contains one active ingredient: dimethylaminoethanol bitartrate (deanol), at 390 mg per capsule. Deanol is thought to increase acetylcholine levels in the brain and body.

The product also contains inactive ingredients — acacia gum and white rice bran — which serve as binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Stimulates cognitive function.
  • We looked for evidence on: Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, Memory, Mental clarity, Brain health.
  • The closest evidence on file: Deanol is rated "Likely Ineffective" for Alzheimer disease (Natural Medicines).
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for deanol is limited. It's rated likely ineffective for Alzheimer disease and tardive dyskinesia (a movement disorder).

For aging skin, ADHD, and athletic performance, the evidence isn't established well enough to rate. In short, we don't have solid proof that this ingredient works for the purposes many people consider taking it.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Deanol is generally well tolerated orally, but side effects can and do occur. The most common ones reported are abdominal cramps, pain, diarrhea, drowsiness, nausea, and vomiting.

Less common but documented effects include constipation, headache, insomnia, overstimulation, lucid dreams, confusion, depression, and mood changes — especially at doses above 1000 mg daily or in people with psychiatric conditions like schizophrenia. The safety data for pregnancy is insufficient; there isn't enough information to know whether it's safe during pregnancy, so talk with your doctor or pharmacist before taking it if you're pregnant.

Avoid use while breastfeeding — the safety data advises against it.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use anticholinergic drugs (for overactive bladder, Parkinson's symptoms, or other conditions) or cholinergic drugs (for myasthenia gravis or other uses). Minor interactions are documented for both types.

Use the medication checker on this page to search your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

DMAE may be worth a conversation with your doctor or pharmacist if you're interested in it, but the evidence that it works for most conditions is weak or lacking. If you take anticholinergic or cholinergic medications, you'll want to check first.

And if you're pregnant, planning to get pregnant, or breastfeeding, talk with your doctor or pharmacist before starting — the safety data doesn't support use in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE 390 mg, straight from the product label.

Brand SuperSmart
Net contents 150 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 250478
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE 390 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
50
IngredientAmount% DV
DMAE390 mg--
Dimethylaminoethanol Bitartrate1053 mg--

Other ingredients: Acacia Gum, White Rice Bran

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Stimulates cognitive function

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take 1 to 3 capsules a day.

Formula

Each vegetarian capsule contains 351 mg of DMAE bitartrate, providing 130 mg of DMAE.

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of children's reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE 390 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE 390 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE 390 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

DMAE

Interacts with
219 drugs
390 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE monograph & interactions

Other (inactive) ingredients: Acacia Gum, White Rice Bran. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE 390 mg by SuperSmart Drug Interactions

Want to check YOUR meds against DMAE 390 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE 219

Individual Drug Interactions

The ingredients in DMAE 390 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE 390 mg interact with drugs. Each result below shows which ingredient is responsible. DMAE

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE 390 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE 390 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, LDA
Street Address
Avenida Do Infante 66 Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

DMAE 390 mg by SuperSmart: Common Questions

Does DMAE 390 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, DMAE 390 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE 390 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DMAE, and what is it supposed to do?
DMAE — dimethylaminoethanol — is thought to increase acetylcholine, a chemical messenger in your brain and body. People take it hoping it'll help with memory, attention, or aging skin, but the evidence is thin or missing for most of those uses.
Does this supplement actually work?
The research doesn't support it well. It's rated likely ineffective for Alzheimer disease and tardive dyskinesia. For ADHD, aging skin, and athletic performance, there just isn't enough reliable evidence to say either way.
What are the most common side effects?
The most common reported side effects are abdominal cramps and pain, diarrhea, drowsiness, nausea, and vomiting. Other less common effects include constipation, headache, insomnia, and mood changes, especially at higher doses.
Is it safe to take while pregnant or breastfeeding?
No — avoid it while breastfeeding; the safety data advises against it. For pregnancy, there isn't enough information to know either way, so talk with your doctor or pharmacist for personalized advice.
Can I take this with anticholinergic or cholinergic medications?
Minor interactions are documented. This supplement may decrease how well anticholinergic drugs work, or it may increase the effects of cholinergic drugs. Talk with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DMAE 390 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE 390 mg label
Go deeper

The Full Monographs Behind DMAE 390 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE 390 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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