Interactions on record — worth a quick check against your medications. Based on 8 of 14 ingredients. Check your meds →
Dietary supplement

Endurance and Recovery Grape Ingredients & Drug Interactions

by True Athlete

Endurance and Recovery Grape label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Endurance and Recovery Grape against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Endurance and Recovery Grape is a dietary supplement by True Athlete with 14 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 505 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ganoderma lucidum, Hericium erinaceus, Cordyceps militaris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Endurance and Recovery Grape by True Athlete

Ask about any prescription or over-the-counter medication and we check it for interactions with Endurance and Recovery Grape by True Athlete — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Endurance and Recovery Grape by True Athlete

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 14 active ingredients.
  • “PeakO2” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Endurance and Recovery Grape contains 14 active ingredients designed to support athletic performance and muscle recovery. The core ingredients include several branched-chain amino acids and amino acid compounds — glycine, L-leucine, L-alanine, L-isoleucine, L-lysine hydrochloride, and L-valine — which your muscles use during exercise and recovery.

L-ornithine hydrochloride is included for athletic performance support. Taurine is an amino acid-like compound found naturally in the body and in meat.

The formula rounds out with mushroom extracts — cordyceps militaris, Ganoderma lucidum (reishi), Pleurotus eryngii, Lentinula edodes (shiitake), Hericium erinaceus (lion's mane), and Trametes versicolor — and a proprietary blend called PeakO2. The powder also contains inactive ingredients like tartaric acid, malic acid, silicon dioxide, natural flavors, grape juice concentrate, sucralose, stevia, and xanthan gum.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Endurance and recovery, delay fatigue.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle soreness, Fatigue, Cancer-related fatigue, Chronic fatigue syndrome (CFS), Stamina — and 3 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence for most ingredients in this product is not well established in our data. Glycine is rated possibly effective for schizophrenia but rated as insufficient evidence for ADHD, benign prostatic hyperplasia, and cystic fibrosis.

Lysine is rated possibly effective for cold sores but insufficient for child growth, pressure ulcers, and diabetic foot ulcers. Ornithine is rated possibly effective for athletic performance but insufficient for dry skin and insomnia.

Taurine is possibly effective for hepatitis and congestive heart failure, though rated possibly ineffective for obesity. The mushroom ingredients — cordyceps, reishi, and lion's mane — carry insufficient evidence ratings for the conditions studied, though cordyceps is rated possibly ineffective for athletic performance.

Overall, the evidence supporting endurance and recovery claims for this specific formula is not established in the data we hold.

The evidence, ingredient by ingredient Glycine Alpha-alanine Lysine Ornithine Taurine Cordyceps Reishi Mushroom Lion's Mane Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, though long-term safety data are limited and safety in pregnancy and breastfeeding hasn't been well studied — rare side effects include mild sedation, soft stools, nausea, vomiting, and GI discomfort, which resolve quickly if you stop taking it. Lysine is generally well tolerated orally, though high amounts may cause stomach upset and long-term safety isn't well studied; supplement use in pregnancy and breastfeeding hasn't been adequately studied.

Ornithine is generally well tolerated short-term, but long-term safety is not well studied, and supplement use is best avoided during pregnancy and breastfeeding due to lack of safety data. Taurine is generally well tolerated short-term in healthy adults, with most common effects being constipation, diarrhea, and stomach upset; serious effects are rare but include hypersensitivity reactions, especially in people with sulfa or sulfite allergies, and taurine is likely safe in breastfeeding.

Cordyceps is generally well tolerated short-term, though a rare case of liver inflammation (cholestasis) has been reported; product quality varies widely and it's best avoided in pregnancy and breastfeeding. Reishi mushroom is generally well tolerated short-term, though long-term safety isn't well studied, and it's best avoided in pregnancy and breastfeeding; common side effects include dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Lion's mane mushroom is generally well tolerated as a food but hasn't been well studied long-term as a supplement; common side effects are GI discomfort, nausea, and skin rash, and it's best avoided in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Glycine Alpha-alanine Lysine Ornithine Taurine Cordyceps Reishi Mushroom Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lysine, Cordyceps, Reishi Mushroom, Taurine, Glycine, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 505 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check these medication types: clozapine (Clozaril) for schizophrenia; antihypertensive drugs for high blood pressure; lithium for bipolar disorder; blood thinners (anticoagulants or antiplatelets); immunosuppressants like cyclosporine; diabetes medications; and 5-HT4 agonists for GI disorders. These are the Moderate and Minor interactions documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula is designed for active people aiming to support endurance and recovery, but the evidence backing most ingredients is limited or absent in our data. If you take clozapine, blood thinners, antihypertensive drugs, lithium, immunosuppressants, diabetes medications, or 5-HT4 agonists, check your exact medications with the tool on this page before you start.

Talk with your pharmacist about whether this product fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Endurance and Recovery Grape, straight from the product label.

Brand True Athlete
Barcode (UPC) 766536043132
Net contents 12.7 Ounce(s); 360.3 Gram(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221536
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Endurance and Recovery Grape by True Athlete, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12 Gram(s)
Maximum serving Sizes:
12 Gram(s)
Servings per container
30
UPC/BARCODE
766536043132
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Glycine500 mg--
L-Leucine2500 mg--
L-Alanine250 mg--
L-Isoleucine1250 mg--
L-Lysine Hydrochloride250 mg--
L-Valine1250 mg--
L-Ornithine Hydrochloride500 mg--
Taurine2500 mg--
Cordyceps militaris0 NP--
Ganoderma lucidum0 NP--
Pleurotus eryngii0 NP--
Lentinula edodes0 NP--
Hericium erinaceus0 NP--
Trametes versicolor0 NP--
PeakO21000 mg--

Other ingredients: Tartaric Acid, Malic Acid, Silicon Dioxide, Natural flavors, Grape juice concentrate, Sucralose, Stevia, Xanthan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

9 g amino acids Features PeakO2 to delay fatigue

High quality vegan BCAAs to promote recovery and delay fatigue. PeakO2, a mushroom blend, which research has shown it can support fatigue delay, lactate reduction, and the capacity to sustain performance during exercise.

Sweetened with sucralose

Formulation

No artificial colors or flavors

Does Not Contain: Gluten, sugar, salt, artificial colors or flavors.

NSF Certified for Sport products have been rigorously tested for more than 270 banned substances and potentially harmful contaminants.

High quality vegan BCAAs to promote recovery and delay fatigue.

Seals/Symbols

NSF Certified Sport

Quality Promise Tested & Trusted

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Mix one (1) scoop (12 g) with 10-12 oz. of water. Consume during or after workout. Can also be consumed on non-training days between meals.

Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

PeakO2 is a registered trademark of and is protected by patents pending of Disruptive Nutrition, LLC and under exclusive global distribution by Compound Solutions, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Endurance and Recovery Grape by True Athlete label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Endurance and Recovery Grape label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Endurance and Recovery Grape by True Athlete

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size12 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycine

Interacts with
1 drug
500 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

L-Leucine

2500 mg per serving

L-Alanine

No known
interactions
250 mg per serving

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most peop...

L-Alanine monograph & interactions

L-Isoleucine

1250 mg per serving

L-Lysine Hydrochloride

Interacts with
1 drug
250 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine Hydrochloride monograph & interactions

L-Valine

1250 mg per serving

L-Ornithine Hydrochloride

No known
interactions
500 mg per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

L-Ornithine Hydrochloride monograph & interactions

Taurine

Interacts with
173 drugs
2500 mg per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

Taurine monograph & interactions

PeakO2

1000 mg per serving

Other (inactive) ingredients: Tartaric Acid, Malic Acid, Silicon Dioxide, Natural flavors, Grape juice concentrate, Sucralose, Stevia, Xanthan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Endurance and Recovery Grape by True Athlete Drug Interactions

Want to check YOUR meds against Endurance and Recovery Grape?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
505Drugs
496 Moderate 9 Minor

Ingredients driving the most interactions

Ganoderma lucidum 375
Hericium erinaceus 327
Cordyceps militaris 249
Taurine 173
Glycine 1

Individual Drug Interactions

The ingredients in Endurance and Recovery Grape interact with 505 drugs. Click any drug to see the details.

6 of the 14 ingredients in Endurance and Recovery Grape interact with drugs. Each result below shows which ingredient is responsible. Ganoderma lucidum Hericium erinaceus Cordyceps militaris Taurine Glycine L-Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Endurance and Recovery Grape with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ganoderma lucidum3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Ganoderma lucidum full monograph & interactions

Hericium erinaceus3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Hericium erinaceus full monograph & interactions

Cordyceps militaris3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps militaris full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Endurance and Recovery Grape, from the product label.

True Athlete

See all True Athlete products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Endurance and Recovery Grape by True Athlete: Common Questions

Does Endurance and Recovery Grape by True Athlete interact with any medications?
Yes. Based on its ingredients, Endurance and Recovery Grape has a known interaction with 505 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Endurance and Recovery Grape contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Most of these ingredients don't have enough safety data in pregnancy and breastfeeding, so the data advises against them — especially ornithine, cordyceps, reishi, and lion's mane. Lysine and glycine also lack adequate safety data for these times. Taurine is rated likely safe while breastfeeding, since it occurs naturally in breast milk, but talk with your OB or midwife before starting any supplement during pregnancy or while nursing.
Will this actually help my athletic performance?
The evidence in our data is mixed or lacking for most ingredients in this formula. Ornithine is rated possibly effective for athletic performance, but cordyceps is rated possibly ineffective. Most other ingredients don't have enough evidence to say whether they work for endurance or recovery, so results may vary from person to person.
What side effects should I watch for?
Most ingredients are generally well tolerated, but possible side effects include gastrointestinal upset (diarrhea, constipation, nausea, abdominal discomfort), dizziness, dry mouth, mild sedation, and skin rash. These are usually mild and go away if you stop the product. If you have a history of allergies to sulfa drugs or sulfites, be especially cautious because of the taurine content.
Is this safe to take long-term?
Long-term safety data are limited for most of these ingredients. Taurine is generally well tolerated for up to one year, and cordyceps for up to one year, but for the others — glycine, lysine, ornithine, reishi, and lion's mane — long-term effects haven't been well studied. If you plan to use this regularly, talk with your pharmacist about monitoring.
What are the amino acids in this product for?
The branched-chain amino acids (leucine, isoleucine, valine) and others like glycine, alanine, lysine, and ornithine are building blocks your muscles use during exercise and recovery. Taurine is an amino acid-like compound that supports muscle and cardiovascular function. These ingredients are intended to support endurance and help your body recover after workouts.
Why are there mushroom extracts in an endurance product?
Cordyceps, reishi, lion's mane, and other medicinal mushrooms are traditionally used to support athletic performance, immune function, and overall energy — though the evidence for these claims in our data is either insufficient or mixed. They're included based on their historical use in sports supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Endurance and Recovery Grape label
Go deeper

The Full Monographs Behind Endurance and Recovery Grape’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Alpha-alanine

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong...

Read the full Alpha-alanine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Endurance and Recovery Grape's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 73 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Alpha-alanine 2 references
  1. Amino acids — MedlinePlus (NIH) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Alpha-alanine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
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Cordyceps 14 references
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Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
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  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
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Lion's Mane Mushroom 6 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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