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Dietary supplement

L-Glutamine 1000 mg Ingredients & Drug Interactions

by Totally Products

Tablet Or Pill Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Glutamine 1000 mg is a dietary supplement by Totally Products with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Glutamine 1000 mg by Totally Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Glutamine at 1000 mg per tablet. L-Glutamine is an amino acid — one of the building blocks your body uses to make protein.

It's also present naturally in foods like meat, eggs, and dairy. The tablet also contains several inactive ingredients (fillers and binders) including dicalcium phosphate, stearic acid, croscarmellose sodium, magnesium stearate, pharmaceutical glaze, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glutamine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Glutamine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Natural Medicines).

L-Glutamine has evidence supporting its use in sickle cell disease. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is currently labeled as possibly effective — meaning there's some promise, but more research is needed to be certain.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults. The most common side effects from taking it by mouth are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.

Headache and musculoskeletal pain have also been reported. People with kidney or liver disease should only use this supplement under their doctor's supervision.

There's not enough reliable safety data in pregnancy, so the data advises using it in pregnancy only if your doctor recommends it. Similarly, safety information while breastfeeding is limited — avoid supplement doses unless a clinician advises otherwise.

Rare cases of mania or hypomania have been reported in people with bipolar disorder taking glutamine; if you have a bipolar condition, talk with your doctor before starting.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (seizure drugs), check with your doctor or pharmacist before starting L-Glutamine — the supplement might theoretically reduce how well they work, though this hasn't been reported in people yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

L-Glutamine may help with sickle cell disease and shows promise for HIV/AIDS-related wasting and recovery from surgery or critical illness. If you take anticonvulsant medications, check with your doctor or pharmacist before you start, since glutamine might interfere with how they work.

It's generally well tolerated, but GI side effects like bloating and nausea can happen. Talk it over with your own doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine 1000 mg, straight from the product label.

Brand Totally Products
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294251
Product type Amino Acid/protein
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine 1000 mg by Totally Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
IngredientAmount% DV
L-Glutamine1000 mg--

Other ingredients: Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Pharmaceutical Glaze, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 1 tablet taken 1 to 3 times daily between meals or as directed by a healthcare professional.

Precautions

Caution: Do not exceed recommended dosage.

This product is not intended for pregnant or nursing mothers or children under the age of 18.

This product is not intended for pregnant or nursing mothers or children under the age of 18.

If you have a known medical condition and have questions about the advisability of taking this product, consult your physician prior to use.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Sourced From A GMP Certified Facility Made in USA

100% Satisfaction Guarantee

FDA Statement of Identity

Dietary Supplement

Formulation

Supports muscle mass Supports recovery from workouts Ultimate recovery fuel

Storage

Store in a cool, dry place.

See for yourself

L-Glutamine 1000 mg by Totally Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutamine 1000 mg by Totally Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
1000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Pharmaceutical Glaze, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine 1000 mg by Totally Products Drug Interactions

Want to check YOUR meds against L-Glutamine 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Glutamine 1000 mg, from the product label.

Totally Products

See all Totally Products products
Name
Totally Products LLC
Street Address
1835 E Hallandale Bch Blvd suite 425
City
Hallandale
State
FL
ZipCode
33009
Phone Number
800-924-0710
Pharmacist Counseling Corner

L-Glutamine 1000 mg by Totally Products: Common Questions

Does L-Glutamine 1000 mg by Totally Products interact with any medications?
Yes. Based on its ingredients, L-Glutamine 1000 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Glutamine safe during pregnancy or while breastfeeding?
The product facts say L-Glutamine is likely safe in pregnancy, so you may use it during pregnancy. For breastfeeding, safety data is limited — the facts advise against supplement doses unless your doctor or lactation specialist recommends it. Talk with your healthcare provider for personalized advice.
What side effects might I experience from this supplement?
The most common are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting. Some people also report headache or muscle pain. These tend to happen, especially at higher doses. If you experience side effects, try lowering your dose and talk with your pharmacist.
Will this work for my condition?
L-Glutamine is effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma — meaning there's evidence it may help, but more research is needed. For other uses, the evidence isn't established in the data we hold. Talk with your doctor about whether it's right for your specific situation.
Can I take this if I have kidney or liver disease?
The supplement facts recommend using L-Glutamine only under medical supervision if you have kidney or liver disease. Don't start this supplement on your own — talk with your doctor first about whether it's appropriate for you.
I have bipolar disorder. Is this supplement safe for me?
There are rare reports of mania and hypomania in people with bipolar disorder taking glutamine. Before you start, talk with your doctor about this risk and whether L-Glutamine is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine 1000 mg label
Go deeper

The Full Monographs Behind L-Glutamine 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutamine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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