Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Extreme Liver Support Ingredients & Drug Interactions

by ExtremeHealthUSA

Extreme Liver Support label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extreme Liver Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extreme Liver Support is a dietary supplement by ExtremeHealthUSA with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 365 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke, Sarsaparilla (Smilax aristolochiaefolia) concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Extreme Liver Support by ExtremeHealthUSA

Ask about any prescription or over-the-counter medication and we check it for interactions with Extreme Liver Support by ExtremeHealthUSA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Extreme Liver Support by ExtremeHealthUSA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (420 mg) without saying how much of each component you get.

Extreme Liver Support contains two active ingredients: artichoke and sarsaparilla concentrate. The product also contains inactive ingredients—glycerin, purified water, and gelatin—which are used as a capsule base and excipient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: general support to the liver.
  • We looked for evidence on: Biliary disorders, Hepatitis C, Nonalcoholic fatty liver disease (NAFLD), liver function, hepatic health, liver detoxification.
  • The closest evidence on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders (Natural Medicines).
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Hepatitis C.

Artichoke is possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia). For nonalcoholic fatty liver disease, the evidence isn't established enough in our data to rate it.

Sarsaparilla's effectiveness for cancer, psoriasis, or rheumatoid arthritis hasn't been reliably established. If liver support is your main goal, the data we hold doesn't spell out how well this combination works for that purpose.

The evidence, ingredient by ingredient Artichoke Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke is generally well tolerated when taken short-term, though quality and dosing vary by product. Most common side effects are abdominal pain, diarrhea, gas, hunger, and nausea.

A small number of people sensitive to inulin have had severe allergic reactions (anaphylaxis). If you're allergic to ragweed, chrysanthemums, marigolds, daisies, or related plants, you're at higher risk for an allergic reaction to artichoke.

Sarsaparilla is likely low-risk at food amounts, but human safety data for supplement doses are sparse. Occupational exposure to sarsaparilla dust can cause nasal inflammation and asthma symptoms.

During pregnancy, the safety data advises against both artichoke and sarsaparilla. Neither should be used while breastfeeding.

Side effects, ingredient by ingredient Artichoke Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sarsaparilla, Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 365 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood pressure-lowering drugs, diabetes medications, lithium, digoxin, or any drug metabolized by CYP2C19 or CYP2B6. Also mention it if you're allergic to ragweed or related plants.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people interested in liver health who don't take blood pressure, diabetes, or heart medications—and who aren't pregnant or breastfeeding. If you take any prescription medication, check it against the interaction tool on this page before starting, and talk it over with your doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extreme Liver Support, straight from the product label.

Brand ExtremeHealthUSA
Barcode (UPC) 658623000022
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5557
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extreme Liver Support by ExtremeHealthUSA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
658623000022
IngredientAmount% DV
Proprietary Blend420 mg--
Artichoke0 NP--
Sarsaparilla (Smilax aristolochiaefolia) concentrate0 NP--

Other ingredients: Glycerin, purified Water, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

10 YEARS OLD AND OVER: Take one to three (1-3) capsules one-half hour before each meal with a glass of water. One (1) capsule before each meal is beneficial for general support to the liver, two (2) capsules before each meal is beneficial when you feel you may need more support than normal, and three (3) capsules before each meal for maximum results with serious health issues.

CHILDREN DOSAGE 4-10 years: Begin with one (1) capsule per day for 5 days. Progress to one (1) in the AM and PM for the next week, then progress to a maximum of two (2) in the AM and two (2) in the PM.

DIRECTIONS It is important to drink 8 glasses of water per day.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Not for use by pregnant or lactating women.

Tamper Resistant Bottle - Do not use if imprinted safety cap is broken or missing.

WARNING: Avoid taking with acidic beverages, especially grapefruit, as the effects are diminished.

Women of childbearing age should consult with their physician.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

To preserve quality and freshness, keep bottle tightly closed. Store in a cool, dry place (59(0)-88(0)F).

Formula

Contains the following naturally occuring flavonoids and polyphenols: silymarin, quercetin, cetechin, hesperidin, rutin, cynarin, and chlorogenic acid.

General Statements

Recommended for those who: - Consume Alcohol - Smoke Tobacco - Take drugs/medications - Have liver complications - Have excessive weight issues - Have been exposed to toxins

Servings per Container 30 to 90

Used by Doctors for 10 years

Formulation

FREE OF: sugar, soy, starch, yeast, salt, gluten, wheat, corn or milk.

No preservatives, artificial colors or flavors.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extreme Liver Support by ExtremeHealthUSA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extreme Liver Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extreme Liver Support by ExtremeHealthUSA

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

420 mg per serving

Other (inactive) ingredients: Glycerin, Purified Water, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extreme Liver Support by ExtremeHealthUSA Drug Interactions

Want to check YOUR meds against Extreme Liver Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
365Drugs
365 Moderate

Ingredients driving the most interactions

Artichoke 363
Sarsaparilla (Smilax aristolochiaefolia) concentrate 2

Individual Drug Interactions

The ingredients in Extreme Liver Support interact with 365 drugs. Click any drug to see the details.

2 of the 2 ingredients in Extreme Liver Support interact with drugs. Each result below shows which ingredient is responsible. Artichoke Sarsaparilla (Smilax aristolochiaefolia) concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Extreme Liver Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke full monograph & interactions

Sarsaparilla (Smilax aristolochiaefolia) concentrate2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla (Smilax aristolochiaefolia) concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extreme Liver Support, from the product label.

ExtremeHealthUSA

See all ExtremeHealthUSA products
Name
ExtremeHealthUSA
City
Walnut Creek
State
CA
ZipCode
94596
Web Address
www.ExtremeLiverSupport.com
Pharmacist Counseling Corner

Extreme Liver Support by ExtremeHealthUSA: Common Questions

Does Extreme Liver Support by ExtremeHealthUSA interact with any medications?
Yes. Based on its ingredients, Extreme Liver Support has a known interaction with 365 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extreme Liver Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm allergic to ragweed?
Probably not. Artichoke can trigger an allergic reaction in people sensitive to ragweed, chrysanthemums, marigolds, daisies, and related plants (the Asteraceae family). If you have a known allergy to any of these, talk to your doctor or pharmacist before taking this product.
What are the most common side effects?
With artichoke, you might experience abdominal pain, diarrhea, gas, hunger, or nausea. Sarsaparilla has limited human safety data at supplement doses, though occupational exposure to its dust can cause nasal inflammation and asthma symptoms.
Is this safe during pregnancy or breastfeeding?
No. The safety data advises against both artichoke and sarsaparilla during pregnancy and while breastfeeding. Talk to your doctor or pharmacist about alternatives if you're pregnant or nursing.
Does artichoke actually help with high cholesterol?
Artichoke is possibly effective for high cholesterol based on the evidence we hold. It's also possibly effective for indigestion. For nonalcoholic fatty liver disease, the evidence isn't established enough to rate it.
What does sarsaparilla do in this product?
The data we hold on sarsaparilla shows insufficient evidence for cancer, psoriasis, or rheumatoid arthritis. Its specific role in this liver support formula isn't spelled out in our information.
Can I take this with my blood pressure medication?
Not without checking first. Artichoke may theoretically increase the risk of excessively low blood pressure when combined with blood pressure-lowering drugs. Talk to your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extreme Liver Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extreme Liver Support label
Go deeper

The Full Monographs Behind Extreme Liver Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph → Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Extreme Liver Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team