Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Estro Freedom Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Advanced

Estro Freedom label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Estro Freedom against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Estro Freedom is a dietary supplement by AOR Advanced Orthomolecular Research Advanced with 5 active ingredients. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lifenol Hops extract, DIM, Broccoli seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Estro Freedom by AOR Advanced Orthomolecular Research Advanced

Ask about any prescription or over-the-counter medication and we check it for interactions with Estro Freedom by AOR Advanced Orthomolecular Research Advanced — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Estro Freedom by AOR Advanced Orthomolecular Research Advanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Broccoli seed extract” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Lifenol Hops extract” is listed as a grouped ingredient — the label gives one combined amount (120 mg) without saying how much of each component you get.

Estro Freedom contains five active ingredients. Choline is a nutrient that supports cell function and brain health.

Calcium D-glucarate is a compound believed to support the body's natural detoxification pathways. DIM (diindolylmethane) is a plant compound from cruciferous vegetables like broccoli and cabbage.

Sulforaphane glucosinolate is another compound from broccoli that may have protective effects. The product also contains broccoli seed extract and Lifenol hops extract, which are plant-based ingredients.

The remaining ingredients are inactive excipients — microcrystalline cellulose, the capsule material itself, and silicon dioxide — that serve as binders and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promotes healthy levels of estrogen.
  • We looked for evidence on: Menopausal symptoms, Premenstrual syndrome (PMS), hormone balance, estrogen metabolism.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Premenstrual syndrome (PMS) (Natural Medicines).

Evidence for these ingredients is mixed and limited. Sulforaphane is rated possibly effective for prostate cancer, and choline is rated possibly ineffective for athletic performance.

The other uses studied — including DIM and calcium D-glucarate for various cancers, choline for cognitive decline and other conditions, and sulforaphane for allergic rhinitis and asthma — all have insufficient reliable evidence to rate, meaning the data we hold doesn't establish whether they work for those purposes.

The evidence, ingredient by ingredient Choline Calcium D-glucarate Diindolylmethane Broccoli Sulforaphane Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is rated likely safe during pregnancy and lactation, though the safety notes advise using only prenatal or supplement doses under your doctor's guidance, since your needs change during these periods. DIM and sulforaphane are both rated likely safe, but DIM should be avoided during pregnancy and breastfeeding due to possible hormonal effects and insufficient safety data, while sulforaphane concentrated supplements should also be avoided in pregnancy — stick to dietary amounts — and used cautiously while breastfeeding.

Calcium D-glucarate should be avoided during pregnancy and breastfeeding due to insufficient safety information. When used at typical doses, choline is well tolerated; however, high doses (9 grams or more daily) can cause nausea, vomiting, diarrhea, and a fishy body odor.

DIM and sulforaphane are generally well tolerated, though DIM may cause diarrhea, gas, headache, nausea, rash, or vomiting, and sulforaphane may cause bowel discomfort, heartburn, stomach upset, or vomiting.

Side effects, ingredient by ingredient Choline Calcium D-glucarate Diindolylmethane Broccoli Sulforaphane Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Calcium D-glucarate, Choline, Diindolylmethane, Sulforaphane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 840 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Estro Freedom, check with your doctor or pharmacist if you take estrogen or hormone replacement therapy (DIM may interfere), diuretics or water pills (DIM increases the risk of low blood sodium), glucuronidated drugs (calcium D-glucarate may speed up how your body clears them), or medications processed by CYP1A2, CYP3A4, or CYP2E1 liver enzymes (sulforaphane may alter their levels). Also check if you take alcohol regularly or the antibiotic kanamycin.

Use the interaction tool on this page to search your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Estro Freedom is a multingredient supplement aimed at hormone support, but the evidence that it works is not established in the data we hold. Because it contains ingredients that interact with a large number of medications — particularly estrogens, diuretics, glucuronidated drugs, and drugs processed by key liver enzymes — you'll want to run your exact medications through the checker on this page before you start.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you, since some ingredients have limited safety data in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Estro Freedom, straight from the product label.

Brand AOR Advanced Orthomolecular Research Advanced
Barcode (UPC) 624917082975
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214585
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Estro Freedom by AOR Advanced Orthomolecular Research Advanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
624917082975
IngredientAmount% DV
Choline30 mg5%
Calcium D-Glucarate150 mg--
DIM108 mg--
Sulforaphane Glucosinolate30 mg--
Broccoli seed extract300 mg--
Lifenol Hops extract120 mg--
8-Prenylnaringenin0.14 mg--

Other ingredients: Microcrystalline Cellulose, Capsule, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Promotes healthy levels of estrogen.

Supports estrogen metabolism and liver function

Vegan

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Note: Herbal extracts will naturally vary in color from one batch to another.

Precautions

Do not use if safety seal is broken

Caution: Do not take if pregnant or breastfeeding. Consult a health care practitioner if you are attempting to conceive, taking hormone replacement therapy, birth control pills or other medications. Consumption of hops with alcohol, other medications, and/or natural health products with sedative properties is not recommended.

Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle, or are involved in activities requiring mental alertness. Discontinue use if you experience joint pain or hot flashes. Discontinue use and consult a health care practitioner if you experience irregular menstruation. May temporarily alter urine color, consult a health care practitioner if urine does not normalize upon discontinued use.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Store tightly sealed in a cool, dry place

Formula

Discussion: Estro Freedom is a multi-nutrient combination. It includes cutting edge ingredients such as D-glucarate, DIM, SGS from broccoli, choline, and hops extract.

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules with breakfast daily, or as directed by a qualified health care practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

MyBlueprint

Product of Canada

Brand IP Statement(s)

Produced under patent US2006/010032 licensed from Caudill Seed Inc. Lifenol is a registered trademark of Naturex, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Estro Freedom by AOR Advanced Orthomolecular Research Advanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Estro Freedom label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Estro Freedom by AOR Advanced Orthomolecular Research Advanced

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Choline

Interacts with
16 drugs
30 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Calcium D-Glucarate

Interacts with
126 drugs
150 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium D-Glucarate monograph & interactions

DIM

Interacts with
269 drugs
108 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

DIM monograph & interactions

Broccoli seed extract

Interacts with
187 drugs
300 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli seed extract monograph & interactions

Lifenol Hops extract

Interacts with
863 drugs
120 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Lifenol Hops extract monograph & interactions
  • › 8-Prenylnaringenin

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Estro Freedom by AOR Advanced Orthomolecular Research Advanced Drug Interactions

Want to check YOUR meds against Estro Freedom?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
954 Moderate 9 Minor

Ingredients driving the most interactions

Lifenol Hops extract 863
DIM 269
Broccoli seed extract 187
Calcium D-Glucarate 126
Choline 16

Individual Drug Interactions

The ingredients in Estro Freedom interact with 963 drugs. Click any drug to see the details.

5 of the 5 ingredients in Estro Freedom interact with drugs. Each result below shows which ingredient is responsible. Lifenol Hops extract DIM Broccoli seed extract Calcium D-Glucarate Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Estro Freedom with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lifenol Hops extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Lifenol Hops extract full monograph & interactions

DIM3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
DIM full monograph & interactions

Broccoli seed extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli seed extract full monograph & interactions

Calcium D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium D-Glucarate full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Estro Freedom, from the product label.

AOR Advanced Orthomolecular Research Advanced

See all AOR Advanced Orthomolecular Research Advanced products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

Estro Freedom by AOR Advanced Orthomolecular Research Advanced: Common Questions

Does Estro Freedom by AOR Advanced Orthomolecular Research Advanced interact with any medications?
Yes. Based on its ingredients, Estro Freedom has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Estro Freedom contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
Calcium D-glucarate and DIM should be avoided during pregnancy due to insufficient safety data. Choline and sulforaphane are rated likely safe, but your choline and sulforaphane needs during pregnancy are specific — talk with your doctor or pharmacist about whether this product or a prenatal supplement is the right fit for you.
Is this safe while breastfeeding?
Calcium D-glucarate and DIM should be avoided while breastfeeding. Choline needs are higher while breastfeeding, but any supplement should be used under professional guidance. Sulforaphane has insufficient data — use caution and prefer dietary amounts if possible. Check with your doctor or pharmacist before starting.
What does DIM do?
DIM is a compound from cruciferous vegetables like broccoli and cabbage. It's included in this product because of its potential role in hormone metabolism, though the evidence that it works for specific conditions is not established in the data we hold.
Can I take this with my birth control or hormone replacement therapy?
DIM in this product might increase or decrease the effects of estrogens, including those in birth control and hormone replacement therapy. You need to check with your doctor or pharmacist before combining them, because interference could affect how well your hormone medication works.
What are the most common side effects?
DIM may cause diarrhea, gas, headache, nausea, rash, or vomiting. Sulforaphane may cause bowel discomfort, heartburn, stomach upset, or vomiting. Choline at typical doses is well tolerated, but high doses can cause nausea, vomiting, diarrhea, and a fishy body odor. If you experience any of these, talk with your pharmacist.
Can you check my medications to see if this is safe?
Use the interaction checker on this page to search your exact medications and over-the-counter drugs — it will show you what we've documented. Then talk with your doctor or pharmacist about whether this product is right for you, since they know your full health picture and can advise on your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Estro Freedom is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Estro Freedom label
Go deeper

The Full Monographs Behind Estro Freedom’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph → Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Estro Freedom's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 69 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Calcium D-glucarate 5 references
  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.

See these in context on the Calcium D-glucarate monograph →

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
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Sulforaphane 16 references
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Broccoli 5 references
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  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Hops 15 references
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  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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