Interactions on record — worth a quick check against your medications. Based on 2 of 14 ingredients. Check your meds →
Dietary supplement

Fodmap DPE Ingredients & Drug Interactions

by Arthur Andrew Medical

Fodmap DPE label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fodmap DPE against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fodmap DPE is a dietary supplement by Arthur Andrew Medical with 14 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fodmap DPE by Arthur Andrew Medical

Ask about any prescription or over-the-counter medication and we check it for interactions with Fodmap DPE by Arthur Andrew Medical — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fodmap DPE by Arthur Andrew Medical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 14 active ingredients.
  • “FODMAP DPE Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (532 mg) without saying how much of each component you get.
  • “Digestive Spore Probiotics Blend” is a proprietary blend — the label gives one combined amount (40 mg) without saying how much of each component you get.

This product contains 14 active ingredients designed to help with digestion, especially if you're sensitive to high-FODMAP foods (a diet concern for some people with digestive symptoms). Most are enzymes — natural proteins that break down different parts of food: amylase breaks down starch, lactase breaks down milk sugar, cellulase breaks down plant fiber, and others target different carbohydrates and complex molecules.

The blend also includes two probiotics, Bacillus subtilis and Bacillus clausii, which are live microorganisms thought to support gut health. One ingredient, lactase, has enough research to be called effective for lactose intolerance (difficulty digesting milk).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive support for FODMAP-containing foods.
  • We looked for evidence on: Constipation, Diarrhea, Flatulence, Dyspepsia, Irritable bowel syndrome (IBS), Lactose intolerance — and 3 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia, Flatulence, and more.

Lactase in this product is effective for lactose intolerance — it helps you digest milk sugar if your body doesn't make enough of its own lactase enzyme. The other 13 ingredients haven't been rated; we don't have enough reliable evidence on file to say whether they work for the purposes they're included in.

That doesn't mean they don't work — just that the data we hold doesn't establish it yet.

The evidence, ingredient by ingredient Lactase Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated, and the data shows it's likely safe in pregnancy and lactation, though you should check with your doctor before regular use while pregnant. Bacillus subtilis is generally well tolerated in healthy adults, but the data on file is limited, so ask your doctor before using it — rare cases of headache and, very rarely, diarrhea have been reported in studies.

One occupational case of an allergic reaction (contact dermatitis and allergic rhinitis) to powdered lactase was documented in a worker, though this is uncommon. Safety data for the other 11 ingredients isn't on file, so discuss those with your pharmacist if you have concerns.

Side effects, ingredient by ingredient Lactase Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, tell your pharmacist — you'll want to separate when you take them from when you take this product, so the antibiotics don't reduce the probiotic's effectiveness. We could not check most of the other ingredients for drug interactions, so use the medication search on this page to look up your exact prescriptions and over-the-counter drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This digestive enzyme and probiotic blend may help if you're managing high-FODMAP foods or have trouble digesting milk. If you take antibiotics, space them out from this product — the antibiotics can kill the live probiotics.

Check your medications with the tool on this page, and talk to your pharmacist if you're pregnant, breastfeeding, or have a history of allergies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fodmap DPE, straight from the product label.

Brand Arthur Andrew Medical
Barcode (UPC) 855822008440
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 327851
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fodmap DPE by Arthur Andrew Medical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
855822008440
IngredientAmount% DV
Amylase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Xylanase0 NP--
Pectinase0 NP--
Maltase0 NP--
Beta-Glucanase0 NP--
Hemicellulase0 NP--
Diastase0 NP--
Bacillus subtilis0 NP--
Alpha-Galactosidase0 NP--
Bacillus clausii0 NP--
FODMAP DPE Proprietary Enzyme Blend532 mg--
Digestive Spore Probiotics Blend40 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

FODMAP DPE is a specialized blend of spore-forming probiotics and digestive enzymes that assists the body in properly digesting highly fermentable foods, commonly known as FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols). Garlic, onions, apples, and many other nutrient dense foods can be very hard for some to digest. By limiting digestive fermentation, FODMAP DPE eases symptoms like gas, bloating, constipation and other digestive discomforts that occur from enjoying FODMAP foods.

Digestive probiotics & enzymes

Star-K (Kosher)

Suggested/Recommended/Usage/Directions

Suggested use: Take FODMAP DPE with 8 oz of water at the beginning of each FODMAP containing meal, or as directed by your healthcare practitioner. Additional capsules may be taken for larger meals or during periods of occasional discomfort. Maintenance: 1 capsule per meal. Increased support: 2 capsules per meal.

FDA Statement of Identity

Dietary Supplement

Formulation

FODMAP digestive support Reduces occasional gas/constipation Supports less restrictive diets Enjoy high fiber/nutrient dense foods

Fodmap is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives.

Certified Vegan AVA American Vegetarian Association

Non GMO Tested

General Statements

For more information about FODMAP DPE, please call 800-448-5015 or visit www.arthurandrew.com

Precautions

Keep out of reach of children.

Storage

Store in a cool dry place with lid tightly closed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Certified Vegan AVA American Vegetarian Association Star-K (Kosher) Non GMO Tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fodmap DPE by Arthur Andrew Medical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fodmap DPE label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fodmap DPE by Arthur Andrew Medical

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

FODMAP DPE Proprietary Enzyme Blend

532 mg per serving
  • › Amylase
  • › Lactase
  • › Cellulase
  • › Invertase
  • › Glucoamylase
  • › Xylanase
  • › Pectinase
  • › Maltase
  • › Beta-Glucanase
  • › Hemicellulase
  • › Diastase
  • › Alpha-Galactosidase

Digestive Spore Probiotics Blend

40 mg per serving

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fodmap DPE by Arthur Andrew Medical Drug Interactions

Want to check YOUR meds against Fodmap DPE?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis 182

Individual Drug Interactions

The ingredients in Fodmap DPE interact with 182 drugs. Click any drug to see the details.

1 of the 14 ingredients in Fodmap DPE interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis

Each ingredient & the kinds of drugs it affects

For each ingredient in Fodmap DPE with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fodmap DPE, from the product label.

Arthur Andrew Medical

See all Arthur Andrew Medical products
Name
Arthur Andrew Medical
Street Address
8350 E Raintree Dr #101
City
Scottsdale
State
AZ
ZipCode
85260
Phone Number
800-448-5015
Web Address
www.arthurandrew.com
Pharmacist Counseling Corner

Fodmap DPE by Arthur Andrew Medical: Common Questions

Does Fodmap DPE by Arthur Andrew Medical interact with any medications?
Yes. Based on its ingredients, Fodmap DPE has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fodmap DPE contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with lactose intolerance?
Lactase, one of the ingredients, is effective for lactose intolerance — it provides the enzyme your body may not be making enough of to digest milk sugar. The rest of the product's enzymes target other carbohydrates and fiber, so how well it works for you will depend on what's causing your digestive trouble.
Is lactase safe if I'm pregnant?
Lactase is rated likely safe in pregnancy and lactation. Still, the data suggests you check with your doctor before regular use while pregnant, just to be sure it's right for your situation.
What are the live organisms in this product?
The product contains two probiotics: Bacillus subtilis and Bacillus clausii. These are live microorganisms meant to support your gut. Bacillus subtilis may help with antibiotic-associated diarrhea, though the evidence is only modest.
Can I take this with antibiotics?
Theoretically, antibiotics might kill some of the live Bacillus subtilis in this product, making the probiotic less effective. Your best bet is to separate when you take them — ask your pharmacist for a schedule that works.
Are there any reported side effects?
Very few have been reported. One person in a study had a headache after taking Bacillus subtilis, and diarrhea has been reported rarely. An allergic reaction to powdered lactase was documented in a worker exposed to high amounts, but that's occupational exposure, not typical use.
What are the inactive ingredients?
The product contains cellulose, an inactive ingredient used as a filler or binder in the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fodmap DPE is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fodmap DPE label
Go deeper

The Full Monographs Behind Fodmap DPE’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

Fodmap DPE's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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