Fish Oil 1240 Sport Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Fish Oil 1240 Sport against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fish Oil 1240 Sport is a dietary supplement by GNC Triple Strength with 3 active ingredients. Its ingredients are commonly taken for high triglycerides, heart health, joint pain and inflammation.Based on those ingredients, 904 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Theanine, Total Fish Oil, Sicilian Blood Orange Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fish Oil 1240 Sport by GNC Triple Strength
Ask about any prescription or over-the-counter medication and we check it for interactions with Fish Oil 1240 Sport by GNC Triple Strength — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fish Oil 1240 Sport by GNC Triple Strength
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 4 active ingredients. The main ones are two omega-3 fatty acids from fish oil — eicosapentaenoic acid and docosahexaenoic acid — plus Sicilian Blood Orange Complex (a source of flavonoids and other plant compounds from sweet orange) and theanine (an amino acid found naturally in tea).
The rest of the softgel capsule is made up of inactive ingredients including gelatin, glycerin, beeswax, an enteric coating, and colorants.
Does it work?
Not established
The product's fish oil components are not rated for any condition in our data. Theanine is rated possibly effective for supporting cognitive function, though evidence for age-related cognitive decline, Alzheimer disease, and anxiety is insufficient to establish it works.
The blood orange complex and other ingredients have insufficient evidence for the conditions listed in our database.
How safe is it?
Well-documented data
Sweet orange fruit in normal food amounts is safe for most people, but concentrated extracts and oils in supplements have less safety data, so use caution — large amounts of the peel have caused intestinal cramping in children. Theanine is generally well tolerated in healthy adults for short-term use, though long-term safety isn't well studied.
Reported side effects of theanine include headaches, drowsiness, and changes in sleep or dreams. The safety data advises against theanine during pregnancy and while breastfeeding.
Theanine is rated likely safe for pregnancy and lactation per the facts, but the safety_notes flag insufficient data — follow your doctor or pharmacist's personalized advice.
Meds to double-check
Major interaction found
Before taking this product, double-check with your doctor or pharmacist if you take pravastatin or other cholesterol drugs, celiprolol or other heart medications, ivermectin or other antiparasitic drugs, blood pressure medications, quinolone antibiotics, antihistamines like fexofenadine, or any drugs that use OATP or P-glycoprotein transport — the blood orange in this product can significantly reduce their absorption or increase their levels. Also mention if you take any sedating drugs or serotonergic antidepressants, since theanine might add to their effects.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
If you take a cholesterol drug like pravastatin, a heart medication like celiprolol, an antiparasitic like ivermectin, a blood pressure medication, certain antibiotics, or any cancer or immune-suppressing drug, check with your doctor or pharmacist before starting this product — the blood orange component can significantly alter how your body handles them. Otherwise, this product is generally well tolerated, though long-term safety of theanine isn't fully established.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fish Oil 1240 Sport, straight from the product label.
| Brand | GNC Triple Strength |
|---|---|
| Barcode (UPC) | 048107134914 |
| Net contents | 90 Mini Softgel(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2014 |
| DSLD ID | 33095 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fish Oil 1240 Sport by GNC Triple Strength, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 {Calories} | -- |
| Calories from Fat | 15 {Calories} | -- |
| Total Fat | 1.5 Gram(s) | 2% |
| Eicosapentaenoic Acid | 714 mg | -- |
| Docosahexaenoic Acid | 288 mg | -- |
| Total Fish Oil | 1240 mg | -- |
| Sicilian Blood Orange Complex | 100 mg | -- |
| Theanine | 25 mg | -- |
Other ingredients: Gelatin, Glycerin, yellow Beeswax, Enteric Coating, Caramel color, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
^60% Smaller than our GNC Triple Strength Fish Oil Sport.
60% SMALLER PILL^
- Promotes exercise recovery with potent antioxidants* - Enteric coated
Conforms to USP <2091> for weight.
FDA Statement of Identity
DIETARY SUPPLEMENT
Formula
- 1240 mg of fish oil in each serving, providing 1000 mg total OMEGA-3 fatty acids EPA and DHA
FDA Disclaimer Statement
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
KEEP OUT OF REACH OF CHILDREN.
WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.
Storage
Store in a cool, dry place.
Seals/Symbols
Suntheanine(R)
5X CERTIFIED PURIFIED
Brand IP Statement(s)
Suntheanine is a registered trademark of Taiyo International, Inc.
Formulation
No Sugar, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Dairy, No Gluten, Yeast Free.
General
CODE 888422 IOG
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take three softgel capsules daily post-workout. On non-workout days, take three softgel capsules in the morning.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fish Oil 1240 Sport by GNC Triple Strength label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fish Oil 1240 Sport by GNC Triple Strength
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Sofgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Total Fish Oil
Interacts with327 drugs
Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health...
Total Fish Oil monograph & interactions- › Eicosapentaenoic Acid
- › Docosahexaenoic Acid
Sicilian Blood Orange Complex
Interacts with246 drugs
Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and es...
Sicilian Blood Orange Complex monograph & interactionsTheanine
Interacts with565 drugs
Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...
Theanine monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Yellow Beeswax, Enteric Coating, Caramel color, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
Fish Oil 1240 Sport by GNC Triple Strength Drug Interactions
HelloPharmacist Interaction Report
GNC Triple Strength Fish Oil 1240 Sport contains eicosapentaenoic acid, docosahexaenoic acid, and theanine — ingredients we could not fully check for interactions — plus Sicilian Blood Orange Complex, which does interact with medications.
The most serious concern is with pravastatin (a cholesterol drug), where blood orange can nearly triple the drug's levels in your system, raising the risk of side effects.
Read the full breakdown — every affected drug type, severity by severity
Sweet orange also interacts with several other drug classes at Major severity. It can dramatically reduce absorption of ivermectin (an antiparasitic), celiprolol (a heart medication), and OATP-substrate drugs — a large group that includes certain cancer treatments and immune suppressants.
Separate any of these medications from this product by at least 4 hours. At Moderate severity, blood orange may reduce the effectiveness of quinolone antibiotics and fexofenadine (an antihistamine), and may affect how your body handles other drugs that use the P-glycoprotein transport system.
Theanine in this product may lower blood pressure and could add to the effect of blood pressure medications (Moderate severity), and theoretically might increase drowsiness with sedating drugs or affect serotonergic antidepressants (Minor severity), though no serotonin syndrome cases have been reported.
We could not check eicosapentaenoic acid or docosahexaenoic acid against our interaction database. Altogether, these interactions span 799 individual medications.
Use the medication checker on this page to look up your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fish Oil 1240 Sport?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fish Oil 1240 Sport interact with 904 drugs. Click any drug to see the details.
3 of the 3 ingredients in Fish Oil 1240 Sport interact with drugs. Each result below shows which ingredient is responsible. Theanine Total Fish Oil Sicilian Blood Orange Complex
AtorvastatinAtorvaliq
How Atorvastatin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Atorvastatin Calcium interactionBosentanTracleer
How Bosentan interacts with Fish Oil 1240 Sport — through 3 ingredients. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Bosentan interactionTotal Fish OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Total Fish Oil + Bosentan interactionTheanineAntihypertensive Drugs Moderate
Interaction Summary
Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Read the full Theanine + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Brincidofovir interactionCeliprololCelicard
How Celiprolol interacts with Fish Oil 1240 Sport — through 3 ingredients. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Sicilian Blood Orange Complex + Celiprolol interactionTheanineAntihypertensive Drugs Moderate
Interaction Summary
Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Read the full Theanine + Celiprolol interactionTotal Fish OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Total Fish Oil + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Sicilian Blood Orange Complex + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Sicilian Blood Orange Complex + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexFexofenadine (allegra), P-glycoprotein Substrates +1 Major
Interaction Summary
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Read the full Sicilian Blood Orange Complex + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Sicilian Blood Orange Complex + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Isoniazid, Rifampin interactionIvermectinMectizan, Sklice, Soolantra, Stromectol
How Ivermectin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexP-glycoprotein Substrates, Ivermectin (stromectol, Others) Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Sicilian Blood Orange Complex + Ivermectin interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Sicilian Blood Orange Complex + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Levofloxacin (ophthalmic) interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Sicilian Blood Orange Complex + Lomefloxacin interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with Fish Oil 1240 Sport — through 1 ingredient. Tap an ingredient for the detail:
Sicilian Blood Orange ComplexOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Sicilian Blood Orange Complex + Lovastatin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fish Oil 1240 Sport with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Theanine
Antihypertensive Drugs
Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.
Cns Depressants
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.
Serotonergic Drugs
Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.
Total Fish Oil
Antihypertensive Drugs
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Clinical evidence indicates that fish oils can modestly lower blood pressure and might have additive effects in patients treated with antihypertensives.
Contraceptive Drugs
Theoretically, taking fish oil with contraceptive drugs might decrease the triglyceride-lowering effects of fish oil.
There is some evidence that contraceptive drugs might interfere with the triglyceride lowering effects of fish oils.
Cyclosporine (Neoral, Sandimmune)
Taking fish oil with cyclosporine might increase levels and adverse effects of cyclosporine.
In kidney transplant recipients on a general immunosuppressive regimen, taking omega-3 fatty acids daily seems to increase peak blood levels of cyclosporine when compared with placebo. This increase was as much as 20% after one month. However, the area under the curve was not significantly affected.
Orlistat (Xenical, Alli)
Theoretically, taking fish oil with orlistat might decrease the absorption of fish oil fatty acids.
Orlistat binds lipase in the gastrointestinal tract and reduces fat absorption. Theoretically, taking fish oil with orlistat might decrease absorption of fish oil fatty acids. To avoid this potential interaction, recommend separating administration of orlistat and fish oil by at least 2 hours.
Sirolimus (Rapamune)
Taking fish oil with sirolimus might increase levels and adverse effects of sirolimus.
Pharmacokinetic research shows that omega-3 fatty acids increase exposure to sirolimus in kidney transplant patients on a calcineurin inhibitor-free immunosuppressive regimen. A 25% dose reduction in sirolimus was required to keep patients within the expected trough-concentration window. Researchers hypothesize that this may be due to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.
Tacrolimus (Prograf)
Taking fish oil with tacrolimus might increase levels and adverse effects of tacrolimus.
In a small group of patients, taking fish oil 2.6 grams (Omacor) daily for 4 weeks increased the 8-hour area under the curve of tacrolimus by 25% when compared with baseline. Peak levels were increased by approximately 22%. Researchers hypothesize that this may be due either to an increase in bioavailability or to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.
Anticoagulant/Antiplatelet Drugs
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, evidence is conflicting.
While fish oil may not be a potent inhibitor of platelet function, high doses of fish oil might have antiplatelet effects. Theoretically, concomitant use of fish oil with anticoagulant or antiplatelet drugs may increase the risk of bleeding. However, the most rigorous research shows that short-term doses of fish oil 10 grams daily or long-term doses of 1.5 grams daily for up to 52 weeks does not increase the risk of bleeding or affect coagulation parameters in chronically ill and vulnerable patients. Other controlled research shows that fish oil does not affect platelet function or increase the risk of bleeding. Some research even suggests that perioperative fish oil use decreases bleeding risk. Some research suggests fish oil does not have additive antiplatelet effects when combined with aspirin, but other clinical evidence suggests that adding fish oil to low-dose aspirin treatment increases antiplatelet effects in patients who are aspirin-resistant. Also, some clinical research seems to show that fish oil has additive antiplatelet effects when used with aspirin and clopidogrel compared to aspirin and clopidogrel alone.
Platinum Agents
Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.
Platinum-induced fatty acids (PIFAs) are fatty acids secreted from human and mouse stem cells when exposed to platinum-based chemotherapy. Animal research suggests that PIFAs cause resistance to chemotherapy by stimulating lysophospholipid production in the spleen, which interferes with the DNA damage caused by certain chemotherapy drugs. One PIFA, known as 16:4(n-3), has been found in both raw fish and some commercially available fish oil products. Mackerel and herring have high PIFA concentrations, while salmon and tuna have low PIFA concentrations. Levels of PIFA in commercial fish oil products ranged from 0.2- 5.7 microMol. Animal research shows that PIFA-containing fish oil products cause resistance to cisplatin, fluorouracil, irinotecan, and oxaliplatin. It is unclear if all commercially available fish oil products contain PIFAs. Additionally, it is argued that levels of PIFA found in some fish oil products are too low to be of clinical concern. Furthermore, a lack of chemotherapy resistance in countries with high fish intake, such as Greenland, Japan, and Norway, suggest that this interaction may not be clinically significant.
Warfarin (Coumadin)
Fish oil may have antiplatelet effects and might increase the risk of bleeding if used with warfarin.
Fish oil has antiplatelet effects at high doses. Case reports show elevated INR in patients taking warfarin and fish oil 1-2 grams daily. However, some clinical research shows that taking fish oil 3-6 grams daily does not significantly increase INR in patients taking warfarin.
Sicilian Blood Orange Complex
Celiprolol (Celicard)
Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
Ivermectin (Stromectol, Others)
Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.
Pravastatin (Pravachol)
Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.
Fexofenadine (Allegra)
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
P-Glycoprotein Substrates
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.
Quinolone Antibiotics
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.
Brand information
Manufacturer and brand details for Fish Oil 1240 Sport, from the product label.
GNC Triple Strength
See all GNC Triple Strength products- Name
- General Nutrition Corporation
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15222
Fish Oil 1240 Sport by GNC Triple Strength: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Fish Oil 1240 Sport’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Fish Oil
Interacts with 327 drugsFish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally...
Read the full Fish Oil monograph → Herb & supplement monographSweet Orange
Interacts with 246 drugsSweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...
Read the full Sweet Orange monograph → Herb & supplement monographTheanine
Interacts with 565 drugsTheanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...
Read the full Theanine monograph →Sources & How We Checked
Fish Oil 1240 Sport's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 180 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fish Oil 157 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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