Major interaction on record — check this product against your medications before combining. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

GH Stack Grape Flavor Ingredients & Drug Interactions

by Universal

GH Stack Grape Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GH Stack Grape Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

GH Stack Grape Flavor is a dietary supplement by Universal with 7 active ingredients. Its ingredients are commonly taken for sleep problems, low mood and depression, anxiety.Based on those ingredients, 552 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Tryptophan, Mucuna pruriens extract, Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GH Stack Grape Flavor by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with GH Stack Grape Flavor by Universal — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of GH Stack Grape Flavor by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Somatopro A(TM) Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

GH Stack contains 7 active ingredients formulated to support growth hormone pathways. The blend includes Glycine, L-Tryptophan, Glutamine, Arginine AKG, Ornithine Hydrochloride, Mucuna pruriens extract (a natural source of levodopa), and Lysine Hydrochloride — all amino acids or amino acid derivatives commonly used in athletic and wellness supplements.

The product comes as a grape-flavored powder and contains inactive ingredients including citric acid, aspartame, and food colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Athletic performance and muscle recovery support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Physical performance, Postoperative recovery, Wound healing — and 3 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.

The ingredients have varied evidence levels. Glutamine is rated Effective for sickle cell disease and Possibly Effective for HIV/AIDS-related wasting and recovery after surgery or critical illness.

Glycine is rated Possibly Effective for schizophrenia. Ornithine is Possibly Effective for athletic performance.

Lysine is Possibly Effective for cold sores. L-Tryptophan is rated Possibly Ineffective for depression — meaning the evidence suggests it doesn't work for that purpose.

For most other claimed uses in this product — such as anxiety, ADHD, insomnia, and growth support — the evidence we hold is rated Insufficient Reliable Evidence To Rate, meaning the science isn't established enough to say whether they work.

The evidence, ingredient by ingredient L-tryptophan Cowhage Glycine Glutamine Ornithine Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Rare side effects include mild sedation, irritability, insomnia, fatigue, memory problems, headache, soft stools, nausea, vomiting, and gastrointestinal discomfort — most resolve quickly if you stop.

L-Tryptophan is generally well tolerated but has a serious history: in 1989, a contaminated batch from a single Japanese manufacturer caused over 1,500 cases of eosinophilia-myalgia syndrome (EMS), a neurological disorder. About 95% of those cases came from that one source, and L-tryptophan was recalled and restricted.

Modern products are considered safer, but you should know this history. Glutamine is well tolerated in healthy adults but should be used under medical supervision if you have kidney or liver disease; possible side effects include bloating, diarrhea, constipation, headache, and nausea.

Ornithine is generally well tolerated short-term, but long-term safety isn't well studied. Lysine is generally well tolerated at typical doses; high doses may cause stomach upset, diarrhea, and abdominal pain.

Mucuna pruriens extract contains levodopa and should be used only with professional guidance because of its drug-like effects.

Side effects, ingredient by ingredient L-tryptophan Cowhage Glycine Glutamine Ornithine Lysine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Lysine, L-tryptophan, Glutamine, Cowhage, Glycine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications; diabetes medications; Parkinson's medications.
  • For scale: 552 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GH Stack, check whether you use blood pressure medications (especially methyldopa or guanethidine), monoamine oxidase inhibitors (MAOIs), levodopa for Parkinson's, CNS depressants like sedatives or opioids, antidepressants (especially SSRIs or SNRIs), antipsychotics like clozapine, anticonvulsants (seizure drugs), antidiabetes medications, tricyclic antidepressants, anesthesia agents, or 5-HT4 agonists. These drug types carry Major or Moderate interactions with one or more ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

GH Stack is a multi-ingredient amino acid supplement best suited for people interested in athletic performance or recovery support who have no relevant medications. If you take any blood pressure medications, antidepressants, seizure medications, diabetes drugs, antipsychotics, or anesthetics, you should check your specific prescriptions with us before starting.

Talk to your pharmacist or doctor before adding this product to your routine — the ingredient list is complex and the interaction profile is significant.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GH Stack Grape Flavor, straight from the product label.

Brand Universal
Barcode (UPC) 039442051905
Net contents 210 Gram(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 37744
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GH Stack Grape Flavor by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Teaspoon(s), 10 Gram(s)
Maximum serving Sizes:
2 Teaspoon(s), 10 Gram(s)
Servings per container
21
UPC/BARCODE
039442051905
IngredientAmount% DV
Glycine1.1 Gram(s)--
L-Tryptophan250 mg--
Glutamine1 Gram(s)--
Arginine AKG1.2 Gram(s)--
Ornithine Hydrochloride3 Gram(s)--
Mucuna pruriens extract250 mg--
Lysine Hydrochloride1.2 Gram(s)--
Somatopro A(TM) Complex0 NP--

Other ingredients: L-Ornithine Hydrochloride, L-Arginine Alpha-Ketoglutarate, L-Lysine Hydrochloride, L-Glycine, L-Glutamine, Citric Acid, natural Grape flavor, Aspartame, Red #40, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

WARNING: This product is not for use by anyone under the age of 18.

Do not take this if you have or are at risk for any medical condition or disease.

Please consult with a physician before using this product, especially if you are using any prescription drug, over-the-counter medication, or supplements.

Immediately discontinue use if any side effects occur. California Residents Proposition 65 Warning: This product contains a substance known to the State of California to cause birth defects or other reproductive harm.

Keep out of reach of children.

INGREDIENT NOTES: Phenylketonurics: contains phenylalanine.

Brand IP Statement(s)

DOSAGE: Mix 2 teaspoons with 8 ounces of your beverage of choice. Swish GH Stack in your mouth for thirty seconds before swallowing. Avoid take this product with foods that are high in fat or high glycemic index carbs. As GH levels peak during deep sleep and in response to intense exercise, to maintain high levels throughout the day, take GH Stack in the morning or afternoon for optimum results.

(C)2014UniversalNutrition

General Statements

Athlete's should consult with their sanctioning authority before use. Do not exceed recommended dose.

Plant #3001104580

MADE PROUDLY IN THE U.S.A.

732-545-3130

WHO WE ARE Universal Nutrition has been providing cutting edge and staple nutritional supplements to bodybuilders and hard training athletes the world over since 1977. As time passes, certain ideals never go out of style. Honesty. Integrity. Respect. These are the values we uphold and are the bedrock upon which we built our business. WHAT IT IS GH Stack provides natural GH support by helping to signal your pituitary gland to release more GH through a unique, "dual action" sub-lingual/oral delivery system which ensures that GH output is maximized. As a sub-lingual, rapid assimilation of GH Stack is ensured. As an oral supplement, GH Stack continues to work in a "time released" fashion to guarantee steady output of GH. It is powerful as it has been specifically formulated for the needs of the elite athlete. HOW WE BACK IT UP What is on the label is on the bottle and what is in the bottle will help you reach your goals. We believe it and proudly stand behind every product we manufacture. Our word is our bond.

The First Sub-Lingual Anabolic GH Formula

Dual Action Secretagogues

Scientifically-Proven Ratios

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

GH Support Supplement

General

K1313-G-32489

Formula

INGREDIENT NOTES: Phenylketonurics: contains phenylalanine.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GH Stack Grape Flavor by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GH Stack Grape Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GH Stack Grape Flavor by Universal

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Teaspoon(s) Dosage formPowder Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Tryptophan

Interacts with
394 drugs
250 mg per serving

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for...

L-Tryptophan monograph & interactions

Mucuna pruriens extract

Interacts with
193 drugs
250 mg per serving Form: L-Dopa

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna pruriens extract monograph & interactions

Somatopro A(TM) Complex

0 NP per serving

Other (inactive) ingredients: L-Ornithine Hydrochloride, L-Arginine Alpha-Ketoglutarate, L-Lysine Hydrochloride, L-Glycine, L-Glutamine, Citric Acid, Natural Grape flavor, Aspartame, Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

GH Stack Grape Flavor by Universal Drug Interactions

Want to check YOUR meds against GH Stack Grape Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
552Drugs
264 Major 288 Moderate

Ingredients driving the most interactions

L-Tryptophan 394
Mucuna pruriens extract 193
Glutamine 50
Glycine 1
Lysine Hydrochloride 1

Individual Drug Interactions

The ingredients in GH Stack Grape Flavor interact with 552 drugs. Click any drug to see the details.

5 of the 7 ingredients in GH Stack Grape Flavor interact with drugs. Each result below shows which ingredient is responsible. L-Tryptophan Mucuna pruriens extract Glutamine Glycine Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in GH Stack Grape Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions

Mucuna pruriens extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna pruriens extract full monograph & interactions

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions

Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GH Stack Grape Flavor, from the product label.

Universal

See all Universal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.UniversalUSA.com
Pharmacist Counseling Corner

GH Stack Grape Flavor by Universal: Common Questions

Does GH Stack Grape Flavor by Universal interact with any medications?
Yes. Based on its ingredients, GH Stack Grape Flavor has a known interaction with 552 medications, including 264 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GH Stack Grape Flavor contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is GH Stack safe to take if I'm pregnant?
The facts on file advise against L-Tryptophan and Ornithine during pregnancy due to insufficient safety data. Glutamine is rated Likely Safe. Glycine and Lysine have limited data, so there isn't enough information to know either way. You should talk with your doctor or pharmacist before taking this product while pregnant — they can give you personalized advice based on your health.
Can I take this while breastfeeding?
L-Tryptophan and Ornithine should be avoided while breastfeeding. Mucuna pruriens extract contains levodopa, which can lower prolactin levels and reduce milk supply, so it should also be avoided. Glycine and Lysine have insufficient data. Only Glutamine is rated Likely Safe. Talk with your pharmacist or doctor before using this product if you're nursing.
What is Mucuna pruriens extract and why is it in this product?
Mucuna pruriens, also called cowhage, is a plant extract that naturally contains levodopa, a compound used to treat Parkinson's disease. It's included in this product for its amino acid and growth-hormone support properties, but because it's a drug-like ingredient, it carries several serious medication interactions you need to check before using.
Does this product actually help with athletic performance?
Ornithine in this blend is rated Possibly Effective for athletic performance. The other ingredients don't have established effectiveness for that purpose in our data — most are rated Insufficient Reliable Evidence To Rate, meaning the science isn't settled on whether they work for muscle growth or recovery.
Will this help with anxiety or depression?
The evidence doesn't support it. L-Tryptophan is rated Possibly Ineffective for depression. For anxiety and other mental health uses, the evidence we hold is Insufficient Reliable Evidence To Rate. If you're dealing with depression or anxiety, talk with your doctor about proven treatments rather than relying on this supplement.
What are the common side effects?
Glycine may rarely cause mild sedation, irritability, insomnia, or gastrointestinal upset. L-Tryptophan can cause drowsiness, diarrhea, nausea, headache, and lightheadedness. Glutamine commonly causes bloating, diarrhea, or nausea at higher doses. Lysine may cause abdominal pain, diarrhea, or stomach discomfort. Most side effects are mild and resolve if you stop taking the product. If you experience anything unusual, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if GH Stack Grape Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GH Stack Grape Flavor label
Go deeper

The Full Monographs Behind GH Stack Grape Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Sources

Sources & How We Checked

GH Stack Grape Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 54 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

L-tryptophan 18 references
  1. Messiha FS. Fluoxetine: adverse effects and drug-drug interactions. J Toxicol Clin Toxicol 1993;31:603-30. PubMed
  2. Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
  3. Lieberman HR, Corkin S, Spring BJ. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 1985;42:366-70. PubMed
  4. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  5. Sullivan EA, Kamb ML, Jones JL, et al. The natural history of eosinophilia-myalgia syndrome in a tryptophan-exposed cohort in South Carolina. Arch Intern Med 1996;156:973-9. DOI
  6. Philen RM, Hill RH, Flanders WD, et al. Tryptophan contaminants associated with eosinophilia-myalgia syndrome. Am J Epidemiol 1993;138:154-9. PubMed
  7. Bohme A, Wolter M, Hoelzer D. L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. Ann Hematol 1998;77:235-8. PubMed
  8. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  9. Priori R, Conti F, Luan FL, et al. Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents. Eur J Pediatr 1994;153:344-6..
  10. Klein R, Berg PA. A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome. Clin Investig 1994;72:541-9.. PubMed
  11. Simat TJ, Kleeberg KK, Muller B, Sierts A. Synthesis, formation, and occurrence of contaminants in biotechnologically manufactured L-tryptophan. Adv Exp Med Biol 1999;467:469-80.. PubMed
  12. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev 2002;(1):CD003198. PubMed
  13. Kilbourne EM, Philen RM, Kamb ML, Falk H. Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:81-8.
  14. Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
  15. Shapiro S. Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. J Rheumatol Suppl 1996;46:44-58.
  16. Mayeno AN, Gleich GJ. The eosinophilia-myalgia syndrome: lessons from Germany. Mayo Clin Proc 1994;69:702-4. PubMed
  17. Carr L, Ruther E, Berg PA, Lehnert H. Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. Mayo Clin Proc 1994;69:620-5. PubMed
  18. Ullrich SS, Fitzgerald PCE, Giesbertz P, Steinert RE, Horowitz M, Feinle-Bisset C. Effects of intragastric administration of tryptophan on the blood glucose response to a nutrient drink and energy intake, in lean and obese men. Nutrients 2018;10(4). pii: PubMed

See these in context on the L-tryptophan monograph →

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
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  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Cowhage 12 references
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  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
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  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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