Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Joint Complex (Single Dose) Ingredients & Drug Interactions

by Pure Encapsulations

Joint Complex (Single Dose) label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Joint Complex (Single Dose) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Joint Complex (Single Dose) is a dietary supplement by Pure Encapsulations with 5 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 5-LOXIN. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Joint Complex (Single Dose) by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Joint Complex (Single Dose) by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Joint Complex (Single Dose) by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “UC-II Standardized Cartilage” is listed as a grouped ingredient — the label gives one combined amount (40 mg) without saying how much of each component you get.

This supplement has 5 active ingredients. Hyaluronic acid and Total Collagen are structural components meant to support joint tissue.

Methylsulfonylmethane is included as a source of sulfur. 5-LOXIN is a standardized extract from Boswellia serrata, a resin used in traditional medicine.

UC-II Standardized Cartilage is a collagen source from chicken cartilage, and Mervia rounds out the blend. The capsule also contains inactive ingredients: cellulose, water, potassium chloride, and ascorbyl palmitate (a form of vitamin C used as a preservative).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint comfort and flexibility support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Knee pain, Joint inflammation, Cartilage support.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Knee pain.
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.

For this product's main ingredients, the evidence is limited. The 5-LOXIN extract (Boswellia serrata) is rated possibly effective for osteoarthritis, which is the condition most people take joint supplements for.

Hyaluronic acid is rated possibly effective for dry eye and venous leg ulcers, but for skin aging and other uses the evidence isn't established. For the other active ingredients in this blend—Methylsulfonylmethane, Total Collagen, UC-II Standardized Cartilage, and Mervia—we don't have effectiveness ratings in our data.

The evidence, ingredient by ingredient Hyaluronic Acid Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, hyaluronic acid and Boswellia serrata extract are generally well tolerated, though long-term safety of either supplement hasn't been fully studied. The most common side effects from Boswellia are stomach upset (abdominal pain, diarrhea, nausea, heartburn) and headache; a small number of people report dizziness or itching.

One rare case of a large stomach obstruction (bezoar) was reported in someone who chewed and swallowed large amounts of boswellia gum resin. For pregnancy and breastfeeding: Boswellia serrata is rated likely safe in pregnancy and lactation based on the data we hold, but hyaluronic acid has insufficient safety data for oral use in pregnancy and lactation—talk with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Hyaluronic Acid Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any medications your liver breaks down, especially antidepressants, blood pressure medications, blood thinners like warfarin, and drugs taken after organ transplants—the 5-LOXIN extract may raise their levels. Also flag any immunosuppressant drugs.

Talk it over with your own doctor or pharmacist with your complete medication list in hand.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking medications processed by your liver—especially antidepressants, blood pressure drugs, blood thinners, or immunosuppressants—check with your own pharmacist or doctor before starting this product because of the 5-LOXIN ingredient. The supplement is generally well tolerated by mouth, though stomach upset and headache can happen.

For joint support, Boswellia serrata has some evidence behind it, but the full blend's effectiveness isn't established in our data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Joint Complex (Single Dose), straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298014791
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 293989
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Joint Complex (Single Dose) by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
766298014791
IngredientAmount% DV
Hyaluronic Acid70 mg--
Methylsulfonylmethane400 mg--
Total Collagen10 mg--
5-LOXIN100 mg--
UC-II Standardized Cartilage40 mg--
Mervia100 mg--

Other ingredients: Cellulose, Water, Potassium Chloride, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule daily, with a meal.

Once-daily joint support formula

Precautions

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Brand IP Statement(s)

HyaMax is a U.S.A. registered trademark of Fenchem. OptiMSM is a registered trademark of Bergstrom Nutrition

5-Loxin is a registered trademark of PL thomas - laila nutrition, LLC and is used under license. International patents pending. UC-II & logo are trademarks of Lonza or its afilliates. Merva bio available curcumin is a trademark of indena S.p.A. Phytosome more bioavailable is a trademark of indena S.p.A.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

Seals/Symbols

GFCO.org (Gluten-free Certification Organization)

Formulation

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Joint Complex (Single Dose) by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Joint Complex (Single Dose) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Joint Complex (Single Dose) by Pure Encapsulations

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hyaluronic Acid

No known
interactions
70 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Methylsulfonylmethane

400 mg per serving

5-LOXIN

Interacts with
952 drugs
100 mg per serving Form: Indian Frankincense Gum Resin Extract

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

5-LOXIN monograph & interactions

UC-II Standardized Cartilage

40 mg per serving Form: Chicken Sternal Cartilage
  • › Total Collagen

Mervia

100 mg per serving Form: Turmeric Phytosome

Other (inactive) ingredients: Cellulose, Water, Potassium Chloride, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Joint Complex (Single Dose) by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Joint Complex (Single Dose)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

5-LOXIN 952

Individual Drug Interactions

The ingredients in Joint Complex (Single Dose) interact with 952 drugs. Click any drug to see the details.

1 of the 5 ingredients in Joint Complex (Single Dose) interact with drugs. Each result below shows which ingredient is responsible. 5-LOXIN

Each ingredient & the kinds of drugs it affects

For each ingredient in Joint Complex (Single Dose) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

5-LOXIN6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
5-LOXIN full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Joint Complex (Single Dose), from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Joint Complex (Single Dose) by Pure Encapsulations: Common Questions

Does Joint Complex (Single Dose) by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Joint Complex (Single Dose) has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Joint Complex (Single Dose) contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
Boswellia serrata is rated likely safe in pregnancy and lactation based on the data we hold. Hyaluronic acid doesn't have enough safety information for oral use during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice before taking this product while pregnant or nursing.
What's 5-LOXIN and why is it in here?
5-LOXIN is a standardized extract from Boswellia serrata, a plant resin used traditionally to support joint health. Research suggests it may help with osteoarthritis symptoms. It's included in this blend for that potential joint-supporting role.
What side effects might I get from this supplement?
The most common ones from Boswellia are stomach upset—like abdominal pain, diarrhea, nausea, or heartburn—and headache. A small number of people report dizziness or itching. Hyaluronic acid taken by mouth is generally well tolerated. Stop and talk to your doctor if you develop serious stomach pain or persistent side effects.
Does this actually work for joint pain?
The 5-LOXIN extract (Boswellia serrata) is rated possibly effective for osteoarthritis. The other active ingredients—collagen, hyaluronic acid, and the others—don't have established effectiveness ratings in our data. Results vary from person to person.
What are the inactive ingredients?
The capsule contains cellulose (a plant-based filler), water, potassium chloride, and ascorbyl palmitate (a form of vitamin C used as a preservative). None of these are active ingredients.
Can I take this with my other supplements?
Since we don't have interaction data for Methylsulfonylmethane, Total Collagen, UC-II Standardized Cartilage, or Mervia, we can't say for sure. The 5-LOXIN may interact with certain medications your liver processes. Check with your pharmacist or doctor before combining this with anything else you're taking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Joint Complex (Single Dose) label
Go deeper

The Full Monographs Behind Joint Complex (Single Dose)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Joint Complex (Single Dose)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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