Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

GH Max Ingredients & Drug Interactions

by Universal

GH Max label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GH Max against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GH Max is a dietary supplement by Universal with 7 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 479 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine Alpha-Ketoglutarate, Vitamin B6, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GH Max by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with GH Max by Universal — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of GH Max by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GH Max contains seven active ingredients. L-Glutamine, L-Arginine Alpha-Ketoglutarate, and L-Ornithine HCl are amino acids — building blocks your body uses for muscle, immune function, and recovery.

The product also includes Vitamin B6, a B vitamin involved in energy and nerve function; Gamma Oryzanol, a plant compound from rice bran; Phytosterols, plant-based compounds; and Carnitine, which plays a role in how your cells produce energy. The tablet also contains inactive ingredients (fillers and binders) including dicalcium phosphate, whey, stearic acid, magnesium stearate, and pharmaceutical glaze.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: strength and power for elite athletes.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Postoperative recovery, Muscle hypertrophy, Anabolic support — and 2 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.

The evidence for this product's individual ingredients is mixed. L-Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness.

L-Arginine has no established effectiveness ratings in our data. L-Ornithine is possibly effective for athletic performance but has insufficient evidence for dry skin, insomnia, and gum disease.

Vitamin B6 is effective for certain types of anemia, vitamin B6 deficiency, and a rare form of epilepsy, and likely effective for high homocysteine levels; it's possibly effective for pregnancy-related nausea. Gamma Oryzanol is possibly effective for high cholesterol but has insufficient evidence for athletic performance or eczema.

We could not evaluate Phytosterols or Carnitine. The product hasn't been tested as a combined formula, so we don't know how these ingredients work together.

The evidence, ingredient by ingredient Glutamine L-arginine Ornithine Vitamin B6 Gamma-oryzanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at standard doses. L-Glutamine commonly causes belching, bloating, constipation, diarrhea, flatulence, nausea, and headache; rare cases of mania have been reported in people with bipolar disorder.

L-Arginine may cause abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing. Vitamin B6 at routine doses is well tolerated, but high doses taken long-term can damage nerves (sensory neuropathy), especially above 1,000 mg daily.

L-Ornithine's long-term safety isn't well studied. For pregnancy, L-Glutamine is likely safe, but L-Ornithine, Gamma Oryzanol, and Carnitine have insufficient safety data — the product advises avoiding them unless your doctor recommends it.

For breastfeeding, L-Glutamine data is limited; L-Ornithine, Gamma Oryzanol, and Carnitine should be avoided unless advised by a clinician. Anyone with kidney or liver disease should use L-Glutamine only under medical supervision.

Side effects, ingredient by ingredient Glutamine L-arginine Ornithine Vitamin B6 Gamma-oryzanol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — L-arginine, Glutamine, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; Parkinson's medications.
  • For scale: 479 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GH Max, double-check with your pharmacist if you take: blood pressure medications (antihypertensives, ACE inhibitors, ARBs), potassium-sparing diuretics, blood thinners or antiplatelet drugs, diabetes medications, heart drugs like isoproterenol or sildenafil, or seizure medications (phenobarbital or phenytoin). These are where the Moderate-severity risks lie.

Vitamin B6 also interacts with amiodarone and may affect levodopa if you're not taking it with carbidopa.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GH Max is marketed for muscle and athletic support, but the evidence is strongest only for L-Glutamine in specific conditions like sickle cell disease. If you take blood pressure medicine, diabetes medication, blood thinners, seizure drugs, or heart medications, check your exact prescriptions with our tool before starting this product — L-Arginine and Vitamin B6 pose real interaction risks.

Talk to your pharmacist or doctor, especially if you have kidney or liver disease or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GH Max, straight from the product label.

Brand Universal
Barcode (UPC) 039442014320
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 275376
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GH Max by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Tablet(s)
Maximum serving Sizes:
6 Tablet(s)
Servings per container
30
UPC/BARCODE
039442014320
IngredientAmount% DV
L-Glutamine100 mg--
L-Arginine Alpha-Ketoglutarate5 Gram(s)--
L-Ornithine HCl2.5 Gram(s)--
Vitamin B620 mg1177%
Gamma Oryzanol50 mg--
Phytosterols100 mg--
Carnitine100 mg--

Other ingredients: Dicalcium Phosphate, Whey, Stearic Acid, Magnesium Stearate, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

YouTube.com Facebook.com Instagram.com Twitter.com @UniversalUSA Who We Are Founded in 1977, we are a family-run company that has been formulating and manufacturing proven nutritional products for dedicated athletes. Our products are found in over 90 countries around the world. Classic Series Since the 70s, we've been dedicated to making some of the finest nutritional products for world-class bodybuilders. Today, the new Classic Series still represents our steadfast commitment to those individuals seeking to achieve strength and perfection in the gym.

Plant US-#3001104580

Formulation

GH Max Growth hormone (GH) can add lean mass by stimulating protein synthesis and increasing nitrogen retention in muscles. Universal Nutrition's GH Max is the ultimate GH support formula.

Increase anabolic potential

Superior GH optimization Support Strength Recovery

Formula

It is designed for the elite strength athlete who is interested in optimizing strength and power.

GH Max is enhanced with arginine and ornithine, along with other anabolic support nutrients, to help you reach your strength goals. Maximum strength GH Enhanced with arginine & ornithine

Brand IP Statement(s)

Universal Starts With U

Seals/Symbols

EAC (Eurasian Union)

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Milk, soy. Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

Warning: Not for use by those under the age of 18.

Consult a physician before using this product.

Do not use if pregnant or nursing.

Do not exceed recommended dose. Use of this product may be banned by some athletic associations. Athletes should consult with their sanctioning authority before use. California residents: Warning: Reproductive harm - www.P65Warnings.ca.gov.

Suggested/Recommended/Usage/Directions

Dosage: On training days, take 6 tablets before working out. On non-training days, take 6 tablets prior to bedtime.

Storage

Store product in a cool, dry place, away from heat, moisture and sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GH Max by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GH Max label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GH Max by Universal

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
100 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

L-Arginine Alpha-Ketoglutarate

Interacts with
403 drugs
5 Gram(s) per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Alpha-Ketoglutarate monograph & interactions

L-Ornithine HCl

No known
interactions
2.5 Gram(s) per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

L-Ornithine HCl monograph & interactions

Vitamin B6

Interacts with
210 drugs
20 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Gamma Oryzanol

No known
interactions
50 mg per serving Form: Rice Bran

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The...

Gamma Oryzanol monograph & interactions

Phytosterols

100 mg per serving Form: Beta-Sitosterol

Carnitine

100 mg per serving Form: L-Carnitine Fumarate

Other (inactive) ingredients: Dicalcium Phosphate, Whey, Stearic Acid, Magnesium Stearate, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

GH Max by Universal Drug Interactions

Want to check YOUR meds against GH Max?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
479Drugs
466 Moderate 13 Minor

Ingredients driving the most interactions

L-Arginine Alpha-Ketoglutarate 403
Vitamin B6 210
L-Glutamine 50

Individual Drug Interactions

The ingredients in GH Max interact with 479 drugs. Click any drug to see the details.

3 of the 7 ingredients in GH Max interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Alpha-Ketoglutarate Vitamin B6 L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in GH Max with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine Alpha-Ketoglutarate9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Alpha-Ketoglutarate full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GH Max, from the product label.

Universal

See all Universal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.UniversalUSA.com
Pharmacist Counseling Corner

GH Max by Universal: Common Questions

Does GH Max by Universal interact with any medications?
Yes. Based on its ingredients, GH Max has a known interaction with 479 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GH Max contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Glutamine safe if I have kidney disease?
L-Glutamine is generally well tolerated, but people with kidney or liver disease should use it only under medical supervision. Talk to your doctor or pharmacist before starting this product if you have either condition.
Will this product help me build muscle or improve athletic performance?
L-Ornithine is possibly effective for athletic performance, but the evidence isn't strong. L-Glutamine and the other ingredients haven't been established as effective for athletic performance specifically. If that's your goal, you'd want to discuss realistic expectations with your pharmacist.
Can I take this while pregnant?
L-Glutamine is likely safe in pregnancy, but L-Ornithine, Gamma Oryzanol, and Carnitine don't have enough safety data — the product advises avoiding them unless your doctor recommends it. Talk to your doctor or pharmacist about whether GH Max is right for you.
What are the most common side effects from L-Glutamine?
The most common are belching, bloating, constipation, diarrhea, flatulence, nausea, headache, and cough. These tend to be mild and often go away on their own.
Is Vitamin B6 in this product safe if I'm taking high doses?
The amount of vitamin B6 in a typical supplement like this is generally safe, but avoid high doses (over 1,000 mg daily) long-term — they can damage nerves. Stick to your supplement's label dose unless your doctor says otherwise.
Why should I check my blood pressure medications before taking this?
L-Arginine Alpha-Ketoglutarate can lower blood pressure and raise potassium levels, which may add to the effect of your blood pressure medicine or potassium-sparing diuretics and increase the risk of low blood pressure or high potassium. Your pharmacist needs to see your exact medication to assess the risk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GH Max label
Go deeper

The Full Monographs Behind GH Max’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph →
Sources

Sources & How We Checked

GH Max's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 110 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
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Ornithine 1 reference
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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