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Dietary supplement

L-Theanine 100 mg Ingredients & Drug Interactions

by Healthy Origins

L-Theanine 100 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Theanine 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Theanine 100 mg is a dietary supplement by Healthy Origins with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Theanine 100 mg by Healthy Origins

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Theanine 100 mg by Healthy Origins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Theanine 100 mg by Healthy Origins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Healthy Origins L-Theanine contains one active ingredient: L-theanine at 100 mg per capsule. L-theanine is an amino acid found naturally in tea that is thought to promote relaxation without causing drowsiness.

The capsule also contains inactive ingredients — a vegetarian capsule shell, microcrystalline cellulose (a binder), and silicon dioxide (an anti-caking agent).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Theanine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: soothing effects and relaxation.
  • We looked for evidence on: Generalized anxiety disorder (GAD), Stress, Insomnia, anxiety, calm, relaxation.
  • The closest evidence on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

L-theanine is possibly effective for cognitive function — the evidence supports potential benefit here. For age-related cognitive decline, Alzheimer disease, generalized anxiety, obsessive-compulsive disorder, and cancer, the evidence we have is insufficient to rate whether it works.

If you're considering it for cognitive support, the data is most solid for that use; for other purposes, talk with your doctor about whether the evidence is enough for your situation.

The evidence, ingredient by ingredient Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated in healthy adults for short-term use, but long-term safety hasn't been well studied. Headaches, drowsiness, increased sleep duration, and increased dream activity have been reported.

There isn't enough safety data during pregnancy, so it's best to avoid L-theanine if you're pregnant. The same applies if you're breastfeeding — safety data is lacking, so talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Healthy Origins L-Theanine, double-check with your doctor or pharmacist if you take blood pressure–lowering medications (antihypertensives), sedating drugs like sleep aids or benzodiazepines, or serotonergic medications like antidepressants. These are the main medication types with documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

L-Theanine 100 mg may help with cognitive function, but the evidence is strongest for that use. If you take blood pressure medication, sedating drugs, or antidepressants, check with your doctor or pharmacist before starting, since theanine can interact with these.

Avoid it if you're pregnant or breastfeeding unless your doctor says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Theanine 100 mg, straight from the product label.

Brand Healthy Origins
Barcode (UPC) 603573170059
Net contents 180 Veggie Cap(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269118
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Theanine 100 mg by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
180
UPC/BARCODE
603573170059
IngredientAmount% DV
L-Theanine100 mg--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take one (1) vegetarian capsule once or twice daily, preferably on an empty stomach, or as directed by a physician.

Formula

L-Theanine is an amino acid found naturally in the Camellia sinensis (tea) plant. L-Theanine has been found to stimulate production of alpha waves in the brain, which may help create desirable soothing effects.

AlphaWave The Calming Wave

Precautions

Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.

Do not exceed the recommended dosage.

Keep out of reach of children

Brand IP Statement(s)

AlphaWave and ProfileProven are registered trademarks of Ethical Naturals, Inc.

Healthy Origins Since 1996

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

General Statements

New look

Formulation

Fermented Supports healthy mental clarity and focus

Not manufactured with wheat, gluten, milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Non GMO

Manufactured in a cGMP facility.

Suitable for vegans

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Seals/Symbols

ProfileProven Quality Assurance 3rd party tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Theanine 100 mg by Healthy Origins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Theanine 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Theanine 100 mg by Healthy Origins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

L-Theanine

Interacts with
565 drugs
100 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Theanine 100 mg by Healthy Origins Drug Interactions

Want to check YOUR meds against L-Theanine 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
565Drugs
172 Moderate 393 Minor

Ingredients driving the most interactions

L-Theanine 565

Individual Drug Interactions

The ingredients in L-Theanine 100 mg interact with 565 drugs. Click any drug to see the details.

1 of the 1 ingredient in L-Theanine 100 mg interact with drugs. Each result below shows which ingredient is responsible. L-Theanine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Theanine 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Theanine 100 mg, from the product label.

Healthy Origins

See all Healthy Origins products
Name
Healthy Origins
City
Pittsburgh
State
PA
ZipCode
15241
Phone Number
1-888-228-6650
Pharmacist Counseling Corner

L-Theanine 100 mg by Healthy Origins: Common Questions

Does L-Theanine 100 mg by Healthy Origins interact with any medications?
Yes. Based on its ingredients, L-Theanine 100 mg has a known interaction with 565 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Theanine 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take L-theanine if I'm pregnant or breastfeeding?
There isn't enough safety data for L-theanine during pregnancy or breastfeeding. It's best to avoid it unless your doctor or pharmacist advises otherwise based on your personal situation.
What are the side effects of L-theanine?
The most common reported side effects are headaches, drowsiness, increased sleep duration, and more vivid dreams. A single case of facial tics was reported in a child, but it wasn't clearly linked to the supplement.
How long has L-theanine been studied for safety?
L-theanine is generally well tolerated in healthy adults for short-term use, but long-term safety hasn't been well studied yet, so ongoing monitoring is important if you plan to take it for months.
Does L-theanine actually improve focus or memory?
L-theanine is possibly effective for cognitive function based on the evidence we have, so there's support for that use — but for Alzheimer disease or age-related decline, the evidence isn't strong enough to rate yet.
Can L-theanine make me drowsy?
Some people have reported drowsiness and increased sleep after taking L-theanine, so it may cause sedation in some individuals — especially if you're also taking sleep aids or other sedating medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Theanine 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Theanine 100 mg label
Go deeper

The Full Monographs Behind L-Theanine 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph →
Sources

Sources & How We Checked

L-Theanine 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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