Hawthorn Berry 600 mg Ingredients & Drug Interactions
by Christopher's Original Formulas
What is this page for?
First and foremost: checking Hawthorn Berry 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Hawthorn Berry 600 mg is a dietary supplement by Christopher's Original Formulas with 1 active ingredient. Its ingredients are commonly taken for heart failure symptoms, high blood pressure, chest pain (angina).Based on those ingredients, 191 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Hawthorn. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Hawthorn Berry 600 mg by Christopher's Original Formulas
Ask about any prescription or over-the-counter medication and we check it for interactions with Hawthorn Berry 600 mg by Christopher's Original Formulas — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Hawthorn Berry 600 mg by Christopher's Original Formulas
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: hawthorn berry at 600 mg per capsule. Hawthorn is a plant extract traditionally used in heart and circulatory health support.
The capsule itself is plant-derived.
Does it work?
Couldn't assess
The evidence we hold rates hawthorn as having insufficient reliable data for angina, anxiety, arrhythmia, atherosclerosis, cardiovascular disease, and cognitive function. That means the studies available don't yet establish whether it works for these uses.
If you're considering hawthorn for a heart or circulation concern, talk with your doctor about whether the evidence supports it for your specific situation.
How safe is it?
Well-documented data
Hawthorn is generally well tolerated in studies, but because it affects the heart and blood vessels, any use needs medical supervision — especially if you have a heart condition. The safety data advises against use during pregnancy and while breastfeeding.
Serious adverse effects are rare. The main side effects reported in studies and case reports are palpitations, a rapid heartbeat (tachycardia), and shortness of breath (bronchitis or slow breathing).
Very rarely, multiorgan hypersensitivity reactions with acute kidney damage have occurred. In large trials of patients with heart failure, a small number reported palpitations or circulation problems, though the relationship to hawthorn wasn't always clear.
Meds to double-check
Major interaction found
Before taking this product, double-check with your doctor or pharmacist if you take nitrates (nitroglycerin, isosorbide), phosphodiesterase-5 inhibitors (sildenafil, tadalafil), beta-blockers, blood thinners, calcium channel blockers, or digoxin. These carry Major or Moderate interaction risks with hawthorn.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Hawthorn may appeal to you if you're interested in traditional heart-health support, but the evidence we hold doesn't yet establish that it works for specific conditions. More importantly, it interacts with common heart and blood pressure medications in ways that require medical oversight.
If you take any heart medication, blood thinner, or blood pressure drug, check with your doctor or pharmacist before starting — hawthorn isn't right for everyone.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Hawthorn Berry 600 mg, straight from the product label.
| Brand | Christopher's Original Formulas |
|---|---|
| Barcode (UPC) | 084783867449 |
| Net contents | 100 Vegetarian Cap(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2019 |
| DSLD ID | 200303 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Hawthorn Berry 600 mg by Christopher's Original Formulas, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 2 capsules up to 3 times a day with a glass of water.
Storage
Store in a cool dry place.
Brand IP Statement(s)
2010 Wholistic Botanicals L.L.C. All Rights Reserved
John R. Christopher
FDA Statement of Identity
Dietary Supplement
Formula
Hawthorn Berry 600 mg each
Formulation
No Fillers or Chemicals.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Hawthorn Berry 600 mg by Christopher's Original Formulas label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Hawthorn Berry 600 mg by Christopher's Original Formulas
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Hawthorn
Interacts with191 drugs
Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when...
Hawthorn monograph & interactionsOther (inactive) ingredients: Plant-derived Capsule. These complete the product’s ingredient list but are not active constituents.
Hawthorn Berry 600 mg by Christopher's Original Formulas Drug Interactions
HelloPharmacist Interaction Report
Hawthorn Berry 600 mg by Christopher's Original Formulas interacts with several medication types, with the most serious concerns involving nitrates and phosphodiesterase-5 inhibitors (PDE-5 inhibitors — drugs like sildenafil for erectile dysfunction).
Both are Major-severity interactions: hawthorn may add to the blood vessel-relaxing effects of these drugs, potentially causing a dangerous drop in blood pressure.
Read the full breakdown — every affected drug type, severity by severity
Hawthorn also carries Moderate-severity interactions with beta-blockers, blood thinners (anticoagulants and antiplatelet drugs), and calcium channel blockers — all can have additive effects on blood pressure and heart rate, or in the case of blood thinners, may raise bleeding risk. Additionally, hawthorn may strengthen the effects of digoxin (Lanoxin), a heart medication, which can be problematic at higher doses.
Altogether, these interactions span 191 individual medications. Because hawthorn affects the heart and blood vessels, and because heart conditions require medical supervision anyway, it's especially important to check your exact medications with your doctor or pharmacist before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Hawthorn Berry 600 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Hawthorn Berry 600 mg interact with 191 drugs. Click any drug to see the details.
1 of the 1 ingredient in Hawthorn Berry 600 mg interact with drugs. Each result below shows which ingredient is responsible. Hawthorn
AvanafilStendra
How Avanafil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Avanafil interactionFinasteride, TadalafilEntadfi
How Finasteride, Tadalafil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Finasteride, Tadalafil interactionGlyceryl TrinitrateNitronal
How Glyceryl Trinitrate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Glyceryl Trinitrate interactionIsosorbide DinitrateAngitak, Cedocard Retard, Isoket, Isoket Retard, Isordil
How Isosorbide Dinitrate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Isosorbide Dinitrate interactionIsosorbide Dinitrate, HydralazineBiDil
How Isosorbide Dinitrate, Hydralazine interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Isosorbide Dinitrate, Hydralazine interactionIsosorbide MononitrateAngeze, Angeze SR, Chemydur 60XL, Dynamin, Elantan, Elantan LA +13 more
How Isosorbide Mononitrate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Isosorbide Mononitrate interactionMacitentan, TadalafilOpsynvi
How Macitentan, Tadalafil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Macitentan, Tadalafil interactionNicorandilAprior, Dancor, Ikorel, Sigmart, Zynicor
How Nicorandil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Nicorandil interactionNitroglycerinGonitro, Nitro Time, Nitro-Bid, Nitrocine Timecaps, Nitrogard, Nitrogard SR +7 more
How Nitroglycerin interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Nitroglycerin interactionPentaerythritol TetranitratePeritrate, Peritrate SA
How Pentaerythritol Tetranitrate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorn + Pentaerythritol Tetranitrate interactionSildenafilRevatio
How Sildenafil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Sildenafil interactionSildenafil CitrateViagra
How Sildenafil Citrate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Sildenafil Citrate interactionTadalafilCialis, Tadliq
How Tadalafil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Tadalafil interactionVardenafilLevitra, Staxyn
How Vardenafil interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorn + Vardenafil interactionAbciximabReoPro
How Abciximab interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Abrocitinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornBeta-blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Read the full Hawthorn + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorn + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmlodipineNorliqva
How Amlodipine interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornCalcium Channel Blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Read the full Hawthorn + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornCalcium Channel Blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Read the full Hawthorn + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornCalcium Channel Blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Read the full Hawthorn + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornCalcium Channel Blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Read the full Hawthorn + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Hawthorn Berry 600 mg — through 1 ingredient. Tap an ingredient for the detail:
HawthornCalcium Channel Blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Read the full Hawthorn + Amlodipine Besylate, Benazepril interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Hawthorn Berry 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Hawthorn
Nitrates
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.
Phosphodiesterase-5 Inhibitors
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Hawthorn might inhibit PDE-5 and cause vasodilation.
Anticoagulant/Antiplatelet Drugs
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that hawthorn can inhibit platelet aggregation. However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract. However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans.
Beta-Blockers
Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Some evidence shows that hawthorn might lower blood pressure and heart rate.
Calcium Channel Blockers
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.
Digoxin (Lanoxin)
Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
Hawthorn appears to improve cardiac output; however, hawthorn does not appear to affect digoxin pharmacokinetics. Case reports suggest that at least one species of hawthorn root extract (Crataegus mexicana) may produce adverse effects similar to digoxin and can cross-react with digoxin assays, leading to falsely elevated plasma digoxin levels.
Brand information
Manufacturer and brand details for Hawthorn Berry 600 mg, from the product label.
Christopher's Original Formulas
See all Christopher's Original Formulas products- Name
- Wholistic Botanicals L.L.C.
- City
- Spanish Fork
- State
- UT
- ZipCode
- 84660
- Phone Number
- 1-800-453-1406
- Web Address
- www.drchristopher.com
Hawthorn Berry 600 mg by Christopher's Original Formulas: Common Questions
Does Hawthorn Berry 600 mg by Christopher's Original Formulas interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take hawthorn if I'm pregnant or breastfeeding?
Does hawthorn actually help with heart problems?
What are the most common side effects?
Why does hawthorn interact with so many heart medications?
Can I take hawthorn with my blood pressure medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Hawthorn Berry 600 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Hawthorn Berry 600 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Hawthorn Berry 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hawthorn 25 references
- Tauchert M. Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure. Am Heart J 2002;143:910-5. PubMed
- Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am J Med 2003;114:665-74.. PubMed
- Chang Q, Zuo Z, Harrison F, Chow MS. Hawthorn. J Clin Pharmacol 2002;42:605-12.
- Holubarsch CJ, Colucci WS, Meinertz T, et al. The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial. Eur J Heart Fail 2008;10:1255-63. PubMed
- Pittler MH, Guo R, and Ernst E. Hawthorn extract for treating chronic heart failure. Cochrane.Database.Syst Rev 2008:CD005312. PubMed
- Zick SM, Vautaw BM, Gillespie B, Aaronson KD. Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Eur J Heart Fail. 2009;11:990-99. PubMed
- Werner NS, Duschek S, and Schandry R. D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study. Phytomedicine. 2009;16:1077-82. PubMed
- Dalli E, Colomer E, Tormos MC, et al. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial. Phytomedicine. 6-15-2011;18:769-75. PubMed
- Maek-a-nantawat W, Phonrat B, Dhitavat J, et al. Safety and efficacy of CKBM-A01, a Chinese herbal medicine, among asymptomatic HIV patients. Southeast Asian J Trop.Med Public Health 2009;40:494-501.
- Asher GN, Viera AJ, Weaver MA, et al. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. BMC.Complement Altern.Med 2012;12:26. PubMed
- Walker AF, Marakis G, Simpson E, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen.Pract 2006;56:437-43.
- Daniele C, Mazzanti G, Pittler MH, et al. Adverse-event profile of Crataegus spp.: a systematic review. Drug Saf 2006;29:523-35. PubMed
- Tankanow R, Tamer HR, Streetman DS, et al. Interaction study between digoxin and a preparation of hawthorn (Crataegus oxyacantha). J.Clin.Pharmacol. 2003;43:637-42. DOI
- Tauchert, M., Gildor, A., and Lipinski, J. [High-dose Crataegus extract WS 1442 in the treatment of NYHA stage II heart failure]. Herz 1999;24(6):465-474.
- Horoz, M., Gok, E., Genctoy, G., Ozcan, T., Olmaz, R., Akca, M., Kiykim, A., and Gurses, I. Crataegus orientalis associated multiorgan hypersensitivity reaction and acute renal failure. Intern.Med 2008;47(23):2039-2042. PubMed
- Dalli, E., Valles, J., Cosin-Sales, J., Santos, M. T., Moscardo, A., Milara, J., and Sotillo, J. F. Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. Thromb.Res 2011;128(4):398-400. PubMed
- Rogov VD. [Toxiderma due to the fruits of the hawthorn]. Vestn Dermatol Venerol 1984;7(7):46-47.
- Loew D, Albrecht M, and Podzuweit H. Efficacy and tolerability of a Hawthorn preparation in patients with heart failure Stage I and II according to NYHA - a surveillance study. Phytomedicine 1996;3(Suppl 1):92.
- Rababa'h AM, Altarabsheh SE, Haddad O, Deo SV, Obeidat Y, Al-Azzam S. Hawthorn Herb Increases the Risk of Bleeding after Cardiac Surgery: An Evidence-Based Approach. Heart Surg Forum 2016;19(4):E175-9. PubMed
- Shatoor AS, Soliman H, Al-Hashem F, Gamal BE, Othman A, El-Menshaw N. Effect of hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino wistar rats. Thromb Res 2012;130(1):75-80. PubMed
- Vibes J, Lasserre B, Gleye J, Declume C. Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (hawthorn) flower heads. Prostaglandins Leukot Essent Fatty Acids 1994;50(4):173-5. PubMed
- Rogers KL, Grice ID, Griffiths LR. Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments. Eur J Pharm Sci 2000;9(4):355-63. PubMed
- Zhou CC, Huang XX, Gao PY, et al. Two new compounds from Crataegus pinnatifida and their antithrombotic activities. J Asian Nat Prod Res 2014;16(2):169-74.
- Palmer KG, Lebin JA, Cronin MT, Mazor SS, Burns RA. Crataegus mexicana (Tejocote) Exposure Associated with Cardiotoxicity and a Falsely Elevated Digoxin Level. J Med Toxicol. 2019;15(4):295-298. PubMed
- Espinosa J, Bassett R, Lucerna A, Finn D. Hawthorne root (Crataegus mexicana) toxicity. Am J Emerg Med. 2024;78:242.e5-242.e6. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC