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Dietary supplement

Enzyme 17 Ingredients & Drug Interactions

by Organixx

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Enzyme 17 is a dietary supplement by Organixx with 18 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Enzyme 17 by Organixx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 18 active ingredients.
  • “Enzyme Blend” is a proprietary blend — the label gives one combined amount (466 mg) without saying how much of each component you get.
  • “Tri-Phase Protease” is listed as a grouped ingredient — the label gives one combined amount (627 mg) without saying how much of each component you get.

Enzyme 17 contains 18 active ingredients, most of them digestive enzymes. The blend includes amylase, glucoamylase, and invertase (which break down carbohydrates); proteases in three forms (which break down proteins); lipase (which breaks down fats); lactase (which breaks down milk sugar); cellulase and hemicellulase (which break down fiber); alpha-galactosidase (which breaks down complex sugars); peptidase (which breaks down peptides); phytase (which breaks down phytic acid); bromelain (a pineapple enzyme); pectinase (which breaks down pectin); beta-glucanase (which breaks down beta-glucans); malt diastase (which breaks down starch); and AstraZyme (a proprietary blend).

The product also contains inactive ingredients: cellulose, water, and rice extract.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“digestive support with optimal digestion”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Lactose intolerance — rated "Effective" (Lactase) (Natural Medicines).

The evidence for most of these enzymes isn't well established in the data we hold. Lactase is rated effective for lactose intolerance—if you have trouble digesting milk sugar, this ingredient may help.

For the others—lipase, bromelain, and phytase—the data shows insufficient evidence to rate them for their intended uses. Protease, cellulase, hemicellulase, alpha-galactosidase, and several other ingredients in the blend have no effectiveness ratings on file.

The evidence, ingredient by ingredient Lipase Lactase Phytase Bromelain Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these enzymes are generally well tolerated by adults. Protease (three forms in this product) and lipase may occasionally cause digestive upset or allergic reactions, though serious side effects are rare.

Bromelain may cause diarrhea, flatulence, gastric upset, headache, or (rarely) allergic reactions. A very small number of people have reported allergic reactions to protease or phytase from airborne exposure in occupational settings, though this is uncommon with oral supplement use.

Lactase is generally well tolerated when used as directed. During pregnancy, the safety data advises against bromelain and the protease ingredients unless prescribed by your doctor.

Lipase and phytase have limited safety data in pregnancy—talk with your doctor before regular use. Lactase is likely safe in pregnancy.

For breastfeeding, there's little data for most of these enzymes; check with your healthcare provider before use.

Side effects, ingredient by ingredient Lipase Lactase Phytase Bromelain Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 5 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners and antiplatelet drugs (anticoagulants or antiplatelet medications) are the main concern with this product—bromelain may increase your bleeding risk (Moderate severity). Tetracycline antibiotics may have their levels increased by bromelain, though clinical evidence is mixed (Minor severity).

Check your exact medications with the search tool before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with carbohydrate, protein, fat, and fiber digestion if your digestive system needs support. If you take blood thinners or antiplatelet drugs, or tetracycline antibiotics, check with your pharmacist before starting—bromelain may interact with them.

Pregnant or breastfeeding women should talk with their doctor or pharmacist first. Most adults tolerate it well, though digestive upset is possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzyme 17 , straight from the product label.

Brand Organixx
Barcode (UPC) 851335007956
Net contents 80 Veggie Cap(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 321821
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzyme 17 by Organixx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
40
UPC/BARCODE
851335007956
IngredientAmount% DV
Enzyme Blend466 mg--
Amylase0 NP--
Glucoamylase0 NP--
Invertase0 NP--
Protease 30 NP--
Lipase0 NP--
Protease 4.50 NP--
Lactase0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Alpha-Galactosidase0 NP--
Protease 60 NP--
Peptidase0 NP--
Phytase0 NP--
Bromelain0 NP--
Pectinase0 NP--
Beta-Glucanase0 NP--
Malt Diastase0 NP--
AstraZyme105 mg--
Tri-Phase Protease627 mg--

Other ingredients: Cellulose, Water, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Essential digestive enzymes 17 full-spectrum enzymes for optimal digestion 5 powerful protease enzymes (300,000 HUT)

Formulation

Helps break down proteins, fats, & sugars

Non-GMO Gluten-free Soy-free

This is a whole food formula. Color and odor may vary from lot to lot.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 2 capsules daily with each meal. (May take 1-2 capsules daily with each meal and 1 capsules between meals.)

Precautions

Do not use if product has been opened or tampered with in any way.

Keep out of reach of children.

Caution: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, or are otherwise under medical supervision.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Enzyme 17 by Organixx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Enzyme 17 by Organixx

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Enzyme Blend

466 mg per serving
  • › Amylase
  • › Glucoamylase
  • › Invertase
  • Lipase
  • Lactase
  • › Cellulase
  • › Hemicellulase
  • › Alpha-Galactosidase
  • Phytase
  • Bromelain
  • › Pectinase
  • › Beta-Glucanase
  • › Malt Diastase
  • › AstraZyme

Tri-Phase Protease

627 mg per serving

Other (inactive) ingredients: Cellulose, Water, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzyme 17 by Organixx Drug Interactions

Want to check YOUR meds against Enzyme 17 ?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzyme 17 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Enzyme 17 , from the product label.

Organixx

See all Organixx products
Name
Organixx
Street Address
297 Kingsbury Grade Suite 1043, Mail Box 4470
City
Stateline
State
NV
ZipCode
89449-4470
Web Address
www.Organixx.com
Pharmacist Counseling Corner

Enzyme 17 by Organixx: Common Questions

Does Enzyme 17 by Organixx interact with any medications?
Yes. Based on its ingredients, Enzyme 17 has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzyme 17 contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest food better if I have a sensitive stomach?
These enzymes are designed to help break down carbs, proteins, fats, and fiber. Many people tolerate them well, but a small number experience digestive upset or allergic reactions. If your stomach is very sensitive, start cautiously or talk with your doctor first.
Is this safe to take while pregnant?
The safety data advises against bromelain and protease during pregnancy unless your doctor prescribes them. Lipase and phytase have very limited pregnancy data, so check with your doctor before regular use. Lactase is likely safe. Talk with your doctor before starting.
Can I take this while breastfeeding?
There's little safety data for most of these enzymes during breastfeeding. Lactase has limited data but acts only in the gut, so it's a lower concern. Check with your doctor or pharmacist first to be safe.
What does bromelain do in this blend?
Bromelain is an enzyme from pineapple that may help break down proteins. The evidence for what it does isn't well established yet, but it's included because it's thought to support digestion.
Are there any fillers in this product?
Yes, it contains inactive ingredients: cellulose, water, and rice extract. These help make the capsule and don't have a digestive role, but they are present in the formula.
Will this work for lactose intolerance?
Lactase, one ingredient in this blend, is rated effective for lactose intolerance. Whether the full formula works as well depends on how much lactase is in each dose and your individual digestive needs—the product label should tell you the amount per capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enzyme 17 is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzyme 17  label
Go deeper

The Full Monographs Behind Enzyme 17 ’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Enzyme 17 's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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