No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Proline 500 mg Ingredients & Drug Interactions

by Douglas Laboratories

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Proline 500 mg is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Proline 500 mg by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Proline, an amino acid, at 500 mg per capsule. L-Proline is one of the amino acids your body uses to build and repair connective tissue, particularly collagen.

The capsule also contains inactive ingredients — gelatin, microcrystalline cellulose, magnesium silicate, and vegetable stearate — which are standard fillers and binders that help hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Proline product and its label doesn't state a use — see Proline's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on L-Proline for athletic performance, bone health (osteoporosis, osteopenia, and fractures), and wound healing is currently insufficient to rate. We don't have reliable data showing it works or doesn't work for any of these uses.

If you're considering it for one of these purposes, talk with your doctor about whether supplementing makes sense for your situation.

The evidence, ingredient by ingredient Proline

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Proline is generally well tolerated when you get it from food sources, but supplement safety at higher doses hasn't been well studied. The safety notes advise caution with supplemental amounts — it's best to avoid extra beyond what your doctor recommends.

There isn't enough data on safety while breastfeeding, so use caution if you're nursing. For pregnancy, we don't have enough reliable information to say either way — talk with your doctor or pharmacist about whether it's appropriate for you.

Side effects, ingredient by ingredient Proline

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for L-Proline in our data. You're clear to use it alongside your medications from an interaction standpoint, though it's always smart to mention any new supplement to your pharmacist or doctor.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.

L-Proline is an amino acid your body uses for connective tissue, but we don't have solid evidence it works for athletic performance, bone health, or wound healing yet. It has no known medication interactions.

If you're thinking about taking it, especially while pregnant or breastfeeding, or if you're taking it for a specific health goal, check with your doctor or pharmacist first to make sure it's the right choice for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Proline 500 mg, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539016831
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232305
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Proline 500 mg by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
310539016831
IngredientAmount% DV
L-Proline500 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Silicate, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 capsule daily or as directed by your health professional.

Precautions

Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

FDA Statement of Identity

Dietary Supplement

See for yourself

L-Proline 500 mg by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Proline 500 mg by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

L-Proline

No known
interactions
500 mg per serving

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...

L-Proline monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Silicate, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Proline 500 mg by Douglas Laboratories Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Proline 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Proline 500 mg, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

L-Proline 500 mg by Douglas Laboratories: Common Questions

Does L-Proline 500 mg by Douglas Laboratories interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Proline 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Proline 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-Proline and what does it do in the body?
L-Proline is an amino acid — one of the building blocks your body uses to make and repair proteins, especially collagen in connective tissue. Your body can make some on its own, and you also get it from protein-rich foods like meat, dairy, and eggs.
Does L-Proline really help with wound healing or bone strength?
The evidence isn't solid yet. The research on L-Proline for wound healing, osteoporosis, fractures, and osteopenia is insufficient to say whether it works. If you're dealing with a bone or wound concern, talk with your doctor about proven treatments.
Is it safe to take L-Proline while I'm pregnant or breastfeeding?
We don't have enough reliable data to know either way for pregnancy. For breastfeeding, there's not enough safety information, so caution is advised. Talk with your doctor or pharmacist about your specific situation before taking it during pregnancy or while nursing.
Are there any side effects from taking L-Proline?
No adverse effects are documented in our data. That said, supplement safety at higher doses hasn't been well studied, so it's best to stick to doses your doctor recommends and avoid extra amounts on your own.
Can I take this with my medications?
No interactions are documented between L-Proline and any medications in our data. Still, mention this supplement to your pharmacist or doctor so they can double-check against your full medication list.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Proline 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Proline 500 mg label
Go deeper

The Full Monographs Behind L-Proline 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Proline 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

See these in context on the Proline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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