No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Proline Powder Ingredients & Drug Interactions

by Source Naturals

Powder Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Proline Powder is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Proline Powder by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-proline, an amino acid your body uses in collagen and connective tissue. There are no inactive ingredients listed for this powder.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Proline's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy joints and musculoskeletal system.
  • We looked for evidence on: Fractures, Osteoporosis, Osteopenia, Wound healing, cartilage health, connective tissue support — and 1 related terms.
  • The closest evidence on file: Proline is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis (Natural Medicines).
  • Also on file: Proline is rated "Insufficient Reliable Evidence To Rate" for Fractures, Wound healing, Osteopenia.

The evidence we hold does not establish that L-proline works for athletic performance, bone health (osteoporosis, osteopenia, or fracture prevention), or wound healing. The available data is rated insufficient to say whether it helps with any of these uses.

If you're considering it for a specific health goal, talk it over with your doctor or pharmacist about whether the current evidence supports trying it.

The evidence, ingredient by ingredient Proline

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-proline is generally considered low-risk when eaten in food, but the safety of taking it as a supplement in extra amounts has not been well studied. The data we hold does not give us reliable information on what dose is safe to use, so it's best to avoid supplemental amounts unless your doctor advises otherwise.

There isn't enough reliable data on whether L-proline is safe to take while breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist about whether this supplement is right for you.

Side effects, ingredient by ingredient Proline

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-proline. If you take any medications, you can confirm there are no concerns using the search tool on this page, or check with your own doctor or pharmacist before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and some safety-information gaps remain.

L-proline is an amino acid with no documented drug interactions, so timing with medications is not a concern. However, the evidence does not yet establish that it works for athletic performance, bone health, or wound healing, and supplement safety at higher doses hasn't been well studied.

If you're thinking about using it, discuss your reason and dose with your doctor or pharmacist to make sure it fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Proline Powder, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078015512
Net contents 4 Ounce(s); 113.4 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295950
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Proline Powder by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
56
UPC/BARCODE
021078015512
IngredientAmount% DV
Calories10 Calorie(s)--
L-Proline2 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

L-Proline is an amino acid involved in the production of collagen and cartilage and may help support healthy joints and a healthy musculoskeletal system. L-Proline can be made in the body, but low protein/vegetarian diets may not always promote optimal production.

Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: 1-2 level teaspoons daily, mixed for 1 to 2 minutes with water or juice.

Formulation

Suitable for vegetarians and hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat.

Suitable for vegetarians and hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat.

Suitable for vegetarians and hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright SOURCE NATURALS, INC.

See for yourself

L-Proline Powder by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Proline Powder by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container56 Amounts shown are per serving.

L-Proline

No known
interactions
2 Gram(s) per serving

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...

L-Proline monograph & interactions
Interaction report

L-Proline Powder by Source Naturals Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Proline Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Proline Powder, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

L-Proline Powder by Source Naturals: Common Questions

Does L-Proline Powder by Source Naturals interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Proline Powder. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Proline Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-proline help with muscle building or athletic performance?
The evidence we hold does not establish that L-proline works for athletic performance. The data is rated insufficient to say whether it helps, so we can't make a claim about it one way or the other.
Can L-proline help with bone health or fracture healing?
The evidence we hold does not establish that L-proline helps with osteoporosis, osteopenia, fractures, or general bone health. The data is rated insufficient for all of these uses.
Is L-proline safe to take at higher doses?
The safety of supplemental doses has not been well studied. It's best to avoid taking extra amounts unless your doctor advises it and monitors your use.
Can I take L-proline while breastfeeding?
There isn't enough reliable data to know whether L-proline is safe at supplemental doses while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What is L-proline and what does it do in my body?
L-proline is an amino acid — one of the building blocks your body uses to make and repair proteins, especially collagen and connective tissue. You get some from food sources like meat and dairy.
Does this powder have any fillers or inactive ingredients?
No inactive ingredients are listed for this product — it is L-proline powder only.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Proline Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Proline Powder label
Go deeper

The Full Monographs Behind L-Proline Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Proline Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

See these in context on the Proline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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