Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Immune Support Ingredients & Drug Interactions

by Theramedix BioSET

Immune Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Immune Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Immune Support is a dietary supplement by Theramedix BioSET with 6 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase, Protease Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Immune Support by Theramedix BioSET

Ask about any prescription or over-the-counter medication and we check it for interactions with Immune Support by Theramedix BioSET — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Immune Support by Theramedix BioSET

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Immune Support contains six active ingredients. Two forms of nattokinase (an enzyme derived from fermented soy) make up the primary active components, alongside a Proprietary Enzyme Blend and Protease Blend for additional enzyme support.

You'll also find Superoxide Dismutase, an enzyme with antioxidant properties, and Trace Mineral Powder to round out the formula. The capsule itself is made from delayed-release vegetable material, designed to release the contents in your lower digestive tract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Immune support via protein breakdown.
  • We looked for evidence on: Chronic fatigue syndrome (CFS), immune function, digestive support, protein digestion.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).

The evidence we hold for nattokinase—the main active ingredient in this product—doesn't establish it as reliably effective for any specific condition. The data rates it as having insufficient reliable evidence for angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome.

We don't have effectiveness ratings for the other ingredients in this formula, so we can't comment on what they may or may not do.

The evidence, ingredient by ingredient Papain Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated short-term, but because it thins the blood, it's something to be cautious about if you have bleeding issues or are at risk for them. Rare reports exist of serious bleeding, including brain bleeding, especially when nattokinase is combined with blood thinners or antiplatelet drugs.

Some people can also have hypersensitivity reactions to nattokinase or related compounds in fermented soy products—symptoms like throat swelling can occur within two hours of taking it. The safety data advises against nattokinase in pregnancy and while breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Papain Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Papain, Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product against blood thinners and antiplatelet medications (such as warfarin, apixaban, clopidogrel, or aspirin) before you start—nattokinase may increase bleeding risk. Also review any blood pressure medications you're on, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, antiplatelet drugs, or blood pressure medications, check with your pharmacist or doctor before starting this product—nattokinase may not be compatible with your regimen. The evidence for what this product actually does is thin.

Talk to us before you use it, especially if you have a bleeding disorder or are pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune Support, straight from the product label.

Brand Theramedix BioSET
Barcode (UPC) 738676954050
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247618
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune Support by Theramedix BioSET, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
738676954050
IngredientAmount% DV
Superoxide Dismutase40 IU--
Proprietary Enzyme Blend0 NP--
Trace Mineral Powder40 mg--
Protease Blend0 NP--
Nattokinase0 NP--
Serratiopeptidase0 NP--
Nattokinase NSK-SD0 NP--

Other ingredients: delayed release vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Immune Support breaks down undigested protein and in turn supports immune health.

Absolutely no fillers added

Professional strength formula

Boosts immune health

Vegetarian

Optimizing enzyme potential

Suggested/Recommended/Usage/Directions

Recommended usage: Take 1 capsule 2 times daily on an empty stomach. (1/2 hour before or 2 hours after a meal)

Formula

Exclusive Thera-Blend formulation Thera-Blend is our exclusive process for formulating enzyme blends. These blends are formulated using multiple enzyme forms selected for their ability to break down numerous bonds in varying pH levels.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children

Storage

Store tightly closed in a cool, dry place.

Do not expose to excessive heat.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Immune Support by Theramedix BioSET label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Immune Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Immune Support by Theramedix BioSET

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Enzyme Blend

0 NP per serving

Trace Mineral Powder

40 mg per serving

Other (inactive) ingredients: Delayed release vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune Support by Theramedix BioSET Drug Interactions

Want to check YOUR meds against Immune Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289
Protease Blend 2

Individual Drug Interactions

The ingredients in Immune Support interact with 289 drugs. Click any drug to see the details.

2 of the 6 ingredients in Immune Support interact with drugs. Each result below shows which ingredient is responsible. Nattokinase Protease Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions

Protease Blend1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Protease Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Immune Support, from the product label.

Theramedix BioSET

See all Theramedix BioSET products
Name
Theramedix BioSET
Street Address
1728 Corporate Drive
City
Boynton Beach
State
FL
ZipCode
33426
Phone Number
877-246-7381
Web Address
www.bioset.net
Pharmacist Counseling Corner

Immune Support by Theramedix BioSET: Common Questions

Does Immune Support by Theramedix BioSET interact with any medications?
Yes. Based on its ingredients, Immune Support has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune Support contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with aspirin or other blood thinners?
No, not without talking to your pharmacist first. Nattokinase has its own blood-thinning effects, and combining it with aspirin, warfarin, or other anticoagulants or antiplatelets raises your bleeding risk. There's even a case report of someone who had brain bleeding after adding nattokinase to aspirin therapy.
Is this safe if I'm pregnant or breastfeeding?
No. The safety data advises against nattokinase during pregnancy because there isn't enough data, and the same goes for breastfeeding. If you're in either situation, talk with your doctor or pharmacist about whether this product is right for you.
Can this product cause allergic reactions?
Yes, if you're sensitive to natto (fermented soy), you can have a hypersensitivity reaction to nattokinase. Symptoms like throat swelling can show up within two hours of taking it. In rare cases, people have had anaphylaxis. If you've had reactions to fermented soy products before, avoid this.
What does nattokinase actually do?
We don't have reliable evidence that it works for any specific condition. The data rates it as having insufficient evidence for cardiovascular disease, chronic fatigue, angina, atherosclerosis, and cancer. It does appear to have blood-thinning properties, which is why it interacts with medications—but whether that translates into a health benefit for you isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune Support label
Go deeper

The Full Monographs Behind Immune Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Immune Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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