Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Five Seed Teapills Wu Ren Wan Ingredients & Drug Interactions

by Plum Flower

Five Seed Teapills Wu Ren Wan label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Five Seed Teapills Wu Ren Wan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Five Seed Teapills Wu Ren Wan is a dietary supplement by Plum Flower with 6 active ingredients. Its ingredients are commonly taken for source of vitamin c, digestive support, aromatherapy and relaxation.Based on those ingredients, 645 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Citrus reticulata Peel Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Five Seed Teapills Wu Ren Wan by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Five Seed Teapills Wu Ren Wan by Plum Flower — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Five Seed Teapills Wu Ren Wan by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,360 mg) without saying how much of each component you get.

Five Seed Teapills contains six active ingredients: a proprietary blend that includes tangerine peel extract, apricot seed extract, peach seed extract, oriental arborvitae extract, Japanese apricot seed extract, and pine seed extract. These are combined with inactive ingredients—dextrin, microcrystalline cellulose, and hydrated magnesium silicate—which serve as binders and fillers to form the tablet.

In traditional Chinese herbalism, seed and pit extracts like these are believed to support digestion and moisture balance. This particular formula is known as Wu Ren Wan, or Five Seed Pill, reflecting its five-seed composition.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The effectiveness data we hold does not establish that tangerine peel works for any condition in clinical trials—the rating for cancer is insufficient evidence. Oriental arborvitae similarly shows insufficient evidence for osteoarthritis.

We have no effectiveness ratings on file for apricot, peach, Japanese apricot, or pine seed extracts.

The evidence, ingredient by ingredient Tangerine Apricot Oriental Arborvitae

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tangerine fruit itself is generally well tolerated as food, but concentrated extracts should be used cautiously and ideally under medical guidance, as safety of supplements has not been thoroughly studied. Very few adverse effects have been reported with medicinal tangerine use, though contact dermatitis has been reported with tangerine essential oil applied to skin.

Oriental arborvitae carries important cautions: long-term or high-dose use may cause adverse effects due to thujone, a constituent that can trigger restlessness, vomiting, dizziness, tremors, kidney damage, hallucinations, and convulsions. The safety data advises against use in pregnancy and lactation.

Apricot fruit as food is fine, but supplement safety is not established, and apricot kernels should be avoided entirely. We hold no pregnancy or lactation data for the tangerine extract in this product.

Side effects, ingredient by ingredient Tangerine Apricot Oriental Arborvitae

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Tangerine.
  • The most serious interaction on file is rated Minor.
  • For scale: 646 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take midazolam (Versed) or other medications metabolized by CYP3A4, talk to your pharmacist or doctor before using this product—tangerine peel may slightly alter how your body processes them, though the clinical effect in humans appears minimal. Altogether, these interactions span 646 individual medications.

Anyone on long-term prescription therapy should clear this formula with their own healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This traditional herbal formula is generally well tolerated as a food-based supplement, though some ingredients (especially oriental arborvitae) carry cautions with long-term or high-dose use. If you take midazolam or any other prescription medication, especially those your liver processes, check with your doctor or pharmacist before starting.

Pregnant or breastfeeding individuals should discuss this product with their own healthcare provider, as safety data for several ingredients are limited or advise against use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Five Seed Teapills Wu Ren Wan, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934838082
Net contents 1.2 Ounce(s); 34 Gram(s); 200 Pill(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298528
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Five Seed Teapills Wu Ren Wan by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Pill(s)
Maximum serving Sizes:
8 Pill(s)
Servings per container
25
UPC/BARCODE
739934838082
IngredientAmount% DV
Proprietary Extract Blend1360 mg--
Citrus reticulata Peel Extract0 NP--
Prunus armeniaca Seed Extract0 NP--
Prunus persica Seed Extract0 NP--
Platycladus orientalis Extract0 NP--
Prunus japonica Seed Extract0 NP--
Pinus tabulaeformis Seed Extract0 NP--

Other ingredients: Dextrin, Microcrystalline Cellulose, Magnesium Silicate, Hydrated

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Take 8 pills 3 times daily or as directed by your health care practitioner

Precautions

Not for use during pregnancy

Contains tree nuts (apricot kernel, peach kernel, biota kernel, bush cherry kernel, pine nuts)

Keep out of reach of children

Formulation

Made in China in partnership with the award-winning Lanzhou Foci Pharmaceutical Co. Ltd.

Plum Flower quality guarantee No pharmaceuticals or dyes Unsulfured, preservative-free herbs when available Microbial and heavy metal tested

Produced at a good manufacturing practices (GMP) certified factory

US Owned & operated since 1969

Formula

Scientifically authenticated herbs

Seals/Symbols

Foci Pharmaceutical 1929

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Five Seed Teapills Wu Ren Wan by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Five Seed Teapills Wu Ren Wan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Five Seed Teapills Wu Ren Wan by Plum Flower

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1360 mg per serving

Other (inactive) ingredients: Dextrin, Microcrystalline Cellulose, Magnesium Silicate, Hydrated. These complete the product’s ingredient list but are not active constituents.

Interaction report

Five Seed Teapills Wu Ren Wan by Plum Flower Drug Interactions

Want to check YOUR meds against Five Seed Teapills Wu Ren Wan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
645Drugs
645 Minor

Ingredients driving the most interactions

Citrus reticulata Peel Extract 645

Individual Drug Interactions

The ingredients in Five Seed Teapills Wu Ren Wan interact with 645 drugs. Click any drug to see the details.

1 of the 6 ingredients in Five Seed Teapills Wu Ren Wan interact with drugs. Each result below shows which ingredient is responsible. Citrus reticulata Peel Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Five Seed Teapills Wu Ren Wan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Citrus reticulata Peel Extract2 drug types · 645 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.

Likelihood Unlikely Evidence B
Midazolam (Versed)

In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.

Likelihood Unlikely Evidence B
Citrus reticulata Peel Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Five Seed Teapills Wu Ren Wan, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Phone Number
(800) 262-9929
Web Address
plumflowerherbs.com
Pharmacist Counseling Corner

Five Seed Teapills Wu Ren Wan by Plum Flower: Common Questions

Does Five Seed Teapills Wu Ren Wan by Plum Flower interact with any medications?
Yes. Based on its ingredients, Five Seed Teapills Wu Ren Wan has a known interaction with 645 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Five Seed Teapills Wu Ren Wan contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is tangerine peel safe to take in a supplement like this?
Tangerine fruit itself is safe as food, but concentrated extracts haven't been well studied for safety in supplement form. Use cautiously and ideally with medical advice. Very few side effects have been reported, though contact dermatitis can occur if applied to skin.
Can I take this if I'm pregnant or breastfeeding?
We hold pregnancy data for apricot seed (likely safe) but not for tangerine or most other ingredients in this blend. Oriental arborvitae is advised against in pregnancy and lactation due to limited safety data. Talk with your doctor or pharmacist about whether this formula is right for you during pregnancy or breastfeeding.
What should I watch out for if I use oriental arborvitae long-term?
Oriental arborvitae contains thujone, which at high doses or with long-term use may cause restlessness, nausea, dizziness, tremors, kidney damage, hallucinations, and convulsions. Use only as directed and under professional guidance if taking it regularly.
Will this interact with my sleep medication?
Tangerine peel may slightly delay how midazolam (Versed) is absorbed, but human studies show it doesn't actually speed up how your body breaks it down. Still, check with your pharmacist or doctor before combining this product with any sedative to be sure.
Why does the label say to avoid apricot kernels?
Apricot kernels (the pit inside) carry safety concerns that whole apricot fruit and seed extracts don't. For this reason, apricot kernels should be avoided entirely—the extract in this product is different and from the seed itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Five Seed Teapills Wu Ren Wan is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Five Seed Teapills Wu Ren Wan label
Go deeper

The Full Monographs Behind Five Seed Teapills Wu Ren Wan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tangerine

Interacts with 645 drugs

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and...

Read the full Tangerine monograph → Herb & supplement monograph

Apricot

Apricot is a nutritious fruit that provides fiber, potassium, and vitamins A and C, and it is safe and healthy to eat as part of a normal diet. There is little strong evidence that apricot f...

Read the full Apricot monograph → Herb & supplement monograph

Oriental Arborvitae

Oriental Arborvitae is an evergreen conifer used in Traditional Chinese Medicine, where the seeds (Bai Zi Ren) are taken to calm the mind and ease constipation, and the leaves (Ce Bai Ye) ar...

Read the full Oriental Arborvitae monograph →
Sources

Sources & How We Checked

Five Seed Teapills Wu Ren Wan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tangerine 3 references
  1. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
  2. Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
  3. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

See these in context on the Tangerine monograph →

Apricot 1 reference
  1. Dietary Supplements - What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Apricot monograph →

Oriental Arborvitae 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Oriental Arborvitae monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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