L-Glutamine Ingredients & Drug Interactions
by Source Naturals
What is this page for?
First and foremost: checking L-Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Glutamine is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Glutamine by Source Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glutamine by Source Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Glutamine by Source Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Glutamine, an amino acid your body produces naturally. It's found in foods and is often used by people recovering from surgery, illness, or intense physical stress.
There are no inactive ingredients listed for this powder.
Does it work?
Not established
L-Glutamine is effective for sickle cell disease. The evidence supports possibly effective use for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.
The strength of that evidence varies — sickle cell is the strongest — but the data we hold shows measurable benefit for these conditions when studied.
How safe is it?
Well-documented data
L-Glutamine is generally well tolerated in healthy adults. The most common side effects are digestive: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.
Headache and musculoskeletal pain have also been reported. People with kidney or liver disease should use it only under medical supervision.
If you're pregnant, the available data rates it likely safe. If you're breastfeeding, not enough reliable safety information exists, so talk with your doctor or pharmacist before taking supplemental doses.
Dizziness has occurred in individual cases and resolved when the dose was reduced.
Meds to double-check
Moderate interaction found
Anticonvulsant medications are the main concern — the ones used to prevent or manage seizures. Glutamine might theoretically work against them, though this hasn't been proven in people.
Check your specific anticonvulsants with your doctor or pharmacist before taking this product.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
L-Glutamine may help if you're recovering from surgery, dealing with critical illness, or managing HIV/AIDS-related wasting, and it's proven effective for sickle cell disease. It's generally well tolerated, though digestive side effects are common.
If you take anticonvulsant medication, check with your doctor or pharmacist before starting it. For personalized advice about whether this supplement fits your situation, talk it over with your own healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Glutamine, straight from the product label.
| Brand | Source Naturals |
|---|---|
| Barcode (UPC) | 021078015482 |
| Net contents | 16 Oz(s); 453.6 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2017 |
| DSLD ID | 75515 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Glutamine by Source Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| L-Glutamine | 2 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
Non GMO Validated
FDA Statement of Identity
Amino Acid Supplement
General Statements
Free-form powder
L-Glutamine, a free-form amino acid, can be converted to glutamic acid. Glutamic acid is a usable energy source for the brain and a precursor to the important inhibitory neurotransmitter GABA (gamma-aminobutyric acid). L-Glutamine also plays an important role in ammonia disposal.
Suggested/Recommended/Usage/Directions
Suggested Use: 1/4 to 1/2 teaspoon daily, mixed with water or juice between meals.
Precautions
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Formulation
Suitable for Vegetarians.
Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
SN1548 REV K152
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Glutamine by Source Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Glutamine by Source Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.25 tsp Dosage formPowder Servings per container226 Amounts shown are per serving.
L-Glutamine
Interacts with50 drugs
Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...
L-Glutamine monograph & interactionsL-Glutamine by Source Naturals Drug Interactions
HelloPharmacist Interaction Report
L-Glutamine by Source Naturals has one documented interaction category: anticonvulsant medications (the drugs used to prevent seizures).
The concern is theoretical rather than proven in humans. Glutamine breaks down into glutamate, an excitatory brain chemical that might work against anticonvulsants, but this specific conflict hasn't been reported in people taking the supplement.
Altogether, these interactions span 50 individual medications.
Read the full breakdown — every affected drug type, severity by severity
If you take an anticonvulsant, it's worth a conversation with your doctor or pharmacist before starting L-Glutamine — not because the risk is certain, but because the mechanism exists and should be monitored. They can help you decide if it's right for you or if your dose needs adjusting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Glutamine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Glutamine interact with 50 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine
AcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Acetazolamide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Aminophylline, Amobarbital, Ephedrine interactionAmobarbitalAmytal
How Amobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital, Secobarbital interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Aprobarbital, Butabarbital, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Butalbital, Phenobarbital, Secobarbital interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Carbamazepine interactionCenobamateXcopri
How Cenobamate interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Cenobamate interactionClobazamFrisium, Onfi, Sympazan
How Clobazam interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clobazam interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clonazepam interactionClorazepateTranxene, Tranxene SD, Tranxene T-Tab
How Clorazepate interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clorazepate interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Diazepam interactionDivalproex SodiumDepakote
How Divalproex Sodium interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Divalproex Sodium interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ephedrine, Phenobarbital, Theophylline interactionEthosuximideZarontin
How Ethosuximide interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ethosuximide interactionEthotoinPaganone
How Ethotoin interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ethotoin interactionFelbamateFelbatol
How Felbamate interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Felbamate interactionFosphenytoinCerebyx
How Fosphenytoin interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Fosphenytoin Sodium interactionGabapentinGralise, Neurontin
How Gabapentin interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Gabapentin interactionGabapentin EnacarbilHorizant
How Gabapentin Enacarbil interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Gabapentin Enacarbil interactionLamotrigineLamictal
How Lamotrigine interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Lamotrigine interactionLevetiracetamElepsia XR, Keppra, Spritam
How Levetiracetam interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Levetiracetam interactionLorazepamAtivan
How Lorazepam interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Lorazepam interactionMagnesium Sulfate (prescription Drug)Bilagog, Magnesium Sulfate
How Magnesium Sulfate (prescription Drug) interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Magnesium Sulfate (prescription Drug) interactionMephenytoinMesantoin
How Mephenytoin interacts with L-Glutamine — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Mephenytoin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Brand information
Manufacturer and brand details for L-Glutamine, from the product label.
Source Naturals
- Name
- Source Naturals, Inc.
- Street Address
- P. O. Box 2118
- City
- Santa Cruz
- State
- CA
- ZipCode
- 95062
- Web Address
- www.sourcenaturals.com
L-Glutamine by Source Naturals: Common Questions
Does L-Glutamine by Source Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-Glutamine safe if I'm pregnant or breastfeeding?
What side effects should I expect?
Does L-Glutamine actually work?
Can I take this if I have kidney or liver disease?
Why would someone take L-Glutamine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Glutamine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Glutamine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC