Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Kava Kava Valerian Ingredients & Drug Interactions

by Pachamama

Kava Kava Valerian label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kava Kava Valerian against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Kava Kava Valerian is a dietary supplement by Pachamama with 3 active ingredients. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 1,339 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Kava Kava root extract, Hemp extract, Valerian root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kava Kava Valerian by Pachamama

Ask about any prescription or over-the-counter medication and we check it for interactions with Kava Kava Valerian by Pachamama — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Kava Kava Valerian by Pachamama

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Hemp extract” is listed as a grouped ingredient — the label gives one combined amount (85 mg) without saying how much of each component you get.

This liquid supplement contains 3 active ingredients. Valerian root extract is included to support sleep and relaxation.

Kava kava root extract is added for its traditionally used calming properties. Hemp extract and cannabidiol (CBD) are also present in the formula.

The product contains MCT coconut oil as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

  • Insomnia via Valerian Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Insomnia — rated "Possibly Effective" (Valerian) (Natural Medicines).

Valerian root is possibly effective for insomnia, meaning there is some evidence it may help with sleep, though the data isn't conclusive. For restless legs syndrome, pre-procedural anxiety, stress, and painful menstrual cramps (dysmenorrhea), the evidence is insufficient to rate whether valerian works.

Kava kava shows a possibly ineffective rating for generalized anxiety disorder—the evidence suggests it may not help with this condition. For insomnia, sexual arousal, and epilepsy, there isn't enough reliable evidence to know if kava works.

The evidence for cannabidiol is not established in the data we hold.

The evidence, ingredient by ingredient Valerian Kava Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Valerian is generally well tolerated in the short term, but long-term safety hasn't been well studied. The most common side effects include dizziness, drowsiness, mental slowness, headache, stomach upset, excitability, and vivid dreams.

If you take it for a long time and then stop abruptly, withdrawal symptoms like rapid heartbeat, anxiety, irritability, and insomnia can occur—so taper your dose slowly if you've been using it for weeks. Rare cases of liver damage have been reported with multi-ingredient products containing valerian, though it's not always clear valerian was the culprit.

Kava is also generally well tolerated and commonly causes drowsiness, dry mouth, dizziness, stomach upset, headache, memory problems, and tremor. The major safety concern is liver injury: over 100 cases of hepatotoxicity have been reported worldwide, and kava is banned or restricted in some countries because of this risk.

Serious liver damage can show up after as little as 3–4 weeks of use. Valerian is not considered safe in pregnancy and should be avoided; the same applies to kava.

Neither ingredient has enough safety data to recommend during breastfeeding. We hold no safety data for cannabidiol in this product.

Side effects, ingredient by ingredient Valerian Kava Hemp

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Valerian, Kava.
  • The most serious interaction on file is rated Major.
  • For scale: 1,178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with a pharmacist if you take CNS depressants (sedatives, sleep aids, anti-anxiety drugs like benzodiazepines, or opioids)—kava poses a Major risk of additive drowsiness and impaired reflexes. Check if you take any medications broken down by your liver, particularly those using the CYP2C19, CYP2C9, CYP2E1, UGT1A1, or UGT2B7 enzyme systems.

Flag any drugs that can harm the liver or alprazolam (Xanax) specifically. Avoid combining this with alcohol.

If you take haloperidol (an antipsychotic) or ropinirole (a Parkinson's medication), talk to your pharmacist—rare but serious effects have been reported.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product combines two herbal sedatives and is best considered if you're looking for sleep or relaxation support and have no active medications. If you take anything for anxiety, sleep, pain, heart rhythm, mood, or Parkinson's disease, or if you drink alcohol regularly, check your medications with the tool on this page before starting.

Pregnant and breastfeeding people should avoid it. Talk to your pharmacist about whether this is right for you, especially if you use it regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kava Kava Valerian, straight from the product label.

Brand Pachamama
Barcode (UPC) 814826026560
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 230108
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kava Kava Valerian by Pachamama, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
814826026560
IngredientAmount% DV
Calories10 Calorie(s)--
Total Fat1 Gram(s)1%
Valerian root extract10 mg--
Kava Kava root extract92 mg--
Hemp extract85 mg--
Cannabidiol59 mg--

Other ingredients: MCT Coconut Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Usage: Shake well before use. Do not exceed 2 servings per day.

Precautions

Do not exceed 2 servings per day.

Caution: This product is not intended for pregnant or lactating mothers. Individuals with any known medical conditions or taking medication should consult with a licensed physician prior to use.

If you experience any adverse symptoms, please discontinue, and consult your doctor.

Keep out of the reach of children.

Please be advised that consuming kava products may pose a risk to consumers and is not recommended for use by persons under 18 years of age or by pregnant or breastfeeding women.

Please be advised that consuming kava products may pose a risk to consumers and is not recommended for use by persons under 18 years of age or by pregnant or breastfeeding women.

Kava is not recommended to be used with alcoholic beverages. More information is available upon request.

Storage

Do not expose to direct sunlight. Store in a cool, dark place to preserve freshness.

General Statements

IN: ELM1700082

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Relax

We don't just love mother earth, we love you. We appreciate that you read the fine print and we are serious about the quality goods created at Pachamama. For more information visit us at: enjoypachamama.com & IG:enjoypachamama

KKV 1750

Fair trade

Seals/Symbols

Clean Label Project Purity Award

Formulation

Solvent free extraction methodology

No artificial flavors No preservatives No sweeteners

Naturally grown + pesticide free

Naturally grown + pesticide free

Single origin Proprietary extraction technology

cGMP compliant

Non GMO

Triple lab tested All naturally sourced ingredients Made in the USA with ingredients from around the world

No propane No butane No hexane No CO2 Solvent free extraction methodology

Formula

Full spectrum hemp extract Tincture 1750 mg delta CBD

This product contains a total delta-9-THC concentration that does not exceed 0.3% on a dry-weight basis.

Kava Kava Use of this sacred root pre-dates written history. Originating out of the most remote and exotic part of the world, this ceremonial plant has been touted for its euphoric and subdued effect; promoting restfulness and deep sleep. Valerian A flowering plant used as far back as ancient Greece, commonly recognized and researched for its relaxing and calming effects.

CBD

Our hemp Whole plant

Less than .3% THC

FDA Statement of Identity

Hemp Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This product has not been evaluated by the Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. This product has not been evaluated by the FDA for safety or efficacy.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kava Kava Valerian by Pachamama label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kava Kava Valerian label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kava Kava Valerian by Pachamama

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Valerian root extract

Interacts with
902 drugs
10 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Valerian root extract monograph & interactions

Kava Kava root extract

Interacts with
1,166 drugs
92 mg per serving

Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety. However,...

Kava Kava root extract monograph & interactions

Hemp extract

Interacts with
938 drugs
85 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp extract monograph & interactions
  • › Cannabidiol

Other (inactive) ingredients: MCT Coconut Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kava Kava Valerian by Pachamama Drug Interactions

Want to check YOUR meds against Kava Kava Valerian?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,339Drugs
248 Major 598 Moderate 493 Minor

Ingredients driving the most interactions

Kava Kava root extract 1,166
Hemp extract 938
Valerian root extract 902

Individual Drug Interactions

The ingredients in Kava Kava Valerian interact with 1,339 drugs. Click any drug to see the details.

3 of the 3 ingredients in Kava Kava Valerian interact with drugs. Each result below shows which ingredient is responsible. Kava Kava root extract Hemp extract Valerian root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Kava Kava Valerian with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Kava Kava root extract12 drug types · 1,166 drugs

Cns Depressants

Combining kava with CNS depressants can have additive sedative effects.
Kava has CNS depressant effects. Concomitant use of kava with other CNS depressants can increase the risk of drowsiness and motor reflex depression. Clinical practice guidelines from a joint taskforce of the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Treatments (CANMAT) recommend that CNS depressants, including alcohol and benzodiazepines, not be used with kava.

Likelihood Probable Evidence A
Alcohol (Ethanol)

Combining kava with alcohol may increase the risk of sedation and/or hepatotoxicity.

Kava has CNS depressant effects. Concomitant use of kava with other CNS depressants can increase the risk of drowsiness and motor reflex depression. Additionally, kava has been associated with over 100 cases of hepatotoxicity. There is some concern that kava can adversely affect the liver, especially when used in combination with hepatotoxic drugs. Clinical practice guidelines from a joint taskforce of the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Treatments (CANMAT) recommend that alcohol not be used with kava.

Likelihood Possible Evidence A
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, kava might increase levels of CYP2C19 substrates.
In vitro research shows that kava significantly inhibits CYP2C19 enzymes. This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, kava might increase levels of CYP2C9 substrates.
In vitro research shows that kava significantly inhibits CYP2C9 enzymes. This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Kava might increase levels of CYP2E1 substrates.
In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days inhibited the metabolism of CYP2E1 substrates.

Likelihood Probable Evidence B
Haloperidol (Haldol)

Combining kava and haloperidol might increase the risk of cardiovascular adverse effects and hypoxia.
Atrial flutter and hypoxia has been reported for a patient who received intramuscular injections of haloperidol and lorazepam after using kava orally. The side effects were attributed to kava-induced inhibition of CYP2D6, but might also have been related to additive adverse effects with the concomitant use of haloperidol, lorazepam, and kava.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.
Kava has been linked with over 100 cases of hepatotoxicity. Most cases occur with excessive and prolonged use. There is some concern that kava can adversely affect the liver, especially when used in combination with hepatotoxic drugs.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.
In vitro research shows that kava can inhibit P-gp efflux. However, a clinical study in healthy volunteers shows that taking kava standardized to provide 225 mg kavalactones daily for 14 days does not affect the pharmacokinetics of digoxin, a P-gp substrate. It is possible that the use of other P-gp substrates or higher doses of kava might still inhibit P-gp.

Likelihood Possible Evidence D
Ropinirole (Requip)

Taking kava with ropinirole might increase the risk for dopaminergic toxicity.
A case of visual hallucinations and paranoid delusions has been reported for a patient who used kava in combination with ropinirole. The adverse effects were attributed to kava-induced inhibition of CYP1A2, which may have reduced the metabolism of ropinirole, resulting in excessive dopaminergic stimulation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

It is unclear if kava inhibits CYP1A2; research is conflicting.
Although in vitro research and a case report suggest that kava inhibits CYP1A2, more robust clinical evidence shows that kava has no effect on CYP1A2. In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days had no effect on CYP1A2 activity.

Likelihood Unlikely Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

It is unclear if kava inhibits CYP1A2; research is conflicting.
In vitro research shows that kava extract significantly inhibits CYP2D6. However, clinical research shows that kava does not affect the metabolism of CYP2D6 substrates in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if kava inhibits CYP3AA; research is conflicting.
Although in vitro research suggests that kava inhibits CYP3A4, more robust clinical evidence shows that kava has no effect on CYP3A4. In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days had no effect on CYP3A4 activity.

Likelihood Unlikely Evidence B
Kava Kava root extract full monograph & interactions

Hemp extract6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp extract full monograph & interactions

Valerian root extract6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kava Kava Valerian, from the product label.

Pachamama

See all Pachamama products
Name
Pachamama
Street Address
1288 S Broadway
City
Denver
State
CO
ZipCode
80210
Web Address
enjoypachamama.com
Pharmacist Counseling Corner

Kava Kava Valerian by Pachamama: Common Questions

Does Kava Kava Valerian by Pachamama interact with any medications?
Yes. Based on its ingredients, Kava Kava Valerian has a known interaction with 1,339 medications, including 248 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kava Kava Valerian contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Valerian safety has not been established in pregnancy, so it's best avoided. Kava is not considered safe during pregnancy and should be avoided. For breastfeeding, neither ingredient has enough safety data, so both should be avoided due to the risk of possible effects on your baby. Talk with your doctor or pharmacist for personalized advice.
Will this help me sleep?
Valerian is possibly effective for insomnia, meaning some evidence suggests it may help, though it's not certain. Kava doesn't have enough reliable evidence to say whether it helps with insomnia. Your individual response may vary.
What are the most common side effects?
From valerian, you might experience dizziness, drowsiness, mental slowness, headache, stomach upset, or vivid dreams. Kava commonly causes drowsiness, dry mouth, dizziness, stomach upset, headache, memory problems, and tremor. If you use it long-term and then stop suddenly, withdrawal symptoms like rapid heartbeat, anxiety, or insomnia can occur—so taper slowly.
Is this safe to use long-term?
Valerian is generally well tolerated short-term, but long-term safety hasn't been well studied. Kava's main long-term concern is liver damage—over 100 cases have been reported, some appearing after as little as 3–4 weeks of use. We don't recommend long-term use without talking to your pharmacist first.
Can I drink alcohol while taking this?
No. Both valerian and kava can cause additive sedative effects when combined with alcohol, meaning you could become excessively drowsy. Avoid alcohol while using this product.
What is cannabidiol (CBD) in this product?
Cannabidiol is one of the active cannabinoids derived from hemp. We don't hold interaction or effectiveness data for it in our database, so we can't tell you what it does or how it might interact with your medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kava Kava Valerian label
Go deeper

The Full Monographs Behind Kava Kava Valerian’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Kava

Interacts with 1,166 drugs

Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety. However, kava has been linked to rare but serious...

Read the full Kava monograph → Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Kava Kava Valerian's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Valerian 37 references
  1. Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
  2. Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
  3. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  4. Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
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Hemp 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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