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Dietary supplement

Fortify Optima Women's Probiotic 50 Billion Ingredients & Drug Interactions

by Nature's Way

Fortify Optima Women's Probiotic 50 Billion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fortify Optima Women's Probiotic 50 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fortify Optima Women's Probiotic 50 Billion is a dietary supplement by Nature's Way with 2 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fortify Optima Women's Probiotic 50 Billion by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Fortify Optima Women's Probiotic 50 Billion by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fortify Optima Women's Probiotic 50 Billion by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Bifidobacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Fortify Optima Women's Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (340 mg) without saying how much of each component you get.
  • “Lactobacilli Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Fortify Optima Women's Probiotic 50 Billion contains 7 active probiotic ingredients: two strains of Lactobacillus acidophilus (LA-14 and NCFM), Lactobacillus gasseri, Bifidobacterium animalis lactis (two strains: BL-04 and Bi-07), Bifidobacterium longum, and Bifidobacterium bifidum. These are live beneficial bacteria designed to support digestive and vaginal health.

The product also contains inactive ingredients — cellulose, hypromellose, gellan gum, magnesium stearate, and silica — which are fillers and capsule materials that help deliver the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Diarrhea, Irritable bowel syndrome (IBS), Lactose intolerance, Clostridioides difficile infection, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for this product is mixed and depends on which strain you're looking at. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori, antibiotic-associated diarrhea, and bacterial vaginosis, though possibly ineffective for atopic disease.

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. For the other ingredients — Lactobacillus gasseri and Bifidobacterium longum — the data we hold show insufficient evidence to rate their effectiveness for the conditions studied.

The evidence overall isn't strong enough to promise results for any one condition, but some strains do show promise for digestive and vaginal health.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy adults. However, since they're live organisms, there is a small theoretical risk of infection in certain patients — specifically those with severely weakened immune systems or serious underlying illness.

Gastrointestinal side effects such as bloating, gas, abdominal discomfort, and diarrhea have been reported but are uncommon. Rare cases of rash and itching have occurred in trials, though it's unclear whether the probiotics themselves were responsible.

There is no pregnancy or breastfeeding safety data on file for most of these strains; Bifidobacterium longum alone is rated possibly safe in pregnancy and lactation. Talk with your doctor or pharmacist before use if you are pregnant, breastfeeding, seriously ill, or immune-compromised.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Gasseri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern here (Moderate severity): taking this probiotic at the same time may kill off the live organisms and make the probiotic less effective. Separate your antibiotic and this probiotic by a few hours.

No other medication interactions are documented for the ingredients we could check, though we hold no data on two of the Bifidobacterium animalis lactis strains. Use the checker on this page to confirm your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with digestive issues and vaginal health, especially if you're taking or have recently taken antibiotics — though you'll need to separate doses. If you take any antibiotic or have a weakened immune system, check with your pharmacist first.

The live organisms are generally safe for healthy adults, but the evidence for specific benefits isn't ironclad.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fortify Optima Women's Probiotic 50 Billion, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674103364
Net contents 30 Delayed-Release Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 333749
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fortify Optima Women's Probiotic 50 Billion by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
033674103364
IngredientAmount% DV
Lactobacillus acidophilus LA-140 NP--
Bifidobacterium animalis lactis BL-040 NP--
Bifidobacteria Blend0 NP--
Fortify Optima Women's Proprietary Probiotic Blend340 mg--
HOWARU Lactobacillus acidophilus NCFM0 NP--
Bifidobacterium animalis lactis Bi-070 NP--
Lactobacillus gasseri LG-360 NP--
Bifidobacterium longum infantis BI-260 NP--
Lactobacilli Blend0 NP--
Bifidobacterium bifidum lactis Bb-020 NP--

Other ingredients: Cellulose, Hypromellose, Gellan Gum, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Guaranteed Potency Targeted delivery Plant-derived, delayed release capsule survives stomach acid to distribute live cultures where they're needed most – in the intestine and colon

Advanced Care Probiotic for Digestive & Immune Support

Gluten and dairy free. No soy or artificial colors.

Packaged and tested in the USA

Daily digestive support

Formula

Guarantees 50 billion live probiotic cultures through the date of expiration Formulated with 7 diverse probiotic strains

50 Billion live cultures 7 Diverse probiotic strains

Howaru Probiotic Quality you can feel

Women's Advanced Care Formula with 50 Billion Live Cultures and 7 Diverse Probiotic Strains With more Lactobacilli to support women's health Supports immune health with clinically studied B. lactis Bi-07 and B. lactis BL-04

Storage

No refrigeration needed

May be refrigerated. Store at room temperature. Avoid excessive heat and direct sunlight.

FDA Disclaimer Statement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 capsule daily. May be taken at any time, with or without food.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.

Seals/Symbols

Howaru Probiotic Quality you can feel

Brand IP Statement(s)

Howaru is a registered trademark of IFF and is used under license. The probiotic strains contained in this product are manufactured by IFF. Copyright 2024

General Statements

Explore more products at NATURESWAY.COM

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fortify Optima Women's Probiotic 50 Billion by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fortify Optima Women's Probiotic 50 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fortify Optima Women's Probiotic 50 Billion by Nature's Way

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fortify Optima Women's Proprietary Probiotic Blend

340 mg per serving
  • › Bifidobacteria Blend
  • › Lactobacilli Blend

Other (inactive) ingredients: Cellulose, Hypromellose, Gellan Gum, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fortify Optima Women's Probiotic 50 Billion by Nature's Way Drug Interactions

Want to check YOUR meds against Fortify Optima Women's Probiotic 50 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Fortify Optima Women's Probiotic 50 Billion interact with 182 drugs. Click any drug to see the details.

0 of the 2 ingredients in Fortify Optima Women's Probiotic 50 Billion interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Fortify Optima Women's Probiotic 50 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Fortify Optima Women's Probiotic 50 Billion, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
fortifyprobiotics.com
Pharmacist Counseling Corner

Fortify Optima Women's Probiotic 50 Billion by Nature's Way: Common Questions

Does Fortify Optima Women's Probiotic 50 Billion by Nature's Way interact with any medications?
Yes. Based on its ingredients, Fortify Optima Women's Probiotic 50 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fortify Optima Women's Probiotic 50 Billion contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while on antibiotics?
You can take both, but not at the same time. Since antibiotics kill bacteria — including the live organisms in this probiotic — you'll want to separate doses by a few hours. Ask your pharmacist for the best timing for your specific antibiotic.
What's the difference between these probiotic strains?
Each strain is a different species of beneficial bacteria with slightly different roles. Lactobacillus acidophilus and Bifidobacterium bifidum have the most evidence for digestive and vaginal health. The others have limited evidence or show promise in specific areas, but all work together to support your microbiome.
Will this help with irritable bowel syndrome?
Lactobacillus acidophilus and Bifidobacterium bifidum are possibly effective for IBS based on the data we hold, but that's not a guarantee. Results vary from person to person, so talk with your doctor about whether this might help your symptoms.
What side effects should I watch for?
Bloating, gas, stomach cramps, and diarrhea can occur but are uncommon. These usually settle down as your body adjusts. Rare cases of rash or itching have been reported in trials. If you develop fever, severe pain, or signs of infection, stop and call your doctor.
Is this safe to take while breastfeeding?
We don't have breastfeeding safety data on file for most of the strains in this product. Bifidobacterium longum is rated possibly safe in breastfeeding. Talk with your doctor or pharmacist before starting if you're breastfeeding.
Can I take this if my immune system is weak or I'm seriously ill?
That's a question for your doctor or pharmacist. Since these are live organisms, there's a small theoretical risk in people with very weak immune systems. Your healthcare provider can advise whether this is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fortify Optima Women's Probiotic 50 Billion is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fortify Optima Women's Probiotic 50 Billion label
Sources

Sources & How We Checked

Fortify Optima Women's Probiotic 50 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 55 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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