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Dietary supplement

Healthy Trinity Ingredients & Drug Interactions

by Natren

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Healthy Trinity is a dietary supplement by Natren with 3 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum Malyoth, Lactobacillus delbrueckii bulgaricus LB-51, Lactobacillus acidophilus NAS. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Healthy Trinity by Natren

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

Healthy Trinity contains 3 active ingredients: three strains of beneficial bacteria. Bifidobacterium bifidum and Lactobacillus acidophilus are both strains that may help with irritable bowel syndrome and other digestive or immune concerns.

Lactobacillus delbrueckii is included for its probiotic support, though evidence for specific uses is less established in our data. The capsules also contain inactive ingredients (sunflower oil, gelatin, and mixed tocopherols) that help deliver and preserve the live cultures.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and probiotic balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence we hold varies by ingredient and use. Bifidobacterium bifidum and Lactobacillus acidophilus are both rated Possibly Effective for irritable bowel syndrome.

Lactobacillus acidophilus is also rated Possibly Effective for antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. For Lactobacillus delbrueckii, the conditions listed in our data show Insufficient Reliable Evidence To Rate — meaning we don't have enough studies to confirm it works for those purposes.

Overall, the strongest evidence in this product backs its use for IBS and antibiotic-related digestive issues.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three probiotic strains are generally well tolerated in healthy people. However, those with weakened immune systems should use caution and check with their doctor first.

Gastrointestinal side effects — bloating, flatulence, abdominal discomfort, and diarrhea — are uncommon but possible, especially when taking multiple probiotics together. Very rare cases of infection have been reported with probiotic use in critically ill patients, though these are not specific to the strains in this product.

Pregnancy safety is rated Possibly Safe for Bifidobacterium bifidum and Lactobacillus acidophilus, though you should confirm with your doctor before use during pregnancy.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum, Lactobacillus Delbrueckii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check your specific medications with the tool on this page before starting Healthy Trinity. Taking antibiotics and this product at the same time can reduce how well the probiotics work — timing them several hours apart usually helps.

No other medication types are documented to interact with these ingredients in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Healthy Trinity is a three-strain probiotic that may help with irritable bowel syndrome and antibiotic-related diarrhea, and it's generally well tolerated. If you're taking antibiotics, you'll want to separate the timing of your doses to protect the live cultures.

Talk with your doctor or pharmacist before starting this product, especially if you have a weakened immune system, are pregnant, or take other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Healthy Trinity, straight from the product label.

Brand Natren
Barcode (UPC) 052557600301
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307086
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Children (All), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Healthy Trinity by Natren, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
052557600301
IngredientAmount% DV
Total Fat0 NP1%
Bifidobacterium bifidum Malyoth0 NP--
Lactobacillus delbrueckii bulgaricus LB-510 NP--
Lactobacillus acidophilus NAS0 NP--

Other ingredients: Sunflower Oil, Gelatin, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Potency Guarantee: each capsule supplies live, active beneficial probiotic bacteria of a minimum of 5 billion cfu of L. acidophilus NAS super strain, 20 billion B. bifidum Malyoth super strain and 5 billion L. bulgaricus LB-51 super strain guaranteed through expiration date, if kept dry and refrigerated.

The Trenev Process unique oil matrix delivery system keeps beneficial bacteria super strains separate and noncompetitive while optimizing survival through low-pH, corrosive stomach acid. Bile resistance is an added feature to ensure 100% survival into the small intestine. This proprietary technology is available only with Natren products.

Viable super strain beneficial bacteria L. acidophilus NAS, B. bifidum Malyoth, and L. bulgaricus LB-51 to optimize digestion, support absorption and regularity

Suggested/Recommended/Usage/Directions

Suggested Use: take one capsule daily with unchilled, filtered (chlorine-free) water, preferably with meals to optimize digestion. Take Healthy Trinity at least 2 hours apart from herbs, garlic and prescription drugs for optimal results.

Precautions

The Healthy Start System (powder formula) is recommended for children under 8 years of age and for those choose not to swallow capsules.

Do not accept if seal is broken.

General Statements

For more information, please call for a complimentary brochure.

Storage

Do not freeze or expose to moisture, heat or direct sunlight. Keep refrigerated and dry to maintain potency guarantee.

Seals/Symbols

IGEN Non-GMO tested

Formulation

IGEN Non-GMO tested This product does not contain common GE genes or proteins. Visit igenprogram.com

Dairy free Gluten free

Works throughout the digestive system 3 in 1 Healthy trinity probiotic system Researched, formulated and manufactured by Natren

Guaranteed 100% Potency through expiration date

Probiotic capsules Researched, formulated and manufactured by Natren

Gluten free Dairy free Soy free No FOS

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Natren The Probiotic Specialist Recognized Worldwide since 1982

Copyright 2022

FDA Statement of Identity

Probiotic Dietary Supplement

See for yourself

Healthy Trinity by Natren label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Healthy Trinity by Natren

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bifidobacterium bifidum Malyoth

Interacts with
182 drugs
0 NP per serving

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance....

Bifidobacterium bifidum Malyoth monograph & interactions
0 NP per serving

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is g...

Lactobacillus delbrueckii bulgaricus LB-51 monograph & interactions

Lactobacillus acidophilus NAS

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus NAS monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Healthy Trinity by Natren Drug Interactions

Want to check YOUR meds against Healthy Trinity?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Each ingredient & the kinds of drugs it affects

For each ingredient in Healthy Trinity with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum Malyoth1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D

Lactobacillus delbrueckii bulgaricus LB-511 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D

Lactobacillus acidophilus NAS1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Healthy Trinity, from the product label.

Natren

See all Natren products
Name
Natren Inc
City
Westlake Village
State
CA
ZipCode
91361
Phone Number
800-992-3323
Web Address
www.natren.com
Pharmacist Counseling Corner

Healthy Trinity by Natren: Common Questions

Does Healthy Trinity by Natren interact with any medications?
Yes. Based on its ingredients, Healthy Trinity has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Healthy Trinity contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on an antibiotic?
Yes, but timing matters. Antibiotics can kill the live bacteria in this product and reduce its effectiveness. Separate your antibiotic dose and your probiotic dose by a few hours — your doctor or pharmacist can advise on the best schedule for your specific antibiotic.
Will this help with my IBS?
Bifidobacterium bifidum and Lactobacillus acidophilus in this product are both rated Possibly Effective for irritable bowel syndrome in our data. That means there's some evidence they may help, but results vary by person — talk it over with your doctor to see if it's right for your situation.
What are the main side effects?
Bloating, flatulence, and abdominal discomfort are uncommon but possible, especially with multiple probiotics together. One case of vomiting and fever was reported in a child, though it's unclear if the probiotics caused it. Most people tolerate these strains well.
Is this safe during pregnancy?
Bifidobacterium bifidum and Lactobacillus acidophilus are rated Possibly Safe in pregnancy, though data are limited. Check with your doctor or pharmacist before taking it during pregnancy to make sure it's the right choice for you.
What does each strain do?
Bifidobacterium bifidum and Lactobacillus acidophilus both have evidence they may help with irritable bowel syndrome. Lactobacillus acidophilus also may help with antibiotic-related diarrhea and bacterial vaginosis. Lactobacillus delbrueckii is included for general probiotic support, though specific evidence for its uses is limited in our data.
Is this safe if I have a weak immune system?
People with weakened immune systems should be cautious with live probiotics and check with their doctor first. While infection is rare, it's been reported in critically ill patients, so personalized medical guidance is important before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Healthy Trinity is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Healthy Trinity label
Sources

Sources & How We Checked

Healthy Trinity's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Delbrueckii 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
  9. Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.

See these in context on the Lactobacillus Delbrueckii monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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